pig-a0a1s6l967

Sus scrofa (Pig). Carboxylic ester hydrolase PLE-B9 pig liver esterase PLE6

Comment

PLE6 prefers to metabolize the esters that contain a small alcohol group and a large bulky acyl group || There are at least 6 isoenzyme (may be different genes Q9TS80 PLE1 A5A4F5 PLE3). Isoenzymes of pig-liver esterase reveal striking differences in enantioselectivities Hummel et al. 2007<\/A>. Polyisoprenylated. methylated protein methyl esterase (PMPMEase). Pig liver esterase 5 (PLE5) (pig-a9gyw6<\/A>) is the isoenzyme crystallized (5FV4<\/A>)

Relationship

Family : Carb_B_Chordata

Block : C

Position in NCBI Life Tree : Sus scrofa

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Laurasiatheria N E > Cetartiodactyla N E > Suina N E > Suidae N E > Sus N E > Sus scrofa N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No inhibitor

Database

Sequence

Peptide

MWLLPLVLTS LASSATWAGQ PASPPVVDTA QGRVLGKYVS LEGLAQPVAV FLGVPFAKPP LGSLRFAPPQ PAEPWSFVKN TTSYPPMCCQ DQLGEQMLSD LFTNRKERLI PEFSEDCLYL NIYTPADLTK RGRLPVMVWI HGGGLVVGGA STYDGLALAA HENVVVVAIQ YRLGIWGFFS TGDEHSRGNW GHLDQVAALH WVQENIANFG GDPGSVTIFG ESAGGESVSV LVLSPLAKNL FHRAISESGV AFTAGLVRKD MKAAAKQIAV LAGCKTTTSA VFVHCLRQKS EDELLDLTLK MKFFALDLHG DPRESHPFLT TVVDGVLLPK MPEEILAEKD FNTVPYIVGI NKQEFGWLLP TMMGFPLSEG KLDQKTATSL LWKSYPIANI PEELTPVATD KYLGGTDDPV KKKDLFLDLM GDVVFGVPSV TVARQHRDAG APTYMYEFQY RPSFSSDKKP KTVIGDHGDE IFSVFGAPFL RGDAPEEEVS LSKMVMKFWA NFARSGNPNG EGLPHWPMYD QEEGYLQIGV NTQAAKRLKG EEVAFWNDLL SKEAAKKPPK IKHAEL

References (5)

Title : Pig Liver Esterases Hydrolyze Endocannabinoids and Promote Inflammatory Response - Zhou_2021_Front.Immunol_12_670427
Author(s) : Zhou Q , Yan B , Sun W , Chen Q , Xiao Q , Xiao Y , Wang X , Shi D
Ref : Front Immunol , 12 :670427 , 2021
Abstract :
PubMedSearch : Zhou_2021_Front.Immunol_12_670427
PubMedID: 34079552
Gene_locus related to this paper: pig-PLE1 , pig-a0a1s6l967

Title : Pig liver esterases PLE1 and PLE6: heterologous expression, hydrolysis of common antibiotics and pharmacological consequences - Zhou_2019_Sci.Rep_9_15564
Author(s) : Zhou Q , Xiao Q , Zhang Y , Wang X , Xiao Y , Shi D
Ref : Sci Rep , 9 :15564 , 2019
Abstract :
PubMedSearch : Zhou_2019_Sci.Rep_9_15564
PubMedID: 31664043
Gene_locus related to this paper: pig-EST1 , pig-a0a1s6l967

Title : Regioselective ester cleavage of di-(2-ethylhexyl) trimellitates by porcine liver esterase - Hollerer_2018_Toxicol.In.Vitro_47_178
Author(s) : Hollerer C , Becker G , Goen T , Eckert E
Ref : Toxicol In Vitro , 47 :178 , 2018
Abstract :
PubMedSearch : Hollerer_2018_Toxicol.In.Vitro_47_178
PubMedID: 29180039
Gene_locus related to this paper: pig-a9gyw6 , pig-EST1 , pig-a0a1s6l948 , pig-a0a1s6l967

Title : Breed Differences in Pig Liver Esterase (PLE) between Tongcheng (Chinese Local Breed) and Large White Pigs - Xiao_2018_Sci.Rep_8_16364
Author(s) : Xiao Q , Zhou Q , Yang L , Tian Z , Wang X , Xiao Y , Shi D
Ref : Sci Rep , 8 :16364 , 2018
Abstract :
PubMedSearch : Xiao_2018_Sci.Rep_8_16364
PubMedID: 30397234
Gene_locus related to this paper: pig-a9gyw6 , pig-EST1 , pig-PLE1 , pig-a0a1s6l948 , pig-a0a1s6l959 , pig-a0a1s6l967

Title : Third-Generation Sequencing and Analysis of Four Complete Pig Liver Esterase Gene Sequences in Clones Identified by Screening BAC Library - Zhou_2016_PLoS.One_11_e0163295
Author(s) : Zhou Q , Sun W , Liu X , Wang X , Xiao Y , Bi D , Yin J , Shi D
Ref : PLoS ONE , 11 :e0163295 , 2016
Abstract :
PubMedSearch : Zhou_2016_PLoS.One_11_e0163295
PubMedID: 27695062
Gene_locus related to this paper: pig-EST1 , pig-PLE1 , pig-a0a1s6l948 , pig-a0a1s6l959 , pig-a0a1s6l967