Hucho F

General

Full name : Hucho Ferdinand

First name : Ferdinand

Mail : Freie Universitat Berlin, Institut fur Biochemie, Thielallee 63, D-14195 Berlin

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City :

Country : Germany

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Website : \/\/de.wikipedia.org\/wiki\/Ferdinand_Hucho

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Comment
Professor Dr. rer. Nat. Ferdinand Hucho was born on August 14, 1939 in Berlin and he died on may 28, 2023, at the age of 83. He was a highly original and innovative bio- and neurochemist. One of his central research subjects was the nicotinic acetylcholine receptor (AChR), while he also worked on Acetylcholinesterase. Moreover, he was able to show for the first time that certain isozymes of protein kinase (PKC) not only migrate to the cell nucleus when signal-activated, but also appear there in special sub-compartments such as the nucleolus and the nuclear pore complex. He was a member of the Berlin-Brandenburg Academy of Science. A translation in English of the obituary written in German by Professor Dr. Dr. h.c. mult. Christoph Markschies can be found here pdf

References (29)

Title : Structure-activity relationships of methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists. 3. Effect of inserting the tetraamine backbone into a macrocyclic structure - Bolognesi_2002_J.Med.Chem_45_3286
Author(s) : Bolognesi ML , Bixel MG , Marucci G , Bartolini M , Krauss M , Angeli P , Antonello A , Rosini M , Tumiatti V , Hucho F , Melchiorre C
Ref : Journal of Medicinal Chemistry , 45 :3286 , 2002
Abstract :
PubMedSearch : Bolognesi_2002_J.Med.Chem_45_3286
PubMedID: 12109912

Title : Design, synthesis, and biological evaluation of symmetrically and unsymmetrically substituted methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists - Rosini_1999_J.Med.Chem_42_5212
Author(s) : Rosini M , Budriesi R , Bixel MG , Bolognesi ML , Chiarini A , Hucho F , Krogsgaard-Larsen P , Mellor IR , Minarini A , Tumiatti V , Usherwood PN , Melchiorre C
Ref : Journal of Medicinal Chemistry , 42 :5212 , 1999
Abstract :
PubMedSearch : Rosini_1999_J.Med.Chem_42_5212
PubMedID: 10602706

Title : Butyrylcholinesterase is complexed with transferrin in chicken serum - Weitnauer_1999_J.Protein.Chem_18_205
Author(s) : Weitnauer E , Ebert C , Hucho F , Robitzki AA , Weise C , Layer PG
Ref : J Protein Chem , 18 :205 , 1999
Abstract :
PubMedSearch : Weitnauer_1999_J.Protein.Chem_18_205
PubMedID: 10333295

Title : The acetylcholinesterase (AChE) of the cobra Naja naja oxiana. Identification of residues involved in insensitivity towards fasciculin -
Author(s) : Weise C , Bon C , Hucho F , Cousin X
Ref : Journal de Physiologie (Paris) , 92 :508 , 1998
PubMedID:

Title : Labeling of Torpedo californica nicotinic acetylcholine receptor subunits by cobratoxin derivatives with photoactivatable groups of different chemical nature at Lys23 - Utkin_1998_Eur.J.Biochem_253_229
Author(s) : Utkin YN , Krivoshein AV , Davydov VL , Kasheverov IE , Franke P , Maslennikov IV , Arseniev AS , Hucho F , Tsetlin VI
Ref : European Journal of Biochemistry , 253 :229 , 1998
Abstract :
PubMedSearch : Utkin_1998_Eur.J.Biochem_253_229
PubMedID: 9578481

Title : Mapping of exposed surfaces of the nicotinic acetylcholine receptor by identification of iodinated tyrosine residues - Mund_1997_J.Protein.Chem_16_161
Author(s) : Mund M , Weise C , Franke P , Hucho F
Ref : J Protein Chem , 16 :161 , 1997
Abstract :
PubMedSearch : Mund_1997_J.Protein.Chem_16_161
PubMedID: 9155087

Title : [Effective binding of alpha-bungarotoxin with the solubilized alpha-subunit of Torpedo californica acetylcholine receptor] - Utkin_1996_Bioorg.Khim_22_387
Author(s) : Utkin Iu N , Mund M , Hucho F , Tsetlin VI
Ref : Bioorganicheskaia Khimiia , 22 :387 , 1996
Abstract :
PubMedSearch : Utkin_1996_Bioorg.Khim_22_387
PubMedID: 8929226

Title : FTIR-Spectroscopic Investigations of the Structure and Temperature Stability of the Acetylcholinesterase from Torpedo californica -
Author(s) : Hucho F , Naumann D , Gorne-Tschelnokow U
Ref : In Enzyme of the Cholinesterase Family - Proceedings of Fifth International Meeting on Cholinesterases , (Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P., Eds) Plenum Publishing Corp. :83 , 1995
PubMedID:

Title : The neurochemistry of Parkinson's disease--comments on present and future developments - Hucho_1995_J.Neural.Transm.Suppl_46_59
Author(s) : Hucho F
Ref : J Neural Transm Suppl , 46 :59 , 1995
Abstract :
PubMedSearch : Hucho_1995_J.Neural.Transm.Suppl_46_59
PubMedID: 8821041

Title : Secondary structure and temperature behaviour of acetylcholinesterase. Studies by Fourier-transform infrared spectroscopy - Gorne-Tschelnokow_1993_Eur.J.Biochem_213_1235
Author(s) : Gorne-Tschelnokow U , Naumann D , Weise C , Hucho F
Ref : European Journal of Biochemistry , 213 :1235 , 1993
Abstract :
PubMedSearch : Gorne-Tschelnokow_1993_Eur.J.Biochem_213_1235
PubMedID: 8389298

Title : Structural Investigations of the Acetylcholinesterase -
Author(s) : Hucho F , Weise C
Ref : In Multidisciplinary approaches to cholinesterase functions - Proceedings of Fourth International Meeting on Cholinesterases , (Shafferman, A. and Velan, B., Eds) Plenum Press, New York :121 , 1992
PubMedID:

Title : Nuclear substrates of protein kinase C - Beckmann_1992_Eur.J.Biochem_210_45
Author(s) : Beckmann R , Buchner K , Jungblut PR , Eckerskorn C , Weise C , Hilbert R , Hucho F
Ref : European Journal of Biochemistry , 210 :45 , 1992
Abstract :
PubMedSearch : Beckmann_1992_Eur.J.Biochem_210_45
PubMedID: 1446684

Title : GTP-binding proteins in bovine brain nuclear membranes - Otto_1992_Neurochem.Int_21_409
Author(s) : Otto H , Buchner K , Beckmann R , Hilbert R , Hucho F
Ref : Neurochem Int , 21 :409 , 1992
Abstract :
PubMedSearch : Otto_1992_Neurochem.Int_21_409
PubMedID: 1303165

Title : Poster: Partial sequence of cobra venom acetylcholinesterase - AChE and Lysophospholipase have similar Sequences -
Author(s) : Weise C , Kreienkamp HJ , Hucho F , Raba R , Aaviksaar A
Ref : In: Cholinesterases: Structure, Function, Mechanism, Genetics, and Cell Biology , (Massoulie J, Barnard EA, Chatonnet A, Bacou F, Doctor BP, Quinn DM) American Chemical Society, Washington, DC :58 , 1991
PubMedID:

Title : Phosphorylation sites of the nicotinic acetylcholine receptor. A novel site detected in position delta S362 - Schroeder_1991_Biochemistry_30_3583
Author(s) : Schroeder W , Meyer HE , Buchner K , Bayer H , Hucho F
Ref : Biochemistry , 30 :3583 , 1991
Abstract :
PubMedSearch : Schroeder_1991_Biochemistry_30_3583
PubMedID: 1707313

Title : Anionic subsites of the catalytic center of acetylcholinesterase from Torpedo and from cobra venom - Kreienkamp_1991_Proc.Natl.Acad.Sci.U.S.A_88_6117
Author(s) : Kreienkamp HJ , Weise C , Raba R , Aaviksaar A , Hucho F
Ref : Proceedings of the National Academy of Sciences of the United States of America , 88 :6117 , 1991
Abstract :
PubMedSearch : Kreienkamp_1991_Proc.Natl.Acad.Sci.U.S.A_88_6117
PubMedID: 2068091

Title : Substrate-binding sites in acetylcholinesterase - Hucho_1991_Trends.Pharmacol.Sci_12_422
Author(s) : Hucho F , Jarv J , Weise C
Ref : Trends in Pharmacological Sciences , 12 :422 , 1991
Abstract :
PubMedSearch : Hucho_1991_Trends.Pharmacol.Sci_12_422
PubMedID: 1796496

Title : Retraction. Heat-resistant inhibitors of protein kinase C from bovine brain -
Author(s) : Pribilla I , Kruger H , Buchner K , Otto H , Schiebler W , Tripier D , Hucho F
Ref : European Journal of Biochemistry , 188 :204 , 1990
PubMedID: 2180696

Title : The active site and partial sequence of cobra venom acetylcholinesterase - Weise_1990_J.Protein.Chem_9_53
Author(s) : Weise C , Kreienkamp HJ , Raba R , Aaviksaar A , Hucho F
Ref : J Protein Chem , 9 :53 , 1990
Abstract :
PubMedSearch : Weise_1990_J.Protein.Chem_9_53
PubMedID: 2340076

Title : Anionic subsites of the acetylcholinesterase from Torpedo californica: affinity labelling with the cationic reagent N,N-dimethyl-2-phenyl- aziridinium - Weise_1990_EMBO.J_9_3885
Author(s) : Weise C , Kreienkamp HJ , Raba R , Pedak A , Aaviksaar A , Hucho F
Ref : EMBO Journal , 9 :3885 , 1990
Abstract :
PubMedSearch : Weise_1990_EMBO.J_9_3885
PubMedID: 2249655

Title : 2-D- and 3-D-ordered structures of acetylcholine receptors -
Author(s) : Giersig M , Hertling-Jaweed S , Hucho F
Ref : J Protein Chem , 8 :330 , 1989
PubMedID: 2789676

Title : Symmetry and dimensions of membrane-bound nicotinic acetylcholine receptors from Torpedo californica electric tissue: rapid rearrangement to two-dimensional ordered lattices - Giersig_1989_Membr.Biochem_8_81
Author(s) : Giersig M , Kunath W , Pribilla I , Bandini G , Hucho F
Ref : Membr Biochem , 8 :81 , 1989
Abstract :
PubMedSearch : Giersig_1989_Membr.Biochem_8_81
PubMedID: 2634235

Title : Rapid preparation of the nicotinic acetylcholine receptor for crystallization in detergent solution - Hertling-Jaweed_1988_FEBS.Lett_241_29
Author(s) : Hertling-Jaweed S , Bandini G , Muller-Fahrnow A , Dommes V , Hucho F
Ref : FEBS Letters , 241 :29 , 1988
Abstract :
PubMedSearch : Hertling-Jaweed_1988_FEBS.Lett_241_29
PubMedID: 3197836

Title : Heat-resistant inhibitors of protein kinase C from bovine brain - Pribilla_1988_Eur.J.Biochem_177_657
Author(s) : Pribilla I , Kruger H , Buchner K , Otto H , Schiebler W , Tripier D , Hucho F
Ref : European Journal of Biochemistry , 177 :657 , 1988
Abstract :
PubMedSearch : Pribilla_1988_Eur.J.Biochem_177_657
PubMedID: 3058479

Title : A 40 kDa inhibitor of protein kinase C purified from bovine brain - Hucho_1987_FEBS.Lett_211_207
Author(s) : Hucho F , Kruger H , Pribilla I , Oberdieck U
Ref : FEBS Letters , 211 :207 , 1987
Abstract :
PubMedSearch : Hucho_1987_FEBS.Lett_211_207
PubMedID: 3803599

Title : Interactions of bisquaternary pyridine salts (H-oximes) with cholinergic receptors - Kuhnen-Clausen_1983_Arch.Toxicol_54_171
Author(s) : Kuhnen-Clausen D , Hagedorn I , Gross G , Bayer H , Hucho F
Ref : Archives of Toxicology , 54 :171 , 1983
Abstract :
PubMedSearch : Kuhnen-Clausen_1983_Arch.Toxicol_54_171
PubMedID: 6661028

Title : Membranes rich in acetylcholine receptor: characterization and reconstitution to excitable membranes from exogenous lipids - Schiebler_1978_Eur.J.Biochem_85_55
Author(s) : Schiebler W , Hucho F
Ref : European Journal of Biochemistry , 85 :55 , 1978
Abstract :
PubMedSearch : Schiebler_1978_Eur.J.Biochem_85_55
PubMedID: 639824

Title : Azidophenantridinium compounds as photoaffinity labels of cholinergic proteins - Stengelin_1978_Biochim.Biophys.Acta_542_107
Author(s) : Stengelin S , Walther C , Hucho F
Ref : Biochimica & Biophysica Acta , 542 :107 , 1978
Abstract :
PubMedSearch : Stengelin_1978_Biochim.Biophys.Acta_542_107
PubMedID: 208646

Title : Selective labeling of anionic binding sites of the acetylcholinesterase from Torpedo californica with a photoaffinity label -
Author(s) : Layer PG , Kiefer HR , Hucho F
Ref : Molecular Pharmacology , 12 :958 , 1976
PubMedID: 1004492