Hagedorn I

General

Full name : Hagedorn Ilse

First name : Ilse

Mail : Chemical Laboratory, University of Freiburg, Freiburg

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Country : Germany

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Comment
Ilse Hagedorn was born on 17 May 1921 in Dresden and died on 17 December 2005 in Freiburg. She first worked on the structure determination and synthesis of Xanthocillin a naturally occuring antibiotic produced by Penicillium species. In Freiburg she started to work on oxime reactivators of acetylcholinesterase inhibited by organophosphorus. Among the more than 1000 oximes synthetized in Hagedorn laboratory (often referred as Hagedorn oximes), the most studied are named after the initials of co workers: LuH6 (Toxogonin) for Luttringhaus and Hagedorn, HS-6 for Schoene, HI-6 for Imro Stark, HLo 7 for Marlies Loffler HGG for Gross G. An obituary paper (ScienceDirect) by Peter Eyer retraces her achievements.

References (15)

Title : HLo 7 dimethanesulfonate, a potent bispyridinium-dioxime against anticholinesterases - Eyer_1992_Arch.Toxicol_66_603
Author(s) : Eyer P , Hagedorn I , Klimmek R , Lippstreu P , Loffler M , Oldiges H , Spohrer U , Steidl I , Szinicz L , Worek F
Ref : Archives of Toxicology , 66 :603 , 1992
Abstract :
PubMedSearch : Eyer_1992_Arch.Toxicol_66_603
PubMedID: 1482283

Title : The bispyridinium-dioxime HLo-7. A potent reactivator for acetylcholinesterase inhibited by the stereoisomers of tabun and soman - De Jong_1989_Biochem.Pharmacol_38_633
Author(s) : De Jong LP , Verhagen MA , Langenberg JP , Hagedorn I , Loffler M
Ref : Biochemical Pharmacology , 38 :633 , 1989
Abstract :
PubMedSearch : De Jong_1989_Biochem.Pharmacol_38_633
PubMedID: 2917018

Title : Study on the stability of the oxime HI 6 in aqueous solution - Eyer_1988_Arch.Toxicol_62_224
Author(s) : Eyer P , Hagedorn I , Ladstetter B
Ref : Archives of Toxicology , 62 :224 , 1988
Abstract :
PubMedSearch : Eyer_1988_Arch.Toxicol_62_224
PubMedID: 3196158

Title : Stability study of HI-6 dichloride in various anticholinergic formulations -
Author(s) : Brown ND , Gray RR , Stermer-Cox MG , Doctor BP , Hagedorn I
Ref : Journal of Chromatography , 315 :389 , 1984
PubMedID: 6526905

Title : Interactions of bisquaternary pyridine salts (H-oximes) with cholinergic receptors - Kuhnen-Clausen_1983_Arch.Toxicol_54_171
Author(s) : Kuhnen-Clausen D , Hagedorn I , Gross G , Bayer H , Hucho F
Ref : Archives of Toxicology , 54 :171 , 1983
Abstract :
PubMedSearch : Kuhnen-Clausen_1983_Arch.Toxicol_54_171
PubMedID: 6661028

Title : Synthesis of pyridinium analogues of acetylcholine and their interactions with intestinal muscarinic receptors - Kuhnen-Clausen_1979_J.Med.Chem_22_177
Author(s) : Kuhnen-Clausen D , Hagedorn I , Bill R
Ref : Journal of Medicinal Chemistry , 22 :177 , 1979
Abstract :
PubMedSearch : Kuhnen-Clausen_1979_J.Med.Chem_22_177
PubMedID: 423196

Title : [Reactivation of phosphorylated acetylcholinesterase. Isomeric bisquaternary salts of pyridine aldoximes] - Hagedorn_1978_Arzneimittelforschung_28_2055
Author(s) : Hagedorn I , Stark I , Schoene K , Schenkel H
Ref : Arzneimittelforschung , 28 :2055 , 1978
Abstract :
PubMedSearch : Hagedorn_1978_Arzneimittelforschung_28_2055
PubMedID: 582905

Title : [Reactivation of phosphorylated acetylcholinesterase (AChE): quaternary salts of vinylogous pyridinaldoxims (author's transl)]. [German] - Hagedorn_1976_Arzneimittelforschung_26_1515
Author(s) : Hagedorn I , Hohler W
Ref : Arzneimittelforschung , 26 :1515 , 1976
Abstract :
PubMedSearch : Hagedorn_1976_Arzneimittelforschung_26_1515
PubMedID: 1036947

Title : [Betaines of quaternary salts of pyridine-2-and -4-aldoxim (author's transl)] - Hagedorn_1976_Arzneimittelforschung_26_753
Author(s) : Hagedorn I , Gundel WH
Ref : Arzneimittelforschung , 26 :753 , 1976
Abstract :
PubMedSearch : Hagedorn_1976_Arzneimittelforschung_26_753
PubMedID: 786301

Title : [Synthesis and Quaternation of Pyridine-aldoxim Alkylethers (author's transl)] - Hagedorn_1976_Arzneimittelforschung_26_1273
Author(s) : Hagedorn I , Gundel WH , Hoose J , Jenter C
Ref : Arzneimittelforschung , 26 :1273 , 1976
Abstract :
PubMedSearch : Hagedorn_1976_Arzneimittelforschung_26_1273
PubMedID: 1036912

Title : Reactivation of phosphorylated acetylcholinesterase--dependence upon activator acidity -
Author(s) : Hagedorn I , Stark I , Lorenz HP
Ref : Angew Chem Int Ed Engl , 11 :307 , 1972
PubMedID: 4626426

Title : [Reactivation of phosphorylated acetylcholine esterase with oximes: contribution to the study of the reaction course] -
Author(s) : Hagedorn I , Gundel WH , Schoene K
Ref : Arzneimittelforschung , 19 :603 , 1969
PubMedID: 5819160

Title : [Quatenary hydroxyiminomethylpyridinium salts. The dischloride of Bis-(4-hydroxyiminomethyl-1-pyridinium-methyl)-ether (LuEH6), a new reactivator of acetylcholinesterase inhibited by organic phosphoric acid esters] -
Author(s) : Luttringhaus A , Hagedorn I
Ref : Arzneimittelforschung , 14 :1 , 1964
PubMedID:

Title : [Structural explanation of xanthocillin\; a new antibiotic] -
Author(s) : Hagedorn I , Tonjes H
Ref : Pharmazie , 12 :567 , 1957
PubMedID: 13494165

Title : [Structure of xanthocillin, a new antibiotic] -
Author(s) : Hagedorn I , Tonjes H
Ref : Pharmazie , 11 :409 , 1956
PubMedID: 13370319