Abhydrolase domain-containing protein 10, Mycophenolic acid acyl-glucuronide esterase, mitochondrial. Mycophenolic acid (MPA), the active metabolite of the immunosuppressant mycophenolate mofetil (MMF), is primarily metabolized by glucuronidation to a phenolic glucuronide (MPAG) and an acyl glucuronide (AcMPAG Mycophenolic-acid-acyl-glucuronide). AcMPAG, may be an immunotoxic, and is deglucuronidated by ABBHD10. ABHD10 is an S-depalmitoylase affecting redox homeostasis through peroxiredoxin-5 (Cao et al.). The name of this family should not be confounded with family Abhydrolase_10 which is quite far related and contains only sequences from bacteria and fungi
Interpro : No interpro
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : No Pfam
Prints : No Print
EC Number : No EC Number
Structures (1)
Genes Proteins in ABHD10 family (151)
Fragments of genes in ABHD10 family (11)
Structures in ABHD10 family (1)Substrates in ABHD10 family (5)
Inhibitors in ABHD10 family (5)
Title : ABHD10 is an S-depalmitoylase affecting redox homeostasis through peroxiredoxin-5 - Cao_2019_Nat.Chem.Biol_15_1232 |
Author(s) : Cao Y , Qiu T , Kathayat RS , Azizi SA , Thorne AK , Ahn D , Fukata Y , Fukata M , Rice PA , Dickinson BC |
Ref : Nat Chemical Biology , 15 :1232 , 2019 |
Abstract : Cao_2019_Nat.Chem.Biol_15_1232 |
ESTHER : Cao_2019_Nat.Chem.Biol_15_1232 |
PubMedSearch : Cao_2019_Nat.Chem.Biol_15_1232 |
PubMedID: 31740833 |
Gene_locus related to this paper: human-ABHD10 , mouse-abhda |
Title : Role of Human Orphan Esterases in Drug-induced Toxicity - Fukami_2015_Yakugaku.Zasshi_135_1235 |
Author(s) : Fukami T |
Ref : Yakugaku Zasshi , 135 :1235 , 2015 |
Abstract : Fukami_2015_Yakugaku.Zasshi_135_1235 |
ESTHER : Fukami_2015_Yakugaku.Zasshi_135_1235 |
PubMedSearch : Fukami_2015_Yakugaku.Zasshi_135_1235 |
PubMedID: 26521872 |
Gene_locus related to this paper: human-ABHD10 |
Title : An Orphan Esterase ABHD10 Modulates Probenecid Acyl Glucuronidation in Human Liver - Ito_2014_Drug.Metab.Dispos_42_2109 |
Author(s) : Ito Y , Fukami T , Yokoi T , Nakajima M |
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 42 :2109 , 2014 |
Abstract : Ito_2014_Drug.Metab.Dispos_42_2109 |
ESTHER : Ito_2014_Drug.Metab.Dispos_42_2109 |
PubMedSearch : Ito_2014_Drug.Metab.Dispos_42_2109 |
PubMedID: 25217485 |
Gene_locus related to this paper: human-ABHD10 , mouse-abhda |
Title : Remodeling natural products: chemistry and serine hydrolase activity of a rocaglate-derived beta-lactone - Lajkiewicz_2014_J.Am.Chem.Soc_136_2659 |
Author(s) : Lajkiewicz NJ , Cognetta AB, 3rd , Niphakis MJ , Cravatt BF , Porco JA, Jr. |
Ref : Journal of the American Chemical Society , 136 :2659 , 2014 |
Abstract : Lajkiewicz_2014_J.Am.Chem.Soc_136_2659 |
ESTHER : Lajkiewicz_2014_J.Am.Chem.Soc_136_2659 |
PubMedSearch : Lajkiewicz_2014_J.Am.Chem.Soc_136_2659 |
PubMedID: 24447064 |
Gene_locus related to this paper: human-ABHD10 , human-ACOT1 , human-ACOT2 , human-CTSA , human-SCPEP1 , mouse-abhda |
Title : Human alpha\/beta hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver - Iwamura_2012_J.Biol.Chem_287_9240 |
Author(s) : Iwamura A , Fukami T , Higuchi R , Nakajima M , Yokoi T |
Ref : Journal of Biological Chemistry , 287 :9240 , 2012 |
Abstract : Iwamura_2012_J.Biol.Chem_287_9240 |
ESTHER : Iwamura_2012_J.Biol.Chem_287_9240 |
PubMedSearch : Iwamura_2012_J.Biol.Chem_287_9240 |
PubMedID: 22294686 |
Gene_locus related to this paper: human-ABHD10 , mouse-abhda |
Title : Competitive activity-based protein profiling identifies aza-beta-lactams as a versatile chemotype for serine hydrolase inhibition - Zuhl_2012_J.Am.Chem.Soc_134_5068 |
Author(s) : Zuhl AM , Mohr JT , Bachovchin DA , Niessen S , Hsu KL , Berlin JM , Dochnahl M , Lopez-Alberca MP , Fu GC , Cravatt BF |
Ref : J Am Chem Soc , 134 :5068 , 2012 |
Abstract : Zuhl_2012_J.Am.Chem.Soc_134_5068 |
ESTHER : Zuhl_2012_J.Am.Chem.Soc_134_5068 |
PubMedSearch : Zuhl_2012_J.Am.Chem.Soc_134_5068 |
PubMedID: 22400490 |
Gene_locus related to this paper: human-ABHD10 |
Title : The emerging role of human esterases - Fukami_2012_Drug.Metab.Pharmacokinet_27_466 |
Author(s) : Fukami T , Yokoi T |
Ref : Drug Metab Pharmacokinet , 27 :466 , 2012 |
Abstract : Fukami_2012_Drug.Metab.Pharmacokinet_27_466 |
ESTHER : Fukami_2012_Drug.Metab.Pharmacokinet_27_466 |
PubMedSearch : Fukami_2012_Drug.Metab.Pharmacokinet_27_466 |
PubMedID: 22813719 |
Gene_locus related to this paper: human-ABHD10 |