Wilson_1988_J.Toxicol.Environ.Health_23_103

Reference

Title : Toxicity of an acute dose of agent VX and other organophosphorus esters in the chicken - Wilson_1988_J.Toxicol.Environ.Health_23_103
Author(s) : Wilson BW , Henderson JD , Chow E , Schreider J , Goldman M , Culbertson R , Dacre JC
Ref : J Toxicol Environ Health , 23 :103 , 1988
Abstract :

The neurotoxicities of single doses of a chemical warfare agent VX [phosphonothioic acid, methyl-S-(2-[bis(1-methylethyl)amino/ethyl) O-ethyl ester], a metabolite of the agricultural chemical parathion, paraoxon, PO (phosphonothioic acid, diethyl paranitrophenyl ester), and the known neuropathic agents DFP] phosphorofluoridic acid, bis(1-methylethyl) ester] and TOCP (phosphoric acid, tri-o-tolyl ester) were compared in the chicken. Single injections (subcutaneous, sc) of VX as high as 150 micrograms/kg (5 times the LD50, intramuscular, im) were tolerated by laying tens if atropine and 2-pralidoxime were used as antidotes before and immediately after injection. The 150 of VX for inhibition of chicken brain acetylcholinesterase was approximately 5 X 10(-10). Plasma acetylcholinesterase, but not butyrylcholinesterase, was depressed 2 h after injections of 2-20 micrograms VX/kg im without antidotes. Levels of plasma enzymes such as creatine kinase, indicative of tissue damage, were increased after exposure to both VX and PO. Injections of up to 150 micrograms/kg of VX with antidotes did not cause locomotor or histological signs of organophosphorus-induced delayed neuropathy, but single injections of 400 mg TOCP/kg did.

PubMedSearch : Wilson_1988_J.Toxicol.Environ.Health_23_103
PubMedID: 3336055

Related information

Inhibitor DFP    Paraoxon    Parathion    Tri-o-cresylphosphate    VX
Reactivator DFP    Paraoxon    Parathion    Tri-o-cresylphosphate    VX    2-PAM

Citations formats

Wilson BW, Henderson JD, Chow E, Schreider J, Goldman M, Culbertson R, Dacre JC (1988)
Toxicity of an acute dose of agent VX and other organophosphorus esters in the chicken
J Toxicol Environ Health 23 :103

Wilson BW, Henderson JD, Chow E, Schreider J, Goldman M, Culbertson R, Dacre JC (1988)
J Toxicol Environ Health 23 :103