Full name : Malinak David
First name : David
Mail : Biomedical Research Centre, University Hospital Hradec Kralove\; Department of Chemistry, University of Hradec Kralove\; Hradec Kralove
Zip Code :
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Country : Czech Republic
Email : davis.malinak@uhk.cz
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Comment
| Title : Phenoxytacrine derivatives: Low-toxicity neuroprotectants exerting affinity to ifenprodil-binding site and cholinesterase inhibition - Misiachna_2024_Eur.J.Med.Chem_266_116130 |
| Author(s) : Misiachna A , Svobodova B , Netolicky J , Chvojkova M , Kleteckova L , Prchal L , Novak M , Hrabinova M , Kucera T , Muckova L , Moravcova Z , Karasova JZ , Pejchal J , Blazek F , Malinak D , Hakenova K , Krausova BH , Kolcheva M , Ladislav M , Korabecny J , Pahnke J , Vales K , Horak M , Soukup O |
| Ref : Eur Journal of Medicinal Chemistry , 266 :116130 , 2024 |
| Abstract : |
| PubMedSearch : Misiachna_2024_Eur.J.Med.Chem_266_116130 |
| PubMedID: 38218127 |
| Title : Halogenated monopyridinium oximes are less effective in reactivation of phosphylated cholinesterases than bisquaternary oximes - Kohoutova_2024_Bioorg.Chem_153_107904 |
| Author(s) : Kohoutova Z , Prchalova E , Andrys R , Knittelova K , Formanova M , Hofmanova T , Psotka M , Musilek K , Derat E , Malinak D |
| Ref : Bioorg Chem , 153 :107904 , 2024 |
| Abstract : |
| PubMedSearch : Kohoutova_2024_Bioorg.Chem_153_107904 |
| PubMedID: 39467508 |
| Title : Brominated oxime nucleophiles are efficiently reactivating cholinesterases inhibited by nerve agents - Prchalova_2024_Arch.Toxicol__ |
| Author(s) : Prchalova E , Andrys R , Pejchal J , Kohoutova Z , Knittelova K , Hofmanova T , Skarka A , Dlabkova A , Psotka M , Prchal L , Musilek K , Karasova JZ , Malinak D |
| Ref : Archives of Toxicology , : , 2024 |
| Abstract : |
| PubMedSearch : Prchalova_2024_Arch.Toxicol__ |
| PubMedID: 38789714 |
| Title : Reactivators of butyrylcholinesterase inhibited by organophosphorus compounds - Kohoutova_2024_Bioorg.Chem_150_107526 |
| Author(s) : Kohoutova Z , Prchalova E , Knittelova K , Musilek K , Malinak D |
| Ref : Bioorg Chem , 150 :107526 , 2024 |
| Abstract : |
| PubMedSearch : Kohoutova_2024_Bioorg.Chem_150_107526 |
| PubMedID: 38878749 |
| Title : Synthesis and Evaluation of Halogenated Pralidoximes in Reactivation of Organophosphate-Inhibited Cholinesterases - Knittelova_2024_ACS.Med.Chem.Lett_15_2181 |
| Author(s) : Knittelova K , Prchalova E , Fuchsova A , Andrys R , Kohoutova Z , Rademacherova S , Prchal L , Musilek K , Malinak D |
| Ref : ACS Med Chem Lett , 15 :2181 , 2024 |
| Abstract : |
| PubMedSearch : Knittelova_2024_ACS.Med.Chem.Lett_15_2181 |
| PubMedID: 39691526 |
| Title : BODIPY-labelled acetylcholinesterase reactivators can be encapsulated into ferritin nanovehicles for enhanced bioavailability in the CNS - Prchalova_2023_Biomed.Pharmacother_167_115490 |
| Author(s) : Prchalova E , Sukupova M , Malinak D , Andrys R , Sivak L , Pekarik V , Skarka A , Svobodova J , Prchal L , Fresser L , Heger Z , Musilek K |
| Ref : Biomed Pharmacother , 167 :115490 , 2023 |
| Abstract : |
| PubMedSearch : Prchalova_2023_Biomed.Pharmacother_167_115490 |
| PubMedID: 37722189 |
| Title : Direct Chiral Supercritical Fluid Chromatography-Mass Spectrometry Analysis of Monoacylglycerol and Diacylglycerol Isomers for the Study of Lipase-Catalyzed Hydrolysis of Triacylglycerols - Kozlov_2023_Anal.Chem__ |
| Author(s) : Kozlov O , Horakova E , Rademacherova S , Malinak D , Andrys R , Prchalova E , Lisa M |
| Ref : Analytical Chemistry , : , 2023 |
| Abstract : |
| PubMedSearch : Kozlov_2023_Anal.Chem__ |
| PubMedID: 36893116 |
| Title : Strategies for enhanced bioavailability of oxime reactivators in the central nervous system - Prchalova_2023_Arch.Toxicol__ |
| Author(s) : Prchalova E , Kohoutova Z , Knittelova K , Malinak D , Musilek K |
| Ref : Archives of Toxicology , : , 2023 |
| Abstract : |
| PubMedSearch : Prchalova_2023_Arch.Toxicol__ |
| PubMedID: 37642747 |
| Title : Halogen substituents enhance oxime nucleophilicity for reactivation of cholinesterases inhibited by nerve agents - Zorbaz_2022_Eur.J.Med.Chem_238_114377 |
| Author(s) : Zorbaz T , Malinak D , Hofmanova T , Marakovic N , Zunec S , Macek Hrvat N , Andrys R , Psotka M , Zandona A , Svobodova J , Prchal L , Fingler S , Katalinic M , Kovarik Z , Musilek K |
| Ref : Eur Journal of Medicinal Chemistry , 238 :114377 , 2022 |
| Abstract : |
| PubMedSearch : Zorbaz_2022_Eur.J.Med.Chem_238_114377 |
| PubMedID: 35526478 |
| Title : Toxicity, pharmacokinetics, and effectiveness of the ortho-chlorinated bispyridinium oxime, K870 - Karasova_2022_Food.Chem.Toxicol__113236 |
| Author(s) : Karasova JZ , Kassa J , Hepnarova V , Pejchal J , Junova L , Andrys R , Malinak D , Bzonek P , Kohoutova Z , Musilek K |
| Ref : Food & Chemical Toxicology , :113236 , 2022 |
| Abstract : |
| PubMedSearch : Karasova_2022_Food.Chem.Toxicol__113236 |
| PubMedID: 35738326 |
| Title : Charged pyridinium oximes with thiocarboxamide moiety are equally or less effective reactivators of organophosphate-inhibited cholinesterases compared to analogous carboxamides - Kohoutova_2022_J.Enzyme.Inhib.Med.Chem_37_760 |
| Author(s) : Kohoutova Z , Malinak D , Andrys R , Svobodova J , Psotka M , Schmidt M , Prchal L , Musilek K |
| Ref : J Enzyme Inhib Med Chem , 37 :760 , 2022 |
| Abstract : |
| PubMedSearch : Kohoutova_2022_J.Enzyme.Inhib.Med.Chem_37_760 |
| PubMedID: 35193448 |
| Title : Pyridinium-2-carbaldoximes with quinolinium carboxamide moiety are simultaneous reactivators of acetylcholinesterase and butyrylcholinesterase inhibited by nerve agent surrogates - Lee_2021_J.Enzyme.Inhib.Med.Chem_36_437 |
| Author(s) : Lee HM , Andrys R , Jonczyk J , Kim K , Vishakantegowda AG , Malinak D , Skarka A , Schmidt M , Vaskova M , Latka K , Bajda M , Jung YS , Malawska B , Musilek K |
| Ref : J Enzyme Inhib Med Chem , 36 :437 , 2021 |
| Abstract : |
| PubMedSearch : Lee_2021_J.Enzyme.Inhib.Med.Chem_36_437 |
| PubMedID: 33467931 |
| Title : Effects of Novel Tacrine Derivatives on Mitochondrial Energy Metabolism and Monoamine Oxidase Activity-In Vitro Study - Hroudova_2021_Mol.Neurobiol_58_1102 |
| Author(s) : Hroudova J , Novakova T , Korabecny J , Malinak D , Gorecki L , Fisar Z |
| Ref : Molecular Neurobiology , 58 :1102 , 2021 |
| Abstract : |
| PubMedSearch : Hroudova_2021_Mol.Neurobiol_58_1102 |
| PubMedID: 33089424 |
| Title : Determination of K869, a novel oxime reactivator of acetylcholinesterase, in rat body fluids and tissues by liquid-chromatography methods: Pharmacokinetic study - Vanova_2021_J.Pharm.Sci__ |
| Author(s) : Vanova N , Hojna A , Pejchal J , Herman D , Malinak D , Prchalova E , Musilek K , Karasova JZ |
| Ref : J Pharm Sci , : , 2021 |
| Abstract : |
| PubMedSearch : Vanova_2021_J.Pharm.Sci__ |
| PubMedID: 33545185 |
| Title : Effects of Charged Oxime Reactivators on the HK-2 Cell Line in Renal Toxicity Screening - Handl_2021_Chem.Res.Toxicol__ |
| Author(s) : Handl J , Malinak D , Capek J , Andrys R , Rousarova E , Hauschke M , Bruckova L , Cesla P , Rousar T , Musilek K |
| Ref : Chemical Research in Toxicology , : , 2021 |
| Abstract : |
| PubMedSearch : Handl_2021_Chem.Res.Toxicol__ |
| PubMedID: 33566584 |
| Title : Development of versatile and potent monoquaternary reactivators of acetylcholinesterase - Gorecki_2021_Arch.Toxicol__ |
| Author(s) : Gorecki L , Hepnarova V , Karasova JZ , Hrabinova M , Courageux C , Dias J , Kucera T , Kobrlova T , Muckova L , Prchal L , Malinak D , Jun D , Musilek K , Worek F , Nachon F , Soukup O , Korabecny J |
| Ref : Archives of Toxicology , : , 2021 |
| Abstract : |
| PubMedSearch : Gorecki_2021_Arch.Toxicol__ |
| PubMedID: 33517499 |
| Title : Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators - Malinak_2020_J.Enzyme.Inhib.Med.Chem_35_478 |
| Author(s) : Malinak D , Dolezal R , Hepnarova V , Hozova M , Andrys R , Bzonek P , Racakova V , Korabecny J , Gorecki L , Mezeiova E , Psotka M , Jun D , Kuca K , Musilek K |
| Ref : J Enzyme Inhib Med Chem , 35 :478 , 2020 |
| Abstract : |
| PubMedSearch : Malinak_2020_J.Enzyme.Inhib.Med.Chem_35_478 |
| PubMedID: 31910701 |
| Title : Butyrylcholinesterase inhibited by nerve agents is efficiently reactivated with chlorinated pyridinium oximes - Zorbaz_2019_Chem.Biol.Interact_13ChEPon_307_16 |
| Author(s) : Zorbaz T , Malinak D , Kuca K , Musilek K , Kovarik Z |
| Ref : Chemico-Biological Interactions , 307 :16 , 2019 |
| Abstract : |
| PubMedSearch : Zorbaz_2019_Chem.Biol.Interact_13ChEPon_307_16 |
| PubMedID: 31004594 |
| Title : Oxime K203: a drug candidate for the treatment of tabun intoxication - Gorecki_2019_Arch.Toxicol_93_673 |
| Author(s) : Gorecki L , Soukup O , Kucera T , Malinak D , Jun D , Kuca K , Musilek K , Korabecny J |
| Ref : Archives of Toxicology , 93 :673 , 2019 |
| Abstract : |
| PubMedSearch : Gorecki_2019_Arch.Toxicol_93_673 |
| PubMedID: 30564897 |
| Title : Donepezil Derivatives Targeting Amyloid-beta Cascade in Alzheimer's Disease - Mezeiova_2019_Curr.Alzheimer.Res_16_772 |
| Author(s) : Mezeiova E , Chalupova K , Nepovimova E , Gorecki L , Prchal L , Malinak D , Kuca K , Soukup O , Korabecny J |
| Ref : Curr Alzheimer Res , 16 :772 , 2019 |
| Abstract : |
| PubMedSearch : Mezeiova_2019_Curr.Alzheimer.Res_16_772 |
| PubMedID: 30819078 |
| Title : Pyridinium Oximes with Ortho-Positioned Chlorine Moiety Exhibit Improved Physicochemical Properties and Efficient Reactivation of Human Acetylcholinesterase Inhibited by Several Nerve Agents - Zorbaz_2018_J.Med.Chem_61_10753 |
| Author(s) : Zorbaz T , Malinak D , Marakovic N , Macek Hrvat N , Zandona A , Novotny M , Skarka A , Andrys R , Benkova M , Soukup O , Katalinic M , Kuca K , Kovarik Z , Musilek K |
| Ref : Journal of Medicinal Chemistry , 61 :10753 , 2018 |
| Abstract : |
| PubMedSearch : Zorbaz_2018_J.Med.Chem_61_10753 |
| PubMedID: 30383374 |
| Title : In vitro and in silico Evaluation of Non-Quaternary Reactivators of AChE as Antidotes of Organophosphorus Poisoning - a New Hope or a Blind Alley? - Soukup_2018_Med.Chem_14_281 |
| Author(s) : Soukup O , Korabecny J , Malinak D , Nepovimova E , Pham NL , Musilek K , Hrabinova M , Hepnarova V , Dolezal R , Pavek P , Jost P , Kobrlova T , Jankockova J , Gorecki L , Psotka M , Nguyen TD , Box K , Outhwaite B , Ceckova M , Sorf A , Jun D , Kuca K |
| Ref : Med Chem , 14 :281 , 2018 |
| Abstract : |
| PubMedSearch : Soukup_2018_Med.Chem_14_281 |
| PubMedID: 29332594 |
| Title : Profiling donepezil template into multipotent hybrids with antioxidant properties - Mezeiova_2018_J.Enzyme.Inhib.Med.Chem_33_583 |
| Author(s) : Mezeiova E , Spilovska K , Nepovimova E , Gorecki L , Soukup O , Dolezal R , Malinak D , Janockova J , Jun D , Kuca K , Korabecny J |
| Ref : J Enzyme Inhib Med Chem , 33 :583 , 2018 |
| Abstract : |
| PubMedSearch : Mezeiova_2018_J.Enzyme.Inhib.Med.Chem_33_583 |
| PubMedID: 29529892 |
| Title : A Review of the Synthesis of Quaternary Acetylcholinesterase Reactivators - Tsai_2021_J.Food.Drug.Anal_29_153 |
| Author(s) : Malinak D , Korabecny J , Soukup O , Gorecki L , Nepovimova E , Psotka M , Dolezal R , Nguyen TD , Mezeiova E , Musilek K , Kuca K |
| Ref : Current Organic Chemistry , 22\ :1619 , 2018 |
| Abstract : |
| PubMedSearch : Tsai_2021_J.Food.Drug.Anal_29_153 |
| PubMedID: |
| Title : Novel Group of AChE Reactivators-Synthesis, In Vitro Reactivation and Molecular Docking Study - Malinak_2018_Molecules_23_ |
| Author(s) : Malinak D , Nepovimova E , Jun D , Musilek K , Kuca K |
| Ref : Molecules , 23 : , 2018 |
| Abstract : |
| PubMedSearch : Malinak_2018_Molecules_23_ |
| PubMedID: 30205495 |
| Title : Progress in acetylcholinesterase reactivators and in the treatment of organophosphorus intoxication: a patent review (2006-2016) - Gorecki_2017_Expert.Opin.Ther.Pat_27_971 |
| Author(s) : Gorecki L , Korabecny J , Musilek K , Nepovimova E , Malinak D , Kucera T , Dolezal R , Jun D , Soukup O , Kuca K |
| Ref : Expert Opin Ther Pat , 27 :971 , 2017 |
| Abstract : |
| PubMedSearch : Gorecki_2017_Expert.Opin.Ther.Pat_27_971 |
| PubMedID: 28569609 |
| Title : HLo-7 - A review of acetylcholinesterase reactivator against organophosphorus intoxication - Psotka_2017_Mil.Med.Sci.Lett_86_70 |
| Author(s) : Psotka M , Malinak D , Gorecki L , Nguyen TD , Soukup O , Jun D , Kuca K , Musilek K , Korabecny J |
| Ref : Military Medical Science Letters , 86 :70 , 2017 |
| Abstract : |
| PubMedSearch : Psotka_2017_Mil.Med.Sci.Lett_86_70 |
| PubMedID: |
| Title : A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication - Nepovimova_2016_Toxicol.Res.(Camb)_5_1012 |
| Author(s) : Nepovimova E , Korabecny J , Dolezal R , Nguyen TD , Jun D , Soukup O , Pasdiorova M , Jost P , Muckova L , Malinak D , Gorecki L , Musilek K , Kuca K |
| Ref : Toxicol Res (Camb) , 5 :1012 , 2016 |
| Abstract : |
| PubMedSearch : Nepovimova_2016_Toxicol.Res.(Camb)_5_1012 |
| PubMedID: 30090408 |
| Title : Towards understanding the mechanism of action of antibacterial N-alkyl-3-hydroxypyridinium salts: Biological activities, molecular modeling and QSAR studies - Dolezal_2016_Eur.J.Med.Chem_121_699 |
| Author(s) : Dolezal R , Soukup O , Malinak D , Savedra RML , Marek J , Dolezalova M , Pasdiorova M , Salajkova S , Korabecny J , Honegr J , Ramalho TC , Kuca K |
| Ref : Eur Journal of Medicinal Chemistry , 121 :699 , 2016 |
| Abstract : |
| PubMedSearch : Dolezal_2016_Eur.J.Med.Chem_121_699 |
| PubMedID: 27341309 |
| Title : SAR study to find optimal cholinesterase reactivator against organophosphorous nerve agents and pesticides - Gorecki_2016_Arch.Toxicol_90_2831 |
| Author(s) : Gorecki L , Korabecny J , Musilek K , Malinak D , Nepovimova E , Dolezal R , Jun D , Soukup O , Kuca K |
| Ref : Archives of Toxicology , 90 :2831 , 2016 |
| Abstract : |
| PubMedSearch : Gorecki_2016_Arch.Toxicol_90_2831 |
| PubMedID: 27582056 |
| Title : 7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment - Korabecny_2015_Molecules_20_22084 |
| Author(s) : Korabecny J , Andrs M , Nepovimova E , Dolezal R , Babkova K , Horova A , Malinak D , Mezeiova E , Gorecki L , Sepsova V , Hrabinova M , Soukup O , Jun D , Kuca K |
| Ref : Molecules , 20 :22084 , 2015 |
| Abstract : |
| PubMedSearch : Korabecny_2015_Molecules_20_22084 |
| PubMedID: 26690394 |
| Title : Tacrine-Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity - Nepovimova_2015_J.Med.Chem_58_8985 |
| Author(s) : Nepovimova E , Korabecny J , Dolezal R , Babkova K , Ondrejicek A , Jun D , Sepsova V , Horova A , Hrabinova M , Soukup O , Bukum N , Jost P , Muckova L , Kassa J , Malinak D , Andrs M , Kuca K |
| Ref : Journal of Medicinal Chemistry , 58 :8985 , 2015 |
| Abstract : |
| PubMedSearch : Nepovimova_2015_J.Med.Chem_58_8985 |
| PubMedID: 26503905 |
| Title : Ligand-based 3D QSAR analysis of reactivation potency of mono- and bis-pyridinium aldoximes toward VX-inhibited rat acetylcholinesterase - Dolezal_2015_J.Mol.Graph.Model_56_113 |
| Author(s) : Dolezal R , Korabecny J , Malinak D , Honegr J , Musilek K , Kuca K |
| Ref : J Mol Graph Model , 56 :113 , 2015 |
| Abstract : |
| PubMedSearch : Dolezal_2015_J.Mol.Graph.Model_56_113 |
| PubMedID: 25588616 |