Diazepanone-Analog-18
General
Type : Trifluoro, Diazepan, Azepane
Chemical_Nomenclature : (3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-methyl-1,4-diazepan-2-one
Canonical SMILES : CC1C(=O)NCCCN1C(=O)CC(CC2=CC(=C(C=C2F)F)F)N
InChI : InChI=1S\/C16H20F3N3O2\/c1-9-16(24)21-3-2-4-22(9)15(23)7-11(20)5-10-6-13(18)14(19)8-12(10)17\/h6,8-9,11H,2-5,7,20H2,1H3,(H,21,24)\/t9-,11-\/m1\/s1
InChIKey : SWKGZJAAGSVROJ-MWLCHTKSSA-N
Other name(s) : 565 || DB07154 || (3R)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-methyl-1,4-diazepan-2-one || 1,4-diazepan-2-one 2b || 2iiv || Diazepanone Analog 18 || CHEMBL385711 || SCHEMBL1394444
MW : 343.35
Formula : C16H20F3N3O2
CAS_number :
PubChem : 10450114
UniChem : SWKGZJAAGSVROJ-MWLCHTKSSA-N
Target
Families : Diazepanone-Analog-18 ligand of proteins in family
DPP4N_Peptidase_S9
Structure :
2IIV
Protein :
human-DPP4
References (2)
| Title : (3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)- 1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes - Biftu_2007_Bioorg.Med.Chem.Lett_17_49 |
| Author(s) : Biftu T , Feng D , Qian X , Liang GB , Kieczykowski G , Eiermann G , He H , Leiting B , Lyons K , Petrov A , Sinha-Roy R , Zhang B , Scapin G , Patel S , Gao YD , Singh S , Wu J , Zhang X , Thornberry NA , Weber AE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 17 :49 , 2007 |
| Abstract : |
| PubMedSearch : Biftu_2007_Bioorg.Med.Chem.Lett_17_49 |
| PubMedID: 17055272 |
| Gene_locus related to this paper: human-DPP4 |
| Title : Optimization of 1,4-diazepan-2-one containing dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes - Liang_2007_Bioorg.Med.Chem.Lett_17_1903 |
| Author(s) : Liang GB , Qian X , Feng D , Biftu T , Eiermann G , He H , Leiting B , Lyons K , Petrov A , Sinha-Roy R , Zhang B , Wu J , Zhang X , Thornberry NA , Weber AE |
| Ref : Bioorganic & Medicinal Chemistry Lett , 17 :1903 , 2007 |
| Abstract : |
| PubMedSearch : Liang_2007_Bioorg.Med.Chem.Lett_17_1903 |
| PubMedID: 17291750 |