Probenecid-glucuronide
Probenecid, a widely used uricosuric agent, is mainly metabolized to probenecid acyl glucuronide (PRAG), which is considered a causal substance of severe allergic or anaphylactoid reactions
General
Type : Lactone, Drug, Not AlphaBeta Hydrolase target, Glucuronide
Chemical_Nomenclature : (2S,3S,4S,5R,6S)-6-[4-(dipropylsulfamoyl)benzoyl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
Canonical SMILES : CCCN(CCC)S(=O)(=O)C1=CC=C(C=C1)C(=O)OC2C(C(C(C(O2)C(=O)O)O)O)O
InChI : InChI=1S\/C19H27NO10S\/c1-3-9-20(10-4-2)31(27,28)12-7-5-11(6-8-12)18(26)30-19-15(23)13(21)14(22)16(29-19)17(24)25\/h5-8,13-16,19,21-23H,3-4,9-10H2,1-2H3,(H,24,25)\/t13-,14-,15+,16-,19-\/m0\/s1
InChIKey : BZOGRYWIYJNLDE-NAHJCDBISA-N
Other name(s) : Probenecid Glucuronide || Probenecid Acyl beta-D-Glucuronide || AC1L4AEK || Probenecid Acyl |A-D-Glucuronide || ZINC31501036
MW : 461.48
Formula : C19H27NO10S
CAS_number : 34017-15-7
PubChem : 182154
UniChem : BZOGRYWIYJNLDE-NAHJCDBISA-N
Target
Structures : No structure
Families : ABHD10
References (1)
| Title : An Orphan Esterase ABHD10 Modulates Probenecid Acyl Glucuronidation in Human Liver - Ito_2014_Drug.Metab.Dispos_42_2109 |
| Author(s) : Ito Y , Fukami T , Yokoi T , Nakajima M |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 42 :2109 , 2014 |
| Abstract : |
| PubMedSearch : Ito_2014_Drug.Metab.Dispos_42_2109 |
| PubMedID: 25217485 |
| Gene_locus related to this paper: human-ABHD10 , mouse-abhda |