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Substrate Report for: Beta-zearalenol

Zearalenol belongs to the family of Macrolides and Analogues. These are organic compounds containing a lactone ring of at least twelve members. The term 'macrolide' encompasses a diverse family of unrelated compounds with large macrolactam rings. Zearalenol derivative of zearalenone. The mycotoxin zearalenone has been contaminating maize and other grains. It can be hydrolyzed and inactivated by the lactonase ZHD. Zearalenone differs from other quorum-sensing lactones


General
Type Mycotoxin-metabolite, Macrolide, Natural, Toxin
Chemical_Nomenclature (2E,7S,11S)-7,15,17-trihydroxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(18),2,14,16-tetraen-13-one
Canonical SMILES CC1CCCC(CCCC=CC2=CC(=CC(=C2C(=O)O1)O)O)O
InChI InChI=1S/C18H24O5/c1-12-6-5-9-14(19)8-4-2-3-7-13-10-15(20)11-16(21)17(13)18(22)23-12/h3,7,10-12,14,19-21H,2,4-6,8-9H2,1H3/b7-3+/t12-,14-/m0/s1
InChIKey FPQFYIAXQDXNOR-PMRAARRBSA-N
Other name(s) CHEMBL372840 ; CHEBI:35072 ; Beta zearalenol ; beta-Zearalenol ; beta-ZOL
________________________________________________________________________________________________
MW|320.38
Formula|C18H24O5
CAS_number|71030-11-0
PubChem|6437352
UniChem|FPQFYIAXQDXNOR-PMRAARRBSA-N
IUPHAR|
Wikipedia|

Target
Families | Beta-zearalenol ligand of proteins in family: Zearalenone-hydrolase
Stucture | 5 structures (e.g. : 5IE6, 5IE7, 6JR5... more)
Protein | biooc-ZHD101

References:
Search PubMed for references concerning: Beta-zearalenol
    Title: The Trp183 is essential in lactonohydrolase ZHD detoxifying zearalenone and zearalenols
    Zhou H, Li L, Zhan B, Wang S, Li J, Hu XJ
    Ref: Biochemical & Biophysical Research Communications, 522:986, 2020 : PubMed

            

    Title: Enhanced alpha-Zearalenol Hydrolyzing Activity of a Mycoestrogen-Detoxifying Lactonase by Structure-Based Engineering
    Xu Z, Liu W, Chen CC, Li Q, Huang JW, Ko TP, Liu G, Peng W, Cheng YS and Guo RT <4 more author(s)>
    Ref: ACS Catal, 6:7657, 2016 : PubMed