[11C]-MP4A

General

Type : Acetate || Piperidine || PET probe

Chemical_Nomenclature : (1-methylpiperidin-4-yl) acetate

Canonical SMILES : CC(=O)OC1CCN(CC1)C

InChI : InChI=1S\/C8H15NO2\/c1-7(10)11-8-3-5-9(2)6-4-8\/h8H,3-6H2,1-2H3\/i2-1

InChIKey : RWPYOAUYOSFJQV-JVVVGQRLSA-N

Other name(s) : [11C]MP4A, [11C]AMP, 11C-MP4A, 1-[11C]methylpiperidin acetate, N-[11C]methylpiperidinyl-4-acetate, (1-methylpiperidin-4-yl) acetate, AC1L9OVG, CHEMBL2311149, MOLI000787, MOLI001520


MW : 156.21

Formula : C8H14N

CAS_number :

PubChem :

UniChem :

Iuphar :

Target

Families : ACHE

References (26)

Title : PET Imaging of Cholinergic Neurotransmission in Neurodegenerative Disorders - Tiepolt_2022_J.Nucl.Med_63_33S
Author(s) : Tiepolt S , Meyer PM , Patt M , Deuther-Conrad W , Hesse S , Barthel H , Sabri O
Ref : J Nucl Med , 63 :33S , 2022
PubMedID: 35649648

Title : Voxel-Based Acetylcholinesterase PET Study in Early and Late Onset Alzheimer's Disease - Hirano_2018_J.Alzheimers.Dis_62_1539
Author(s) : Hirano S , Shinotoh H , Shimada H , Ota T , Sato K , Tanaka N , Zhang MR , Higuchi M , Fukushi K , Irie T , Kuwabara S , Suhara T
Ref : J Alzheimers Dis , 62 :1539 , 2018
PubMedID: 29562505

Title : Dementia with Lewy bodies can be well-differentiated from Alzheimer's disease by measurement of brain acetylcholinesterase activity-[(11)C]MP4A PET study -
Author(s) : Bohnen NI , Muller ML , Kaufer DI
Ref : Int J Geriatr Psychiatry , 31 :951 , 2016
PubMedID: 27001751

Title : PET probes for imaging brain acetylcholinesterase - Kikuchi_2013_J.Labelled.Comp.Radiopharm_56_172
Author(s) : Kikuchi T , Okamura T , Zhang MR , Irie T
Ref : J Labelled Comp Radiopharm , 56 :172 , 2013
PubMedID: 24285323

Title : Cholinergic system function and cognition in mild cognitive impairment - Haense_2012_Neurobiol.Aging_33_867
Author(s) : Haense C , Kalbe E , Herholz K , Hohmann C , Neumaier B , Krais R , Heiss WD
Ref : Neurobiology of Aging , 33 :867 , 2012
PubMedID: 20961662

Title : Reduced acetylcholinesterase activity in the fusiform gyrus in adults with autism spectrum disorders - Suzuki_2011_Arch.Gen.Psychiatry_68_306
Author(s) : Suzuki K , Sugihara G , Ouchi Y , Nakamura K , Tsujii M , Futatsubashi M , Iwata Y , Tsuchiya KJ , Matsumoto K , Takebayashi K , Wakuda T , Yoshihara Y , Suda S , Kikuchi M , Takei N , Sugiyama T , Irie T , Mori N
Ref : Arch Gen Psychiatry , 68 :306 , 2011
PubMedID: 21383265

Title : Use of a novel radiometric method to assess the inhibitory effect of donepezil on acetylcholinesterase activity in minimally diluted tissue samples - Kikuchi_2010_Br.J.Pharmacol_159_1732
Author(s) : Kikuchi T , Okamura T , Arai T , Obata T , Fukushi K , Irie T , Shiraishi T
Ref : British Journal of Pharmacology , 159 :1732 , 2010
PubMedID: 20401964

Title : Development of Alzheimer's disease imaging agents for clinical studies - Ryu_2008_Front.Biosci_13_777
Author(s) : Ryu EK , Chen X
Ref : Front Biosci , 13 :777 , 2008
PubMedID: 17981587

Title : Cerebral acetylcholinesterase imaging: development of the radioprobes - Kikuchi_2007_Curr.Top.Med.Chem_7_1790
Author(s) : Kikuchi T , Okamura T , Fukushi K , Takahashi K , Toyohara J , Okada M , Zhang MR , Irie T
Ref : Curr Top Med Chem , 7 :1790 , 2007
PubMedID: 17979787

Title : [Imaging of brain acetylcholinesterase activity in dementias and extrapyramidal disorders] - Shinotoh_2007_Rinsho.Shinkeigaku_47_822
Author(s) : Shinotoh H
Ref : Rinsho Shinkeigaku , 47 :822 , 2007
PubMedID: 18210807

Title : Cortical acetylcholine esterase activity and ApoE4-genotype in Alzheimer disease - Eggers_2006_Neurosci.Lett_408_46
Author(s) : Eggers C , Herholz K , Kalbe E , Heiss WD
Ref : Neuroscience Letters , 408 :46 , 2006
PubMedID: 16996687

Title : Estimation of plasma IC50 of donepezil hydrochloride for brain acetylcholinesterase inhibition in monkey using N-[11C]methylpiperidin-4-yl acetate ([11C]MP4A) and PET - Shiraishi_2005_Neuropsychopharmacology_30_2154
Author(s) : Shiraishi T , Kikuchi T , Fukushi K , Shinotoh H , Nagatsuka S , Tanaka N , Ota T , Sato K , Hirano S , Tanada S , Iyo M , Irie T
Ref : Neuropsychopharmacology , 30 :2154 , 2005
PubMedID: 15920507

Title : Effects of acute acetylcholinesterase inhibition on the cerebral cholinergic neuronal system and cognitive function: Functional imaging of the conscious monkey brain using animal PET in combination with microdialysis - Tsukada_2004_Synapse_52_1
Author(s) : Tsukada H , Nishiyama S , Fukumoto D , Ohba H , Sato K , Kakiuchi T
Ref : Synapse , 52 :1 , 2004
PubMedID: 14755627

Title : Acetylcholinesterase imaging: its use in therapy evaluation and drug design - Shinotoh_2004_Curr.Pharm.Des_10_1505
Author(s) : Shinotoh H , Fukushi K , Nagatsuka S , Irie T
Ref : Curr Pharm Des , 10 :1505 , 2004
PubMedID: 15134572

Title : Brain acetylcholinesterase activity in mild cognitive impairment and early Alzheimer's disease - Rinne_2003_J.Neurol.Neurosurg.Psychiatry_74_113
Author(s) : Rinne JO , Kaasinen V , Jarvenpaa T , Nagren K , Roivainen A , Yu M , Oikonen V , Kurki T
Ref : Journal of Neurology Neurosurg Psychiatry , 74 :113 , 2003
PubMedID: 12486280

Title : Positron emission tomography: quantitative measurement of brain acetylcholinesterase activity using radiolabeled substrates - Namba_2002_Methods_27_242
Author(s) : Namba H , Fukushi K , Nagatsuka S , Iyo M , Shinotoh H , Tanada S , Irie T
Ref : Methods , 27 :242 , 2002
PubMedID: 12183113

Title : Synthesis and preliminary evaluation of [18F]FEtP4A, a promising PET tracer for mapping acetylcholinesterase in vivo - Zhang_2002_Nucl.Med.Biol_29_463
Author(s) : Zhang MR , Tsuchiyama A , Haradahira T , Furutsuka K , Yoshida Y , Kida T , Noguchi J , Irie T , Suzuki K
Ref : Nucl Med Biol , 29 :463 , 2002
PubMedID: 12031881

Title : Positron emission tomographic measurement of brain acetylcholinesterase activity using N-[(11)C]methylpiperidin-4-yl acetate without arterial blood sampling: methodology of shape analysis and its diagnostic power for Alzheimer's disease - Tanaka_2001_J.Cereb.Blood.Flow.Metab_21_295
Author(s) : Tanaka N , Fukushi K , Shinotoh H , Nagatsuka S , Namba H , Iyo M , Aotsuka A , Ota T , Tanada S , Irie T
Ref : Journal of Cerebral Blood Flow & Metabolism , 21 :295 , 2001
PubMedID: 11295884

Title : Kinetic analysis of [(11)C]MP4A using a high-radioactivity brain region that represents an integrated input function for measurement of cerebral acetylcholinesterase activity without arterial blood sampling - Nagatsuka_2001_J.Cereb.Blood.Flow.Metab_21_1354
Author(s) : Nagatsuka Si S , Fukushi K , Shinotoh H , Namba H , Iyo M , Tanaka N , Aotsuka A , Ota T , Tanada S , Irie T
Ref : Journal of Cerebral Blood Flow & Metabolism , 21 :1354 , 2001
PubMedID: 11702050

Title : In-vivo measurements of regional acetylcholine esterase activity in degenerative dementia: comparison with blood flow and glucose metabolism - Herholz_2000_J.Neural.Transm.(Vienna)_107_1457
Author(s) : Herholz K , Bauer B , Wienhard K , Kracht L , Mielke R , Lenz MO , Strotmann T , Heiss WD
Ref : J Neural Transm (Vienna) , 107 :1457 , 2000
PubMedID: 11458998

Title : Human cerebral acetylcholinesterase activity measured with positron emission tomography: procedure, normal values and effect of age - Namba_1999_Eur.J.Nucl.Med_26_135
Author(s) : Namba H , Iyo M , Fukushi K , Shinotoh H , Nagatsuka S , Suhara T , Sudo Y , Suzuki K , Irie T
Ref : Eur J Nucl Med , 26 :135 , 1999
PubMedID: 9933347

Title : Positron emission tomographic measurement of acetylcholinesterase activity reveals differential loss of ascending cholinergic systems in Parkinson's disease and progressive supranuclear palsy - Shinotoh_1999_Ann.Neurol_46_62
Author(s) : Shinotoh H , Namba H , Yamaguchi M , Fukushi K , Nagatsuka S , Iyo M , Asahina M , Hattori T , Tanada S , Irie T
Ref : Annals of Neurology , 46 :62 , 1999
PubMedID: 10401781

Title : N-[11C]methylpiperidine esters as acetylcholinesterase substrates: an in vivo structure-reactivity study - Kilbourn_1998_Nucl.Med.Biol_25_755
Author(s) : Kilbourn MR , Nguyen TB , Snyder SE , Sherman P
Ref : Nucl Med Biol , 25 :755 , 1998
PubMedID: 9863563

Title : Syntheses of carbon-11 labeled piperidine esters as potential in vivo substrates for acetylcholinesterase - Nguyen_1998_Nucl.Med.Biol_25_761
Author(s) : Nguyen TB , Snyder SE , Kilbourn MR
Ref : Nucl Med Biol , 25 :761 , 1998
PubMedID: 9863564

Title : Measurement of acetylcholinesterase by positron emission tomography in the brains of healthy controls and patients with Alzheimer's disease - Iyo_1997_Lancet_349_1805
Author(s) : Iyo M , Namba H , Fukushi K , Shinotoh H , Nagatsuka S , Suhara T , Sudo Y , Suzuki K , Irie T
Ref : Lancet , 349 :1805 , 1997
PubMedID: 9269216

Title : Brain acetylcholinesterase activity: validation of a PET tracer in a rat model of Alzheimer's disease - Irie_1996_J.Nucl.Med_37_649
Author(s) : Irie T , Fukushi K , Namba H , Iyo M , Tamagami H , Nagatsuka S , Ikota N
Ref : J Nucl Med , 37 :649 , 1996
PubMedID: 8691261