3OPM

Name : Crystal Structure of Human DPP4 Bound to TAK-294

Revelation date : 19-Oct-2011

Family : DPP4N_Peptidase_S9

Gene_locus : human-DPP4

PDB file : ESTHER: header of PDB entry RCSB: Full entry

Comment
Yoshihiro Banno, Yasufumi Miyamoto, Mitsuru Sasaki, Satoru Oi, Tomoko Asakawa, Osamu Kataoka, Koji Takeuchi, Nobuhiro Suzuki, Koji Ikedo, Takuo Kosaka, Shigetoshi Tsubotani, Akiyoshi Tani, Miyuki Funami, Michiko Tawada, Yoshio Yamamoto, Kathleen Aertgeerts, Jason Yano, Hironobu Maezaki

Ligand :

References (2)

Title : Identification of 3-aminomethyl-1,2-dihydro-4-phenyl-1-isoquinolones: a new class of potent, selective, and orally active non-peptide dipeptidyl peptidase IV inhibitors that form a unique interaction with Lys554 - Banno_2011_Bioorg.Med.Chem_19_4953
Author(s) : Banno Y , Miyamoto Y , Sasaki M , Oi S , Asakawa T , Kataoka O , Takeuchi K , Suzuki N , Ikedo K , Kosaka T , Tsubotani S , Tani A , Funami M , Tawada M , Yamamoto Y , Aertgeerts K , Yano J , Maezaki H
Ref : Bioorganic & Medicinal Chemistry , 19 :4953 , 2011
PubMedID: 21764322
Gene_locus related to this paper: human-DPP4

Title : Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554 - Maezaki_2011_Bioorg.Med.Chem_19_4482
Author(s) : Maezaki H , Banno Y , Miyamoto Y , Moritoh Y , Asakawa T , Kataoka O , Takeuchi K , Suzuki N , Ikedo K , Kosaka T , Sasaki M , Tsubotani S , Tani A , Funami M , Yamamoto Y , Tawada M , Aertgeerts K , Yano J , Oi S
Ref : Bioorganic & Medicinal Chemistry , 19 :4482 , 2011
PubMedID: 21741847
Gene_locus related to this paper: human-DPP4

Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server

Databases

PDB-Sum : 3OPM Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server

FSSP : 3OPM Fold classification based on Structure-Structure alignment of Proteins - FSSP server

SCOP : 3OPM Structural Classification Of Protein - SCOP server

PROTEOPEDIA : 3OPM 3D, interactive encyclopedia of proteins - PROTEOPEDIA server