ABHD10

Relationship

Family: ABHD10

Block: X

Parent Family: Hydrolase_4

Comment

Abhydrolase domain-containing protein 10, Mycophenolic acid acyl-glucuronide esterase, mitochondrial. Mycophenolic acid (MPA), the active metabolite of the immunosuppressant mycophenolate mofetil (MMF), is primarily metabolized by glucuronidation to a phenolic glucuronide (MPAG) and an acyl glucuronide (AcMPAG Mycophenolic-acid-acyl-glucuronide). AcMPAG, may be an immunotoxic, and is deglucuronidated by ABBHD10. ABHD10 is an S-depalmitoylase affecting redox homeostasis through peroxiredoxin-5 (Cao et al.). The name of this family should not be confounded with family Abhydrolase_10 which is quite far related and contains only sequences from bacteria and fungi

Database

Interpro : No interpro

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : No Pfam

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (1)

Genes Proteins in ABHD10 family (151)

Fragments of genes in ABHD10 family (11)

Structures in ABHD10 family (1)

Substrates in ABHD10 family (5)

Inhibitors in ABHD10 family (5)

References (7)

Title : ABHD10 is an S-depalmitoylase affecting redox homeostasis through peroxiredoxin-5 - Cao_2019_Nat.Chem.Biol_15_1232
Author(s) : Cao Y , Qiu T , Kathayat RS , Azizi SA , Thorne AK , Ahn D , Fukata Y , Fukata M , Rice PA , Dickinson BC
Ref : Nat Chemical Biology , 15 :1232 , 2019
PubMedID: 31740833
Gene_locus related to this paper: human-ABHD10 , mouse-abhda

Title : Role of Human Orphan Esterases in Drug-induced Toxicity - Fukami_2015_Yakugaku.Zasshi_135_1235
Author(s) : Fukami T
Ref : Yakugaku Zasshi , 135 :1235 , 2015
PubMedID: 26521872
Gene_locus related to this paper: human-ABHD10

Title : An Orphan Esterase ABHD10 Modulates Probenecid Acyl Glucuronidation in Human Liver - Ito_2014_Drug.Metab.Dispos_42_2109
Author(s) : Ito Y , Fukami T , Yokoi T , Nakajima M
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 42 :2109 , 2014
PubMedID: 25217485
Gene_locus related to this paper: human-ABHD10 , mouse-abhda

Title : Remodeling natural products: chemistry and serine hydrolase activity of a rocaglate-derived beta-lactone - Lajkiewicz_2014_J.Am.Chem.Soc_136_2659
Author(s) : Lajkiewicz NJ , Cognetta AB, 3rd , Niphakis MJ , Cravatt BF , Porco JA, Jr.
Ref : Journal of the American Chemical Society , 136 :2659 , 2014
PubMedID: 24447064
Gene_locus related to this paper: human-ABHD10 , human-ACOT1 , human-ACOT2 , human-CTSA , human-SCPEP1 , mouse-abhda

Title : Human alpha\/beta hydrolase domain containing 10 (ABHD10) is responsible enzyme for deglucuronidation of mycophenolic acid acyl-glucuronide in liver - Iwamura_2012_J.Biol.Chem_287_9240
Author(s) : Iwamura A , Fukami T , Higuchi R , Nakajima M , Yokoi T
Ref : Journal of Biological Chemistry , 287 :9240 , 2012
PubMedID: 22294686
Gene_locus related to this paper: human-ABHD10 , mouse-abhda

Title : Competitive activity-based protein profiling identifies aza-beta-lactams as a versatile chemotype for serine hydrolase inhibition - Zuhl_2012_J.Am.Chem.Soc_134_5068
Author(s) : Zuhl AM , Mohr JT , Bachovchin DA , Niessen S , Hsu KL , Berlin JM , Dochnahl M , Lopez-Alberca MP , Fu GC , Cravatt BF
Ref : J Am Chem Soc , 134 :5068 , 2012
PubMedID: 22400490
Gene_locus related to this paper: human-ABHD10

Title : The emerging role of human esterases - Fukami_2012_Drug.Metab.Pharmacokinet_27_466
Author(s) : Fukami T , Yokoi T
Ref : Drug Metab Pharmacokinet , 27 :466 , 2012
PubMedID: 22813719
Gene_locus related to this paper: human-ABHD10