| Title : The discovery of azetidine-piperazine di-amides as potent, selective and reversible monoacylglycerol lipase (MAGL) inhibitors - Zhu_2020_Bioorg.Med.Chem.Lett_30_127243 |
| Author(s) : Zhu B , Connolly PJ , Zhang YM , McDonnell ME , Bian H , Lin SC , Liu L , Zhang SP , Chevalier KM , Brandt MR , Milligan CM , Flores CM , Macielag MJ |
| Ref : Bioorganic & Medicinal Chemistry Lett , 30 :127243 , 2020 |
| Abstract : |
| PubMedSearch : Zhu_2020_Bioorg.Med.Chem.Lett_30_127243 |
| PubMedID: 32527545 |
| Gene_locus related to this paper: human-MGLL |
| Title : Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor - Wyatt_2020_J.Pharmacol.Exp.Ther_372_339 |
| Author(s) : Wyatt RM , Fraser I , Welty N , Lord B , Wennerholm M , Sutton S , Ameriks MK , Dugovic C , Yun S , White A , Nguyen L , Koudriakova T , Tian G , Suarez J , Szewczuk L , Bonnette W , Ahn K , Ghosh B , Flores CM , Connolly PJ , Zhu B , Macielag MJ , Brandt MR , Chevalier K , Zhang SP , Lovenberg T , Bonaventure P |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 372 :339 , 2020 |
| Abstract : |
| PubMedSearch : Wyatt_2020_J.Pharmacol.Exp.Ther_372_339 |
| PubMedID: 31818916 |
| Title : The discovery of diazetidinyl diamides as potent and reversible inhibitors of monoacylglycerol lipase (MAGL) - Zhu_2020_Bioorg.Med.Chem.Lett_30_127198 |
| Author(s) : Zhu B , Connolly PJ , Zhang SP , Chevalier KM , Milligan CM , Flores CM , Macielag MJ |
| Ref : Bioorganic & Medicinal Chemistry Lett , 30 :127198 , 2020 |
| Abstract : |
| PubMedSearch : Zhu_2020_Bioorg.Med.Chem.Lett_30_127198 |
| PubMedID: 32334914 |
| Title : Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 A resolution - Schalk-Hihi_2011_Protein.Sci_20_670 |
| Author(s) : Schalk-Hihi C , Schubert C , Alexander R , Bayoumy S , Clemente JC , Deckman I , Desjarlais RL , Dzordzorme KC , Flores CM , Grasberger B , Kranz JK , Lewandowski F , Liu L , Ma H , Maguire D , Macielag MJ , McDonnell ME , Mezzasalma Haarlander T , Miller R , Milligan C , Reynolds C , Kuo LC |
| Ref : Protein Science , 20 :670 , 2011 |
| Abstract : |
| PubMedSearch : Schalk-Hihi_2011_Protein.Sci_20_670 |
| PubMedID: 21308848 |
| Gene_locus related to this paper: human-MGLL |