DFP
Inhibitor of cholinesterases and many serine hydrolases (not only alpha/beta hydrolases but also trypsin chymotrypsin etc.). DFP is a parasympathomimetic drug used in ophthalmology as a miotic agent in treatment of chronic glaucoma, as a miotic in veterinary medicine, and as an experimental agent in neuroscience because of its acetylcholinesterase inhibitory properties and ability to induce delayed peripheral neuropathy. DFP can phosphorylate other residues than active serine (tyrosine, lysine) see pdb 1TRN and Grigoryan et al. BChE appears to be about 100-200 times as sensitive as AChE to DFP and DFP was used to distinguish AChE and BChE before BW284C51 and Iso-OMPA were discovered. DFP is the oxygen analogue of Mipafox.(Structures of not alpha/beta hydrolases inhibited by DFP include: 4V08, 4H1D, 3VTA, 3TT7, 3TXT, 3MH5, 3MH6, 1RS0, 1CI9, 1DUI, 1AT3, 1SUE, 1DFP, 2TGD, 4PKA, 3LH3, 3GCN, 3GCO, 3GDS, 3GDU, 3GDV, 2RCE, 2Z2X, 1PPZ, 1GNV, 1A2Q, 5PTP)
General
Type : Organophosphate
Chemical_Nomenclature : Diisopropylphosphorofluoridate
Canonical SMILES : CC(C)OP(=O)(OC(C)C)F
InChI : InChI=1S\/C6H14FO3P\/c1-5(2)9-11(7,8)10-6(3)4\/h5-6H,1-4H3
InChIKey : MUCZHBLJLSDCSD-UHFFFAOYSA-N
Other name(s) : Diisopropylphosphorofluoridate || Dyflos || Diflupyl || Floropyl || isofluorophate || Fluostigmine || Isoflurophate || Difluorophate || Diflurphate || Dyphlos || isofluorphate || Neoglaucit || PF-3 || PF3 || T-1703 || TL 466
MW : 184.1
Formula : C6H14FO3P
CAS_number : 55-91-4
PubChem : 5936
UniChem : MUCZHBLJLSDCSD-UHFFFAOYSA-N
Wikipedia : Diisopropyl_fluorophosphate
Target
Families : DFP ligand of proteins in family
PAF-Acetylhydrolase
A85-IroE-IroD-Fes-Yiel
DPP4N_Peptidase_S9
Cutinase
ACHE
BCHE
Peptidase_S15
Lactobacillus_peptidase
Cocaine_esterase
Prolylcarboxypeptidase
PolyAspartate-hydrolase
ACPH_Peptidase_S9
6_AlphaBeta_hydrolase
Carb_B_Chordata
Carb_B_Arthropoda
Arylacetamide_deacetylase
Carboxypeptidase_S10
Lipase_3
Structure :
2DFP
5HCU
5DTG
5DTJ
3F9C
2QM0
2JGM
2JGI
2GZS
6WIA
1TKR
1XLU
1XZK
Protein :
arcfu-AF1763
human-DPP4
human-ACHE
human-BCHE
human-PLA2G7
bacce-BC3734
ecoli-IROE
fusso-cutas
human-FAP
human-CTSA
aspni-FAEA
References (57)
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| Author(s) : Tsai YH , Gonzalez EA , Grodzki ACG , Bruun DA , Saito NH , Harvey DJ , Lein PJ |
| Ref : Front Toxicol , 6 :1360359 , 2024 |
| Abstract : |
| PubMedSearch : Tsai_2024_Front.Toxicol_6_1360359 |
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| Title : Structural and Kinetic Evidence of Aging after Organophosphate Inhibition of Human Cathepsin A - Bouknight_2020_Biochem.Pharmacol__113980 |
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| Abstract : |
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| Gene_locus related to this paper: human-CTSA |
| Title : Discovery of New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by Organophosphates - Katz_2015_Chembiochem_16_2205 |
| Author(s) : Katz FS , Pecic S , Tran TH , Trakht I , Schneider L , Zhu Z , Ton-That L , Luzac M , Zlatanic V , Damera S , MacDonald J , Landry DW , Tong L , Stojanovic MN |
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| Gene_locus related to this paper: mouse-ACHE |
| Title : Structural characterization of enterobactin hydrolase IroE - Larsen_2006_Biochemistry_45_10184 |
| Author(s) : Larsen NA , Lin H , Wei R , Fischbach MA , Walsh CT |
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| Gene_locus related to this paper: ecoli-IROE |
| Title : Role of water in aging of human butyrylcholinesterase inhibited by echothiophate: the crystal structure suggests two alternative mechanisms of aging - Nachon_2005_Biochemistry_44_1154 |
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| Abstract : |
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| Gene_locus related to this paper: human-BCHE |
| Title : Tyrosine 547 constitutes an essential part of the catalytic mechanism of dipeptidyl peptidase IV - Bjelke_2004_J.Biol.Chem_279_34691 |
| Author(s) : Bjelke JR , Christensen J , Branner S , Wagtmann N , Olsen C , Kanstrup AB , Rasmussen HB |
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| Abstract : |
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| Gene_locus related to this paper: human-DPP4 |
| Title : Effects of mutations of active site residues and amino acids interacting with the Omega loop on substrate activation of butyrylcholinesterase - Masson_2001_Biochim.Biophys.Acta_1544_166 |
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| Abstract : |
| PubMedSearch : Masson_2001_Biochim.Biophys.Acta_1544_166 |
| PubMedID: 11341926 |
| Gene_locus related to this paper: human-BCHE |
| Title : Mutagenesis of organophosphorus hydrolase to enhance hydrolysis of the nerve agent VX - Gopal_2000_Biochem.Biophys.Res.Commun_279_516 |
| Author(s) : Gopal S , Rastogi V , Ashman W , Mulbry W |
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| Title : Identification of serine esterases in tissue homogenates - Keshavarz-Shokri_1999_Anal.Biochem_267_406 |
| Author(s) : Keshavarz-Shokri A , Suntornwat O , Kitos PA |
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| Abstract : |
| PubMedSearch : Keshavarz-Shokri_1999_Anal.Biochem_267_406 |
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| Title : Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level - Millard_1999_Biochemistry_38_7032 |
| Author(s) : Millard CB , Kryger G , Ordentlich A , Greenblatt HM , Harel M , Raves ML , Segall Y , Barak D , Shafferman A , Silman I , Sussman JL |
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| Abstract : |
| PubMedSearch : Millard_1999_Biochemistry_38_7032 |
| PubMedID: 10353814 |
| Gene_locus related to this paper: torca-ACHE |
| Title : Evidence for homeostatic adjustments of rat somatosensory cortical neurons to changes in extracellular acetylcholine concentrations produced by iontophoretic administration of acetylcholine and by systemic diisopropylfluorophosphate treatment - Testylier_1999_Neurosci_91_843 |
| Author(s) : Testylier G , Maalouf M , Butt AE , Miasnikov AA , Dykes RW |
| Ref : Neuroscience , 91 :843 , 1999 |
| Abstract : |
| PubMedSearch : Testylier_1999_Neurosci_91_843 |
| PubMedID: 10391467 |
| Title : Inhibition of carboxylesterases in SH-SY5Y human and NB41A3 mouse neuroblastoma cells by organophosphorus esters - Ehrich_1998_J.Toxicol.Environ.Health_53_385 |
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| Ref : J Toxicol Environ Health , 53 :385 , 1998 |
| Abstract : |
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| Title : Modification of the rate of aging of diisopropylfluorophosphate- inhibited neuropathy target esterase of hen brain - Jokanovic_1998_Toxicol.Lett_95_93 |
| Author(s) : Jokanovic M , Stepanovic RM , Maksimovic M , Kosanovic M , Stojiljkovic MP |
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| PubMedID: 9635412 |
| Title : Identification of active site residues in a ferulic acid esterase (FAE-III) from Aspergillus niger - |
| Author(s) : Aliwan FO , Williamson G |
| Ref : Biochemical Society Transactions , 26 :S164 , 1998 |
| PubMedID: 9649839 |
| Gene_locus related to this paper: aspni-FAEA |
| Title : Importance of aspartate-70 in organophosphate inhibition, oxime re-activation and aging of human butyrylcholinesterase - Masson_1997_Biochem.J_325_53 |
| Author(s) : Masson P , Froment MT , Bartels CF , Lockridge O |
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| Abstract : |
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| PubMedID: 9224629 |
| Title : Down-regulation of cardiac muscarinic receptors induced by di- isopropylfluorophosphate - Valette_1997_J.Nucl.Med_38_1430 |
| Author(s) : Valette H , Syrota A , Fuseau C |
| Ref : J Nucl Med , 38 :1430 , 1997 |
| Abstract : |
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| PubMedID: 9293803 |
| Title : Augmented hydrolysis of diisopropyl fluorophosphate in engineered mutants of phosphotriesterase - Watkins_1997_J.Biol.Chem_272_25596 |
| Author(s) : Watkins LM , Mahoney HJ , McCulloch JK , Raushel FM |
| Ref : Journal of Biological Chemistry , 272 :25596 , 1997 |
| Abstract : |
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| PubMedID: 9325279 |
| Title : Characterization of monoclonal antibodies that inhibit the catalytic activity of acetylcholinesterases - Gentry_1995_J.Neurochem_64_842 |
| Author(s) : Gentry MK , Moorad DR , Hur RS , Saxena A , Ashani Y , Doctor BP |
| Ref : Journal of Neurochemistry , 64 :842 , 1995 |
| Abstract : |
| PubMedSearch : Gentry_1995_J.Neurochem_64_842 |
| PubMedID: 7830078 |
| Title : Comparison of the relative inhibition of acetylcholinesterase and neuropathy target esterase in rats and hens given cholinesterase inhibitors - Ehrich_1995_Fundam.Appl.Toxicol_24_94 |
| Author(s) : Ehrich M , Jortner BS , Padilla S |
| Ref : Fundamental & Applied Toxicology , 24 :94 , 1995 |
| Abstract : |
| PubMedSearch : Ehrich_1995_Fundam.Appl.Toxicol_24_94 |
| PubMedID: 7713347 |
| Title : Strain differences in the laboratory rat: impact on the autonomic, behavioral, and biochemical response to cholinesterase inhibition - Gordon_1995_J.Toxicol.Env.Health_45_59 |
| Author(s) : Gordon CJ , Watkinson WP |
| Ref : Journal of Toxicology & Environmental Health , 45 :59 , 1995 |
| Abstract : |
| PubMedSearch : Gordon_1995_J.Toxicol.Env.Health_45_59 |
| PubMedID: 7752289 |
| Title : Raman spectroscopic study of conjugates of butyrylcholinesterase with organophosphates - Aslanian_1995_Biochim.Biophys.Acta_1249_37 |
| Author(s) : Aslanian D , Grof P , Renault F , Masson P |
| Ref : Biochimica & Biophysica Acta , 1249 :37 , 1995 |
| Abstract : |
| PubMedSearch : Aslanian_1995_Biochim.Biophys.Acta_1249_37 |
| PubMedID: 7766682 |
| Title : Allosteric modulation of acetylcholinesterase activity by peripheral ligands involves a conformational transition of the anionic subsite - Barak_1995_Biochemistry_34_15444 |
| Author(s) : Barak D , Ordentlich A , Bromberg A , Kronman C , Marcus D , Lazar A , Ariel N , Velan B , Shafferman A |
| Ref : Biochemistry , 34 :15444 , 1995 |
| Abstract : |
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| PubMedID: 7492545 |
| Title : The timing of channel opening during miniature endplate currents at the frog and mouse neuromuscular junctions: effects of fasciculin-2, other anti-cholinesterases and vesamicol - Van der Kloot_1994_Pflugers.Arch_428_114 |
| Author(s) : Van der Kloot W , Balezina OP , Molgo J , Naves LA |
| Ref : Pflugers Arch , 428 :114 , 1994 |
| Abstract : |
| PubMedSearch : Van der Kloot_1994_Pflugers.Arch_428_114 |
| PubMedID: 7971167 |
| Title : [A kinetic study of the blood serum cholinesterase activity in the freshwater fish Abramis ballerus] - Zhukovskii_1994_Zh.Evol.Biokhim.Fiziol_30_177 |
| Author(s) : Zhukovskii Iu G , Kutsenko SA , Kuznetsova LP , Sochilina EE , Dmitrieva EN , Fartseiger NL , Tonkopii VD , Korkishko NN , Kozlovskaia VI , Fel'd VE |
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| Abstract : |
| PubMedSearch : Zhukovskii_1994_Zh.Evol.Biokhim.Fiziol_30_177 |
| PubMedID: 7817653 |
| Title : Choline derivatives and sodium fluoride protect acetylcholinesterase against irreversible inhibition and aging by DFP and paraoxon - Dehlawi_1994_J.Biochem.Toxicol_9_261 |
| Author(s) : Dehlawi MS , Eldefrawi AT , Eldefrawi ME , Anis NA , Valdes JJ |
| Ref : Journal of Biochemical Toxicology , 9 :261 , 1994 |
| Abstract : |
| PubMedSearch : Dehlawi_1994_J.Biochem.Toxicol_9_261 |
| PubMedID: 7853361 |
| Title : Phosphotriesterase--a promising candidate for use in detoxification of organophosphates - Tuovinen_1994_Fundam.Appl.Toxicol_23_578 |
| Author(s) : Tuovinen K , Kaliste-Korhonen E , Raushel FM , Hanninen O |
| Ref : Fundamental & Applied Toxicology , 23 :578 , 1994 |
| Abstract : |
| PubMedSearch : Tuovinen_1994_Fundam.Appl.Toxicol_23_578 |
| PubMedID: 7867909 |
| Title : Physiologically based pharmacokinetic model for the inhibition of acetylcholinesterase by organophosphate esters - Gearhart_1994_Environ.Health.Perspect_11_51 |
| Author(s) : Gearhart JM , Jepson GW , Clewell HJ , Andersen ME , Conolly RB |
| Ref : Environmental Health Perspectives , 11 :51 , 1994 |
| Abstract : |
| PubMedSearch : Gearhart_1994_Environ.Health.Perspect_11_51 |
| PubMedID: 7737042 |
| Title : The molecular forms of acetylcholinesterase from Necator americanus (Nematoda), a hookworm parasite of the human intestine - Pritchard_1994_Eur.J.Biochem_219_317 |
| Author(s) : Pritchard DI , Brown A , Toutant JP |
| Ref : European Journal of Biochemistry , 219 :317 , 1994 |
| Abstract : |
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| PubMedID: 8306998 |
| Title : Site-directed mutagenesis of active site residues reveals plasticity of human butyrylcholinesterase in substrate and inhibitor interactions - Gnatt_1994_J.Neurochem_62_749 |
| Author(s) : Gnatt A , Loewenstein Y , Yaron A , Schwarz M , Soreq H |
| Ref : Journal of Neurochemistry , 62 :749 , 1994 |
| Abstract : |
| PubMedSearch : Gnatt_1994_J.Neurochem_62_749 |
| PubMedID: 8294937 |
| Title : Immunochemical characterization of anti-acetylcholinesterase inhibitory monoclonal antibodies - Gentry_1993_Chem.Biol.Interact_87_227 |
| Author(s) : Gentry MK , Saxena A , Ashani Y , Doctor BP |
| Ref : Chemico-Biological Interactions , 87 :227 , 1993 |
| Abstract : |
| PubMedSearch : Gentry_1993_Chem.Biol.Interact_87_227 |
| PubMedID: 7688272 |
| Title : Correlation of the anticholinesterase activity of a series of organophosphates with their ability to compete with agonist binding to muscarinic receptors - Ward_1993_Toxicol.Appl.Pharmacol_122_300 |
| Author(s) : Ward TR , Ferris DJ , Tilson HA , Mundy WR |
| Ref : Toxicology & Applied Pharmacology , 122 :300 , 1993 |
| Abstract : |
| PubMedSearch : Ward_1993_Toxicol.Appl.Pharmacol_122_300 |
| PubMedID: 8212012 |
| Title : Cholinesterases of heart muscle. Characterization of multiple enzymes using kinetics of irreversible organophosphorus inhibition - Chemnitius_1992_Biochem.Pharmacol_43_823 |
| Author(s) : Chemnitius JM , Chemnitius GC , Haselmeyer KH , Kreuzer H , Zech R |
| Ref : Biochemical Pharmacology , 43 :823 , 1992 |
| Abstract : |
| PubMedSearch : Chemnitius_1992_Biochem.Pharmacol_43_823 |
| PubMedID: 1540236 |
| Title : Acylpeptide hydrolase: inhibitors and some active site residues of the human enzyme - Scaloni_1992_J.Biol.Chem_267_3811 |
| Author(s) : Scaloni A , Jones WM , Barra D , Pospischil M , Sassa S , Popowicz AM , Manning LR , Schneewind O , Manning JM |
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| Abstract : |
| PubMedSearch : Scaloni_1992_J.Biol.Chem_267_3811 |
| PubMedID: 1740429 |
| Title : Isolation of a tripeptide (Ala-Gly-Ser) exhibiting weak acetylthiocholine hydrolyzing activity from a high-salt soluble form of monkey diaphragm acetylcholinesterase - Jayanthi_1992_Neurochem.Res_17_351 |
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| Abstract : |
| PubMedSearch : Jayanthi_1992_Neurochem.Res_17_351 |
| PubMedID: 1513418 |
| Title : Therapeutic efficacy of bis-pyridinium oximes against diisopropyl fluorophosphate (DFP) and soman intoxication in rodents - |
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| Ref : Pharmazie , 47 :68 , 1992 |
| PubMedID: 1608992 |
| Title : In vitro protection of acetylcholinesterase and butyrylcholinesterase by tetrahydroaminoacridine. Comparison with physostigmine - Galli_1992_Biochem.Pharmacol_43_2427 |
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| Abstract : |
| PubMedSearch : Galli_1992_Biochem.Pharmacol_43_2427 |
| PubMedID: 1610407 |
| Title : Hypothermia: limited tolerance to repeated soman administration and cross-tolerance to oxotremorine - Clement_1991_Pharmacol.Biochem.Behav_39_305 |
| Author(s) : Clement JG |
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| Abstract : |
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| Author(s) : Alberts P |
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| Abstract : |
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| Title : Inhibition of cholinesterases by DFP and induction of organophosphate-detoxicating enzymes in rats - Kaliste-Korhonen_1990_Gen.Pharmacol_21_527 |
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| Ref : General Pharmacology , 21 :527 , 1990 |
| Abstract : |
| PubMedSearch : Kaliste-Korhonen_1990_Gen.Pharmacol_21_527 |
| PubMedID: 2165959 |
| Title : Repeated exposure to diisopropylfluorophosphate (DFP) produces increased sensitivity to cholinergic antagonists in discrimination retention and reversal - Raffaele_1990_Psychopharmacology_100_267 |
| Author(s) : Raffaele K , Olton D , Annau Z |
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| Abstract : |
| PubMedSearch : Raffaele_1990_Psychopharmacology_100_267 |
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| Title : Down-regulation of muscarinic receptors in the striatum of organophosphate-treated swine - Yang_1990_Toxicol.Appl.Pharmacol_104_375 |
| Author(s) : Yang CM , Dwyer TM , Mohan PM , Ho IK , Farley JM |
| Ref : Toxicol Appl Pharmacol , 104 :375 , 1990 |
| Abstract : |
| PubMedSearch : Yang_1990_Toxicol.Appl.Pharmacol_104_375 |
| PubMedID: 2385834 |
| Title : [Catalytic properties of cholinesterases immobilized in a gelatin membrane] - Kuznetsova_1990_Ukr.Biokhim.Zh_62_42 |
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| Ref : Ukr Biokhim Zh , 62 :42 , 1990 |
| Abstract : |
| PubMedSearch : Kuznetsova_1990_Ukr.Biokhim.Zh_62_42 |
| PubMedID: 2087792 |
| Title : A microassay-based procedure for measuring low levels of toxic organophosphorus compounds through acetylcholinesterase inhibition - Hammond_1989_Anal.Biochem_180_380 |
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| Abstract : |
| PubMedSearch : Hammond_1989_Anal.Biochem_180_380 |
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| Title : Cold exposure decreases the effectiveness of atropine-oxime treatment in organophosphate intoxication in rats and mice - Kaliste-Korhonen_1989_Gen.Pharmacol_20_805 |
| Author(s) : Kaliste-Korhonen E , Ryhanen R , Ylitalo P , Hanninen O |
| Ref : General Pharmacology , 20 :805 , 1989 |
| Abstract : |
| PubMedSearch : Kaliste-Korhonen_1989_Gen.Pharmacol_20_805 |
| PubMedID: 2687080 |
| Title : Comparison of the effects of diisopropylfluorophosphate, sarin, soman, and tabun on toxicity and brain acetylcholinesterase activity in mice - Tripathi_1989_J.Toxicol.Environ.Health_26_437 |
| Author(s) : Tripathi HL , Dewey WL |
| Ref : J Toxicol Environ Health , 26 :437 , 1989 |
| Abstract : |
| PubMedSearch : Tripathi_1989_J.Toxicol.Environ.Health_26_437 |
| PubMedID: 2709438 |
| Title : Toxicity of an acute dose of agent VX and other organophosphorus esters in the chicken - Wilson_1988_J.Toxicol.Environ.Health_23_103 |
| Author(s) : Wilson BW , Henderson JD , Chow E , Schreider J , Goldman M , Culbertson R , Dacre JC |
| Ref : J Toxicol Environ Health , 23 :103 , 1988 |
| Abstract : |
| PubMedSearch : Wilson_1988_J.Toxicol.Environ.Health_23_103 |
| PubMedID: 3336055 |
| Title : Effect of the cold environment on organophosphate toxicity and inhibition of cholinesterase activity - Ryhanen_1988_Gen.Pharmacol_19_741 |
| Author(s) : Ryhanen R , Honkakoski P , Harri M , Ylitalo P , Hanninen O |
| Ref : General Pharmacology , 19 :741 , 1988 |
| Abstract : |
| PubMedSearch : Ryhanen_1988_Gen.Pharmacol_19_741 |
| PubMedID: 3215484 |
| Title : A peptidase activity exhibited by human serum pseudocholinesterase - Boopathy_1987_Eur.J.Biochem_162_191 |
| Author(s) : Boopathy R , Balasubramanian AS |
| Ref : European Journal of Biochemistry , 162 :191 , 1987 |
| Abstract : |
| PubMedSearch : Boopathy_1987_Eur.J.Biochem_162_191 |
| PubMedID: 3545820 |
| Title : Effects of the organophosphate cholinesterase inhibitor (DFP) on hypothalamic acetylcholinesterase and pituitary-adrenal activity - |
| Author(s) : Kokka N , Clemons GK , Lomax P |
| Ref : Proc West Pharmacol Soc , 30 :219 , 1987 |
| PubMedID: 3628281 |
| Title : Kinetic investigations into the interactions of aprophen with cholinesterases and a carboxylesterase - Rush_1986_Biochem.Pharmacol_35_4167 |
| Author(s) : Rush RS , Doctor BP , Wolfe AD |
| Ref : Biochemical Pharmacology , 35 :4167 , 1986 |
| Abstract : |
| PubMedSearch : Rush_1986_Biochem.Pharmacol_35_4167 |
| PubMedID: 3098245 |
| Title : In-vitro and in-vivo protection of acetylcholinesterase by eseroline against inactivation by diisopropyl fluorophosphate and carbamates - Galli_1985_J.Pharm.Pharmacol_37_42 |
| Author(s) : Galli A , Malmberg-Aiello P , Renzi G , Bartolini A |
| Ref : J Pharm Pharmacol , 37 :42 , 1985 |
| Abstract : |
| PubMedSearch : Galli_1985_J.Pharm.Pharmacol_37_42 |
| PubMedID: 2858526 |
| Title : Polymorphism of pseudocholinesterase in Torpedo marmorata tissues: comparative study of the catalytic and molecular properties of this enzyme with acetylcholinesterase - Toutant_1985_J.Neurochem_44_580 |
| Author(s) : Toutant JP , Massoulie J , Bon S |
| Ref : Journal of Neurochemistry , 44 :580 , 1985 |
| Abstract : |
| PubMedSearch : Toutant_1985_J.Neurochem_44_580 |
| PubMedID: 2578181 |
| Title : Mechanisms involved in the development of tolerance to DFP toxicity - Gupta_1985_Fundam.Appl.Toxicol_5_S17 |
| Author(s) : Gupta RC , Patterson GT , Dettbarn WD |
| Ref : Fundamental & Applied Toxicology , 5 :S17 , 1985 |
| Abstract : |
| PubMedSearch : Gupta_1985_Fundam.Appl.Toxicol_5_S17 |
| PubMedID: 4092885 |
| Title : Brain cholinesterases. Differentiation of target enzymes for toxic organophosphorus compounds - Chemnitius_1983_Biochem.Pharmacol_32_1693 |
| Author(s) : Chemnitius JM , Haselmeyer KH , Zech R |
| Ref : Biochemical Pharmacology , 32 :1693 , 1983 |
| Abstract : |
| PubMedSearch : Chemnitius_1983_Biochem.Pharmacol_32_1693 |
| PubMedID: 6870909 |
| Title : Differential effects of di-isopropylfluorophosphate poisoning and its treatment on opioid antinociception in the mouse - Kitchen_1983_Life.Sci_1_669 |
| Author(s) : Kitchen I , Green PG |
| Ref : Life Sciences , 1 :669 , 1983 |
| Abstract : |
| PubMedSearch : Kitchen_1983_Life.Sci_1_669 |
| PubMedID: 6664242 |
| Title : Evaluation of cytotoxic responses caused by selected organophosphorus esters in chick sympathetic ganglia cultures - Obersteiner_1978_Can.J.Comp.Med_42_80 |
| Author(s) : Obersteiner EJ , Sharma RP |
| Ref : Can J Comp Med , 42 :80 , 1978 |
| Abstract : |
| PubMedSearch : Obersteiner_1978_Can.J.Comp.Med_42_80 |
| PubMedID: 565668 |
| Title : A radiometric study of cholinesterase and its inhibition - |
| Author(s) : Winteringham FP , Disney RW |
| Ref : Biochemical Journal , 91 :506 , 1964 |
| PubMedID: 5840710 |