Xu_2007_PLoS.Biol_5_e156

Reference

Title : Evolution of symbiotic bacteria in the distal human intestine - Xu_2007_PLoS.Biol_5_e156
Author(s) : Xu J , Mahowald MA , Ley RE , Lozupone CA , Hamady M , Martens EC , Henrissat B , Coutinho PM , Minx P , Latreille P , Cordum H , Van Brunt A , Kim K , Fulton RS , Fulton LA , Clifton SW , Wilson RK , Knight RD , Gordon JI
Ref : PLoS Biol , 5 :e156 , 2007
Abstract :

The adult human intestine contains trillions of bacteria, representing hundreds of species and thousands of subspecies. Little is known about the selective pressures that have shaped and are shaping this community's component species, which are dominated by members of the Bacteroidetes and Firmicutes divisions. To examine how the intestinal environment affects microbial genome evolution, we have sequenced the genomes of two members of the normal distal human gut microbiota, Bacteroides vulgatus and Bacteroides distasonis, and by comparison with the few other sequenced gut and non-gut Bacteroidetes, analyzed their niche and habitat adaptations. The results show that lateral gene transfer, mobile elements, and gene amplification have played important roles in affecting the ability of gut-dwelling Bacteroidetes to vary their cell surface, sense their environment, and harvest nutrient resources present in the distal intestine. Our findings show that these processes have been a driving force in the adaptation of Bacteroidetes to the distal gut environment, and emphasize the importance of considering the evolution of humans from an additional perspective, namely the evolution of our microbiomes.

PubMedSearch : Xu_2007_PLoS.Biol_5_e156
PubMedID: 17579514
Gene_locus related to this paper: 9bace-b6w170 , 9bace-c6z6f2 , 9bace-e1z049 , 9porp-c7xbp3 , 9porp-c7xci2 , 9porp-c7xdx2 , bacv8-a6kwf6 , bacv8-a6kzc1 , bacv8-a6kze8 , bacv8-a6l0d9 , bacv8-a6l1d0 , bacv8-a6l1u9 , bacv8-a6l7p9 , bacv8-a6l7w1 , bacv8-a6l018 , bacv8-a6l378 , bacv8-a6l415 , bacv8-a6l715 , pard8-a6lc23 , pard8-a6lca7 , pard8-a6ld87 , pard8-a6le10 , pard8-a6le63 , pard8-a6lfj2 , pard8-a6lgh2 , pard8-a6lgi6 , pard8-a6lgn7 , pard8-a6lhe1 , pard8-a6li91 , bacv8-a6l3w9 , pard8-a6lfk1

Related information

Gene_locus 9bace-b6w170    9bace-c6z6f2    9bace-e1z049    9porp-c7xbp3    9porp-c7xci2    9porp-c7xdx2    bacv8-a6kwf6    bacv8-a6kzc1    bacv8-a6kze8    bacv8-a6l0d9    bacv8-a6l1d0    bacv8-a6l1u9    bacv8-a6l7p9    bacv8-a6l7w1    bacv8-a6l018    bacv8-a6l378    bacv8-a6l415    bacv8-a6l715    pard8-a6lc23    pard8-a6lca7    pard8-a6ld87    pard8-a6le10    pard8-a6le63    pard8-a6lfj2    pard8-a6lgh2    pard8-a6lgi6    pard8-a6lgn7    pard8-a6lhe1    pard8-a6li91    bacv8-a6l3w9    pard8-a6lfk1

Citations formats

Xu J, Mahowald MA, Ley RE, Lozupone CA, Hamady M, Martens EC, Henrissat B, Coutinho PM, Minx P, Latreille P, Cordum H, Van Brunt A, Kim K, Fulton RS, Fulton LA, Clifton SW, Wilson RK, Knight RD, Gordon JI (2007)
Evolution of symbiotic bacteria in the distal human intestine
PLoS Biol 5 :e156

Xu J, Mahowald MA, Ley RE, Lozupone CA, Hamady M, Martens EC, Henrissat B, Coutinho PM, Minx P, Latreille P, Cordum H, Van Brunt A, Kim K, Fulton RS, Fulton LA, Clifton SW, Wilson RK, Knight RD, Gordon JI (2007)
PLoS Biol 5 :e156