Family: Cholinesterase-like

Block: C

Parent Family: Cholinesterase


Analysis of the complete genome sequences of numerous representatives of the various metazoan phyla show that moderate amplification of cholinesterase genes is not uncommon in molluscs, echinoderms, hemichordates, prochordates or lepidosauria. Amplification of acetylcholinesterase genes is also a feature of parasitic nematodes or ticks. This family is now called Cholinesterase like. It also contains sequences very close to AChE but which are either incomplete or are missing W84 or one of the residue of the catalytic triad or are pseudogenes with deletions or errors of conceptual splicing Before this family was called Dictyostelium_crys as it contained only Dict proteins. These proteins have an active site serine and have probably an esterase activity but are in membrane-enclosed crystals and probably have non catalytic functions.


Interpro : IPR000997 Cholinesterase , IPR002018 Carboxylesterase, type B

PIRSF : PIRSF005676 COesterase

Pdoc : No Pdoc

Pfam : PF00135 COesterase

Prints : No Print

EC Number : No EC Number


Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

No structure scheme yet for this family

Genes Proteins in Cholinesterase-like family (556)

Fragments of genes in Cholinesterase-like family (394)

No fragment of genes

Substrates in Cholinesterase-like family (4)

Inhibitors in Cholinesterase-like family (1)

References (6)

Title : Molecular biology of tick acetylcholinesterases - Temeyer_2018_Front.Biosci.(Landmark.Ed)_23_1320
Author(s) : Temeyer KB
Ref : Front Biosci (Landmark Ed) , 23 :1320 , 2018
PubMedID: 28930602
Gene_locus related to this paper: boomi-ACHE1 , boomi-ACHE2 , boomi-ACHE3

Title : Natural genomic amplification of cholinesterase genes in animals - Chatonnet_2017_J.Neurochem_142 Suppl 2_73
Author(s) : Chatonnet A , Lenfant N , Marchot P , Selkirk ME
Ref : Journal of Neurochemistry , 142 Suppl 2 :73 , 2017
PubMedID: 28382676

Title : Nematode acetylcholinesterases are encoded by multiple genes and perform non-overlapping functions - Selkirk_2005_Chem.Biol.Interact_157-158_263
Author(s) : Selkirk ME , Lazari O , Hussein AS , Matthews JB
Ref : Chemico-Biological Interactions , 157-158 :263 , 2005
PubMedID: 16243303

Title : Cholinesterase-like domains in enzymes and structural proteins: functional and evolutionary relationships and identification of a catalytically essential aspartic acid - Krejci_1991_Proc.Natl.Acad.Sci.U.S.A_88_6647
Author(s) : Krejci E , Duval N , Chatonnet A , Vincens P , Massoulie J
Ref : Proceedings of the National Academy of Sciences of the United States of America , 88 :6647 , 1991
PubMedID: 1862088

Title : Membrane-enclosed crystals in Dictyostelium discoideum cells, consisting of developmentally regulated proteins with sequence similarities to known esterases - Bomblies_1990_J.Cell.Biol_110_669
Author(s) : Bomblies L , Biegelmann E , Doring V , Gerisch G , Krafft-Czepa H , Noegel AA , Schleicher M , Humbel BM
Ref : Journal of Cell Biology , 110 :669 , 1990
PubMedID: 2307702
Gene_locus related to this paper: dicdi-crd2p , dicdi-crysp , dicdi-drgen

Title : Molecular analysis of a developmentally regulated gene required for Dictyostelium aggregation - Rubino_1989_Dev.Biol_131_27
Author(s) : Rubino S , Mann SK , Hori RT , Pinko C , Firtel RA
Ref : Developmental Biology , 131 :27 , 1989
PubMedID: 2909407
Gene_locus related to this paper: dicdi-drgen