Dipalmitoylphosphatidylcholine
Pulmonary surfactant is a surface-active complex of phospholipids and proteins formed by type II alveolar cells. The proteins and lipids that make up the surfactant have both hydrophilic and hydrophobic regions. By adsorbing to the air-water interface of alveoli, with hydrophilic head groups in the water and the hydrophobic tails facing towards the air, the main lipid component of surfactant, dipalmitoylphosphatidylcholine (DPPC), reduces surface tension. Colfosceril palmitate is a drug used as a pulmonary surfactant. It is a drug that is used in surfactant deficient conditions such as IRDS in newborns.
General
Type : Phospholipid, Phosphatidylcholine, Diacylglycerol, Trimethylammonium, Choline ester, Hexadecanoate, Palmitate, Surfactant
Chemical_Nomenclature : 2,3-di(hexadecanoyloxy)propyl 2-(trimethylazaniumyl)ethyl phosphate
Canonical SMILES : CCCCCCCCCCCCCCCC(=O)OCC(COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC
InChI : InChI=1S\/C40H80NO8P\/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-39(42)46-36-38(37-48-50(44,45)47-35-34-41(3,4)5)49-40(43)33-31-29-27-25-23-21-19-17-15-13-11-9-7-2\/h38H,6-37H2,1-5H3
InChIKey : KILNVBDSWZSGLL-UHFFFAOYSA-N
Other name(s) : Dipalmitoyl phosphatidylcholine || Dipalmitoyl phosphatidylcholine[PC] || DPPC || Colfosceril palmitate || DPPC (phosphatide) || Coatsome MC 6060 || 1,2-Dipalmitoyllecithin || 1,2-Dipalmitoyl-L-lecithin || 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine || 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine || DiPalmitoylphosphatidylcholine
MW : 734.03
Formula : C40H80NO8P
CAS_number : 2644-64-6, 2797-68-4, 63-89-8
PubChem : 6138
UniChem : KILNVBDSWZSGLL-UHFFFAOYSA-N
Wikipedia : Dipalmitoylphosphatidylcholine
Target
Structures : No structure
Families : PlaB, PC-sterol_acyltransferase
References (2)
| Title : Phospholipase PlaB of Legionella pneumophila represents a novel lipase family: protein residues essential for lipolytic activity, substrate specificity, and hemolysis - Bender_2009_J.Biol.Chem_284_27185 |
| Author(s) : Bender J , Rydzewski K , Broich M , Schunder E , Heuner K , Flieger A |
| Ref : Journal of Biological Chemistry , 284 :27185 , 2009 |
| Abstract : |
| PubMedSearch : Bender_2009_J.Biol.Chem_284_27185 |
| PubMedID: 19640837 |
| Gene_locus related to this paper: legpn-i7i328 , legsp-a3fmk8 |
| Title : The stability of liposomes in vitro to pH, bile salts and pancreatic lipase - Rowland_1980_Biochim.Biophys.Acta_620_400 |
| Author(s) : Rowland RN , Woodley JF |
| Ref : Biochimica & Biophysica Acta , 620 :400 , 1980 |
| Abstract : |
| PubMedSearch : Rowland_1980_Biochim.Biophys.Acta_620_400 |
| PubMedID: 7016185 |