2FJP

Name : Human dipeptidyl peptidase IV\/CD26 in complex with an inhibitor

Revelation date : 04-Jul-2006

Family : DPP4N_Peptidase_S9

Gene_locus : human-DPP4

PDB file : ESTHER: header of PDB entry RCSB: Full entry

Comment
Edmondson, S.D., Mastracchio, A., Mathwink, R.J., He, J., Harper, B, Park, Y-J., Beconi, M., Di Salvo, J., Eirmann, G.J., He, H, Leiting, B., Leone, J.F., Levorse, D.A., Lyons, K., Patel, R.A., Patel, S.B., Petrov, A., Scapin, G., Shang, J., Roy, R.S., Sm

Ligand :

References (1)

Title : (2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]tr iazolo[1,5-a]-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes - Edmondson_2006_J.Med.Chem_49_3614
Author(s) : Edmondson SD , Mastracchio A , Mathvink RJ , He J , Harper B , Park YJ , Beconi M , Di Salvo J , Eiermann GJ , He H , Leiting B , Leone JF , Levorse DA , Lyons K , Patel RA , Patel SB , Petrov A , Scapin G , Shang J , Roy RS , Smith A , Wu JK , Xu S , Zhu B , Thornberry NA , Weber AE
Ref : Journal of Medicinal Chemistry , 49 :3614 , 2006
PubMedID: 16759103
Gene_locus related to this paper: human-DPP4

Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server

Databases

PDB-Sum : 2FJP Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server

FSSP : 2FJP Fold classification based on Structure-Structure alignment of Proteins - FSSP server

SCOP : 2FJP Structural Classification Of Protein - SCOP server

PROTEOPEDIA : 2FJP 3D, interactive encyclopedia of proteins - PROTEOPEDIA server