Craddock N

References (2)

Title : Genome-wide association study of major recurrent depression in the U.K. population - Lewis_2010_Am.J.Psychiatry_167_949
Author(s) : Lewis CM , Ng MY , Butler AW , Cohen-Woods S , Uher R , Pirlo K , Weale ME , Schosser A , Paredes UM , Rivera M , Craddock N , Owen MJ , Jones L , Jones I , Korszun A , Aitchison KJ , Shi J , Quinn JP , Mackenzie A , Vollenweider P , Waeber G , Heath S , Lathrop M , Muglia P , Barnes MR , Whittaker JC , Tozzi F , Holsboer F , Preisig M , Farmer AE , Breen G , Craig IW , McGuffin P
Ref : Am J Psychiatry , 167 :949 , 2010
Abstract : OBJECTIVE: Studies of major depression in twins and families have shown moderate to high heritability, but extensive molecular studies have failed to identify susceptibility genes convincingly. To detect genetic variants contributing to major depression, the authors performed a genome-wide association study using 1,636 cases of depression ascertained in the U.K. and 1,594 comparison subjects screened negative for psychiatric disorders. METHOD: Cases were collected from 1) a case-control study of recurrent depression (the Depression Case Control [DeCC] study; N=1346), 2) an affected sibling pair linkage study of recurrent depression (probands from the Depression Network [DeNT] study; N=332), and 3) a pharmacogenetic study (the Genome-Based Therapeutic Drugs for Depression [GENDEP] study; N=88). Depression cases and comparison subjects were genotyped at Centre National de Genotypage on the Illumina Human610-Quad BeadChip. After applying stringent quality control criteria for missing genotypes, departure from Hardy-Weinberg equilibrium, and low minor allele frequency, the authors tested for association to depression using logistic regression, correcting for population ancestry. RESULTS: Single nucleotide polymorphisms (SNPs) in BICC1 achieved suggestive evidence for association, which strengthened after imputation of ungenotyped markers, and in analysis of female depression cases. A meta-analysis of U.K. data with previously published results from studies in Munich and Lausanne showed some evidence for association near neuroligin 1 (NLGN1) on chromosome 3, but did not support findings at BICC1. CONCLUSIONS: This study identifies several signals for association worthy of further investigation but, as in previous genome-wide studies, suggests that individual gene contributions to depression are likely to have only minor effects, and very large pooled analyses will be required to identify them.
ESTHER : Lewis_2010_Am.J.Psychiatry_167_949
PubMedSearch : Lewis_2010_Am.J.Psychiatry_167_949
PubMedID: 20516156

Title : Analysis of the neuroligin 3 and 4 genes in autism and other neuropsychiatric patients -
Author(s) : Yan J , Oliveira G , Coutinho A , Yang C , Feng J , Katz C , Sram J , Bockholt A , Jones IR , Craddock N , Cook EH, Jr. , Vicente A , Sommer SS
Ref : Mol Psychiatry , 10 :329 , 2005
PubMedID: 15622415
Gene_locus related to this paper: human-NLGN3 , human-NLGN4X