Full name : Dougherty Dennis A
First name : Dennis A
Mail : Division of Chemistry & Chemical Engineering, California Institute of Technology, Pasadena, California
Zip Code :
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Country : USA
Email : dadougherty@caltech.edu
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Comment
| Title : Mutation Linked to Autosomal Dominant Nocturnal Frontal Lobe Epilepsy Reduces Low-Sensitivity alpha4beta2, and Increases alpha5alpha4beta2, Nicotinic Receptor Surface Expression - Nichols_2016_PLoS.One_11_e0158032 |
| Author(s) : Nichols WA , Henderson BJ , Marotta CB , Yu CY , Richards C , Dougherty DA , Lester HA , Cohen BN |
| Ref : PLoS ONE , 11 :e0158032 , 2016 |
| Abstract : |
| PubMedSearch : Nichols_2016_PLoS.One_11_e0158032 |
| PubMedID: 27336596 |
| Title : An Unaltered Orthosteric Site and a Network of Long-Range Allosteric Interactions for PNU-120596 in alpha7 Nicotinic Acetylcholine Receptors - Marotta_2015_Chem.Biol_22_1063 |
| Author(s) : Marotta CB , Lester HA , Dougherty DA |
| Ref : Chemical Biology , 22 :1063 , 2015 |
| Abstract : |
| PubMedSearch : Marotta_2015_Chem.Biol_22_1063 |
| PubMedID: 26211363 |
| Title : Heterologous expression and nonsense suppression provide insights into agonist behavior at alpha6beta2 nicotinic acetylcholine receptors - Post_2015_Neuropharmacol_97_376 |
| Author(s) : Post MR , Limapichat W , Lester HA , Dougherty DA |
| Ref : Neuropharmacology , 97 :376 , 2015 |
| Abstract : |
| PubMedSearch : Post_2015_Neuropharmacol_97_376 |
| PubMedID: 25908401 |
| Title : The nicotinic alpha6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2\/3 receptors - Wieskopf_2015_Sci.Transl.Med_7_287ra72 |
| Author(s) : Wieskopf JS , Mathur J , Limapichat W , Post MR , Al-Qazzaz M , Sorge RE , Martin LJ , Zaykin DV , Smith SB , Freitas K , Austin JS , Dai F , Zhang J , Marcovitz J , Tuttle AH , Slepian PM , Clarke S , Drenan RM , Janes J , Al Sharari S , Segall SK , Aasvang EK , Lai W , Bittner R , Richards CI , Slade GD , Kehlet H , Walker J , Maskos U , Changeux JP , Devor M , Maixner W , Diatchenko L , Belfer I , Dougherty DA , Su AI , Lummis SC , Damaj MI , Lester HA , Patapoutian A , Mogil JS |
| Ref : Sci Transl Med , 7 :287ra72 , 2015 |
| Abstract : |
| PubMedSearch : Wieskopf_2015_Sci.Transl.Med_7_287ra72 |
| PubMedID: 25972004 |
| Title : Probing the non-canonical interface for agonist interaction with an alpha5 containing nicotinic acetylcholine receptor - Marotta_2014_Neuropharmacol_77_342 |
| Author(s) : Marotta CB , Dilworth CN , Lester HA , Dougherty DA |
| Ref : Neuropharmacology , 77 :342 , 2014 |
| Abstract : |
| PubMedSearch : Marotta_2014_Neuropharmacol_77_342 |
| PubMedID: 24144909 |
| Title : Binding interactions with the complementary subunit of nicotinic receptors - Blum_2013_J.Biol.Chem_288_6991 |
| Author(s) : Blum AP , Van Arnam EB , German LA , Lester HA , Dougherty DA |
| Ref : Journal of Biological Chemistry , 288 :6991 , 2013 |
| Abstract : |
| PubMedSearch : Blum_2013_J.Biol.Chem_288_6991 |
| PubMedID: 23349463 |
| Title : An Unusual Pattern of Ligand-Receptor Interactions for the alpha7 Nicotinic Acetylcholine Receptor, with Implications for the Binding of Varenicline - Van Arnam_2013_Mol.Pharmacol_84_201 |
| Author(s) : Van Arnam EB , Blythe EE , Lester HA , Dougherty DA |
| Ref : Molecular Pharmacology , 84 :201 , 2013 |
| Abstract : |
| PubMedSearch : Van Arnam_2013_Mol.Pharmacol_84_201 |
| PubMedID: 23680636 |
| Title : Forster Resonance Energy Transfer (FRET) Correlates of Altered Subunit Stoichiometry in Cys-Loop Receptors, Exemplified by Nicotinic alpha4beta2 - Srinivasan_2012_Int.J.Mol.Sci_13_10022 |
| Author(s) : Srinivasan R , Richards CI , Dilworth C , Moss FJ , Dougherty DA , Lester HA |
| Ref : Int J Mol Sci , 13 :10022 , 2012 |
| Abstract : |
| PubMedSearch : Srinivasan_2012_Int.J.Mol.Sci_13_10022 |
| PubMedID: 22949846 |
| Title : Pharmacological chaperoning of nicotinic acetylcholine receptors reduces the endoplasmic reticulum stress response - Srinivasan_2012_Mol.Pharmacol_81_759 |
| Author(s) : Srinivasan R , Richards CI , Xiao C , Rhee D , Pantoja R , Dougherty DA , Miwa JM , Lester HA |
| Ref : Molecular Pharmacology , 81 :759 , 2012 |
| Abstract : |
| PubMedSearch : Srinivasan_2012_Mol.Pharmacol_81_759 |
| PubMedID: 22379121 |
| Title : Probing the effects of residues located outside the agonist binding site on drug-receptor selectivity in the nicotinic receptor - Puskar_2012_ACS.Chem.Biol_7_841 |
| Author(s) : Puskar NL , Lester HA , Dougherty DA |
| Ref : ACS Chemical Biology , 7 :841 , 2012 |
| Abstract : |
| PubMedSearch : Puskar_2012_ACS.Chem.Biol_7_841 |
| PubMedID: 22296725 |
| Title : Variations in binding among several agonists at two stoichiometries of the neuronal, alpha4beta2 nicotinic receptor - Tavares_2012_J.Am.Chem.Soc_134_11474 |
| Author(s) : Tavares Xda S , Blum AP , Nakamura DT , Puskar NL , Shanata JA , Lester HA , Dougherty DA |
| Ref : J Am Chem Soc , 134 :11474 , 2012 |
| Abstract : |
| PubMedSearch : Tavares_2012_J.Am.Chem.Soc_134_11474 |
| PubMedID: 22716019 |
| Title : Live-cell imaging of single receptor composition using zero-mode waveguide nanostructures - Richards_2012_Nano.Lett_12_3690 |
| Author(s) : Richards CI , Luong K , Srinivasan R , Turner SW , Dougherty DA , Korlach J , Lester HA |
| Ref : Nano Lett , 12 :3690 , 2012 |
| Abstract : |
| PubMedSearch : Richards_2012_Nano.Lett_12_3690 |
| PubMedID: 22668081 |
| Title : A cation-pi interaction at a phenylalanine residue in the glycine receptor binding site is conserved for different agonists - Pless_2011_Mol.Pharmacol_79_742 |
| Author(s) : Pless SA , Hanek AP , Price KL , Lynch JW , Lester HA , Dougherty DA , Lummis SC |
| Ref : Molecular Pharmacology , 79 :742 , 2011 |
| Abstract : |
| PubMedSearch : Pless_2011_Mol.Pharmacol_79_742 |
| PubMedID: 21266487 |
| Title : Two neuronal nicotinic acetylcholine receptors, alpha4beta4 and alpha7, show differential agonist binding modes - Puskar_2011_J.Biol.Chem_286_14618 |
| Author(s) : Puskar NL , Xiu X , Lester HA , Dougherty DA |
| Ref : Journal of Biological Chemistry , 286 :14618 , 2011 |
| Abstract : |
| PubMedSearch : Puskar_2011_J.Biol.Chem_286_14618 |
| PubMedID: 21343288 |
| Title : Evidence for an extended hydrogen bond network in the binding site of the nicotinic receptor: role of the vicinal disulfide of the alpha1 subunit - Blum_2011_J.Biol.Chem_286_32251 |
| Author(s) : Blum AP , Gleitsman KR , Lester HA , Dougherty DA |
| Ref : Journal of Biological Chemistry , 286 :32251 , 2011 |
| Abstract : |
| PubMedSearch : Blum_2011_J.Biol.Chem_286_32251 |
| PubMedID: 21757705 |
| Title : Chemical scale studies of the Phe-Pro conserved motif in the cys loop of Cys loop receptors - Limapichat_2010_J.Biol.Chem_285_8976 |
| Author(s) : Limapichat W , Lester HA , Dougherty DA |
| Ref : Journal of Biological Chemistry , 285 :8976 , 2010 |
| Abstract : |
| PubMedSearch : Limapichat_2010_J.Biol.Chem_285_8976 |
| PubMedID: 20068044 |
| Title : Nicotinic pharmacophore: the pyridine N of nicotine and carbonyl of acetylcholine hydrogen bond across a subunit interface to a backbone NH - Blum_2010_Proc.Natl.Acad.Sci.U.S.A_107_13206 |
| Author(s) : Blum AP , Lester HA , Dougherty DA |
| Ref : Proc Natl Acad Sci U S A , 107 :13206 , 2010 |
| Abstract : |
| PubMedSearch : Blum_2010_Proc.Natl.Acad.Sci.U.S.A_107_13206 |
| PubMedID: 20616056 |
| Title : Single-molecule imaging of a fluorescent unnatural amino acid incorporated into nicotinic receptors - Pantoja_2009_Biophys.J_96_226 |
| Author(s) : Pantoja R , Rodriguez EA , Dibas MI , Dougherty DA , Lester HA |
| Ref : Biophysical Journal , 96 :226 , 2009 |
| Abstract : |
| PubMedSearch : Pantoja_2009_Biophys.J_96_226 |
| PubMedID: 19134478 |
| Title : Nicotine binding to brain receptors requires a strong cation-pi interaction - Xiu_2009_Nature_458_534 |
| Author(s) : Xiu X , Puskar NL , Shanata JA , Lester HA , Dougherty DA |
| Ref : Nature , 458 :534 , 2009 |
| Abstract : |
| PubMedSearch : Xiu_2009_Nature_458_534 |
| PubMedID: 19252481 |
| Title : Probing the role of the cation-pi interaction in the binding sites of GPCRs using unnatural amino acids - Torrice_2009_Proc.Natl.Acad.Sci.U.S.A_106_11919 |
| Author(s) : Torrice MM , Bower KS , Lester HA , Dougherty DA |
| Ref : Proc Natl Acad Sci U S A , 106 :11919 , 2009 |
| Abstract : |
| PubMedSearch : Torrice_2009_Proc.Natl.Acad.Sci.U.S.A_106_11919 |
| PubMedID: 19581583 |
| Title : Probing the role of backbone hydrogen bonding in a critical beta sheet of the extracellular domain of a cys-loop receptor - Gleitsman_2009_Chembiochem_10_1385 |
| Author(s) : Gleitsman KR , Lester HA , Dougherty DA |
| Ref : Chembiochem , 10 :1385 , 2009 |
| Abstract : |
| PubMedSearch : Gleitsman_2009_Chembiochem_10_1385 |
| PubMedID: 19405066 |
| Title : Long-range coupling in an allosteric receptor revealed by mutant cycle analysis - Gleitsman_2009_Biophys.J_96_3168 |
| Author(s) : Gleitsman KR , Shanata JA , Frazier SJ , Lester HA , Dougherty DA |
| Ref : Biophysical Journal , 96 :3168 , 2009 |
| Abstract : |
| PubMedSearch : Gleitsman_2009_Biophys.J_96_3168 |
| PubMedID: 19383461 |
| Title : Nicotine is a selective pharmacological chaperone of acetylcholine receptor number and stoichiometry. Implications for drug discovery - Lester_2009_AAPS.J_11_167 |
| Author(s) : Lester HA , Xiao C , Srinivasan R , Son CD , Miwa JM , Pantoja R , Banghart MR , Dougherty DA , Goate AM , Wang JC |
| Ref : AAPS J , 11 :167 , 2009 |
| Abstract : |
| PubMedSearch : Lester_2009_AAPS.J_11_167 |
| PubMedID: 19280351 |
| Title : An intersubunit hydrogen bond in the nicotinic acetylcholine receptor that contributes to channel gating - Gleitsman_2008_J.Biol.Chem_283_35638 |
| Author(s) : Gleitsman KR , Kedrowski SM , Lester HA , Dougherty DA |
| Ref : Journal of Biological Chemistry , 283 :35638 , 2008 |
| Abstract : |
| PubMedSearch : Gleitsman_2008_J.Biol.Chem_283_35638 |
| PubMedID: 18952603 |
| Title : A stereochemical test of a proposed structural feature of the nicotinic acetylcholine receptor - Hanek_2008_J.Am.Chem.Soc_130_13216 |
| Author(s) : Hanek AP , Lester HA , Dougherty DA |
| Ref : J Am Chem Soc , 130 :13216 , 2008 |
| Abstract : |
| PubMedSearch : Hanek_2008_J.Am.Chem.Soc_130_13216 |
| PubMedID: 18781739 |
| Title : Chemical-scale studies on the role of a conserved aspartate in preorganizing the agonist binding site of the nicotinic acetylcholine receptor - Cashin_2007_Biochemistry_46_630 |
| Author(s) : Cashin AL , Torrice MM , McMenimen KA , Lester HA , Dougherty DA |
| Ref : Biochemistry , 46 :630 , 2007 |
| Abstract : |
| PubMedSearch : Cashin_2007_Biochemistry_46_630 |
| PubMedID: 17223685 |
| Title : A cation-pi binding interaction with a tyrosine in the binding site of the GABAC receptor - Lummis_2005_Chem.Biol_12_993 |
| Author(s) : Lummis SC , D LB , Harrison NJ , Lester HA , Dougherty DA |
| Ref : Chemical Biology , 12 :993 , 2005 |
| Abstract : |
| PubMedSearch : Lummis_2005_Chem.Biol_12_993 |
| PubMedID: 16183023 |
| Title : Using physical chemistry to differentiate nicotinic from cholinergic agonists at the nicotinic acetylcholine receptor - Cashin_2005_J.Am.Chem.Soc_127_350 |
| Author(s) : Cashin AL , Petersson EJ , Lester HA , Dougherty DA |
| Ref : J Am Chem Soc , 127 :350 , 2005 |
| Abstract : |
| PubMedSearch : Cashin_2005_J.Am.Chem.Soc_127_350 |
| PubMedID: 15631485 |
| Title : A unified view of the role of electrostatic interactions in modulating the gating of Cys loop receptors - Xiu_2005_J.Biol.Chem_280_41655 |
| Author(s) : Xiu X , Hanek AP , Wang J , Lester HA , Dougherty DA |
| Ref : Journal of Biological Chemistry , 280 :41655 , 2005 |
| Abstract : |
| PubMedSearch : Xiu_2005_J.Biol.Chem_280_41655 |
| PubMedID: 16216879 |
| Title : A fluorophore attached to nicotinic acetylcholine receptor beta M2 detects productive binding of agonist to the alpha delta site - Dahan_2004_Proc.Natl.Acad.Sci.U.S.A_101_10195 |
| Author(s) : Dahan DS , Dibas MI , Petersson EJ , Auyeung VC , Chanda B , Bezanilla F , Dougherty DA , Lester HA |
| Ref : Proc Natl Acad Sci U S A , 101 :10195 , 2004 |
| Abstract : |
| PubMedSearch : Dahan_2004_Proc.Natl.Acad.Sci.U.S.A_101_10195 |
| PubMedID: 15218096 |
| Title : Conformation-dependent hydrophobic photolabeling of the nicotinic receptor: electrophysiology-coordinated photochemistry and mass spectrometry - Leite_2003_Proc.Natl.Acad.Sci.U.S.A_100_13054 |
| Author(s) : Leite JF , Blanton MP , Shahgholi M , Dougherty DA , Lester HA |
| Ref : Proc Natl Acad Sci U S A , 100 :13054 , 2003 |
| Abstract : |
| PubMedSearch : Leite_2003_Proc.Natl.Acad.Sci.U.S.A_100_13054 |
| PubMedID: 14569028 |
| Title : Investigation of apparent mass deviations in electrospray ionization tandem mass spectrometry of a benzophenone-labeled peptide - Leite_2003_Rapid.Commun.Mass.Spectrom_17_1677 |
| Author(s) : Leite JF , Dougherty DA , Lester HA , Shahgholi M |
| Ref : Rapid Commun Mass Spectrom , 17 :1677 , 2003 |
| Abstract : |
| PubMedSearch : Leite_2003_Rapid.Commun.Mass.Spectrom_17_1677 |
| PubMedID: 12872270 |
| Title : Site-specific incorporation of unnatural amino acids into receptors expressed in Mammalian cells - Monahan_2003_Chem.Biol_10_573 |
| Author(s) : Monahan SL , Lester HA , Dougherty DA |
| Ref : Chemical Biology , 10 :573 , 2003 |
| Abstract : |
| PubMedSearch : Monahan_2003_Chem.Biol_10_573 |
| PubMedID: 12837390 |
| Title : A perturbed pK(a) at the binding site of the nicotinic acetylcholine receptor: implications for nicotine binding - Petersson_2002_J.Am.Chem.Soc_124_12662 |
| Author(s) : Petersson EJ , Choi A , Dahan DS , Lester HA , Dougherty DA |
| Ref : J Am Chem Soc , 124 :12662 , 2002 |
| Abstract : |
| PubMedSearch : Petersson_2002_J.Am.Chem.Soc_124_12662 |
| PubMedID: 12392404 |
| Title : Cation-pi interactions in ligand recognition by serotonergic (5-HT3A) and nicotinic acetylcholine receptors: the anomalous binding properties of nicotine - Beene_2002_Biochemistry_41_10262 |
| Author(s) : Beene DL , Brandt GS , Zhong W , Zacharias NM , Lester HA , Dougherty DA |
| Ref : Biochemistry , 41 :10262 , 2002 |
| Abstract : |
| PubMedSearch : Beene_2002_Biochemistry_41_10262 |
| PubMedID: 12162741 |
| Title : Neurobiology. Snails, synapses and smokers - |
| Author(s) : Dougherty DA , Lester HA |
| Ref : Nature , 411 :252 , 2001 |
| PubMedID: 11357112 |
| Title : The tethered agonist approach to mapping ion channel proteins--toward a structural model for the agonist binding site of the nicotinic acetylcholine receptor - Li_2001_Chem.Biol_8_47 |
| Author(s) : Li L , Zhong W , Zacharias N , Gibbs C , Lester HA , Dougherty DA |
| Ref : Chemical Biology , 8 :47 , 2001 |
| Abstract : |
| PubMedSearch : Li_2001_Chem.Biol_8_47 |
| PubMedID: 11182318 |
| Title : Mapping disulfide connectivity using backbone ester hydrolysis - England_1999_Biochemistry_38_14409 |
| Author(s) : England PM , Lester HA , Dougherty DA |
| Ref : Biochemistry , 38 :14409 , 1999 |
| Abstract : |
| PubMedSearch : England_1999_Biochemistry_38_14409 |
| PubMedID: 10572015 |
| Title : Backbone mutations in transmembrane domains of a ligand-gated ion channel: implications for the mechanism of gating - England_1999_Cell_96_89 |
| Author(s) : England PM , Zhang Y , Dougherty DA , Lester HA |
| Ref : Cell , 96 :89 , 1999 |
| Abstract : |
| PubMedSearch : England_1999_Cell_96_89 |
| PubMedID: 9989500 |
| Title : From ab initio quantum mechanics to molecular neurobiology: a cation-pi binding site in the nicotinic receptor - Zhong_1998_Proc.Natl.Acad.Sci.U.S.A_95_12088 |
| Author(s) : Zhong W , Gallivan JP , Zhang Y , Li L , Lester HA , Dougherty DA |
| Ref : Proc Natl Acad Sci U S A , 95 :12088 , 1998 |
| Abstract : |
| PubMedSearch : Zhong_1998_Proc.Natl.Acad.Sci.U.S.A_95_12088 |
| PubMedID: 9770444 |
| Title : Flash decaging of tyrosine sidechains in an ion channel - Miller_1998_Neuron_20_619 |
| Author(s) : Miller JC , Silverman SK , England PM , Dougherty DA , Lester HA |
| Ref : Neuron , 20 :619 , 1998 |
| Abstract : |
| PubMedSearch : Miller_1998_Neuron_20_619 |
| PubMedID: 9581754 |
| Title : Expression and circular dichroism studies of the extracellular domain of the alpha subunit of the nicotinic acetylcholine receptor - West_1997_J.Biol.Chem_272_25468 |
| Author(s) : West AP, Jr. , Bjorkman PJ , Dougherty DA , Lester HA |
| Ref : Journal of Biological Chemistry , 272 :25468 , 1997 |
| Abstract : |
| PubMedSearch : West_1997_J.Biol.Chem_272_25468 |
| PubMedID: 9325259 |
| Title : Site-specific, photochemical proteolysis applied to ion channels in vivo - England_1997_Proc.Natl.Acad.Sci.U.S.A_94_11025 |
| Author(s) : England PM , Lester HA , Davidson N , Dougherty DA |
| Ref : Proc Natl Acad Sci U S A , 94 :11025 , 1997 |
| Abstract : |
| PubMedSearch : England_1997_Proc.Natl.Acad.Sci.U.S.A_94_11025 |
| PubMedID: 9380753 |
| Title : Site-specific incorporation of biotinylated amino acids to identify surface-exposed residues in integral membrane proteins - Gallivan JP_1997_Chem.Biol_4_739 |
| Author(s) : Gallivan JP , Lester HA , Dougherty DA |
| Ref : Chemical Biology , 4 :739 , 1997 |
| Abstract : |
| PubMedSearch : Gallivan JP_1997_Chem.Biol_4_739 |
| PubMedID: 9375252 |
| Title : A regenerative link in the ionic fluxes through the weaver potassium channel underlies the pathophysiology of the mutation - Silverman_1996_Proc.Natl.Acad.Sci.U.S.A_93_15429 |
| Author(s) : Silverman SK , Kofuji P , Dougherty DA , Davidson N , Lester HA |
| Ref : Proc Natl Acad Sci U S A , 93 :15429 , 1996 |
| Abstract : |
| PubMedSearch : Silverman_1996_Proc.Natl.Acad.Sci.U.S.A_93_15429 |
| PubMedID: 8986828 |
| Title : Dose-response relations for unnatural amino acids at the agonist binding site of the nicotinic acetylcholine receptor: tests with novel side chains and with several agonists - Kearney_1996_Mol.Pharmacol_50_1401 |
| Author(s) : Kearney PC , Nowak MW , Zhong W , Silverman SK , Lester HA , Dougherty DA |
| Ref : Molecular Pharmacology , 50 :1401 , 1996 |
| Abstract : |
| PubMedSearch : Kearney_1996_Mol.Pharmacol_50_1401 |
| PubMedID: 8913372 |
| Title : Determinants of nicotinic receptor gating in natural and unnatural side chain structures at the M2 9' position - Kearney_1996_Neuron_17_1221 |
| Author(s) : Kearney PC , Zhang H , Zhong W , Dougherty DA , Lester HA |
| Ref : Neuron , 17 :1221 , 1996 |
| Abstract : |
| PubMedSearch : Kearney_1996_Neuron_17_1221 |
| PubMedID: 8982168 |
| Title : An engineered Tetrahymena tRNAGln for in vivo incorporation of unnatural amino acids into proteins by nonsense suppression - Saks_1996_J.Biol.Chem_271_23169 |
| Author(s) : Saks ME , Sampson JR , Nowak MW , Kearney PC , Du F , Abelson JN , Lester HA , Dougherty DA |
| Ref : Journal of Biological Chemistry , 271 :23169 , 1996 |
| Abstract : |
| PubMedSearch : Saks_1996_J.Biol.Chem_271_23169 |
| PubMedID: 8798511 |