| Title : Dualsteric GPCR targeting: a novel route to binding and signaling pathway selectivity - Antony_2009_FASEB.J_23_442 |
| Author(s) : Antony J , Kellershohn K , Mohr-Andra M , Kebig A , Prilla S , Muth M , Heller E , Disingrini T , Dallanoce C , Bertoni S , Schrobang J , Trankle C , Kostenis E , Christopoulos A , Holtje HD , Barocelli E , De Amici M , Holzgrabe U , Mohr K |
| Ref : FASEB Journal , 23 :442 , 2009 |
| Abstract : Antony_2009_FASEB.J_23_442 |
| ESTHER : Antony_2009_FASEB.J_23_442 |
| PubMedSearch : Antony_2009_FASEB.J_23_442 |
| PubMedID: 18842964 |
| Title : Identification of inhibitors of the nicotine metabolising CYP2A6 enzyme--an in silico approach - Rahnasto_2008_Pharmacogenomics.J_8_328 |
| Author(s) : Rahnasto M , Wittekindt C , Juvonen RO , Turpeinen M , Petsalo A , Pelkonen O , Poso A , Stahl G , Holtje HD , Raunio H |
| Ref : Pharmacogenomics J , 8 :328 , 2008 |
| Abstract : Rahnasto_2008_Pharmacogenomics.J_8_328 |
| ESTHER : Rahnasto_2008_Pharmacogenomics.J_8_328 |
| PubMedSearch : Rahnasto_2008_Pharmacogenomics.J_8_328 |
| PubMedID: 17923852 |
| Title : Allosteric small molecules unveil a role of an extracellular E2\/transmembrane helix 7 junction for G protein-coupled receptor activation - Jager_2007_J.Biol.Chem_282_34968 |
| Author(s) : Jager D , Schmalenbach C , Prilla S , Schrobang J , Kebig A , Sennwitz M , Heller E , Trankle C , Holzgrabe U , Holtje HD , Mohr K |
| Ref : Journal of Biological Chemistry , 282 :34968 , 2007 |
| Abstract : Jager_2007_J.Biol.Chem_282_34968 |
| ESTHER : Jager_2007_J.Biol.Chem_282_34968 |
| PubMedSearch : Jager_2007_J.Biol.Chem_282_34968 |
| PubMedID: 17890226 |
| Title : Allosteric interactions with muscarinic acetylcholine receptors: complex role of the conserved tryptophan M2422Trp in a critical cluster of amino acids for baseline affinity, subtype selectivity, and cooperativity - Prilla_2006_Mol.Pharmacol_70_181 |
| Author(s) : Prilla S , Schrobang J , Ellis J , Holtje HD , Mohr K |
| Ref : Molecular Pharmacology , 70 :181 , 2006 |
| Abstract : Prilla_2006_Mol.Pharmacol_70_181 |
| ESTHER : Prilla_2006_Mol.Pharmacol_70_181 |
| PubMedSearch : Prilla_2006_Mol.Pharmacol_70_181 |
| PubMedID: 16641315 |
| Title : Different environments for a realistic simulation of GPCRs-application to the M2 muscarinic receptor - Johren_2005_Arch.Pharm.(Weinheim)_338_260 |
| Author(s) : Johren K , Holtje HD |
| Ref : Arch Pharm (Weinheim) , 338 :260 , 2005 |
| Abstract : Johren_2005_Arch.Pharm.(Weinheim)_338_260 |
| ESTHER : Johren_2005_Arch.Pharm.(Weinheim)_338_260 |
| PubMedSearch : Johren_2005_Arch.Pharm.(Weinheim)_338_260 |
| PubMedID: 15924369 |
| Title : Atypical muscarinic allosteric modulation: cooperativity between modulators and their atypical binding topology in muscarinic M2 and M2\/M5 chimeric receptors - Trankle_2005_Mol.Pharmacol_68_1597 |
| Author(s) : Trankle C , Dittmann A , Schulz U , Weyand O , Buller S , Johren K , Heller E , Birdsall NJ , Holzgrabe U , Ellis J , Holtje HD , Mohr K |
| Ref : Molecular Pharmacology , 68 :1597 , 2005 |
| Abstract : Trankle_2005_Mol.Pharmacol_68_1597 |
| ESTHER : Trankle_2005_Mol.Pharmacol_68_1597 |
| PubMedSearch : Trankle_2005_Mol.Pharmacol_68_1597 |
| PubMedID: 16157694 |
| Title : Allosteric site on muscarinic acetylcholine receptors: identification of two amino acids in the muscarinic M2 receptor that account entirely for the M2\/M5 subtype selectivities of some structurally diverse allosteric ligands in N-methylscopolamine-occupied receptors - Voigtlander_2003_Mol.Pharmacol_64_21 |
| Author(s) : Voigtlander U , Johren K , Mohr M , Raasch A , Trankle C , Buller S , Ellis J , Holtje HD , Mohr K |
| Ref : Molecular Pharmacology , 64 :21 , 2003 |
| Abstract : Voigtlander_2003_Mol.Pharmacol_64_21 |
| ESTHER : Voigtlander_2003_Mol.Pharmacol_64_21 |
| PubMedSearch : Voigtlander_2003_Mol.Pharmacol_64_21 |
| PubMedID: 12815157 |
| Title : A model of the human M2 muscarinic acetylcholine receptor - Johren_2002_J.Comput.Aided.Mol.Des_16_795 |
| Author(s) : Johren K , Holtje HD |
| Ref : J Comput Aided Mol Des , 16 :795 , 2002 |
| Abstract : Johren_2002_J.Comput.Aided.Mol.Des_16_795 |
| ESTHER : Johren_2002_J.Comput.Aided.Mol.Des_16_795 |
| PubMedSearch : Johren_2002_J.Comput.Aided.Mol.Des_16_795 |
| PubMedID: 12825791 |
| Title : Relaxant activity in rat aorta and trachea, conversion to a muscarinic receptor antagonist and structure-activity relationships of new K(ATP) activating 6-varied benzopyrans - Lemoine_1999_Eur.J.Pharmacol_378_85 |
| Author(s) : Lemoine H , Weber H , Derix A , Uhrig U , Holtje HD , Mannhold R |
| Ref : European Journal of Pharmacology , 378 :85 , 1999 |
| Abstract : Lemoine_1999_Eur.J.Pharmacol_378_85 |
| ESTHER : Lemoine_1999_Eur.J.Pharmacol_378_85 |
| PubMedSearch : Lemoine_1999_Eur.J.Pharmacol_378_85 |
| PubMedID: 10478568 |
| Title : Conformational analysis and receptor modelling of m1 and m2 selective antagonists - Kerckhoff_1994_Pharmazie_49_566 |
| Author(s) : Kerckhoff H , Holtje HD |
| Ref : Pharmazie , 49 :566 , 1994 |
| Abstract : Kerckhoff_1994_Pharmazie_49_566 |
| ESTHER : Kerckhoff_1994_Pharmazie_49_566 |
| PubMedSearch : Kerckhoff_1994_Pharmazie_49_566 |
| PubMedID: 7938144 |
| Title : [New findings in the molecular mechanisms of drugs] - |
| Author(s) : Holtje HD , Batzenschlager A , Briem H , Bruggmann J |
| Ref : Pharm Unserer Zeit , 20 :59 , 1991 |
| PubMedID: 2047390 |
| Title : Poster: Pharmacophore model for antimuscarinic agents related to difenidol and siladifenidol - a molecular modeling study - |
| Author(s) : Bruggmann J , Holtje HD , Mutschler E , Lambrecht G , Tacke R |
| Ref : Trends in Pharmacological Sciences , Suppl :114 , 1989 |
| PubMedID: |
| Title : [Structure- and conformation-activity relationships of heterocyclic acetylcholine analogues. 16. Conformational behaviour and cholinergic properties of isoarecaidine and sulfoisoarecaidine esters] - Holtje_1983_Arzneimittelforschung_33_190 |
| Author(s) : Holtje HD , Lambrecht G , Moser U , Mutschler E |
| Ref : Arzneimittelforschung , 33 :190 , 1983 |
| Abstract : Holtje_1983_Arzneimittelforschung_33_190 |
| ESTHER : Holtje_1983_Arzneimittelforschung_33_190 |
| PubMedSearch : Holtje_1983_Arzneimittelforschung_33_190 |
| PubMedID: 6601954 |
| Title : [Structure- and conformation-activity relationships of heterocyclic acetylcholine analogs. 17. Conformational behavior and cholinergic properties of arecaidine and sulfoarecaidine esters] - Mutschler_1983_Arzneimittelforschung_33_806 |
| Author(s) : Mutschler E , Holtje HD , Lambrecht G , Moser U |
| Ref : Arzneimittelforschung , 33 :806 , 1983 |
| Abstract : Mutschler_1983_Arzneimittelforschung_33_806 |
| ESTHER : Mutschler_1983_Arzneimittelforschung_33_806 |
| PubMedSearch : Mutschler_1983_Arzneimittelforschung_33_806 |
| PubMedID: 6684432 |
| Title : Nature of anionic or alpha-site of cholinesterase - Holtje_1975_J.Pharm.Sci_64_418 |
| Author(s) : Holtje HD , Kier LB |
| Ref : J Pharm Sci , 64 :418 , 1975 |
| Abstract : Holtje_1975_J.Pharm.Sci_64_418 |
| ESTHER : Holtje_1975_J.Pharm.Sci_64_418 |
| PubMedSearch : Holtje_1975_J.Pharm.Sci_64_418 |
| PubMedID: 1151625 |