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Substrate Report for: Cyflumetofen

Benzoylacetonitile acaricide developed by Otsuka AgriTechno Co., Ltd. Cyflumetofen provides effectiveness against mites that have developed resistance to existing acaricides. Cyflumetofen inhibits the mitochondrial electron-transport function of complex II


General
Type Acaricide, Cyanide, Propionate, Not A/B H target
Chemical_Nomenclature 2-methoxyethyl 2-(4-~{tert}-butylphenyl)-2-cyano-3-oxo-3-[2-(trifluoromethyl)phenyl]propanoate
Canonical SMILES CC(C)(C)C1=CC=C(C=C1)C(C#N)(C(=O)C2=CC=CC=C2C(F)(F)F)C(=O)OCCOC
InChI InChI=1S/C24H24F3NO4/c1-22(2,3)16-9-11-17(12-10-16)23(15-28,21(30)32-14-13-31-4)20(29)18-7-5-6-8-19(18)24(25,26)27/h5-12H,13-14H2,1-4H3
InChIKey AWSZRJQNBMEZOI-UHFFFAOYSA-N
Other name(s) SCHEMBL27174 ; CHEMBL2268728 ; DTXSID8058089 ; CHEBI:81798 ; CHEBI:136837
________________________________________________________________________________________________
MW|447.45
Formula|C24H24F3NO4
CAS_number|400882-07-7
PubChem|11496052
UniChem|AWSZRJQNBMEZOI-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | Cyflumetofen ligand of proteins in family: Cholinesterase-like
Protein | tetur-t1kth5, 9acar-q5s1p7

References:
Search PubMed for references concerning: Cyflumetofen

2 more
    Title: Downregulation of carboxylesterase contributes to cyflumetofen resistance in Tetranychus cinnabarinus (Boisduval)
    Wei P, Chen M, Nan C, Feng K, Shen G, Cheng J, He L
    Ref: Pest Manag Sci, 75:2166, 2019 : PubMed

            

    Title: Functional Analysis of Esterase TCE2 Gene from Tetranychus cinnabarinus (Boisduval) involved in Acaricide Resistance
    Shi L, Wei P, Wang X, Shen G, Zhang J, Xiao W, Xu Z, Xu Q, He L
    Ref: Sci Rep, 6:18646, 2016 : PubMed

            

    Title: Resistance selection and biochemical mechanism of resistance against cyflumetofen in Tetranychus cinnabarinus (Boisduval)
    Wang Y, Zhao S, Shi L, Xu Z, He L
    Ref: Pestic Biochem Physiol, 111:24, 2014 : PubMed