Skyllamycin-like-precursor
Skyllamycin: Cyclic depsipeptide produced by Streptomyces sp.; skyllamycin A inhibits the binding of PDGF to the extracellular domain of its receptor. 11mer macrolactone peptide with an N-terminal 2-[1-(Z)-propenyl]-cinnamoyl moiety attached; Skyxy-TE that catalyzes both epimerization and cyclization in skyllamycin biosynthesis
General
Type : Peptide, Natural, Polyketide, Macrolide, Antibiotic
Chemical_Nomenclature :
Canonical SMILES : COC1=CC=C(C=C1)CC(NC(=O)C2CCCN2C(=O)C(NC(=O)CNC(=O)C(NC(=O)C(C)NC(=O)C(NC(=O)C=CC3=CC=CC=C3)C(C)O)CC(O)=O)CC4=CC=CC=C4)C(NC(C(NC(=O)NC(C(NC(C(=O)SCCNC(C)=O)CC(C)C)=O)CC(C)C)=O)CC5=C[N]C6=CC=CC=C56)=O
InChI : InChI=1S\/C74H95N13O17S\/c1-42(2)34-54(67(96)83-59(35-43(3)4)73(102)105-33-31-75-46(7)89)84-74(103)86-69(98)56(38-50-40-76-53-23-16-15-22-52(50)53)81-68(97)55(36-49-25-28-51(104-8)29-26-49)82-70(99)60-24-17-32-87(60)72(101)58(37-48-20-13-10-14-21-48)79-62(91)41-77-66(95)57(39-63(92)93)80-65(94)44(5)78-71(100)64(45(6)88)85-61(90)30-27-47-18-11-9-12-19-47\/h9-16,18-23,25-30,40,42-45,54-60,64,76,88H,17,24,31-39,41H2,1-8H3,(H,75,89)(H,77,95)(H,78,100)(H,79,91)(H,80,94)(H,81,97)(H,82,99)(H,83,96)(H,85,90)(H,92,93)(H2,84,86,98,103)\/b30-27+
InChIKey : VDHCBNNLJGQPCC-KDJFERLWSA-N
Other name(s) :
Target
Structures : No structure
Families : Thioesterase
References (1)
| Title : Functional Characterization and Crystal Structure of the Bifunctional Thioesterase Catalyzing Epimerization and Cyclization in Skyllamycin Biosynthesis - Yu_2021_ACS.Catalysis_11_11733 |
| Author(s) : Yu J , Juan S , Chi C , Liu T , Geng T , Cai Z , Dong W , Shi C , Ma X , Zhang Z , Xing B , Jin H , Zhang L , Dong S , Yang D , Ma M |
| Ref : ACS Catal , 11 :11733 , 2021 |
| Abstract : |
| PubMedSearch : Yu_2021_ACS.Catalysis_11_11733 |
| PubMedID: |
| Gene_locus related to this paper: strsq-a0a1j0r317 |