Ramipril
General
Type : Not A\/B H target, Pro-Drug, Drug
Chemical_Nomenclature : (2S,3aS,6aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carboxylic acid
Canonical SMILES : CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2C3CCCC3CC2C(=O)O
InChI : InChI=1S\/C23H32N2O5\/c1-3-30-23(29)18(13-12-16-8-5-4-6-9-16)24-15(2)21(26)25-19-11-7-10-17(19)14-20(25)22(27)28\/h4-6,8-9,15,17-20,24H,3,7,10-14H2,1-2H3,(H,27,28)\/t15-,17-,18-,19-,20-\/m0\/s1
InChIKey : HDACQVRGBOVJII-JBDAPHQKSA-N
Other name(s) : Tritace || Altace || Ramace || CHEBI:8774 || CHEMBL1168
MW : 416.5
Formula : C23H32N2O5
CAS_number : 87333-19-5
PubChem : 5362129
UniChem : HDACQVRGBOVJII-JBDAPHQKSA-N
Target
Families : Carb_B_Chordata
References (8)
| Title : Lipid-Gelucire based rectal delivery of ramipril prodrug exhibits significant lowering of intra-ocular pressure in normotensive rabbit: Sustained structural relaxation release kinetics and IVIVC - Nandi_2024_Pharm.Dev.Technol__1 |
| Author(s) : Nandi S , Swain R , Habibullah S , Sahoo RN , Nayak AK , Mallick S |
| Ref : Pharm Dev Technol , :1 , 2024 |
| Abstract : |
| PubMedSearch : Nandi_2024_Pharm.Dev.Technol__1 |
| PubMedID: 38662798 |
| Title : CES1 genetic variation affects the activation of angiotensin-converting enzyme inhibitors - Wang_2016_Pharmacogenomics.J_16_220 |
| Author(s) : Wang X , Wang G , Shi J , Aa JY , Comas R , Liang Y , Zhu HJ |
| Ref : Pharmacogenomics J , 16 :220 , 2016 |
| Abstract : |
| PubMedSearch : Wang_2016_Pharmacogenomics.J_16_220 |
| PubMedID: 26076923 |
| Gene_locus related to this paper: human-CES1 |
| Title : A population-based study of the drug interaction between clopidogrel and angiotensin converting enzyme inhibitors - Cressman_2015_Br.J.Clin.Pharmacol_80_662 |
| Author(s) : Cressman AM , Macdonald EM , Fernandes KA , Gomes T , Paterson JM , Mamdani MM , Juurlink DN |
| Ref : British Journal of Clinical Pharmacology , 80 :662 , 2015 |
| Abstract : |
| PubMedSearch : Cressman_2015_Br.J.Clin.Pharmacol_80_662 |
| PubMedID: 25980448 |
| Title : A comparative study of neuroprotective effect of angiotensin converting enzyme inhibitors against scopolamine-induced memory impairments in rats - Jawaid_2015_J.Adv.Pharm.Technol.Res_6_130 |
| Author(s) : Jawaid T , Jahan S , Kamal M |
| Ref : J Adv Pharm Technol Res , 6 :130 , 2015 |
| Abstract : |
| PubMedSearch : Jawaid_2015_J.Adv.Pharm.Technol.Res_6_130 |
| PubMedID: 26317078 |
| Title : Cognitive enhancing effect of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers on learning and memory - Nade_2015_Indian.J.Pharmacol_47_263 |
| Author(s) : Nade VS , Kawale LA , Valte KD , Shendye NV |
| Ref : Indian J Pharmacol , 47 :263 , 2015 |
| Abstract : |
| PubMedSearch : Nade_2015_Indian.J.Pharmacol_47_263 |
| PubMedID: 26069362 |
| Title : Contribution of human esterases to the metabolism of selected drugs of abuse - Meyer_2014_Toxicol.Lett_232_159 |
| Author(s) : Meyer MR , Schutz A , Maurer HH |
| Ref : Toxicol Lett , 232 :159 , 2014 |
| Abstract : |
| PubMedSearch : Meyer_2014_Toxicol.Lett_232_159 |
| PubMedID: 25445008 |
| Title : In vitro drug metabolism by human carboxylesterase 1: focus on Angiotensin-converting enzyme inhibitors - Thomsen_2014_Drug.Metab.Dispos_42_126 |
| Author(s) : Thomsen R , Rasmussen HB , Linnet K |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 42 :126 , 2014 |
| Abstract : |
| PubMedSearch : Thomsen_2014_Drug.Metab.Dispos_42_126 |
| PubMedID: 24141856 |
| Gene_locus related to this paper: human-CES1 |
| Title : Oculohypotensive effect of angiotensin-converting enzyme inhibitors in acute and chronic models of glaucoma - Shah_2000_J.Cardiovasc.Pharmacol_36_169 |
| Author(s) : Shah GB , Sharma S , Mehta AA , Goyal RK |
| Ref : J Cardiovasc Pharmacol , 36 :169 , 2000 |
| Abstract : |
| PubMedSearch : Shah_2000_J.Cardiovasc.Pharmacol_36_169 |
| PubMedID: 10942157 |