Name : Crystal structure of DPP8 in complex with a 4-oxo-b-lactam based inhibitor, B114 (replaces 6T6T withdrawn)

Revelation date : 30-Jun-2021

Family : DPP4N_Peptidase_S9

Gene_locus : human-DPP8

PDB file : ESTHER: header of PDB entry RCSB: Full entry

Fehr, L., Carvalho, L.A.R., Ross, B.H., Lum, K., Vieira, A.C., Kiefersauer, R., Geiss-Friedlander, R., Kaiser, M., Rodrigues, T., Lucas, S.D., Cravatt, B.F., Huber, R., Moreira, R. || In the structure the beta-lactam ring is described as open

Ligand :

References (1)

Title : Chemoproteomics-Enabled Identification of 4-Oxo-beta-Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9 - Carvalho_2022_Angew.Chem.Int.Ed.Engl_61_e202210498
Author(s) : Carvalho LAR , Ross B , Fehr L , Bolgi O , Wohrle S , Lum KM , Podlesainski D , Vieira AC , Kiefersauer R , Felix R , Rodrigues T , Lucas SD , Gross O , Geiss-Friedlander R , Cravatt BF , Huber R , Kaiser M , Moreira R
Ref : Angew Chem Int Ed Engl , : , 2022
PubMedID: 36089535
Gene_locus related to this paper: human-DPP8 , human-DPP9

Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server


PDB-Sum : 7AYQ Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server

FSSP : 7AYQ Fold classification based on Structure-Structure alignment of Proteins - FSSP server

SCOP : 7AYQ Structural Classification Of Protein - SCOP server

PROTEOPEDIA : 7AYQ 3D, interactive encyclopedia of proteins - PROTEOPEDIA server