culpi-ACHE1

Culex pipiens acetylcholinesterase (Northern house mosquito) Culex quinquefasciatus (Southern house mosquito) (Culex pungens)(ache1 gene)

Comment

This gene is duplicated independently in many strains Labb et al. AJ489456 is mRNA of the strain SLAB and AJ515147 is for the resistant G119S SR strain. genbank accession numbers AJ512688 to AJ512717 are partial sequences of different strain of the Culex pipiens complex (C.pip.pip. and C.pip.quinq) || Partial sequence from this gene found in 14 other mosquitos Aedes albopictus (Forest day mosquito) AJ438598 Anopheles albimanus (New world malaria mosquito) AJ438608 Anopheles arabiensis (Mosquito) AJ438603 Anopheles darlingi AJ438599Anopheles funestus AJ438604 Anopheles minimus AJ438601 Anopheles moucheti AJ438602 Anopheles nili AJ438609 Anopheles pseudopunctipennis AJ438605 Anopheles sacharovi AJ438606 Anopheles stephensi (Indo-Pakistan malaria mosquito) AJ438607Anopheles sundaicus AJ438600 and ACES_CULP\; Culex pipiens pipiens (Northern house mosquito) NCBI_TaxID 38569 ACES_CULQU Q867X2\; Q867X1\; Q867X4 Q1WKR8 Culex quinquefasciatus (Southern house mosquito).\;ACES_CULTO Q86GC9 Culex torrentium (Mosquito) NCBI_TaxID=42433 || Culex pipiens pallens Q5XL61_CULPI acetylcholinesterase (EC 3.1.1.7) by Li et al. 2004 identical except for a 9 aa deletion in N-term || In Culex quinquefasciatus Q1WKR8 is for Gongdi-S Q1WKR9 is for Gongdi-R The G119S mutation

Relationship

Family : ACHE

Block : C

Position in NCBI Life Tree : Culex pipiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Protostomia N E > Ecdysozoa N E > Panarthropoda N E > Arthropoda N E > Mandibulata N E > Pancrustacea N E > Hexapoda N E > Insecta N E > Dicondylia N E > Pterygota N E > Neoptera N E > Holometabola N E > Diptera N E > Nematocera N E > Culicomorpha N E > Culicoidea N E > Culicidae N E > Culicinae N E > Culicini N E > Culex [genus] N E > Culex [subgenus] N E > Culex pipiens complex N E > Culex pipiens N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

No inhibitor

Database

Sequence

Peptide

MEIRGLITRL LGPCHLRHLI LCSLGLYSIL VQSVHCRHHD IGSSVAHQLG SKYSQSSSLS SSSQSSSSLA EEATLNKDSD AFFTPYIGHG DSVRIVDAEL GTLEREHIHS TTTRRRGLTR RESSSDATDS DPLVITTDKG KIRGTTLEAP SGKKVDAWMG IPYAQPPLGP LRFRHPRPAE RWTGVLNATK PPNSCVQIVD TVFGDFPGAT MWNPNTPLSE DCLYINVVVP RPRPKNAAVM LWIFGGGFYS GTATLDVYDH RTLASEENVI VVSLQYRVAS LGFLFLGTPE APGNAGLFDQ NLALRWVRDN IHRFGGDPSR VTLFGESAGA VSVSLHLLSA LSRDLFQRAI LQSGSPTAPW ALVSREEATL RALRLAEAVN CPHDATKLSD AVECLRTKDP NELVDNEWGT LGICEFPFVP VVDGAFLDET PQRSLASGRF KKTDILTGSN TEEGYYFIIY YLTELLRKEE GVTVTREEFL QAVRELNPYV NGAARQAIVF EYTDWIEPDN PNSNRDALDK MVGDYHFTCN VNEFAQRYAE EGNNVFMYLY THRSKGNPWP RWTGVMHGDE INYVFGEPLN SALGYQDDEK DFSRKIMRYW SNFAKTGNPN PSTPSVDLPE WPKHTAHGRH YLELGLNTTF VGRGPRLRQC AFWKKYLPQL VAATSNLQVT PAPSVPCESS STSYRSTLLL IVTLLLVTRF KI

References (14)

Title : The evolutionary fate of heterogeneous gene duplications: A precarious overdominant equilibrium between environment, sublethality and complementation - Milesi_2018_Mol.Ecol_27_493
Author(s) : Milesi P , Assogba BS , Atyame CM , Pocquet N , Berthomieu A , Unal S , Makoundou P , Weill M , Labbe P
Ref : Mol Ecol , 27 :493 , 2018
PubMedID: 29230902
Gene_locus related to this paper: culpi-ACHE1 , culqu-ACHE1

Title : Point Mutations Associated with Organophosphate and Carbamate Resistance in Chinese Strains of Culex pipiens quinquefasciatus (Diptera: Culicidae) - Zhao_2014_PLoS.One_9_e952607
Author(s) : Zhao M , Dong Y , Ran X , Wu Z , Guo X , Zhang Y , Xing D , Yan T , Wang G , Zhu X , Zhang H , Li C , Zhao T
Ref : PLoS ONE , 9 :e95260 , 2014
PubMedID: 24788312
Gene_locus related to this paper: culpi-ACHE1

Title : First molecular genotyping of insensitive acetylcholinesterase associated with malathion resistance in Culex quinquefasciatus Say populations in Malaysia - Low_2013_Pest.Manag.Sci_69_1362
Author(s) : Low VL , Chen CD , Lim PE , Lee HL , Lim YA , Tan TK , Sofian-Azirun M
Ref : Pest Manag Sci , 69 :1362 , 2013
PubMedID: 23404830
Gene_locus related to this paper: culpi-ACHE1

Title : Susceptibility status of Culex quinquefasciatus (Diptera: Culicidae) populations to the chemical insecticide temephos in Pernambuco, Brazil - Amorim_2013_Pest.Manag.Sci_69_1307
Author(s) : Amorim LB , Helvecio E , de Oliveira CM , Ayres CF
Ref : Pest Manag Sci , 69 :1307 , 2013
PubMedID: 23576326
Gene_locus related to this paper: culpi-ACHE1

Title : Insecticide resistance to organophosphates in Culex pipiens complex from Lebanon - Osta_2012_Parasit.Vectors_5_132
Author(s) : Osta MA , Rizk ZJ , Labbe P , Weill M , Knio K
Ref : Parasit Vectors , 5 :132 , 2012
PubMedID: 22759898
Gene_locus related to this paper: culpi-ACHE1

Title : Independent duplications of the acetylcholinesterase gene conferring insecticide resistance in the mosquito Culex pipiens - Labbe_2007_Mol.Biol.Evol_24_1056
Author(s) : Labbe P , Berthomieu A , Berticat C , Alout H , Raymond M , Lenormand T , Weill M
Ref : Molecular Biology Evolution , 24 :1056 , 2007
PubMedID: 17283366
Gene_locus related to this paper: culpi-ACHE1 , culqu-ACHE1

Title : A new amino-acid substitution in acetylcholinesterase 1 confers insecticide resistance to Culex pipiens mosquitoes from Cyprus - Alout_2007_Insect.Biochem.Mol.Biol_37_41
Author(s) : Alout H , Berthomieu A , Hadjivassilis A , Weill M
Ref : Insect Biochemistry & Molecular Biology , 37 :41 , 2007
PubMedID: 17175445
Gene_locus related to this paper: culpi-ACHE1

Title : Different amino-acid substitutions confer insecticide resistance through acetylcholinesterase 1 insensitivity in Culex vishnui and Culex tritaeniorhynchus (Diptera: Culicidae) from China - Alout_2007_J.Med.Entomol_44_463
Author(s) : Alout H , Berthomieu A , Cui F , Tan Y , Berticat C , Qiao C , Weill M
Ref : Journal of Medical Entomology , 44 :463 , 2007
PubMedID: 17547232
Gene_locus related to this paper: culpi-ACHE1

Title : Recent emergence of insensitive acetylcholinesterase in Chinese populations of the mosquito Culex pipiens (Diptera: Culicidae) - Cui_2006_J.Med.Entomol_43_878
Author(s) : Cui F , Raymond M , Berthomieu A , Alout H , Weill M , Qiao CL
Ref : Journal of Medical Entomology , 43 :878 , 2006
PubMedID: 17017223
Gene_locus related to this paper: culpi-ACHE1

Title : Acetylcholinesterase genes within the Diptera: takeover and loss in true flies - Huchard_2006_Proc.Biol.Sci_273_2595
Author(s) : Huchard E , Martinez M , Alout H , Douzery EJ , Lutfalla G , Berthomieu A , Berticat C , Raymond M , Weill M
Ref : Proc Biol Sci , 273 :2595 , 2006
PubMedID: 17002944
Gene_locus related to this paper: culpi-ACHE1 , culpi-ACHE2 , drobs-ACHE2 , drosi-ACHE , drowi-ACHE , gloff-ACHE2

Title : The unique mutation in ace-1 giving high insecticide resistance is easily detectable in mosquito vectors - Weill_2004_Insect.Mol.Biol_13_1
Author(s) : Weill M , Malcolm C , Chandre F , Mogensen K , Berthomieu A , Marquine M , Raymond M
Ref : Insect Molecular Biology , 13 :1 , 2004
PubMedID: 14728661
Gene_locus related to this paper: anoga-ACHE1 , culpi-ACHE1

Title : Cloning of culex pipiens pallens cDNA encoding acetylcholinesterase and homology modeling of ache. -
Author(s) : Li CX , Zhao TY , Dong YD
Ref : Ji Sheng Chong Yu Yi Xue Kun Chong Xue Bao , 11 :161 , 2004
PubMedID:
Gene_locus related to this paper: culpi-ACHE1

Title : Comparative genomics: Insecticide resistance in mosquito vectors - Weill_2003_Nature_423_136
Author(s) : Weill M , Lutfalla G , Mogensen K , Chandre F , Berthomieu A , Berticat C , Pasteur N , Philips A , Fort P , Raymond M
Ref : Nature , 423 :136 , 2003
PubMedID: 12736674
Gene_locus related to this paper: anoga-ACHE1 , culpi-ACHE1

Title : A novel acetylcholinesterase gene in mosquitoes codes for the insecticide target and is non-homologous to the ace gene Drosophila - Weill_2002_Proc.R.Soc.Lond.B.Biol.Sci_269_2007
Author(s) : Weill M , Fort P , Berthomieu A , Dubois MP , Pasteur N , Raymond M
Ref : Proc R Soc Lond B Biol Sci , 269 :2007 , 2002
PubMedID: 12396499
Gene_locus related to this paper: aedae-ACHE1 , anoga-ACHE1 , anoga-ACHE2 , cioin-ACHE1 , ciosa-ACHE , culpi-ACHE1