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Substrate Report for: Probenecid-glucuronide

Probenecid, a widely used uricosuric agent, is mainly metabolized to probenecid acyl glucuronide (PRAG), which is considered a causal substance of severe allergic or anaphylactoid reactions


General
Type Lactone, Drug, Not A/B H target
Chemical_Nomenclature (2S,3S,4S,5R,6S)-6-[4-(dipropylsulfamoyl)benzoyl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
Canonical SMILES CCCN(CCC)S(=O)(=O)C1=CC=C(C=C1)C(=O)OC2C(C(C(C(O2)C(=O)O)O)O)O
InChI InChI=1S/C19H27NO10S/c1-3-9-20(10-4-2)31(27,28)12-7-5-11(6-8-12)18(26)30-19-15(23)13(21)14(22)16(29-19)17(24)25/h5-8,13-16,19,21-23H,3-4,9-10H2,1-2H3,(H,24,25)/t13-,14-,15+,16-,19-/m0/s1
InChIKey BZOGRYWIYJNLDE-NAHJCDBISA-N
Other name(s) Probenecid Glucuronide ; Probenecid Acyl beta-D-Glucuronide ; AC1L4AEK ; Probenecid Acyl |A-D-Glucuronide ; ZINC31501036
________________________________________________________________________________________________
MW|461.48
Formula|C19H27NO10S
CAS_number|34017-15-7
PubChem|182154
UniChem|BZOGRYWIYJNLDE-NAHJCDBISA-N
IUPHAR|
Wikipedia|

Target
Families | Probenecid-glucuronide ligand of proteins in family: ABHD10
Protein | human-ABHD10

References:
Search PubMed for references concerning: Probenecid-glucuronide
    Title: An Orphan Esterase ABHD10 Modulates Probenecid Acyl Glucuronidation in Human Liver
    Ito Y, Fukami T, Yokoi T, Nakajima M
    Ref: Drug Metabolism & Disposition: The Biological Fate of Chemicals, 42:2109, 2014 : PubMed