| Title : HLo-7 - A review of acetylcholinesterase reactivator against organophosphorus intoxication - Psotka_2017_Mil.Med.Sci.Lett_86_70 |
| Author(s) : Psotka M , Malinak D , Gorecki L , Nguyen TD , Soukup O , Jun D , Kuca K , Musilek K , Korabecny J |
| Ref : Military Medical Science Letters , 86 :70 , 2017 |
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Abstract :
The treatment of organophosphate (OP) poisoning consists of the administration of a parasympatholytic agent, an anticonvulsant and an acetylcholinesterase (AChE) reactivator. Since there is no broad AChE reactivator available, a post-treatment strategy currently exploits administration of different types of oximes depending on the exposure of OP. In this contribution, we summarize all the available data about AChE reactivator HL-7 including its synthesis, physico-chemical properties, pharmacokinetic and pharmacodynamics profile, and its efficacy in vitro and in vitro. |
| PubMedSearch : Psotka_2017_Mil.Med.Sci.Lett_86_70 |
| PubMedID: |
| Reactivator | HLo-7 |
Psotka M, Malinak D, Gorecki L, Nguyen TD, Soukup O, Jun D, Kuca K, Musilek K, Korabecny J (2017)
HLo-7 - A review of acetylcholinesterase reactivator against organophosphorus intoxication
Military Medical Science Letters
86 :70
Psotka M, Malinak D, Gorecki L, Nguyen TD, Soukup O, Jun D, Kuca K, Musilek K, Korabecny J (2017)
Military Medical Science Letters
86 :70