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ABL-127

ABL127 is reported to inhibit protein phosphatase methylesterase 1 (PPME1)

General

Type : Azetidin

Chemical_Nomenclature : dimethyl (3R)-3-cyclopentyl-4-oxo-3-phenyldiazetidine-1,2-dicarboxylate

Canonical SMILES : COC(=O)N1C(=O)C(N1C(=O)OC)(C2CCCC2)C3=CC=CC=C3

InChI : InChI=1S\/C17H20N2O5\/c1-23-15(21)18-14(20)17(13-10-6-7-11-13,19(18)16(22)24-2)12-8-4-3-5-9-12\/h3-5,8-9,13H,6-7,10-11H2,1-2H3\/t17-\/m0\/s1

InChIKey : ZRHWCAFAIHTQKD-KRWDZBQOSA-N

Other name(s) : ABL127,ML174,SR-01000786812,SR-01000786812-5,MLS001250337

MW : 332.35

Formula : C17H20N2O5

CAS_number :

PubChem : 24856225

UniChem : ZRHWCAFAIHTQKD-KRWDZBQOSA-N

IUPHAR : 8608

Target

Families : ABL-127 ligand of proteins in family
PPase_methylesterase_euk

Protein :
human-PPME1

References (3)

Title : Involvement of PP2A methylation in the adipogenic differentiation of bone marrow-derived mesenchymal stem cell - Ikeda_2020_J.Biochem_168_643
Author(s) : Ikeda S , Tsuji S , Ohama T , Sato K
Ref : J Biochem , 168 :643 , 2020
Abstract : Ikeda_2020_J.Biochem_168_643
ESTHER : Ikeda_2020_J.Biochem_168_643
PubMedSearch : Ikeda_2020_J.Biochem_168_643
PubMedID: 32663263
Gene_locus related to this paper: human-PPME1

Title : A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity - Bachovchin_2014_Nat.Chem.Biol_10_656
Author(s) : Bachovchin DA , Koblan LW , Wu W , Liu Y , Li Y , Zhao P , Woznica I , Shu Y , Lai JH , Poplawski SE , Kiritsy CP , Healey SE , DiMare M , Sanford DG , Munford RS , Bachovchin WW , Golub TR
Ref : Nat Chemical Biology , 10 :656 , 2014
Abstract : Bachovchin_2014_Nat.Chem.Biol_10_656
ESTHER : Bachovchin_2014_Nat.Chem.Biol_10_656
PubMedSearch : Bachovchin_2014_Nat.Chem.Biol_10_656
PubMedID: 24997602
Gene_locus related to this paper: human-PPME1

Title : Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors - Bachovchin_2011_Proc.Natl.Acad.Sci.U.S.A_108_6811
Author(s) : Bachovchin DA , Mohr JT , Speers AE , Wang C , Berlin JM , Spicer TP , Fernandez-Vega V , Chase P , Hodder PS , Schurer SC , Nomura DK , Rosen H , Fu GC , Cravatt BF
Ref : Proc Natl Acad Sci U S A , 108 :6811 , 2011
Abstract : Bachovchin_2011_Proc.Natl.Acad.Sci.U.S.A_108_6811
ESTHER : Bachovchin_2011_Proc.Natl.Acad.Sci.U.S.A_108_6811
PubMedSearch : Bachovchin_2011_Proc.Natl.Acad.Sci.U.S.A_108_6811
PubMedID: 21398589
Gene_locus related to this paper: human-PPME1 
Array
(
    [id] => 4005
    [inhibitor] => ABL-127
    [type] => Array
        (
            [0] => Azetidin
        )

    [other_name] => Array
        (
            [0] => ABL127
            [1] => ML174
            [2] => SR-01000786812
            [3] => SR-01000786812-5
            [4] => MLS001250337
        )

    [chemical_nomenclature] => dimethyl (3R)-3-cyclopentyl-4-oxo-3-phenyldiazetidine-1,2-dicarboxylate
    [formula] => C17H20N2O5
    [cas_number] => 
    [mw] => 332.35
    [pick_me_to_call] => display_script
    [kinetic_parameter] => 
    [paper] => Bachovchin_2014_Nat.Chem.Biol_10_656 || Ikeda_2020_J.Biochem_168_643 || Bachovchin_2011_Proc.Natl.Acad.Sci.U.S.A_108_6811
    [comment] => ABL127 is reported to inhibit protein phosphatase methylesterase 1 (PPME1)
    [gene_locus] => human-PPME1
    [kin_inhibitor] => 
    [cid] => 24856225
    [family] => PPase_methylesterase_euk
    [inchikey] => ZRHWCAFAIHTQKD-KRWDZBQOSA-N
    [canonicalsmiles] => COC(=O)N1C(=O)C(N1C(=O)OC)(C2CCCC2)C3=CC=CC=C3
    [inchi] => InChI=1S\/C17H20N2O5\/c1-23-15(21)18-14(20)17(13-10-6-7-11-13,19(18)16(22)24-2)12-8-4-3-5-9-12\/h3-5,8-9,13H,6-7,10-11H2,1-2H3\/t17-\/m0\/s1
    [wikipedia] => 
    [iupharlig] => 8608
    [structure] => 
    [substrate] => 
    [interact_gene_locus] => 
    [mutation] => 
    [comment2] => 
    [extoxnet] => 
    [news] => 
    [theoretical_model] => 
)