Full name : Hagedorn Ilse
First name : Ilse
Mail : Chemical Laboratory, University of Freiburg, Freiburg
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Country : Germany
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Comment
Ilse Hagedorn was born on 17 May 1921 in Dresden and died on 17 December 2005 in Freiburg. She first worked on the structure determination and synthesis of Xanthocillin a naturally occuring antibiotic produced by Penicillium species. In Freiburg she started to work on oxime reactivators of acetylcholinesterase inhibited by organophosphorus. Among the more than 1000 oximes synthetized in Hagedorn laboratory (often referred as Hagedorn oximes), the most studied are named after the initials of co workers: LuH6 (Toxogonin) for Luttringhaus and Hagedorn, HS-6 for Schoene, HI-6 for Imro Stark, HLo 7 for Marlies Loffler HGG for Gross G. An obituary paper (ScienceDirect) by Peter Eyer retraces her achievements.
| Title : HLo 7 dimethanesulfonate, a potent bispyridinium-dioxime against anticholinesterases - Eyer_1992_Arch.Toxicol_66_603 |
| Author(s) : Eyer P , Hagedorn I , Klimmek R , Lippstreu P , Loffler M , Oldiges H , Spohrer U , Steidl I , Szinicz L , Worek F |
| Ref : Archives of Toxicology , 66 :603 , 1992 |
| Abstract : |
| PubMedSearch : Eyer_1992_Arch.Toxicol_66_603 |
| PubMedID: 1482283 |
| Title : The bispyridinium-dioxime HLo-7. A potent reactivator for acetylcholinesterase inhibited by the stereoisomers of tabun and soman - De Jong_1989_Biochem.Pharmacol_38_633 |
| Author(s) : De Jong LP , Verhagen MA , Langenberg JP , Hagedorn I , Loffler M |
| Ref : Biochemical Pharmacology , 38 :633 , 1989 |
| Abstract : |
| PubMedSearch : De Jong_1989_Biochem.Pharmacol_38_633 |
| PubMedID: 2917018 |
| Title : Study on the stability of the oxime HI 6 in aqueous solution - Eyer_1988_Arch.Toxicol_62_224 |
| Author(s) : Eyer P , Hagedorn I , Ladstetter B |
| Ref : Archives of Toxicology , 62 :224 , 1988 |
| Abstract : |
| PubMedSearch : Eyer_1988_Arch.Toxicol_62_224 |
| PubMedID: 3196158 |
| Title : Stability study of HI-6 dichloride in various anticholinergic formulations - |
| Author(s) : Brown ND , Gray RR , Stermer-Cox MG , Doctor BP , Hagedorn I |
| Ref : Journal of Chromatography , 315 :389 , 1984 |
| PubMedID: 6526905 |
| Title : Interactions of bisquaternary pyridine salts (H-oximes) with cholinergic receptors - Kuhnen-Clausen_1983_Arch.Toxicol_54_171 |
| Author(s) : Kuhnen-Clausen D , Hagedorn I , Gross G , Bayer H , Hucho F |
| Ref : Archives of Toxicology , 54 :171 , 1983 |
| Abstract : |
| PubMedSearch : Kuhnen-Clausen_1983_Arch.Toxicol_54_171 |
| PubMedID: 6661028 |
| Title : Synthesis of pyridinium analogues of acetylcholine and their interactions with intestinal muscarinic receptors - Kuhnen-Clausen_1979_J.Med.Chem_22_177 |
| Author(s) : Kuhnen-Clausen D , Hagedorn I , Bill R |
| Ref : Journal of Medicinal Chemistry , 22 :177 , 1979 |
| Abstract : |
| PubMedSearch : Kuhnen-Clausen_1979_J.Med.Chem_22_177 |
| PubMedID: 423196 |
| Title : [Reactivation of phosphorylated acetylcholinesterase. Isomeric bisquaternary salts of pyridine aldoximes] - Hagedorn_1978_Arzneimittelforschung_28_2055 |
| Author(s) : Hagedorn I , Stark I , Schoene K , Schenkel H |
| Ref : Arzneimittelforschung , 28 :2055 , 1978 |
| Abstract : |
| PubMedSearch : Hagedorn_1978_Arzneimittelforschung_28_2055 |
| PubMedID: 582905 |
| Title : [Betaines of quaternary salts of pyridine-2-and -4-aldoxim (author's transl)] - Hagedorn_1976_Arzneimittelforschung_26_753 |
| Author(s) : Hagedorn I , Gundel WH |
| Ref : Arzneimittelforschung , 26 :753 , 1976 |
| Abstract : |
| PubMedSearch : Hagedorn_1976_Arzneimittelforschung_26_753 |
| PubMedID: 786301 |
| Title : [Synthesis and Quaternation of Pyridine-aldoxim Alkylethers (author's transl)] - Hagedorn_1976_Arzneimittelforschung_26_1273 |
| Author(s) : Hagedorn I , Gundel WH , Hoose J , Jenter C |
| Ref : Arzneimittelforschung , 26 :1273 , 1976 |
| Abstract : |
| PubMedSearch : Hagedorn_1976_Arzneimittelforschung_26_1273 |
| PubMedID: 1036912 |
| Title : [Reactivation of phosphorylated acetylcholinesterase (AChE): quaternary salts of vinylogous pyridinaldoxims (author's transl)]. [German] - Hagedorn_1976_Arzneimittelforschung_26_1515 |
| Author(s) : Hagedorn I , Hohler W |
| Ref : Arzneimittelforschung , 26 :1515 , 1976 |
| Abstract : |
| PubMedSearch : Hagedorn_1976_Arzneimittelforschung_26_1515 |
| PubMedID: 1036947 |
| Title : Reactivation of phosphorylated acetylcholinesterase--dependence upon activator acidity - |
| Author(s) : Hagedorn I , Stark I , Lorenz HP |
| Ref : Angew Chem Int Ed Engl , 11 :307 , 1972 |
| PubMedID: 4626426 |
| Title : [Reactivation of phosphorylated acetylcholine esterase with oximes: contribution to the study of the reaction course] - |
| Author(s) : Hagedorn I , Gundel WH , Schoene K |
| Ref : Arzneimittelforschung , 19 :603 , 1969 |
| PubMedID: 5819160 |
| Title : [Quatenary hydroxyiminomethylpyridinium salts. The dischloride of Bis-(4-hydroxyiminomethyl-1-pyridinium-methyl)-ether (LuEH6), a new reactivator of acetylcholinesterase inhibited by organic phosphoric acid esters] - |
| Author(s) : Luttringhaus A , Hagedorn I |
| Ref : Arzneimittelforschung , 14 :1 , 1964 |
| PubMedID: |
| Title : [Structural explanation of xanthocillin\; a new antibiotic] - |
| Author(s) : Hagedorn I , Tonjes H |
| Ref : Pharmazie , 12 :567 , 1957 |
| PubMedID: 13494165 |
| Title : [Structure of xanthocillin, a new antibiotic] - |
| Author(s) : Hagedorn I , Tonjes H |
| Ref : Pharmazie , 11 :409 , 1956 |
| PubMedID: 13370319 |