| Title : Comparative genomics: Insecticide resistance in mosquito vectors - Weill_2003_Nature_423_136 |
| Author(s) : Weill M , Lutfalla G , Mogensen K , Chandre F , Berthomieu A , Berticat C , Pasteur N , Philips A , Fort P , Raymond M |
| Ref : Nature , 423 :136 , 2003 |
|
Abstract :
Resistance to insecticides among mosquitoes that act as vectors for malaria (Anopheles gambiae) and West Nile virus (Culex pipiens) emerged more than 25 years ago in Africa, America and Europe; this resistance is frequently due to a loss of sensitivity of the insect's acetylcholinesterase enzyme to organophosphates and carbamates1. Here we show that this insensitivity results from a single amino-acid substitution in the enzyme, which we found in ten highly resistant strains of C. pipiens from tropical (Africa and Caribbean) and temperate (Europe) areas, as well as in one resistant African strain of A. gambiae. Our identification of this mutation may pave the way for designing new insecticides. |
| PubMedSearch : Weill_2003_Nature_423_136 |
| PubMedID: 12736674 |
| Gene_locus related to this paper: anoga-ACHE1 , culpi-ACHE1 |
| Mutation | G119S_culpi-ACHE1 G119S_anoga-ACHE1 |
| Gene_locus | G119S_culpi-ACHE1 G119S_anoga-ACHE1 anoga-ACHE1 culpi-ACHE1 |
Weill M, Lutfalla G, Mogensen K, Chandre F, Berthomieu A, Berticat C, Pasteur N, Philips A, Fort P, Raymond M (2003)
Comparative genomics: Insecticide resistance in mosquito vectors
Nature
423 :136
Weill M, Lutfalla G, Mogensen K, Chandre F, Berthomieu A, Berticat C, Pasteur N, Philips A, Fort P, Raymond M (2003)
Nature
423 :136