Holtje HD

References (15)

Title : Dualsteric GPCR targeting: a novel route to binding and signaling pathway selectivity - Antony_2009_FASEB.J_23_442
Author(s) : Antony J , Kellershohn K , Mohr-Andra M , Kebig A , Prilla S , Muth M , Heller E , Disingrini T , Dallanoce C , Bertoni S , Schrobang J , Trankle C , Kostenis E , Christopoulos A , Holtje HD , Barocelli E , De Amici M , Holzgrabe U , Mohr K
Ref : FASEB Journal , 23 :442 , 2009
Abstract :
PubMedSearch : Antony_2009_FASEB.J_23_442
PubMedID: 18842964

Title : Identification of inhibitors of the nicotine metabolising CYP2A6 enzyme--an in silico approach - Rahnasto_2008_Pharmacogenomics.J_8_328
Author(s) : Rahnasto M , Wittekindt C , Juvonen RO , Turpeinen M , Petsalo A , Pelkonen O , Poso A , Stahl G , Holtje HD , Raunio H
Ref : Pharmacogenomics J , 8 :328 , 2008
Abstract :
PubMedSearch : Rahnasto_2008_Pharmacogenomics.J_8_328
PubMedID: 17923852

Title : Allosteric small molecules unveil a role of an extracellular E2\/transmembrane helix 7 junction for G protein-coupled receptor activation - Jager_2007_J.Biol.Chem_282_34968
Author(s) : Jager D , Schmalenbach C , Prilla S , Schrobang J , Kebig A , Sennwitz M , Heller E , Trankle C , Holzgrabe U , Holtje HD , Mohr K
Ref : Journal of Biological Chemistry , 282 :34968 , 2007
Abstract :
PubMedSearch : Jager_2007_J.Biol.Chem_282_34968
PubMedID: 17890226

Title : Allosteric interactions with muscarinic acetylcholine receptors: complex role of the conserved tryptophan M2422Trp in a critical cluster of amino acids for baseline affinity, subtype selectivity, and cooperativity - Prilla_2006_Mol.Pharmacol_70_181
Author(s) : Prilla S , Schrobang J , Ellis J , Holtje HD , Mohr K
Ref : Molecular Pharmacology , 70 :181 , 2006
Abstract :
PubMedSearch : Prilla_2006_Mol.Pharmacol_70_181
PubMedID: 16641315

Title : Atypical muscarinic allosteric modulation: cooperativity between modulators and their atypical binding topology in muscarinic M2 and M2\/M5 chimeric receptors - Trankle_2005_Mol.Pharmacol_68_1597
Author(s) : Trankle C , Dittmann A , Schulz U , Weyand O , Buller S , Johren K , Heller E , Birdsall NJ , Holzgrabe U , Ellis J , Holtje HD , Mohr K
Ref : Molecular Pharmacology , 68 :1597 , 2005
Abstract :
PubMedSearch : Trankle_2005_Mol.Pharmacol_68_1597
PubMedID: 16157694

Title : Different environments for a realistic simulation of GPCRs-application to the M2 muscarinic receptor - Johren_2005_Arch.Pharm.(Weinheim)_338_260
Author(s) : Johren K , Holtje HD
Ref : Arch Pharm (Weinheim) , 338 :260 , 2005
Abstract :
PubMedSearch : Johren_2005_Arch.Pharm.(Weinheim)_338_260
PubMedID: 15924369

Title : Allosteric site on muscarinic acetylcholine receptors: identification of two amino acids in the muscarinic M2 receptor that account entirely for the M2\/M5 subtype selectivities of some structurally diverse allosteric ligands in N-methylscopolamine-occupied receptors - Voigtlander_2003_Mol.Pharmacol_64_21
Author(s) : Voigtlander U , Johren K , Mohr M , Raasch A , Trankle C , Buller S , Ellis J , Holtje HD , Mohr K
Ref : Molecular Pharmacology , 64 :21 , 2003
Abstract :
PubMedSearch : Voigtlander_2003_Mol.Pharmacol_64_21
PubMedID: 12815157

Title : A model of the human M2 muscarinic acetylcholine receptor - Johren_2002_J.Comput.Aided.Mol.Des_16_795
Author(s) : Johren K , Holtje HD
Ref : J Comput Aided Mol Des , 16 :795 , 2002
Abstract :
PubMedSearch : Johren_2002_J.Comput.Aided.Mol.Des_16_795
PubMedID: 12825791

Title : Relaxant activity in rat aorta and trachea, conversion to a muscarinic receptor antagonist and structure-activity relationships of new K(ATP) activating 6-varied benzopyrans - Lemoine_1999_Eur.J.Pharmacol_378_85
Author(s) : Lemoine H , Weber H , Derix A , Uhrig U , Holtje HD , Mannhold R
Ref : European Journal of Pharmacology , 378 :85 , 1999
Abstract :
PubMedSearch : Lemoine_1999_Eur.J.Pharmacol_378_85
PubMedID: 10478568

Title : Conformational analysis and receptor modelling of m1 and m2 selective antagonists - Kerckhoff_1994_Pharmazie_49_566
Author(s) : Kerckhoff H , Holtje HD
Ref : Pharmazie , 49 :566 , 1994
Abstract :
PubMedSearch : Kerckhoff_1994_Pharmazie_49_566
PubMedID: 7938144

Title : [New findings in the molecular mechanisms of drugs] -
Author(s) : Holtje HD , Batzenschlager A , Briem H , Bruggmann J
Ref : Pharm Unserer Zeit , 20 :59 , 1991
PubMedID: 2047390

Title : Poster: Pharmacophore model for antimuscarinic agents related to difenidol and siladifenidol - a molecular modeling study -
Author(s) : Bruggmann J , Holtje HD , Mutschler E , Lambrecht G , Tacke R
Ref : Trends in Pharmacological Sciences , Suppl :114 , 1989
PubMedID:

Title : [Structure- and conformation-activity relationships of heterocyclic acetylcholine analogues. 16. Conformational behaviour and cholinergic properties of isoarecaidine and sulfoisoarecaidine esters] - Holtje_1983_Arzneimittelforschung_33_190
Author(s) : Holtje HD , Lambrecht G , Moser U , Mutschler E
Ref : Arzneimittelforschung , 33 :190 , 1983
Abstract :
PubMedSearch : Holtje_1983_Arzneimittelforschung_33_190
PubMedID: 6601954

Title : [Structure- and conformation-activity relationships of heterocyclic acetylcholine analogs. 17. Conformational behavior and cholinergic properties of arecaidine and sulfoarecaidine esters] - Mutschler_1983_Arzneimittelforschung_33_806
Author(s) : Mutschler E , Holtje HD , Lambrecht G , Moser U
Ref : Arzneimittelforschung , 33 :806 , 1983
Abstract :
PubMedSearch : Mutschler_1983_Arzneimittelforschung_33_806
PubMedID: 6684432

Title : Nature of anionic or alpha-site of cholinesterase - Holtje_1975_J.Pharm.Sci_64_418
Author(s) : Holtje HD , Kier LB
Ref : J Pharm Sci , 64 :418 , 1975
Abstract :
PubMedSearch : Holtje_1975_J.Pharm.Sci_64_418
PubMedID: 1151625