Choline ester

Acylcholines are acyl chain esterified to choline. Acetylcholine acts as a neurotransmitter in the central and peripheral nervous systems as well as an inhibitor of cytokine production by macrophages and immune cells. Acylcholines are metabolized by cholinesterases acetylcholinesterase (ACHE) and butyrylcholinesterase (BCHE). Long-chain acylcholines show greater stability in circulation. Metabolomic profiling studies have expanded endogenously produced members of the acylcholine class to include long-chain esters. This entry also contains phosphatidylcholine (phospholipids that incorporate choline as a headgroup) major component of biological membranes
Substrate Main targeted enzyme families Type Structure
QA-Cbl BCHE Pro-Drug Drug Choline ester Trimethylammonium
DNPG PAF-Acetylhydrolase Choline ester pNP Trimethylammonium Phospholipid
RedGreen-BODIPY-PC-A2 Fluorescent Probe BODIPY-derivative Choline ester Boron compound Not A\/B H target Trimethylammonium Phospholipid
Heptadecanoylphosphatidylcholine Hepatic_Lipase AlphaBeta_hydrolase PlaB Trimethylammonium Choline ester Lysophospholipid Phospholipid
Diheptadecanoylphosphatidylcholine Hepatic_Lipase Trimethylammonium Phospholipid Choline ester
Dipalmitoylphosphatidylcholine PlaB PC-sterol_acyltransferase Phospholipid Phosphatidylcholine Diacylglycerol Trimethylammonium Choline ester Hexadecanoate Palmitate Surfactant
1-Stearoyl-2-arachidonylphosphatidylcholine PC-sterol_acyltransferase Hepatic_Lipase Phospholipid Phosphatidylcholine Diacylglycerol Choline ester Trimethylammonium
1-palmitoyl-2-linoleoylphosphatidylcholine Plant_phospholipase PC-sterol_acyltransferase Hepatic_Lipase Lipoprotein_Lipase Phospholipid Phosphatidylcholine Diacylglycerol Choline ester Trimethylammonium
Dioleoyllecithin Phospholipase Phospholipid Phosphatidylcholine Diacylglycerol Choline ester Trimethylammonium
POPC Mbeg1-like Phospholipase Plant_phospholipase PC-sterol_acyltransferase Trimethylammonium Phospholipid Phosphatidylcholine Diacylglycerol Choline ester Hexadecanoate Palmitate
Arachidonoylcholine BCHE Choline ester Trimethylammonium
PAF-2-Thio PAF-Acetylhydrolase LYsophospholipase_carboxylesterase Trimethylammonium Choline ester Phospholipid Phosphatidylcholine
PAF PAF-Acetylhydrolase LYsophospholipase_carboxylesterase Natural Trimethylammonium Water-insoluble medium and long chain ester Choline ester Not A\/B H target Phosphatidylcholine
Myristoylcholine Trimethylammonium Choline ester
Carbachol ACHE Drug Not A\/B H target Carbamate Trimethylammonium Choline ester Analogue of substrate
Succinylcholine~Suxamethonium BCHE Trimethylammonium Choline ester
Acetylazacholine ACHE Acetate Trimethylammonium Choline ester
Acetylbetamethylcholine ACHE Acetate Trimethylammonium Choline ester
Acetylbetamethylthiocholine ACHE Acetate Trimethylammonium Choline ester Chromogen
Acetylcholine ACHE BCHE Cholinesterase Cholinesterase-like Acetate Trimethylammonium Natural Choline ester
Acetylselenocholine ACHE Acetate Trimethylammonium Choline ester
Acetylthiocholine ACHE BCHE Cholinesterase Cholinesterase-like Acetate Trimethylammonium Choline ester Chromogen
Benzoylcholine BCHE ACHE Trimethylammonium Benzoate Choline ester
Butyrylcholine BCHE Butyrate Trimethylammonium Choline ester
Butyrylthiocholine BCHE Butyrate Trimethylammonium Choline ester Chromogen
Heptanoylcholine BCHE Choline ester Trimethylammonium
Hexanoylcholine BCHE Hexanoate Trimethylammonium Choline ester
Pentanoylcholine BCHE Trimethylammonium Choline ester
Propionylcholine BCHE ACHE Propionate Trimethylammonium Choline ester
Propionylthiocholine ACHE BCHE Propionate Trimethylammonium Choline ester Chromogen
Succinyldithiocholine BCHE Trimethylammonium Choline ester Chromogen
Benzoylthiocholine BCHE ACHE Trimethylammonium Choline ester Chromogen
1-Myristoyl-2-linoleoylphosphatidylcholine abh_upf0017 Phospholipid Phosphatidylcholine Diacylglycerol Choline ester Trimethylammonium
C14-lysophosphatidylcholine abh_upf0017 Phospholipid Lysophospholipid Trimethylammonium Choline ester