TOTM
Plasticizer that is added to PVC plastic to impart flexibility
General
Type : Plasticizer
Chemical_Nomenclature : tris(2-ethylhexyl) benzene-1,2,4-tricarboxylate
Canonical SMILES : CCCCC(CC)COC(=O)C1=CC(=C(C=C1)C(=O)OCC(CC)CCCC)C(=O)OCC(CC)CCCC
InChI : InChI=1S\/C33H54O6\/c1-7-13-16-25(10-4)22-37-31(34)28-19-20-29(32(35)38-23-26(11-5)17-14-8-2)30(21-28)33(36)39-24-27(12-6)18-15-9-3\/h19-21,25-27H,7-18,22-24H2,1-6H3
InChIKey : KRADHMIOFJQKEZ-UHFFFAOYSA-N
Other name(s) : Trioctyl trimellitate || Tris(2-ethylhexyl) Trimellitate || Totm || Tri-2-ethylhexyl trimellitate || Staflex TOTM || Morflex 510 || Hatcol 200 || Trimex T 08 || TEHTM || CHEMBL1425782 || SCHEMBL29351184 || CHEBI:184113
MW : 546.8
Formula : C33H54O6
CAS_number : 3319-31-1
PubChem : 18725
UniChem : KRADHMIOFJQKEZ-UHFFFAOYSA-N
Target
Structures : No structure
Families : Hormone-sensitive_lipase_like, Carb_B_Chordata
References (15)
| Title : Multi-omics-Guided Discovery of Broad-Spectrum Plasticizer Degrader Rhodococcus sp. SPR1 and Key Enzymes Driving Tris(2-ethylhexyl) Trimellitate (TOTM) Degradation - Kang_2025_J.Hazard.Mater__140086 |
| Author(s) : Kang X , Wang X , Zhang Y , Ju F |
| Ref : J Hazard Mater , :140086 , 2025 |
| Abstract : |
| PubMedSearch : Kang_2025_J.Hazard.Mater__140086 |
| PubMedID: 41106000 |
| Gene_locus related to this paper: rhosg-TOTMaseB |
| Title : Development and validation of an analytical method for metabolites of the plasticizer tri-(2-ethylhexyl) trimellitate (TOTM) in human urine by LC-MS\/MS - Cleys_2025_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_1256_124569 |
| Author(s) : Cleys P , Panneel L , Jorens PG , Mulder A , Covaci A |
| Ref : Journal of Chromatography B Analyt Technol Biomed Life Sciences , 1256 :124569 , 2025 |
| Abstract : |
| PubMedSearch : Cleys_2025_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_1256_124569 |
| PubMedID: 40153917 |
| Title : Multi-omics-Guided Discovery of Broad-Spectrum Plasticizer Degrader Rhodococcus sp. SPR1 and Key Enzymes Driving Tris(2-ethylhexyl) Trimellitate (TOTM) Degradation - Kang_2025_J.Hazard.Mater__140086 |
| Author(s) : Kang X , Wang X , Zhang Y , Ju F |
| Ref : J Hazard Mater , :140086 , 2025 |
| Abstract : |
| PubMedSearch : Kang_2025_J.Hazard.Mater__140086 |
| PubMedID: 41106000 |
| Gene_locus related to this paper: rhosg-TOTMaseB |
| Title : Multi-omics-Guided Discovery of Broad-Spectrum Plasticizer Degrader Rhodococcus sp. SPR1 and Key Enzymes Driving Tris(2-ethylhexyl) Trimellitate (TOTM) Degradation - Kang_2025_J.Hazard.Mater__140086 |
| Author(s) : Kang X , Wang X , Zhang Y , Ju F |
| Ref : J Hazard Mater , :140086 , 2025 |
| Abstract : |
| PubMedSearch : Kang_2025_J.Hazard.Mater__140086 |
| PubMedID: 41106000 |
| Gene_locus related to this paper: rhosg-TOTMaseB |
| Title : Development and validation of an analytical method for metabolites of the plasticizer tri-(2-ethylhexyl) trimellitate (TOTM) in human urine by LC-MS\/MS - Cleys_2025_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_1256_124569 |
| Author(s) : Cleys P , Panneel L , Jorens PG , Mulder A , Covaci A |
| Ref : Journal of Chromatography B Analyt Technol Biomed Life Sciences , 1256 :124569 , 2025 |
| Abstract : |
| PubMedSearch : Cleys_2025_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_1256_124569 |
| PubMedID: 40153917 |
| Title : Development and validation of an analytical method for metabolites of the plasticizer tri-(2-ethylhexyl) trimellitate (TOTM) in human urine by LC-MS\/MS - Cleys_2025_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_1256_124569 |
| Author(s) : Cleys P , Panneel L , Jorens PG , Mulder A , Covaci A |
| Ref : Journal of Chromatography B Analyt Technol Biomed Life Sciences , 1256 :124569 , 2025 |
| Abstract : |
| PubMedSearch : Cleys_2025_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_1256_124569 |
| PubMedID: 40153917 |
| Title : Regioselective ester cleavage of di-(2-ethylhexyl) trimellitates by porcine liver esterase - Hollerer_2018_Toxicol.In.Vitro_47_178 |
| Author(s) : Hollerer C , Becker G , Goen T , Eckert E |
| Ref : Toxicol In Vitro , 47 :178 , 2018 |
| Abstract : |
| PubMedSearch : Hollerer_2018_Toxicol.In.Vitro_47_178 |
| PubMedID: 29180039 |
| Gene_locus related to this paper: pig-a9gyw6 , pig-EST1 , pig-a0a1s6l948 , pig-a0a1s6l967 |
| Title : Human metabolism and kinetics of tri-(2-ethylhexyl) trimellitate (TEHTM) after oral administration - Hollerer_2018_Arch.Toxicol_92_2793 |
| Author(s) : Hollerer C , Becker G , Goen T , Eckert E |
| Ref : Archives of Toxicology , 92 :2793 , 2018 |
| Abstract : |
| PubMedSearch : Hollerer_2018_Arch.Toxicol_92_2793 |
| PubMedID: 30027468 |
| Title : Regioselective ester cleavage of di-(2-ethylhexyl) trimellitates by porcine liver esterase - Hollerer_2018_Toxicol.In.Vitro_47_178 |
| Author(s) : Hollerer C , Becker G , Goen T , Eckert E |
| Ref : Toxicol In Vitro , 47 :178 , 2018 |
| Abstract : |
| PubMedSearch : Hollerer_2018_Toxicol.In.Vitro_47_178 |
| PubMedID: 29180039 |
| Gene_locus related to this paper: pig-a9gyw6 , pig-EST1 , pig-a0a1s6l948 , pig-a0a1s6l967 |
| Title : Regioselective ester cleavage of di-(2-ethylhexyl) trimellitates by porcine liver esterase - Hollerer_2018_Toxicol.In.Vitro_47_178 |
| Author(s) : Hollerer C , Becker G , Goen T , Eckert E |
| Ref : Toxicol In Vitro , 47 :178 , 2018 |
| Abstract : |
| PubMedSearch : Hollerer_2018_Toxicol.In.Vitro_47_178 |
| PubMedID: 29180039 |
| Gene_locus related to this paper: pig-a9gyw6 , pig-EST1 , pig-a0a1s6l948 , pig-a0a1s6l967 |
| Title : Human metabolism and kinetics of tri-(2-ethylhexyl) trimellitate (TEHTM) after oral administration - Hollerer_2018_Arch.Toxicol_92_2793 |
| Author(s) : Hollerer C , Becker G , Goen T , Eckert E |
| Ref : Archives of Toxicology , 92 :2793 , 2018 |
| Abstract : |
| PubMedSearch : Hollerer_2018_Arch.Toxicol_92_2793 |
| PubMedID: 30027468 |
| Title : Human metabolism and kinetics of tri-(2-ethylhexyl) trimellitate (TEHTM) after oral administration - Hollerer_2018_Arch.Toxicol_92_2793 |
| Author(s) : Hollerer C , Becker G , Goen T , Eckert E |
| Ref : Archives of Toxicology , 92 :2793 , 2018 |
| Abstract : |
| PubMedSearch : Hollerer_2018_Arch.Toxicol_92_2793 |
| PubMedID: 30027468 |
| Title : Simultaneous determination of polyvinylchloride plasticizers di(2-ethylhexyl) phthalate and tri(2-ethylhexyl) trimellitate and its degradation products in blood by liquid chromatography-tandem mass spectrometry - Eckert_2015_J.Chromatogr.A_1410_173 |
| Author(s) : Eckert E , Muller J , Goen T |
| Ref : Journal of Chromatography A , 1410 :173 , 2015 |
| Abstract : |
| PubMedSearch : Eckert_2015_J.Chromatogr.A_1410_173 |
| PubMedID: 26243703 |
| Title : Simultaneous determination of polyvinylchloride plasticizers di(2-ethylhexyl) phthalate and tri(2-ethylhexyl) trimellitate and its degradation products in blood by liquid chromatography-tandem mass spectrometry - Eckert_2015_J.Chromatogr.A_1410_173 |
| Author(s) : Eckert E , Muller J , Goen T |
| Ref : Journal of Chromatography A , 1410 :173 , 2015 |
| Abstract : |
| PubMedSearch : Eckert_2015_J.Chromatogr.A_1410_173 |
| PubMedID: 26243703 |
| Title : Simultaneous determination of polyvinylchloride plasticizers di(2-ethylhexyl) phthalate and tri(2-ethylhexyl) trimellitate and its degradation products in blood by liquid chromatography-tandem mass spectrometry - Eckert_2015_J.Chromatogr.A_1410_173 |
| Author(s) : Eckert E , Muller J , Goen T |
| Ref : Journal of Chromatography A , 1410 :173 , 2015 |
| Abstract : |
| PubMedSearch : Eckert_2015_J.Chromatogr.A_1410_173 |
| PubMedID: 26243703 |