Name : Human dipeptidyl peptidase 4 in complex with a diazepan-2-one inhibitor (compound 18)

Revelation date : 28-Nov-2006

Family : DPP4N_Peptidase_S9

Gene_locus : human-DPP4

PDB file : ESTHER: header of PDB entry RCSB: Full entry

Biftu, T., Feng, D., Qian, X., Linag, G.-B., Kieczykowsky, G., Eiermann, G., He, H., Leiting, B., Lyons, K.A., Sinha-Roy, R., Zhang, B., Scapin, G, Patel, S.B., Gao, Y.-D., Singh, S., Wu, J., Zhang, X., Thornberry, N.A., Weber, A. E.

Ligand :

References (1)

Title : (3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)- 1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes - Biftu_2007_Bioorg.Med.Chem.Lett_17_49
Author(s) : Biftu T , Feng D , Qian X , Liang GB , Kieczykowski G , Eiermann G , He H , Leiting B , Lyons K , Petrov A , Sinha-Roy R , Zhang B , Scapin G , Patel S , Gao YD , Singh S , Wu J , Zhang X , Thornberry NA , Weber AE
Ref : Bioorganic & Medicinal Chemistry Lett , 17 :49 , 2007
PubMedID: 17055272
Gene_locus related to this paper: human-DPP4

Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server


PDB-Sum : 2IIV Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server

FSSP : 2IIV Fold classification based on Structure-Structure alignment of Proteins - FSSP server

SCOP : 2IIV Structural Classification Of Protein - SCOP server

PROTEOPEDIA : 2IIV 3D, interactive encyclopedia of proteins - PROTEOPEDIA server