Prilocaine
A local anesthetic that is similar pharmacologically to lidocaine. Currently, it is used most often for infiltration anesthesia in dentistry.
General
Type : Local anesthetic, Drug, Not AlphaBeta Hydrolase target
Chemical_Nomenclature : N-(2-methylphenyl)-2-(propylamino)propanamide
Canonical SMILES : CCCNC(C)C(=O)NC1=CC=CC=C1C
InChI : InChI=1S\/C13H20N2O\/c1-4-9-14-11(3)13(16)15-12-8-6-5-7-10(12)2\/h5-8,11,14H,4,9H2,1-3H3,(H,15,16)
InChIKey : MVFGUOIZUNYYSO-UHFFFAOYSA-N
Other name(s) : prilocaine base || Prilocaina || Prilocainum || N-(2-Methylphenyl)-2-(propylamino)propanamide || Propanamide, N-(2-methylphenyl)-2-(propylamino)- || Astra 1515 || Prilocaine hydrochloride || \; Prilocaine HCl || \; Citanest hydrochloride || \; Citanest plain\; ... || L-(+)-Prilocaine HCl || L-(+)-Prilocaine hydrochloride || NIOSH\/TX1480020 || TX14800200 || o-Propionotoluidide, 2-(propylamino)-, hydrochloride, L-(+)- || D-(-)-Prilocaine HCl || D-(-)-Prilocaine hydrochloride || NIOSH\/TX1480010 || TX14800100 || o-Propionotoluidide, 2-(propylamino)-, hydrochloride, D-(-)- || Prilocaine-d7 (hydrochloride) || HY-B0137AS || CS-0375178 || Prilocaine-d7 Hydrochloride
Target
Structures : No structure
Families : Carb_B_Chordata
References (7)
| Title : Difference in substrate specificity of carboxylesterase and arylacetamide deacetylase between dogs and humans - Yoshida_2018_Eur.J.Pharm.Sci_111_167 |
| Author(s) : Yoshida T , Fukami T , Kurokawa T , Gotoh S , Oda A , Nakajima M |
| Ref : Eur J Pharm Sci , 111 :167 , 2018 |
| Abstract : |
| PubMedSearch : Yoshida_2018_Eur.J.Pharm.Sci_111_167 |
| PubMedID: 28966098 |
| Gene_locus related to this paper: canfa-CESDD1 , canfa-f1p6w8 , canlf-e2r2h2 |
| Title : Metabolic Hydrolysis of Aromatic Amides in Selected Rat, Minipig, and Human In Vitro Systems - Bradshaw_2018_Sci.Rep_8_2405 |
| Author(s) : Bradshaw PR , Wilson ID , Gill RU , Butler PJ , Dilworth C , Athersuch TJ |
| Ref : Sci Rep , 8 :2405 , 2018 |
| Abstract : |
| PubMedSearch : Bradshaw_2018_Sci.Rep_8_2405 |
| PubMedID: 29402925 |
| Title : Prilocaine- and lidocaine-induced methemoglobinemia is caused by human carboxylesterase-, CYP2E1-, and CYP3A4-mediated metabolic activation - Higuchi_2013_Drug.Metab.Dispos_41_1220 |
| Author(s) : Higuchi R , Fukami T , Nakajima M , Yokoi T |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 41 :1220 , 2013 |
| Abstract : |
| PubMedSearch : Higuchi_2013_Drug.Metab.Dispos_41_1220 |
| PubMedID: 23530020 |
| Title : A structure-based approach to nicotinic receptor pharmacology - Ryan_1999_Mol.Pharmacol_55_348 |
| Author(s) : Ryan SE , Baenziger JE |
| Ref : Molecular Pharmacology , 55 :348 , 1999 |
| Abstract : |
| PubMedSearch : Ryan_1999_Mol.Pharmacol_55_348 |
| PubMedID: 9927628 |
| Title : Adverse effects and drug interactions associated with local and regional anaesthesia - Naguib_1998_Drug.Saf_18_221 |
| Author(s) : Naguib M , Magboul MM , Samarkandi AH , Attia M |
| Ref : Drug Safety , 18 :221 , 1998 |
| Abstract : |
| PubMedSearch : Naguib_1998_Drug.Saf_18_221 |
| PubMedID: 9565736 |
| Title : Low-dose mivacurium supplementation of prilocaine i.v. regional anaesthesia - Torrance_1997_Br.J.Anaesth_78_222 |
| Author(s) : Torrance JM , Lewer BM , Galletly DC |
| Ref : British Journal of Anaesthesia , 78 :222 , 1997 |
| Abstract : |
| PubMedSearch : Torrance_1997_Br.J.Anaesth_78_222 |
| PubMedID: 9068344 |
| Title : Clinical pharmacokinetics of local anaesthetics - Tucker_1979_Clin.Pharmacokinet_4_241 |
| Author(s) : Tucker GT , Mather LE |
| Ref : Clinical Pharmacokinetics , 4 :241 , 1979 |
| Abstract : |
| PubMedSearch : Tucker_1979_Clin.Pharmacokinet_4_241 |
| PubMedID: 385208 |