Ferro ES

References (6)

Title : Acute cocaine treatment increases thimet oligopeptidase in the striatum of rat brain - Dalio_2012_Biochem.Biophys.Res.Commun_419_724
Author(s) : Dalio FM , Visniauskas B , Bicocchi ES , Perry JC , Freua R , Gesteira TF , Nader HB , Machado MF , Tufik S , Ferro ES , Andersen ML , Toledo CA , Chagas JR , Oliveira V
Ref : Biochemical & Biophysical Research Communications , 419 :724 , 2012
Abstract : Many studies indicate that thimet oligopeptidase (EC3.4.24.15; TOP) can be implicated in the metabolism of bioactive peptides, including dynorphin 1-8, alpha-neoendorphin, beta-neoendorphin and GnRH. Furthermore, the higher levels of this peptidase are found in neuroendocrine tissue and testis. In the present study, we have evaluated the effect of acute cocaine administration in male rats on TOP specific activity and mRNA levels in prosencephalic brain areas related with the reward circuitry; ventral striatum, hippocampus, and frontal cortex. No significant differences on TOP specific activity were detected in the hippocampus and frontal cortex of cocaine treated animals compared to control vehicle group. However, a significant increase in activity was observed in the ventral striatum of cocaine treated-rats. The increase occurred in both, TOP specific activity and TOP relative mRNA amount determined by real time RT-PCR. As TOP can be implicated in the processing of many neuropeptides, and previous studies have shown that cocaine also alters the gene expression of proenkephalin and prodynorphin in the striatum, the present findings suggest that TOP changes in the brain could play important role in the balance of neuropeptide level correlated with cocaine effects.
ESTHER : Dalio_2012_Biochem.Biophys.Res.Commun_419_724
PubMedSearch : Dalio_2012_Biochem.Biophys.Res.Commun_419_724
PubMedID: 22387539

Title : The genome sequence of the gram-positive sugarcane pathogen Leifsonia xyli subsp. xyli - Monteiro-Vitorello_2004_Mol.Plant.Microbe.Interact_17_827
Author(s) : Monteiro-Vitorello CB , Camargo LE , Van Sluys MA , Kitajima JP , Truffi D , do Amaral AM , Harakava R , de Oliveira JC , Wood D , de Oliveira MC , Miyaki C , Takita MA , da Silva AC , Furlan LR , Carraro DM , Camarotte G , Almeida NF, Jr. , Carrer H , Coutinho LL , El-Dorry HA , Ferro MI , Gagliardi PR , Giglioti E , Goldman MH , Goldman GH , Kimura ET , Ferro ES , Kuramae EE , Lemos EG , Lemos MV , Mauro SM , Machado MA , Marino CL , Menck CF , Nunes LR , Oliveira RC , Pereira GG , Siqueira W , de Souza AA , Tsai SM , Zanca AS , Simpson AJ , Brumbley SM , Setubal JC
Ref : Mol Plant Microbe Interact , 17 :827 , 2004
Abstract : The genome sequence of Leifsonia xyli subsp. xyli, which causes ratoon stunting disease and affects sugarcane worldwide, was determined. The single circular chromosome of Leifsonia xyli subsp. xyli CTCB07 was 2.6 Mb in length with a GC content of 68% and 2,044 predicted open reading frames. The analysis also revealed 307 predicted pseudogenes, which is more than any bacterial plant pathogen sequenced to date. Many of these pseudogenes, if functional, would likely be involved in the degradation of plant heteropolysaccharides, uptake of free sugars, and synthesis of amino acids. Although L. xyli subsp. xyli has only been identified colonizing the xylem vessels of sugarcane, the numbers of predicted regulatory genes and sugar transporters are similar to those in free-living organisms. Some of the predicted pathogenicity genes appear to have been acquired by lateral transfer and include genes for cellulase, pectinase, wilt-inducing protein, lysozyme, and desaturase. The presence of the latter may contribute to stunting, since it is likely involved in the synthesis of abscisic acid, a hormone that arrests growth. Our findings are consistent with the nutritionally fastidious behavior exhibited by L. xyli subsp. xyli and suggest an ongoing adaptation to the restricted ecological niche it inhabits.
ESTHER : Monteiro-Vitorello_2004_Mol.Plant.Microbe.Interact_17_827
PubMedSearch : Monteiro-Vitorello_2004_Mol.Plant.Microbe.Interact_17_827
PubMedID: 15305603
Gene_locus related to this paper: leixx-q6ack2 , leixx-q6acm6 , leixx-q6acw2 , leixx-q6ad78 , leixx-q6adb9 , leixx-q6aed1 , leixx-q6aee6 , leixx-q6af15 , leixx-q6agt3 , leixx-q6ah78

Title : Comparative genomics of two Leptospira interrogans serovars reveals novel insights into physiology and pathogenesis - Nascimento_2004_J.Bacteriol_186_2164
Author(s) : Nascimento AL , Ko AI , Martins EA , Monteiro-Vitorello CB , Ho PL , Haake DA , Verjovski-Almeida S , Hartskeerl RA , Marques MV , Oliveira MC , Menck CF , Leite LC , Carrer H , Coutinho LL , Degrave WM , Dellagostin OA , El-Dorry H , Ferro ES , Ferro MI , Furlan LR , Gamberini M , Giglioti EA , Goes-Neto A , Goldman GH , Goldman MH , Harakava R , Jeronimo SM , Junqueira-de-Azevedo IL , Kimura ET , Kuramae EE , Lemos EG , Lemos MV , Marino CL , Nunes LR , de Oliveira RC , Pereira GG , Reis MS , Schriefer A , Siqueira WJ , Sommer P , Tsai SM , Simpson AJ , Ferro JA , Camargo LE , Kitajima JP , Setubal JC , Van Sluys MA
Ref : Journal of Bacteriology , 186 :2164 , 2004
Abstract : Leptospira species colonize a significant proportion of rodent populations worldwide and produce life-threatening infections in accidental hosts, including humans. Complete genome sequencing of Leptospira interrogans serovar Copenhageni and comparative analysis with the available Leptospira interrogans serovar Lai genome reveal that despite overall genetic similarity there are significant structural differences, including a large chromosomal inversion and extensive variation in the number and distribution of insertion sequence elements. Genome sequence analysis elucidates many of the novel aspects of leptospiral physiology relating to energy metabolism, oxygen tolerance, two-component signal transduction systems, and mechanisms of pathogenesis. A broad array of transcriptional regulation proteins and two new families of afimbrial adhesins which contribute to host tissue colonization in the early steps of infection were identified. Differences in genes involved in the biosynthesis of lipopolysaccharide O side chains between the Copenhageni and Lai serovars were identified, offering an important starting point for the elucidation of the organism's complex polysaccharide surface antigens. Differences in adhesins and in lipopolysaccharide might be associated with the adaptation of serovars Copenhageni and Lai to different animal hosts. Hundreds of genes encoding surface-exposed lipoproteins and transmembrane outer membrane proteins were identified as candidates for development of vaccines for the prevention of leptospirosis.
ESTHER : Nascimento_2004_J.Bacteriol_186_2164
PubMedSearch : Nascimento_2004_J.Bacteriol_186_2164
PubMedID: 15028702
Gene_locus related to this paper: lepin-AXEA , lepin-ESTA , lepin-LA0357 , lepin-LA0587 , lepin-LA0932 , lepin-LA1069 , lepin-LA1345 , lepin-LA1541 , lepin-LA1861 , lepin-LA1902 , lepin-LA1936 , lepin-LA1955 , lepin-LA2034 , lepin-LA2132 , lepin-LA2501 , lepin-LA2505 , lepin-LA2526 , lepin-LA2544 , lepin-LA2857 , lepin-LA2958 , lepin-LA3100 , lepin-LA3107 , lepin-LA3147 , lepin-LA3604 , lepin-LA3661 , lepin-LA3672 , lepin-LA3788 , lepin-LA3851 , lepin-LA3897 , lepin-LA3998 , lepin-METX , lepin-q8f7a8 , lepin-q72tt9

Title : Comparative analyses of the complete genome sequences of Pierce's disease and citrus variegated chlorosis strains of Xylella fastidiosa - Van Sluys_2003_J.Bacteriol_185_1018
Author(s) : Van Sluys MA , de Oliveira MC , Monteiro-Vitorello CB , Miyaki CY , Furlan LR , Camargo LE , da Silva AC , Moon DH , Takita MA , Lemos EG , Machado MA , Ferro MI , da Silva FR , Goldman MH , Goldman GH , Lemos MV , El-Dorry H , Tsai SM , Carrer H , Carraro DM , de Oliveira RC , Nunes LR , Siqueira WJ , Coutinho LL , Kimura ET , Ferro ES , Harakava R , Kuramae EE , Marino CL , Giglioti E , Abreu IL , Alves LM , do Amaral AM , Baia GS , Blanco SR , Brito MS , Cannavan FS , Celestino AV , da Cunha AF , Fenille RC , Ferro JA , Formighieri EF , Kishi LT , Leoni SG , Oliveira AR , Rosa VE, Jr. , Sassaki FT , Sena JA , de Souza AA , Truffi D , Tsukumo F , Yanai GM , Zaros LG , Civerolo EL , Simpson AJ , Almeida NF, Jr. , Setubal JC , Kitajima JP
Ref : Journal of Bacteriology , 185 :1018 , 2003
Abstract : Xylella fastidiosa is a xylem-dwelling, insect-transmitted, gamma-proteobacterium that causes diseases in many plants, including grapevine, citrus, periwinkle, almond, oleander, and coffee. X. fastidiosa has an unusually broad host range, has an extensive geographical distribution throughout the American continent, and induces diverse disease phenotypes. Previous molecular analyses indicated three distinct groups of X. fastidiosa isolates that were expected to be genetically divergent. Here we report the genome sequence of X. fastidiosa (Temecula strain), isolated from a naturally infected grapevine with Pierce's disease (PD) in a wine-grape-growing region of California. Comparative analyses with a previously sequenced X. fastidiosa strain responsible for citrus variegated chlorosis (CVC) revealed that 98% of the PD X. fastidiosa Temecula genes are shared with the CVC X. fastidiosa strain 9a5c genes. Furthermore, the average amino acid identity of the open reading frames in the strains is 95.7%. Genomic differences are limited to phage-associated chromosomal rearrangements and deletions that also account for the strain-specific genes present in each genome. Genomic islands, one in each genome, were identified, and their presence in other X. fastidiosa strains was analyzed. We conclude that these two organisms have identical metabolic functions and are likely to use a common set of genes in plant colonization and pathogenesis, permitting convergence of functional genomic strategies.
ESTHER : Van Sluys_2003_J.Bacteriol_185_1018
PubMedSearch : Van Sluys_2003_J.Bacteriol_185_1018
PubMedID: 12533478
Gene_locus related to this paper: xylfa-ACVB , xylfa-cxest , xylfa-metx , xylfa-PD1038 , xylfa-PD1211 , xylfa-PD1300 , xylfa-PD1702 , xylfa-PD2024 , xylfa-pip , xylfa-XF0015 , xylfa-XF0357 , xylfa-XF0754 , xylfa-XF0863 , xylfa-XF1029 , xylfa-XF1181 , xylfa-XF1253 , xylfa-XF1282 , xylfa-XF1356 , xylfa-XF1479 , xylfa-XF1965 , xylfa-XF2330 , xylfa-XF2551

Title : Effects of cholinergic deafferentation upon the expression of the alpha2 subunit of the nicotinic acetylcholine receptors in the chick lateral spiriform nucleus - Torrao_2000_Brain.Res_863_249
Author(s) : Torrao AS , Ferro ES , Lindstrom JM , Britto LR
Ref : Brain Research , 863 :249 , 2000
Abstract : Lesion, immunohistochemical, and immunoblotting methods were used to evaluate the effects of cholinergic deafferentation upon the expression of the alpha2 subunit of the nicotinic acetylcholine receptors in the lateral spiriform nucleus (SpL) of the chick brain. The expression of the alpha2 subunit in the SpL showed biphasic changes after lesion of its cholinergic source (nucleus semilunaris), with an increase after 2 days postlesion and a decrease after 3-7 days. Our results could represent a correlate of the phenomena of nicotinic receptor up- and down-regulation, induced by removal of the cholinergic input.
ESTHER : Torrao_2000_Brain.Res_863_249
PubMedSearch : Torrao_2000_Brain.Res_863_249
PubMedID: 10773214

Title : Neurons of the chick brain and retina expressing both alpha-bungarotoxin-sensitive and alpha-bungarotoxin-insensitive nicotinic acetylcholine receptors: an immunohistochemical analysis - Britto_1992_Brain.Res_590_193
Author(s) : Britto LR , Hamassaki-Britto DE , Ferro ES , Keyser KT , Karten HJ , Lindstrom JM
Ref : Brain Research , 590 :193 , 1992
Abstract : Immunohistochemical methods were used to study the possible co-localization of two alpha-bungarotoxin-sensitive (alpha 7 and alpha 8) and two alpha-bungarotoxin-insensitive (beta 2 and alpha 3) subunits of the nicotinic acetylcholine receptors in neurons of the chick brain and retina. Several structures contained neurons that were doubly-labeled with antibodies against the alpha 7 subunit and the beta 2 subunit. These structures included, for example, the interpeduncular nucleus, nucleus spiriformis lateralis, optic tectum, pretectal visual nuclei, and the lateral hypothalamus. Double-labeling with antibodies against the alpha 7 and alpha 8 subunits was also seen in several regions, which included the interpeduncular nucleus, visual pretectum, lateral hypothalamus, dorsal thalamus, and the habenular complex. In the retina, many cells in the inner nuclear layer were observed to contain alpha 8 and alpha 3 subunits, whereas neurons in the ganglion cell layer were seen to contain alpha 7 and alpha 8 or, less frequently, alpha 7 and alpha 3 subunits. These results indicate that alpha-bungarotoxin-sensitive and alpha-bungarotoxin-insensitive subunits of the nicotinic receptors are co-expressed by neurons of the chick brain and retina.
ESTHER : Britto_1992_Brain.Res_590_193
PubMedSearch : Britto_1992_Brain.Res_590_193
PubMedID: 1422831