PPase_methylesterase_euk
Relationship
Comment
PIRSF022950 This group represents protein phosphatase methylesterase, eukaryotic type. Carboxymethylation of proteins is a highly conserved means of regulation in eukaryotic cells. The protein phosphatase 2A (PP2A) catalytic (C) subunit is reversibly methylated at its carboxyl terminus by specific methyltransferase and methylesterase enzymes. Protein phosphatase 2A (PP2A) is an important serine/threonine phosphatase that plays a role in many biological processes. Reversible carboxyl methylation of the PP2A catalytic subunit is an essential regulatory mechanism for its function. Demethylation and negative regulation of PP2A is mediated by a PP2A-specific methylesterase PME-1, which is conserved from yeast to humans. PME-1 directly binds to the active site of PP2A. This interaction results in the activation of PME-1 by rearranging the catalytic triad into an active conformation. Interactions also lead to inactivation of PP2A by evicting the manganese ions required for the phosphatase activity (Xing et al. ). PPME proteins show false positive hits with the prosite PS00120 of lipases
Database
Interpro : IPR016812 Protein phosphatase methylesterase, eukaryotic type
PIRSF : PIRSF022950 protein phosphatase methylesterase, eukaryotic type
Pdoc : No Pdoc
Pfam : No Pfam
Prints : No Print
EC Number : No EC Number
Sequences
| Peptide in | Fasta |
| Nucleotide in | Fasta |
| Alignment with Multalin | Text only |
| Seed alignment with MAFFT | No colour / coloured with Mview |
| Alignment with MAFFT | No colour / coloured with Mview |
| Dendrogram | The dnd file |
| Structure | Name | Proteins |
|---|---|---|
| 3C5V | PP2A-specific methylesterase apo form (PME) | human-PPME1 |
| 3C5W | Complex between PP2A-specific methylesterase PME-1 and PP2A core enzyme | human-PPME1 |
| Gene_locus | Name | Species |
|---|---|---|
| 9stra-f0w3s0 | Albugo laibachii Nc14 Protein phosphatase methylesterase 1 | Albugo laibachii Nc14 |
| aedae-q17m26 | Aedes aegypti (Yellowfever mosquito) putative uncharacterized protein | Aedes aegypti |
| ajecg-c0nbz4 | Ajellomyces capsulata (Darling's disease fungus) (Histoplasma capsulatum) Protein phosphatase methylesterase 1 | Ajellomyces capsulata |
| ajech-c6haa3 | Ajellomyces capsulata (strain H143) (Darling's disease fungus) (Histoplasma capsulatum) Protein phosphatase methylesterase 1 | Ajellomyces capsulata |
| ajedr-c5gd08 | Ajellomyces dermatitidis (Blastomyces dermatitidis) Protein phosphatase methylesterase 1 | Ajellomyces dermatitidis |
| anoga-AGCG52253 | Anopheles gambiae str. PEST agcp10902 ensangp00000028687 (fragment) | Anopheles gambiae |
| arall-d7ly06 | Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress) Protein phosphatase methylesterase 1 | Arabidopsis lyrata subsp. lyrata |
| arath-T5L19.180 | Arabidopsis thaliana (Mouse-ear cress) lipase-like protein At4g10050 T5L19.180 | Arabidopsis thaliana |
| artbc-d4ajq5 | Arthroderma benhamiae (strain CBS 112371) (Trichophyton mentagrophytes) Protein phosphatase methylesterase 1 | Arthroderma benhamiae |
| artoc-c5ft88 | Arthroderma otae (strain CBS 113480) (Microsporum canis) Protein phosphatase methylesterase 1 | Arthroderma otae |
| ascsu-f1la00 | Ascaris suum (Pig roundworm) (Ascaris lumbricoides) Protein phosphatase methylesterase 1 | Ascaris suum |
| ashgo-ppme1 | Ashbya gossypii ATCC 10895 (Yeast) (Eremothecium gossypii) protein phosphatase methylesterase 1 (EC 3.1.1.-) (pme-1) agr359cp | Ashbya gossypii ATCC 10895 |
| aspcl-a1cs04 | Aspergillus clavatus (strain ATCC 1007 \/ CBS 513.65 \/ DSM 816 \/ NCT 3887 \/ NRRL 1) Protein phosphatase methylesterase 1 | Aspergillus clavatus |
| aspfn-b8myc3 | Aspergillus flavus (strain ATCC 200026 \/ FGSC A1120 \/ NRRL 3357 \/ JC 12722 \/ SRRC 167) Protein phosphatase methylesterase 1 | Aspergillus flavus |
| aspfu-ppme1 | Aspergillus fumigatus (Sartorya fumigata), Neosartorya fumigata, Neosartorya fischeri (Aspergillus fischerianus) Protein phosphatase methylesterase 1 | Aspergillus fumigatus |
| aspnc-a2q8r7 | Aspergillus niger (strain CBS 513.88 \/ FGSC A1513) Protein phosphatase methylesterase 1 | Aspergillus niger |
| aspor-ppme1 | Aspergillus oryzae Protein phosphatase methylesterase 1 | Aspergillus oryzae |
| asptn-q0cwi5 | Aspergillus terreus (strain NIH 2624 \/ FGSC A1156) Protein phosphatase methylesterase 1 | Aspergillus terreus |
| blaho-d8m103 | Blastocystis hominis Protein phosphatase methylesterase 1 | Blastocystis hominis |
| botfb-a6rj71 | Botryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis cinerea) Protein phosphatase methylesterase 1 | Botryotinia fuckeliana |
| bovin-ppme1 | Bos taurus (Bovine) protein phosphatase methylesterase-1 | Bos taurus |
| bruma-a8pek5 | Brugia malayi (Filarial nematode worm) Protein phosphatase methylesterase 1 | Brugia malayi |
| caebr-a8xac7 | Caenorhabditis briggsae Protein phosphatase methylesterase 1 | Caenorhabditis briggsae |
| caeel-ppme1 | Caenorhabditis elegans Probable protein phosphatase methylesterase 1 42.9 kda protein b0464.7 in chromosome III | Caenorhabditis elegans |
| caere-e3lsf8 | Caenorhabditis remanei (Caenorhabditis vulgaris) Protein phosphatase methylesterase 1 | Caenorhabditis remanei |
| calro-c1bn43 | Caligus rogercresseyi Protein phosphatase methylesterase 1 Salmo salar (Atlantic salmon) contaminant? | Caligus rogercresseyi |
| calro-c1bqq3 | Caligus rogercresseyi Protein phosphatase methylesterase 1 | Caligus rogercresseyi |
| camfo-e1zwv0 | Camponotus floridanus (Florida carpenter ant) Protein phosphatase methylesterase 1 | Camponotus floridanus |
| canal-ppme1 | Candida albicans (and strain WO-1)Candida dubliniensis (strain CD36 \/ CBS 7987 \/ NCPF 3949 \/ NRR Y-17841) protein phosphatase methylesterase 1 (EC 3.1.1.-) (pme-1) | Candida albicans SC5314 |
| canfa-e2rkq0 | Canis lupus familiaris (Dog) (Canis familiaris) Protein phosphatase methylesterase 1 | Canis lupus familiaris |
| canga-ppme1 | Candida glabrata (Yeast) (Torulopsis glabrata) protein phosphatase methylesterase 1 (EC 3.1.1.-) (pme-1) | Candida glabrata |
| cantt-c5m5w2 | Candida tropicalis (strain ATCC MYA-3404 \/ T1) (Yeast) Protein phosphatase methylesterase 1 | Candida tropicalis |
| capo3-e9c102 | Capsaspora owczarzaki (strain ATCC 30864) Protein phosphatase methylesterase 1 | Capsaspora owczarzaki |
| chick-q5zhm0 | Gallus gallus (Chicken) hypothetical protein | Gallus gallus |
| chlre-a8j5w6 | Chlamydomonas reinhardtii (Chlamydomonas smithii) Protein phosphatase methylesterase 1 | Chlamydomonas reinhardtii |
| clal4-c4y538 | Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae) Protein phosphatase methylesterase 1 | Clavispora lusitaniae |
| cocp7-c5p129 | Coccidioides posadasii (Valley fever fungus) Protein phosphatase methylesterase 1 | Coccidioides posadasii |
| colgm-e3qei9 | Colletotrichum graminicola (strain M1.001 \/ M2 \/ FGSC 10212) (Maize anthracnose fungus) (Glomerella graminicola) Protein phosphatase methylesterase 1 | Colletotrichum graminicola |
| copc7-a8nvb5 | Coprinopsis cinerea (strain Okayama-7 \/ 130 \/ FGSC 9003) (Inky cap fungus) (Hormographiella aspergillata) Protein phosphatase methylesterase 1 | Coprinopsis cinerea |
| crygw-e6rbd6 | Cryptococcus gattii serotype B (strain WM276 \/ ATCC MYA-4071) (Filobasidiella gattii) (Cryptococcus bacillisporus) Protein phosphatase methylesterase 1 | Cryptococcus gattii WM276 |
| cryne-ppme1 | Cryptococcus neoformans (Filobasidiella neoformans) (and B-3501A) protein phosphatase methylesterase 1 (EC 3.1.1.-) (pme-1) | Cryptococcus neoformans |
| culqu-b0wub2 | Culex quinquefasciatus (Southern house mosquito) (Culex pungens) Protein phosphatase methylesterase 1 | Culex quinquefasciatus |
| danre-Q7ZV37 | Danio rerio (Zebrafish) (Brachydanio rerio) similar to protein phosphatase methylesterase-1 | Danio rerio |
| dappu-e9gzn7 | Daphnia pulex (Water flea) Protein phosphatase methylesterase 1 | Daphnia pulex |
| debha-ppme1 | Debaryomyces hansenii (Yeast) (Torulaspora hansenii) hansenii protein phosphatase methylesterase 1 (EC 3.1.1.-) (pme-1) | Debaryomyces hansenii |
| dicdi-ppme1 | Dictyostelium discoideum (Slime mold) Probable protein phosphatase methylesterase 1 | Dictyostelium discoideum |
| dicpu-f1a3n5 | Dictyostelium purpureum (Slime mold) Protein phosphatase methylesterase 1 | Dictyostelium purpureum |
| droan-b3m5w1 | Drosophila ananassae (Fruit fly) Protein phosphatase methylesterase 1 | Drosophila ananassae |
| droer-b3nfq9 | Drosophila erecta (Fruit fly) Protein phosphatase methylesterase 1 | Drosophila erecta |
| drogr-b4j156 | Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi) Protein phosphatase methylesterase 1 | Drosophila grimshawi |
| drome-CG5068 | Drosophila melanogaster (Fruit fly) epoxide hydrolase (EC 3.3.2.3) | Drosophila melanogaster |
| dromo-b4kvw2 | Drosophila mojavensis (Fruit fly) Protein phosphatase methylesterase 1 | Drosophila mojavensis |
| drope-b4hb18 | Drosophila persimilis (Fruit fly) Protein phosphatase methylesterase 1 | Drosophila persimilis |
| drops-q29f66 | Drosophila pseudoobscura (Fruit fly) ga18635-pa (fragment) | Drosophila pseudoobscura |
| drose-b4hkj5 | Drosophila sechellia (Fruit fly) Protein phosphatase methylesterase 1 | Drosophila sechellia |
| drosi-b4qmn9 | Drosophila simulans (Fruit fly) Protein phosphatase methylesterase 1 | Drosophila simulans |
| drovi-b4lev2 | Drosophila virilis (Fruit fly) Protein phosphatase methylesterase 1 | Drosophila virilis |
| drowi-b4n6n7 | Drosophila willistoni (Fruit fly) Protein phosphatase methylesterase 1 | Drosophila willistoni |
| droya-b4pff9 | Drosophila yakuba (Fruit fly) Protein phosphatase methylesterase 1 | Drosophila yakuba |
| ectsi-d7fsv3 | Ectocarpus siliculosus (Brown alga) Putative uncharacterized protein | Ectocarpus siliculosus |
| emeni-ppme1 | Emericella nidulans (Aspergillus nidulans and FGSC A4) protein phosphatase methylesterase 1 (EC 3.1.1.-) (pme-1) | Aspergillus nidulans FGSC A4 |
| giaib-c6lvg5 | Giardia intestinalis (strain ATCC 50581 \/ GS clone H7) (Giardia lamblia) Protein phosphatase methylesterase 1 | Giardia intestinalis |
| giaic-a8ba82 | Giardia intestinalis (strain ATCC 50803 \/ WB clone C6\; P15) (Giardia lamblia) Protein phosphatase methylesterase 1 | Giardia intestinalis |
| gibze-ppme1 | Gibberella zeae (Wheat head blight fungus) (Fusarium graminearum) Protein phosphatase methylesterase 1 | Gibberella zeae |
| glomm-d3tn19 | Glossina morsitans morsitans (Savannah tsetse fly) Protein phosphatase methylesterase 1 | Glossina morsitans morsitans |
| grocl-f0x9d5 | Grosmannia clavigera (strain kw1407 \/ UAMH 11150) (Blue stain fungus) (Graphiocladiella clavigera) Protein phosphatase methylesterase 1 | Grosmannia clavigera |
| harsa-e2bh58 | Harpegnathos saltator (Jerdon's jumping ant) Protein phosphatase methylesterase 1 | Harpegnathos saltator |
| horvd-f2de38 | Hordeum vulgare var. distichum (Two-rowed barley) Protein phosphatase methylesterase 1 | Hordeum vulgare var. distichum |
| human-PPME1 |  Homo sapiens (Human) protein phosphatase PP2A methylesterase-1 (EC 3.1.1.-) (pme-1) |
Homo sapiens |
| ixosc-b7p9y9 | Ixodes scapularis (Black-legged tick) (Deer tick) Protein phosphatase methylesterase 1 | Ixodes scapularis |
| klula-ppme1 | Kluyveromyces lactis (Yeast) 1140 of kluyveromyces lactis (Candida sphaerica) protein phosphatase methylesterase 1 (EC 3.1.1.-) (pme-1) | Kluyveromyces lactis |
| lacbs-b0dmt4 | Laccaria bicolor (strain S238N-H82) (Bicoloured deceiver) (Laccaria laccata var. bicolor) Protein phosphatase methylesterase 1 | Laccaria bicolor |
| lactc-c5e3n5 | Lachancea thermotolerans (strain CBS 6340) (Yeast) (Kluyveromyces thermotolerans) Protein phosphatase methylesterase 1 | Lachancea thermotolerans |
| leibr-a4hk72 | Leishmania braziliensis Protein phosphatase methylesterase 1 | Leishmania braziliensis |
| leiin-a4i7q7 | Leishmania infantum, Leishmania mexicana, Leishmania donovani (strain BPK282A1) Protein phosphatase methylesterase 1 | Leishmania infantum |
| leima-q4q5j1 | Leishmania major Protein phosphatase methylesterase 1 | Leishmania major |
| lepmj-e4zvh3 | Leptosphaeria maculans (strain JN3 \/ isolate v23.1.3 \/ rac Av1-4-5-6-7-8) (Blackleg fungus) (Phoma lingam) Protein phosphatase methylesterase 1 | Leptosphaeria maculans |
| loalo-e1fzk7 | Loa loa (Eye worm) (Filaria loa) Protein phosphatase methylesterase 1 | Loa loa |
| lodel-a5duu4 | Lodderomyces elongisporus (strain ATCC 11503 \/ CBS 2605 \/ JCM 1781 \/ NBRC 1676 \/ NRRL YB-4239) (Yeast) (Saccharomyces elongisporus) Protein phosphatase methylesterase 1 | Lodderomyces elongisporus |
| mago7-a4uc22 | Magnaporthe oryzae (strain 70-15 \/ FGSC 8958) (Rice blast fungus) (Pyricularia oryzae) Protein phosphatase methylesterase 1 | Magnaporthe oryzae |
| maize-b6til5 | Zea mays (Maize) Protein phosphatase methylesterase 1 | Zea mays |
| malgo-a8q7d0 | Malassezia globosa (strain ATCC 96807 \/ CBS 7966) (Dandruff-associated fungus) Protein phosphatase methylesterase 1 | Malassezia globosa |
| micpc-c1n5d2 | Micromonas pusilla (strain CCMP1545) (Picoplanktonic green alga) Protein phosphatase methylesterase 1 | Micromonas pusilla |
| micsr-c1fi89 | Micromonas sp. (strain RCC299 \/ NOUM17) (Picoplanktonic green alga) Predicted protein | Micromonas sp. |
| monbe-a9uqa7 | Monosiga brevicollis (Choanoflagellate) Protein phosphatase methylesterase 1 | Monosiga brevicollis |
| mouse-PPME1 | Mus musculus (Mouse) similar to protein phosphatase methylesterase-1 | Mus musculus |
| naegr-d2vr44 | Naegleria gruberi (Amoeba) Predicted protein | Naegleria gruberi |
| nech7-c7yh18 | Nectria haematococca (strain 77-13-4 \/ FGSC 9596 \/ MPVI) (Fusarium solani subsp. pisi) Protein phosphatase methylesterase 1 | Nectria haematococca |
| nemve-a7s3l3 | Nematostella vectensis (Starlet sea anemone) Protein phosphatase methylesterase 1 | Nematostella vectensis |
| neucr-ppme1 | Neurospora crassa protein phosphatase methylesterase 1 (EC 3.1.1.-) (pme-1) | Neurospora crassa |
| oikdi-e4x7y6 | Oikopleura dioica (Tunicate) Protein phosphatase methylesterase 1 | Oikopleura dioica |
| orysa-Q0JCY4 | Oryza sativa (Rice) p0041a24.6 protein Oryza sativa subsp. japonica subsp. indica (Rice) os04g0443500 | Oryza sativa |
| ostlu-a4sac2 | Ostreococcus lucimarinus (strain CCE9901) Predicted protein | Ostreococcus lucimarinus |
| ostta-q01dg2 | Ostreococcus tauri Predicted acetyltransferases and hydrolases with the alpha\/beta hydrolase fold (ISS) | Ostreococcus tauri |
| parba-c1h4e8 | Paracoccidioides brasiliensis (strains ATCC MYA-826 \/ Pb01\; Pb18\; Pb03) Protein phosphatase methylesterase 1 | Paracoccidioides brasiliensis |
| parte-a0cur9 | Paramecium tetraurelia chromosome undetermined scaffold_28, whole genome shotgun sequence | Paramecium tetraurelia |
| parte-a0drx0 | Paramecium tetraurelia chromosome undetermined scaffold_61, whole genome shotgun sequence | Paramecium tetraurelia |
| parte-a0e4m9 | Paramecium tetraurelia Chromosome undetermined scaffold_78, whole genome shotgun sequence | Paramecium tetraurelia |
| parte-a0ef67 | Paramecium tetraurelia Chromosome undetermined scaffold_93, whole genome shotgun sequence | Paramecium tetraurelia |
| pedhc-e0vwv3 | Pediculus humanus subsp. corporis (Body louse) Protein phosphatase methylesterase 1 | Pediculus humanus corporis |
| pencw-b6hs49 | Penicillium chrysogenum (strain ATCC 28089 \/ DSM 1075 \/ Wisconsin 54-1255) (Penicillium notatum) Protein phosphatase methylesterase 1 | Penicillium chrysogenum |
| penmq-b6qmy9 | Penicillium marneffei (strain ATCC 18224 \/ CBS 334.59 \/ QM 7333) Protein phosphatase methylesterase 1 | Penicillium marneffei |
| phano-q0uuc4 | Phaeosphaeria nodorum (strain SN15 \/ FGSC 10173) (Glume blotch fungus) (Septoria nodorum) Protein phosphatase methylesterase 1 | Phaeosphaeria nodorum |
| phyit-d0p3z2 | Phytophthora infestans (strain T30-4) (Potato late blight fungus) Protein phosphatase methylesterase 1 | Phytophthora infestans |
| phypa-a9u2u7 | Physcomitrella patens subsp. patens (Moss) Protein phosphatase methylesterase 1 | Physcomitrella patens subsp. patens |
| picad-e7r7h3 | Pichia angusta (strain ATCC 26012 \/ NRRL Y-7560 \/ DL-1) (Yeast) (Hansenula polymorpha) Protein phosphatase methylesterase 1 | Pichia angusta |
| picgu-a5dnt6 | Meyerozyma guilliermondii (strain ATCC 6260 \/ CBS 566 \/ DSM 6381 \/ JC 1539 \/ NBRC 10279 \/ NRRL Y-324) (Yeast) (Candida guilliermondii) Protein phosphatase methylesterase 1 | Meyerozyma guilliermondii |
| picpg-c4r788 | Pichia pastoris) (Yeast) Protein phosphatase methylesterase 1 | Pichia pastoris |
| picsi-d5a9p8 | Picea sitchensis (Sitka spruce) (Pinus sitchensis) Protein phosphatase methylesterase 1 | Picea sitchensis |
| picst-a3ln59 | Scheffersomyces stipitis (strain ATCC 58785 \/ CBS 6054 \/ NBRC 10063 \/ NRRL Y-11545) (Yeast) (Pichia stipitis) Protein phosphatase methylesterase 1 | Scheffersomyces stipitis |
| podan-b2a8u1 | Podospora anserina (strain S \/ DSM 980 \/ FGSC 10383) (Pleuraga anserina) Protein phosphatase methylesterase 1 | Podospora anserina |
| polpa-d3b0m1 | Polysphondylium pallidum (Cellular slime mold) Pyruvate kinase | Polysphondylium pallidum |
| ponab-ppme1 | Pongo abelii (Sumatran orangutan)(Pongo pygmaeus abelii) Protein phosphatase methylesterase 1 (EC 3.1.1.-) (pme-1) hypothetical protein dkfzp459i243 | Pongo abelii |
| poptr-b9iqa0 | Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa) Protein phosphatase methylesterase 1 | Populus trichocarpa |
| poptr-b9mwi8 | Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa) Protein phosphatase methylesterase 1 | Populus trichocarpa |
| pospm-b8pce4 | Postia placenta (strain ATCC 44394 \/ Madison 698-R) (Brown rot fungus) (Poria monticola) Protein phosphatase methylesterase 1 | Postia placenta |
| pyrtr-b2wcq8 | Pyrenophora tritici-repentis (Wheat tan spot fungus) (Drechslera tritici-repentis) Pyrenophora teres f. teres (Barley net blotch fungus) Protein phosphatase methylesterase 1 | Pyrenophora tritici-repentis |
| ricco-b9shr5 | Ricinus communis (Castor bean) Protein phosphatase methylesterase 1 | Ricinus communis |
| sals5-f2u409 | Salpingoeca rosetta Protein phosphatase methylesterase 1 | Salpingoeca rosetta |
| salsa-b5x315 | Salmo salar (Atlantic salmon) Protein phosphatase methylesterase 1 | Salmo salar |
| salsa-c0h930 | Salmo salar (Atlantic salmon) Protein phosphatase methylesterase 1 | Salmo salar |
| schjy-b6jyg6 | Schizosaccharomyces japonicus (strain yFS275 \/ FY16936) (Fission yeast) Protein phosphatase methylesterase 1 | Schizosaccharomyces japonicus |
| schma-c4qb79 | Schistosoma mansoni (Blood fluke) Protein phosphatase methylesterase 1 (S33 family) | Schistosoma mansoni |
| schpo-ppme1 | Schizosaccharomyces pombe (Fission yeast) putative phosphatase methylesterase 1 (EC 3.1.1.-) (pme-1) | Schizosaccharomyces pombe |
| scls1-a7egi9 | Sclerotinia sclerotiorum (strain ATCC 18683 \/ 1980 \/ Ss-1) (White mold) (Whetzelinia sclerotiorum) Protein phosphatase methylesterase 1 | Sclerotinia sclerotiorum |
| selml-d8qza0 | Selaginella moellendorffii (Spikemoss) Protein phosphatase methylesterase 1 | Selaginella moellendorffii |
| solin-e9iiv7 | Solenopsis invicta (Red imported fire ant) (Solenopsis wagneri) Protein phosphatase methylesterase 1 | Solenopsis invicta |
| sormk-d1z746 | Sordaria macrospora (strain ATCC MYA-333 \/ DSM 997 \/ K(L3346) \/ K-hell) Protein phosphatase methylesterase 1 | Sordaria macrospora |
| spore-e6zlt6 | Sporisorium reilianum (strain SRZ2) (Maize head smut fungus) Protein phosphatase methylesterase 1 | Sporisorium reilianum |
| talsn-b8mhb1 | Talaromyces stipitatus (strain ATCC 10500 \/ CBS 375.48 \/ QM 6759 \/ NRRL 1006) (Penicillium stipitatum) Protein phosphatase methylesterase 1 | Talaromyces stipitatus |
| tetng-q4s8t5 | Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) chromosome 7 scaf14703, whole genome shotgun sequence | Tetraodon nigroviridis |
| tetng-q4spa7 | Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) | Tetraodon nigroviridis |
| tetts-q244c7 | Tetrahymena thermophila SB210 hydrolase, alpha\/beta fold family protein | Tetrahymena thermophila SB210 |
| triad-b3rxn2 | Trichoplax adhaerens (Trichoplax reptans) Protein phosphatase methylesterase 1 | Trichoplax adhaerens |
| trica-d6w855 | Tribolium castaneum (Red flour beetle) Protein phosphatase methylesterase 1 | Tribolium castaneum |
| trisp-e5sbp4 | Trichinella spiralis (Trichina worm) Protein phosphatase methylesterase 1 | Trichinella spiralis |
| triva-a2fla2 | Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase | Trichomonas vaginalis |
| trivh-d4d960 | Trichophyton verrucosum, Trichophyton tonsurans (Scalp ringworm fungus), T. equinum (Horse ringworm fungus), T. rubrum (Athlete's foot fungus) Arthroderma gypseum (Microsporum gypseum), Protein phosphatase methylesterase 1 | Trichophyton verrucosum |
| tryb2-q382c1 | Trypanosoma brucei Protein phosphatase methylesterase 1 | Trypanosoma brucei |
| tryb9-d0a9w2 | Trypanosoma brucei gambiense (strain MHOM\/CI\/86\/DAL972) Protein phosphatase methylesterase 1 | Trypanosoma brucei gambiense |
| trycr-q4dy49 | Trypanosoma cruzi hypothetical protein | Trypanosoma cruzi |
| tubmm-d5giz0 | Tuber melanosporum (strain Mel28) (Perigord black truffle) Protein phosphatase methylesterase 1 | Tuber melanosporum |
| uncre-c4jw09 | Uncinocarpus reesii (strain UAMH 1704) Protein phosphatase methylesterase 1 | Uncinocarpus reesii |
| ustma-q4p082 | Ustilago maydis (strain 521 \/ FGSC 9021) (Smut fungus) Putative uncharacterized protein | Ustilago maydis |
| vanpo-a7tmw4 | Vanderwaltozyma polyspora (strain ATCC 22028 \/ DSM 70294) (Kluyveromyces polysporus) Protein phosphatase methylesterase 1 | Vanderwaltozyma polyspora |
| vitvi-d7tle9 | Vitis vinifera (Grape) Protein phosphatase methylesterase 1 | Vitis vinifera |
| volca-d8uhi9 | Volvox carteri (Green alga) Protein phosphatase methylesterase 1 | Volvox carteri |
| xenla-q6ddg7 | Xenopus laevis (African clawed frog) mgc84506 protein | Xenopus laevis |
| yarli-ppme1 | Yarrowia lipolytica (Candida lipolytica) protein phosphatase methylesterase 1 (EC 3.1.1.-) (pme-1) | Yarrowia lipolytica |
| yeast-ppme1 | Saccharomyces cerevisiae (Baker's yeast) protein phosphatase methylesterase 1 (EC 3.1.1.-) (pme-1) (yms2) | Saccharomyces cerevisiae |
| zygrc-c5dvz8 | Zygosaccharomyces rouxii (strain ATCC 2623 \/ CBS 732 \/ NBRC 1130 \/ NCYC 568 \/ NRRL Y-229) (Candida mogii) Protein phosphatase methylesterase 1 | Zygosaccharomyces rouxii |
| Gene_locus_frgt | Name | Species |
|---|---|---|
| brafl-c3yz73 | Branchiostoma floridae (Florida lancelet) (Amphioxus) Putative uncharacterized protein | Branchiostoma floridae |
| chlva-e1zkq4 | Chlorella variabilis (Green alga) Putative uncharacterized protein | Chlorella variabilis |
| metaq-e9dzk1 | Metarhizium acridum (strain CQMa 102) Protein phosphatase methylesterase 1 | Metarhizium acridum |
| neocl-f0vgb7 | Neospora caninum (strain Liverpool) Putative uncharacterized protein | Neospora caninum |
| pucgt-e3l252 | Puccinia graminis f. sp. tritici (strain CRL 75-36-700-3 \/ race SCCL) (Black stem rust fungus) Putative uncharacterized protein | Puccinia graminis f. sp. tritici |
| rat-q4fzt2 | Rattus norvegicus (Rat) Ppme1 protein | Rattus norvegicus |
| schcm-d8qiy7 | Schizophyllum commune (strain H4-8 \/ FGSC 9210) (Split gill fungus) Putative uncharacterized protein | Schizophyllum commune |
| schja-q5by96 | Schistosoma japonicum (Blood fluke, platyhelminth) sjchgc03406 protein (fragment) | Schistosoma japonicum |
| toxgo-b9plt5 | Toxoplasma gondii Protein phosphatase methylesterase 1 | Toxoplasma gondii |
| vera1-c9sjh8 | Verticillium albo-atrum (strain VaMs.102) (Verticillium wilt) Protein phosphatase methylesterase | Verticillium albo-atrum |
| Inhibitor | Chemical Nomenclature | Proteins |
|---|---|---|
| ABL-127 | dimethyl (3R)-3-cyclopentyl-4-oxo-3-phenyldiazetidine-1,2-dicarboxylate | human-PPME1 |
| ABP-C6 | Hexyl 4-nitrophenyl (3-azidopropyl)phosphonate | mouse-hslip mouse-MGLL mouse-Abhd11 mouse-Ces1d mouse-ES10 mouse-lypla2 drome-CG18815 mouse-lypla1 mouse-Ces1c mouse-Ces1f mouse-Ces1g mouse-PPME1 mouse-apeh mouse-abhd5 mouse-lypl1 mouse-Ces2c mouse-Ces2a mouse-Ces2e mouse-aryla mouse-BCHE mouse-dpp2 mouse-dpp4 mouse-C87498 |
| NBD-HE-HP | N-[2-[hexyl-(4-nitrophenoxy)phosphoryl]oxyethyl]-6-[(4-nitro-2,1,3-benzoxadiazol-7-yl)amino]hexanamide | mouse-hslip mouse-Ces1d mouse-MGLL mouse-ES10 mouse-Abhd11 drome-CG2059 mouse-lypla2 drome-CG18815 mouse-lypla1 mouse-Ces1c mouse-Ces1f mouse-PPME1 mouse-apeh mouse-abhd5 drome-CG1882 mouse-lypl1 burce-lipaa rhidl-lipas drome-EST23aes07 drome-este6 drome-CG5355 drome-aes05 drome-aes02 drome-CG8425 |
| VX-Biotin | human-CTSA human-ACHE human-BCHE |
References (2)
| Title : Structural mechanism of demethylation and inactivation of protein phosphatase 2A - Xing_2008_Cell_133_154 |
| Author(s) : Xing Y , Li Z , Chen Y , Stock JB , Jeffrey PD , Shi Y |
| Ref : Cell , 133 :154 , 2008 |
| Abstract : |
| PubMedSearch : Xing_2008_Cell_133_154 |
| PubMedID: 18394995 |
| Gene_locus related to this paper: human-PPME1 |
| Title : A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A - Ogris_1999_J.Biol.Chem_274_14382 |
| Author(s) : Ogris E , Du X , Nelson KC , Mak EK , Yu XX , Lane WS , Pallas DC |
| Ref : Journal of Biological Chemistry , 274 :14382 , 1999 |
| Abstract : |
| PubMedSearch : Ogris_1999_J.Biol.Chem_274_14382 |
| PubMedID: 10318862 |
| Gene_locus related to this paper: human-PPME1 , mouse-PPME1 |