Aldicarb
Insecticide, acaricide, nematocide || Aldicarb is a synthetic oxime carbamate compound and carbamate acetylcholinesterase inhibitor, endocrine disruptor, and neurotoxin. aldicarb is a mixture of E and Z isomers; it is not known which isomer is more active. It has a role as a carbamate insecticide, an EC 3.1.1.7 (acetylcholinesterase) inhibitor, an acaricide and a nematicide. CocH1 the A199S/S287G/A328W/Y332G mutant of human BChE , truncated after amino acid 529, was fused with human serum albumin (HSA) to prolong the biological t1/2 . This HSA-fused BChE mutant is also known as Albu-CocH, Albu-CocH1, AlbuBChE, or TV-1380. CocH3-Fc(M3) a triple mutant (i.e., A1V/D142E/L144M), denoted Fc(M3). CocH3-Fc(M3) also has significant catalytic activity for aldicarb hydrolysis
General
Type : Insecticide, Carbamate, Sulfur Compound
Chemical_Nomenclature : [(E)-(2-methyl-2-methylsulfanylpropylidene)amino] N-methylcarbamate
Canonical SMILES : CC(C)(C=NOC(=O)NC)SC
InChI : InChI=1S\/C7H14N2O2S\/c1-7(2,12-4)5-9-11-6(10)8-3\/h5H,1-4H3,(H,8,10)\/b9-5+
InChIKey : QGLZXHRNAYXIBU-WEVVVXLNSA-N
Other name(s) : 2-Methyl-2-(methylthio)propanal O-[(methylamino)carbonyl]oxime || 2-methyl-2-(methylthio)propionaldehyde O-methylcarbamoyloxime || aldicarbe || Temik || UC21149 || temik g10 || temik 10 g || UNII-OR2E6B4F2X || CHEBI:2555 || SCHEMBL9781 || CHEMBL91732
MW : 190.27
Formula : C7H14N2O2S
CAS_number : 116-06-3
UniChem : QGLZXHRNAYXIBU-WEVVVXLNSA-N
Wikipedia : Aldicarb
Target
Structures : No structure
Families : ACHE
References (3)
| Title : A cocaine hydrolase engineered from human butyrylcholinesterase as a medical countermeasure for aldicarb poisoning - LeSaint_2025_Chem.Biol.Interact_15ChEPon_416_111675 |
| Author(s) : LeSaint JE , Chandar NB , Kyomuhangi A , Wei H , Zheng F , Zhan CG |
| Ref : Chemico-Biological Interactions , :111675 , 2025 |
| Abstract : |
| PubMedSearch : LeSaint_2025_Chem.Biol.Interact_15ChEPon_416_111675 |
| PubMedID: 40752825 |
| Gene_locus related to this paper: human-BCHE |
| Title : A cocaine hydrolase engineered from human butyrylcholinesterase as a medical countermeasure for aldicarb poisoning - LeSaint_2025_Chem.Biol.Interact_15ChEPon_416_111675 |
| Author(s) : LeSaint JE , Chandar NB , Kyomuhangi A , Wei H , Zheng F , Zhan CG |
| Ref : Chemico-Biological Interactions , :111675 , 2025 |
| Abstract : |
| PubMedSearch : LeSaint_2025_Chem.Biol.Interact_15ChEPon_416_111675 |
| PubMedID: 40752825 |
| Gene_locus related to this paper: human-BCHE |
| Title : A cocaine hydrolase engineered from human butyrylcholinesterase as a medical countermeasure for aldicarb poisoning - LeSaint_2025_Chem.Biol.Interact_15ChEPon_416_111675 |
| Author(s) : LeSaint JE , Chandar NB , Kyomuhangi A , Wei H , Zheng F , Zhan CG |
| Ref : Chemico-Biological Interactions , :111675 , 2025 |
| Abstract : |
| PubMedSearch : LeSaint_2025_Chem.Biol.Interact_15ChEPon_416_111675 |
| PubMedID: 40752825 |
| Gene_locus related to this paper: human-BCHE |