8,9-EET
important dilator in a number of vascular beds. Synthetized by cytochrome P450 epoxygenase from arachidonic acid
General
Type : Epoxide, Fatty acid, Epoxy-fatty-acid
Chemical_Nomenclature : (Z)-7-[3-[(2Z,5Z)-undeca-2,5-dienyl]oxiran-2-yl]hept-5-enoic acid
Canonical SMILES : CCCCC\/C=CC\/C=CCC1C(O1)C\/C=CCCCC(=O)O
InChI : InChI=1S\/C20H32O3\/c1-2-3-4-5-6-7-8-9-12-15-18-19(23-18)16-13-10-11-14-17-20(21)22\/h6-7,9-10,12-13,18-19H,2-5,8,11,14-17H2,1H3,(H,21,22)\/b7-6-,12-9-,13-10-
InChIKey : DBWQSCSXHFNTMO-TYAUOURKSA-N
Other name(s) : (+\/-)8,9-EpETrE\; 8,9-epoxyeicosatrienoic acid || 8,9-epoxy-5Z,11Z,14Z-eicosatrienoic acid || CHEBI:34490 || (5Z,11Z,14Z)-8,9-Epoxyeicosa-5,11,14-trienoic acid || (5Z,11Z,14Z)-8,9-Epoxyicosa-5,11,14-trienoic acid || 8(9)-EpETrE
Target
Structures : No structure
Families : Epoxide_hydrolase
References (4)
| Title : Putative receptors and signaling pathways responsible for the biological actions of epoxyeicosatrienoic acids - Edin_2025_J.Biol.Chem__110737 |
| Author(s) : Edin ML , Graves JP , Zeldin DC |
| Ref : Journal of Biological Chemistry , :110737 , 2025 |
| Abstract : |
| PubMedSearch : Edin_2025_J.Biol.Chem__110737 |
| PubMedID: 40975174 |
| Gene_locus related to this paper: human-EPHX2 |
| Title : Altered behavioral phenotypes in soluble epoxide hydrolase knockout mice: effects of traumatic brain injury - Strauss_2013_Prostaglandins.Other.Lipid.Mediat_104-105_18 |
| Author(s) : Strauss KI , Gruzdev A , Zeldin DC |
| Ref : Prostaglandins Other Lipid Mediat , 104-105 :18 , 2013 |
| Abstract : |
| PubMedSearch : Strauss_2013_Prostaglandins.Other.Lipid.Mediat_104-105_18 |
| PubMedID: 22922090 |
| Title : A soluble epoxide hydrolase inhibitor--8-HUDE increases pulmonary vasoconstriction through inhibition of K(ATP) channels - Liu_2012_Pulm.Pharmacol.Ther_25_69 |
| Author(s) : Liu Y , Zhang J , Yu L , Cao F , Rao J , Li J , Jiang C , Falck JR , Jacobs ER , Zhu D |
| Ref : Pulm Pharmacol Ther , 25 :69 , 2012 |
| Abstract : |
| PubMedSearch : Liu_2012_Pulm.Pharmacol.Ther_25_69 |
| PubMedID: 22155000 |
| Title : 8,9-Epoxyeicosatrienoic acid inhibits antibody production of B lymphocytes in mice - Gao_2012_PLoS.One_7_e40258 |
| Author(s) : Gao Y , Feng J , Ma K , Zhou Z , Zhu Y , Xu Q , Wang X |
| Ref : PLoS ONE , 7 :e40258 , 2012 |
| Abstract : |
| PubMedSearch : Gao_2012_PLoS.One_7_e40258 |
| PubMedID: 22802958 |