Zearalanone
The mycotoxin zearalanone has been contaminating maize and other grains. It can be hydrolyzed and inactivated by the lactonase ZHD. Zearalanone is a natural member of resorcinols and a macrolide
General
Type : Natural, Toxin, Macrolide, Polyketide, Mycotoxin-metabolite
Chemical_Nomenclature : (4S)-16,18-dihydroxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),15,17-triene-2,8-dione
Canonical SMILES : C[C@H]1CCCC(=O)CCCCCC2=C(C(=CC(=C2)O)O)C(=O)O1
InChI : InChI=1S\/C18H24O5\/c1-12-6-5-9-14(19)8-4-2-3-7-13-10-15(20)11-16(21)17(13)18(22)23-12\/h10-12,20-21H,2-9H2,1H3\/t12-\/m0\/s1
InChIKey : APJDQUGPCJRQRJ-LBPRGKRZSA-N
Other name(s) : (S)-Zearalanone || Zanone || P 1502 || MLS000069626 || MR000058193 || 133DU2F2VS || CHEMBL491499 || CHEBI:3505
MW : 320.4
Formula : C18H24O5
CAS_number : 5975-78-0
PubChem : 108003
UniChem : APJDQUGPCJRQRJ-LBPRGKRZSA-N
Target
Structures : 8CLU
Families : Zearalenone-hydrolase-fam2, Zearalenone-hydrolase
References (2)
| Title : Bacterial Lactonases ZenA with Noncanonical Structural Features Hydrolyse the Mycotoxin Zearalenone - Fruhauf_2024_ACS.Catal_14_3392 |
| Author(s) : Fruhauf S , Puhringer D , Thamhesl M , Fajtl P , Kunz-Vekiru E , Hobartner-Gussl A , Schatzmayr G , Adam G , Damborsky J , Djinovic-Carugo K , Prokop Z , Moll WD |
| Ref : ACS Catal , 14 :3392 , 2024 |
| Abstract : |
| PubMedSearch : Fruhauf_2024_ACS.Catal_14_3392 |
| PubMedID: 38449531 |
| Gene_locus related to this paper: 9actn-ZenA , 9noca-a0aa46n777 |
| Title : Metabolism of zearalenone by genetically modified organisms expressing the detoxification gene from Clonostachys rosea - Takahashi-Ando_2004_Appl.Environ.Microbiol_70_3239 |
| Author(s) : Takahashi-Ando N , Ohsato S , Shibata T , Hamamoto H , Yamaguchi I , Kimura M |
| Ref : Applied Environmental Microbiology , 70 :3239 , 2004 |
| Abstract : |
| PubMedSearch : Takahashi-Ando_2004_Appl.Environ.Microbiol_70_3239 |
| PubMedID: 15184117 |
| Gene_locus related to this paper: biooc-ZHD101 |