Full name : Trankle Christian
First name : Christian
Mail : Pharmakologie und Toxikologie, Pharmazeutisches Institut, Universitat Bonn, Gerhard-Domagk-Str. 3, 53121 Bonn
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Country : Germany
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Comment
| Title : Beta and gamma carboline derivatives as potential anti-Alzheimer agents: A comparison - Otto_2014_Eur.J.Med.Chem_87C_63 |
| Author(s) : Otto R , Penzis R , Gaube F , Winckler T , Appenroth D , Fleck C , Trankle C , Lehmann J , Enzensperger C |
| Ref : Eur Journal of Medicinal Chemistry , 87C :63 , 2014 |
| Abstract : |
| PubMedSearch : Otto_2014_Eur.J.Med.Chem_87C_63 |
| PubMedID: 25240096 |
| Title : The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling - Bock_2012_Nat.Commun_3_1044 |
| Author(s) : Bock A , Merten N , Schrage R , Dallanoce C , Batz J , Klockner J , Schmitz J , Matera C , Simon K , Kebig A , Peters L , Muller A , Schrobang-Ley J , Trankle C , Hoffmann C , De Amici M , Holzgrabe U , Kostenis E , Mohr K |
| Ref : Nat Commun , 3 :1044 , 2012 |
| Abstract : |
| PubMedSearch : Bock_2012_Nat.Commun_3_1044 |
| PubMedID: 22948826 |
| Title : A hydrazide linker strategy for heterobivalent compounds as ortho- and allosteric ligands of acetylcholine-binding proteins - Elsinghorst_2011_Curr.Top.Med.Chem_11_2731 |
| Author(s) : Elsinghorst PW , Hartig W , Gundisch D , Mohr K , Trankle C , Gutschow M |
| Ref : Curr Top Med Chem , 11 :2731 , 2011 |
| Abstract : |
| PubMedSearch : Elsinghorst_2011_Curr.Top.Med.Chem_11_2731 |
| PubMedID: 22039876 |
| Title : Rational design of dualsteric GPCR ligands: quests and promise - Mohr_2010_Br.J.Pharmacol_159_997 |
| Author(s) : Mohr K , Trankle C , Kostenis E , Barocelli E , De Amici M , Holzgrabe U |
| Ref : British Journal of Pharmacology , 159 :997 , 2010 |
| Abstract : |
| PubMedSearch : Mohr_2010_Br.J.Pharmacol_159_997 |
| PubMedID: 20136835 |
| Title : Hybrid molecules from xanomeline and tacrine: enhanced tacrine actions on cholinesterases and muscarinic M1 receptors - Fang_2010_J.Med.Chem_53_2094 |
| Author(s) : Fang L , Jumpertz S , Zhang Y , Appenroth D , Fleck C , Mohr K , Trankle C , Decker M |
| Ref : Journal of Medicinal Chemistry , 53 :2094 , 2010 |
| Abstract : |
| PubMedSearch : Fang_2010_J.Med.Chem_53_2094 |
| PubMedID: 20158205 |
| Title : Dualsteric GPCR targeting: a novel route to binding and signaling pathway selectivity - Antony_2009_FASEB.J_23_442 |
| Author(s) : Antony J , Kellershohn K , Mohr-Andra M , Kebig A , Prilla S , Muth M , Heller E , Disingrini T , Dallanoce C , Bertoni S , Schrobang J , Trankle C , Kostenis E , Christopoulos A , Holtje HD , Barocelli E , De Amici M , Holzgrabe U , Mohr K |
| Ref : FASEB Journal , 23 :442 , 2009 |
| Abstract : |
| PubMedSearch : Antony_2009_FASEB.J_23_442 |
| PubMedID: 18842964 |
| Title : First gallamine-tacrine hybrid: design and characterization at cholinesterases and the M2 muscarinic receptor - Elsinghorst_2007_J.Med.Chem_50_5685 |
| Author(s) : Elsinghorst PW , Cieslik JS , Mohr K , Trankle C , Gutschow M |
| Ref : Journal of Medicinal Chemistry , 50 :5685 , 2007 |
| Abstract : |
| PubMedSearch : Elsinghorst_2007_J.Med.Chem_50_5685 |
| PubMedID: 17944454 |
| Title : Allosteric small molecules unveil a role of an extracellular E2\/transmembrane helix 7 junction for G protein-coupled receptor activation - Jager_2007_J.Biol.Chem_282_34968 |
| Author(s) : Jager D , Schmalenbach C , Prilla S , Schrobang J , Kebig A , Sennwitz M , Heller E , Trankle C , Holzgrabe U , Holtje HD , Mohr K |
| Ref : Journal of Biological Chemistry , 282 :34968 , 2007 |
| Abstract : |
| PubMedSearch : Jager_2007_J.Biol.Chem_282_34968 |
| PubMedID: 17890226 |
| Title : Allosteric site in M2 acetylcholine receptors: evidence for a major conformational change upon binding of an orthosteric agonist instead of an antagonist - Grossmuller_2006_Naunyn.Schmiedebergs.Arch.Pharmacol_372_267 |
| Author(s) : Grossmuller M , Antony J , Trankle C , Holzgrabe U , Mohr K |
| Ref : Naunyn Schmiedebergs Arch Pharmacol , 372 :267 , 2006 |
| Abstract : |
| PubMedSearch : Grossmuller_2006_Naunyn.Schmiedebergs.Arch.Pharmacol_372_267 |
| PubMedID: 16362429 |
| Title : Atypical muscarinic allosteric modulation: cooperativity between modulators and their atypical binding topology in muscarinic M2 and M2\/M5 chimeric receptors - Trankle_2005_Mol.Pharmacol_68_1597 |
| Author(s) : Trankle C , Dittmann A , Schulz U , Weyand O , Buller S , Johren K , Heller E , Birdsall NJ , Holzgrabe U , Ellis J , Holtje HD , Mohr K |
| Ref : Molecular Pharmacology , 68 :1597 , 2005 |
| Abstract : |
| PubMedSearch : Trankle_2005_Mol.Pharmacol_68_1597 |
| PubMedID: 16157694 |
| Title : Allosteric site on muscarinic acetylcholine receptors: identification of two amino acids in the muscarinic M2 receptor that account entirely for the M2\/M5 subtype selectivities of some structurally diverse allosteric ligands in N-methylscopolamine-occupied receptors - Voigtlander_2003_Mol.Pharmacol_64_21 |
| Author(s) : Voigtlander U , Johren K , Mohr M , Raasch A , Trankle C , Buller S , Ellis J , Holtje HD , Mohr K |
| Ref : Molecular Pharmacology , 64 :21 , 2003 |
| Abstract : |
| PubMedSearch : Voigtlander_2003_Mol.Pharmacol_64_21 |
| PubMedID: 12815157 |
| Title : Systematic development of high affinity bis(ammonio)alkane-type allosteric enhancers of muscarinic ligand binding - Muth_2003_J.Med.Chem_46_1031 |
| Author(s) : Muth M , Bender W , Scharfenstein O , Holzgrabe U , Balatkova E , Trankle C , Mohr K |
| Ref : Journal of Medicinal Chemistry , 46 :1031 , 2003 |
| Abstract : |
| PubMedSearch : Muth_2003_J.Med.Chem_46_1031 |
| PubMedID: 12620079 |
| Title : Interactions of orthosteric and allosteric ligands with [3H]dimethyl-W84 at the common allosteric site of muscarinic M2 receptors - Trankle_2003_Mol.Pharmacol_64_180 |
| Author(s) : Trankle C , Weyand O , Voigtlander U , Mynett A , Lazareno S , Birdsall NJ , Mohr K |
| Ref : Molecular Pharmacology , 64 :180 , 2003 |
| Abstract : |
| PubMedSearch : Trankle_2003_Mol.Pharmacol_64_180 |
| PubMedID: 12815174 |
| Title : Structure\/activity relationships of M2 muscarinic allosteric modulators - Mohr_2003_Receptors.Channels_9_229 |
| Author(s) : Mohr K , Trankle C , Holzgrabe U |
| Ref : Receptors Channels , 9 :229 , 2003 |
| Abstract : |
| PubMedSearch : Mohr_2003_Receptors.Channels_9_229 |
| PubMedID: 12893536 |
| Title : Cooperative interactions at M2 muscarinic acetylcholine receptors: structure\/activity relationships in stepwise shortened bispyridinium- and bis(ammonio)alkane-type allosteric modulators - Gilsbach_2003_Neurochem.Res_28_667 |
| Author(s) : Gilsbach R , Grossmuller M , Alptuzun V , Erciyas E , Trankle C , Holzgrabe U , Mohr K |
| Ref : Neurochem Res , 28 :667 , 2003 |
| Abstract : |
| PubMedSearch : Gilsbach_2003_Neurochem.Res_28_667 |
| PubMedID: 12675159 |
| Title : Allosteric modulation of muscarinic receptor signaling: alcuronium-induced conversion of pilocarpine from an agonist into an antagonist - Zahn_2002_J.Pharmacol.Exp.Ther_301_720 |
| Author(s) : Zahn K , Eckstein N , Trankle C , Sadee W , Mohr K |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 301 :720 , 2002 |
| Abstract : |
| PubMedSearch : Zahn_2002_J.Pharmacol.Exp.Ther_301_720 |
| PubMedID: 11961078 |
| Title : Elevation of ligand binding to muscarinic M(2) acetylcholine receptors by bis(ammonio)alkane-type allosteric modulators - Raasch_2002_J.Med.Chem_45_3809 |
| Author(s) : Raasch A , Scharfenstein O , Trankle C , Holzgrabe U , Mohr K |
| Ref : Journal of Medicinal Chemistry , 45 :3809 , 2002 |
| Abstract : |
| PubMedSearch : Raasch_2002_J.Med.Chem_45_3809 |
| PubMedID: 12166953 |
| Title : Muscarinic allosteric modulation: M2\/M3 subtype selectivity of gallamine is independent of G-protein coupling specificity - Trankle_2001_Naunyn.Schmiedebergs.Arch.Pharmacol_364_172 |
| Author(s) : Trankle C , Kostenis E , Mohr K |
| Ref : Naunyn Schmiedebergs Arch Pharmacol , 364 :172 , 2001 |
| Abstract : |
| PubMedSearch : Trankle_2001_Naunyn.Schmiedebergs.Arch.Pharmacol_364_172 |
| PubMedID: 11534857 |
| Title : Poster: Binding of the radiolabelled allosteric ligand [3H]dimethyl-W84 to M4 muscarinic receptors - |
| Author(s) : Trankle C , Weyand O , Lazareno S , Birdsall NJ , Mohr K |
| Ref : Life Sciences , 68 :2619 , 2001 |
| PubMedID: |
| Title : Poster: Ligand for the common allosteric site of M2-receptors of subnanomolar potency - |
| Author(s) : Holzgrabe U , Bender W , Balatkova E , Trankle C , Mohr K |
| Ref : Life Sciences , 68 :2620 , 2001 |
| PubMedID: |
| Title : Poster: Effects of atypical allosteric agents on the binding of [3H]dimethyl-w84 to M2 receptors - |
| Author(s) : Weyand O , Lazareno S , Birdsall NJ , Mohr K , Trankle C |
| Ref : Life Sciences , 68 :2621 , 2001 |
| PubMedID: |
| Title : Probing the size of a hydrophobic binding pocket within the allosteric site of muscarinic acetylcholine M2-receptors - Bender_2000_Life.Sci_66_1675 |
| Author(s) : Bender W , Staudt M , Trankle C , Mohr K , Holzgrabe U |
| Ref : Life Sciences , 66 :1675 , 2000 |
| Abstract : |
| PubMedSearch : Bender_2000_Life.Sci_66_1675 |
| PubMedID: 10809164 |
| Title : Ligands for the common allosteric site of acetylcholine M2-receptors: development and application - Holzgrabe_2000_Pharm.Acta.Helv_74_149 |
| Author(s) : Holzgrabe U , Bender W , Cid HM , Staudt M , Pick R , Pfletschinger C , Balatkova E , Trankle C , Mohr K |
| Ref : Pharm Acta Helv , 74 :149 , 2000 |
| Abstract : |
| PubMedSearch : Holzgrabe_2000_Pharm.Acta.Helv_74_149 |
| PubMedID: 10812952 |
| Title : Probing the selectivity of allosteric modulators of muscarinic receptors at other G-protein-coupled receptors - Pfaffendorf_2000_J.Auton.Pharmacol_20_55 |
| Author(s) : Pfaffendorf M , Batink HD , Trankle C , Mohr K , van Zwieten PA |
| Ref : J Auton Pharmacol , 20 :55 , 2000 |
| Abstract : |
| PubMedSearch : Pfaffendorf_2000_J.Auton.Pharmacol_20_55 |
| PubMedID: 11048962 |
| Title : Testing the specificity of allosteric modulators of muscarinic receptors in phylogenetically closely related histamine H1-receptors - Franken_2000_Naunyn.Schmiedebergs.Arch.Pharmacol_361_107 |
| Author(s) : Franken C , Trankle C , Mohr K |
| Ref : Naunyn Schmiedebergs Arch Pharmacol , 361 :107 , 2000 |
| Abstract : |
| PubMedSearch : Franken_2000_Naunyn.Schmiedebergs.Arch.Pharmacol_361_107 |
| PubMedID: 10685864 |
| Title : Structure-activity relationships in a series of bisquaternary bisphthalimidine derivatives modulating the muscarinic M(2)-receptor allosterically - Botero Cid_2000_J.Med.Chem_43_2155 |
| Author(s) : Botero Cid HM , Trankle C , Baumann K , Pick R , Mies-Klomfass E , Kostenis E , Mohr K , Holzgrabe U |
| Ref : Journal of Medicinal Chemistry , 43 :2155 , 2000 |
| Abstract : |
| PubMedSearch : Botero Cid_2000_J.Med.Chem_43_2155 |
| PubMedID: 10841794 |
| Title : Poster: Modes of allosteric interactions with muscarinic M2 receptors as deduced from buffer-dependent potency shifts - |
| Author(s) : Schroter A , Trankle C , Mohr K |
| Ref : Life Sciences , 64 :560 , 1999 |
| PubMedID: |
| Title : Using a radioalloster to test predictions of the cooperativity model for gallamine binding to the allosteric site of muscarinic acetylcholine M(2) receptors - Trankle_1999_Mol.Pharmacol_56_962 |
| Author(s) : Trankle C , Weyand O , Schroter A , Mohr K |
| Ref : Molecular Pharmacology , 56 :962 , 1999 |
| Abstract : |
| PubMedSearch : Trankle_1999_Mol.Pharmacol_56_962 |
| PubMedID: 10531401 |
| Title : Poster: Assessment of cooperativity factors by the use of a [3H]ligand for the allosteric site of muscarinic M2 receptors - |
| Author(s) : Trankle C , Weyand O , Schroter A , Mohr K |
| Ref : Life Sciences , 64 :559 , 1999 |
| PubMedID: |
| Title : Bisquaternary ligands of the common allosteric site of M2 acetylcholine receptors: search for the minimum essential distances between the pharmacophoric elements - Nassif-Makki_1999_J.Med.Chem_42_849 |
| Author(s) : Nassif-Makki T , Trankle C , Zlotos D , Bejeuhr G , Cambareri A , Pfletschinger C , Kostenis E , Mohr K , Holzgrabe U |
| Ref : Journal of Medicinal Chemistry , 42 :849 , 1999 |
| Abstract : |
| PubMedSearch : Nassif-Makki_1999_J.Med.Chem_42_849 |
| PubMedID: 10072682 |
| Title : Interaction of Mg2+ with the allosteric site of muscarinic M2 receptors - Burgmer_1998_Naunyn.Schmiedebergs.Arch.Pharmacol_357_363 |
| Author(s) : Burgmer U , Schulz U , Trankle C , Mohr K |
| Ref : Naunyn Schmiedebergs Arch Pharmacol , 357 :363 , 1998 |
| Abstract : |
| PubMedSearch : Burgmer_1998_Naunyn.Schmiedebergs.Arch.Pharmacol_357_363 |
| PubMedID: 9606020 |
| Title : M2 receptor binding of the selective antagonist AF-DX 384: possible involvement of the common allosteric site - Trankle_1998_Mol.Pharmacol_53_304 |
| Author(s) : Trankle C , Andresen I , Lambrecht G , Mohr K |
| Ref : Molecular Pharmacology , 53 :304 , 1998 |
| Abstract : |
| PubMedSearch : Trankle_1998_Mol.Pharmacol_53_304 |
| PubMedID: 9463489 |
| Title : Identification of a [3H]Ligand for the common allosteric site of muscarinic acetylcholine M2 receptors - Trankle_1998_Mol.Pharmacol_54_139 |
| Author(s) : Trankle C , Mies-Klomfass E , Botero Cid HM , Holzgrabe U , Mohr K |
| Ref : Molecular Pharmacology , 54 :139 , 1998 |
| Abstract : |
| PubMedSearch : Trankle_1998_Mol.Pharmacol_54_139 |
| PubMedID: 9658199 |
| Title : Poster: Influence of the lateral substituents of bispyridinium compounds on the mode of allosteric action on muscarinic M2-receptors - |
| Author(s) : Schulz U , Trankle C , Botero Cid HM , Holzgrabe U , Mohr K |
| Ref : Life Sciences , 60 :1172 , 1997 |
| PubMedID: |
| Title : Poster: Influence of allosteric modulators of muscarinic receptors on the dissociation characteristics of radioligands of A1-adenosine-, alpha 1 - and beta-adrenergic receptors - |
| Author(s) : Pfaffendorf M , Batink HD , Trankle C , Mohr K , van Zwieten PA |
| Ref : Life Sciences , 60 :1172 , 1997 |
| PubMedID: |
| Title : Molecular rigidity and potency of bispyridinium type allosteric modulators at muscarinic M2-receptors - Trankle_1997_Life.Sci_60_1995 |
| Author(s) : Trankle C , Elis K , Wiese M , Mohr K |
| Ref : Life Sciences , 60 :1995 , 1997 |
| Abstract : |
| PubMedSearch : Trankle_1997_Life.Sci_60_1995 |
| PubMedID: 9180353 |
| Title : Divergent modes of action among cationic allosteric modulators of muscarinic M2 receptors - Trankle_1997_Mol.Pharmacol_51_674 |
| Author(s) : Trankle C , Mohr K |
| Ref : Molecular Pharmacology , 51 :674 , 1997 |
| Abstract : |
| PubMedSearch : Trankle_1997_Mol.Pharmacol_51_674 |
| PubMedID: 9106634 |
| Title : Search for lead structures to develop new allosteric modulators of muscarinic receptors - Trankle_1996_J.Pharmacol.Exp.Ther_279_926 |
| Author(s) : Trankle C , Kostenis E , Burgmer U , Mohr K |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 279 :926 , 1996 |
| Abstract : |
| PubMedSearch : Trankle_1996_J.Pharmacol.Exp.Ther_279_926 |
| PubMedID: 8930201 |
| Title : Search for the pharmacophore of bispyridinium-type allosteric modulators of muscarinic receptors - Botero Cid_1994_J.Med.Chem_37_1439 |
| Author(s) : Botero Cid HM , Holzgrabe U , Kostenis E , Mohr K , Trankle C |
| Ref : Journal of Medicinal Chemistry , 37 :1439 , 1994 |
| Abstract : |
| PubMedSearch : Botero Cid_1994_J.Med.Chem_37_1439 |
| PubMedID: 8182702 |
| Title : Allosteric effects of the alkane-bis-ammonium compound W84 and of tacrine on [3H]pirenzepine binding at M1-receptors in rat cerebral cortex - Mohr_1994_Pharmacol.Toxicol_75_391 |
| Author(s) : Mohr K , Trankle C |
| Ref : Pharmacol Toxicol , 75 :391 , 1994 |
| Abstract : |
| PubMedSearch : Mohr_1994_Pharmacol.Toxicol_75_391 |
| PubMedID: 7899262 |
| Title : Poster: On the over-additive antimuscarinic action with atropine of potent allosteric stabilizers of antagonist binding to M2-receptors - |
| Author(s) : Mohr K , Holzgrabe U , Luss H , Trankle C |
| Ref : Life Sciences , 52(5-6) :564 , 1993 |
| PubMedID: |