| Title : Pharmacologic Characterization of JNJ-42226314, [1-(4-Fluorophenyl)indol-5-yl]-[3-[4-(thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone, a Reversible, Selective, and Potent Monoacylglycerol Lipase Inhibitor - Wyatt_2020_J.Pharmacol.Exp.Ther_372_339 |
| Author(s) : Wyatt RM , Fraser I , Welty N , Lord B , Wennerholm M , Sutton S , Ameriks MK , Dugovic C , Yun S , White A , Nguyen L , Koudriakova T , Tian G , Suarez J , Szewczuk L , Bonnette W , Ahn K , Ghosh B , Flores CM , Connolly PJ , Zhu B , Macielag MJ , Brandt MR , Chevalier K , Zhang SP , Lovenberg T , Bonaventure P |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 372 :339 , 2020 |
| Abstract : |
| PubMedSearch : Wyatt_2020_J.Pharmacol.Exp.Ther_372_339 |
| PubMedID: 31818916 |
| Title : The discovery of diazetidinyl diamides as potent and reversible inhibitors of monoacylglycerol lipase (MAGL) - Zhu_2020_Bioorg.Med.Chem.Lett_30_127198 |
| Author(s) : Zhu B , Connolly PJ , Zhang SP , Chevalier KM , Milligan CM , Flores CM , Macielag MJ |
| Ref : Bioorganic & Medicinal Chemistry Lett , 30 :127198 , 2020 |
| Abstract : |
| PubMedSearch : Zhu_2020_Bioorg.Med.Chem.Lett_30_127198 |
| PubMedID: 32334914 |
| Title : The discovery of azetidine-piperazine di-amides as potent, selective and reversible monoacylglycerol lipase (MAGL) inhibitors - Zhu_2020_Bioorg.Med.Chem.Lett_30_127243 |
| Author(s) : Zhu B , Connolly PJ , Zhang YM , McDonnell ME , Bian H , Lin SC , Liu L , Zhang SP , Chevalier KM , Brandt MR , Milligan CM , Flores CM , Macielag MJ |
| Ref : Bioorganic & Medicinal Chemistry Lett , 30 :127243 , 2020 |
| Abstract : |
| PubMedSearch : Zhu_2020_Bioorg.Med.Chem.Lett_30_127243 |
| PubMedID: 32527545 |
| Gene_locus related to this paper: human-MGLL |
| Title : Screening and characterization of human monoglyceride lipase active site inhibitors using orthogonal binding and functional assays - Clemente_2012_J.Biomol.Screen_17_629 |
| Author(s) : Clemente JC , Nulton E , Nelen M , Todd MJ , Maguire D , Schalk-Hihi C , Kuo LC , Zhang SP , Flores CM , Kranz JK |
| Ref : J Biomol Screen , 17 :629 , 2012 |
| Abstract : |
| PubMedSearch : Clemente_2012_J.Biomol.Screen_17_629 |
| PubMedID: 22496098 |
| Title : Crystal structure of a soluble form of human monoglyceride lipase in complex with an inhibitor at 1.35 A resolution - Schalk-Hihi_2011_Protein.Sci_20_670 |
| Author(s) : Schalk-Hihi C , Schubert C , Alexander R , Bayoumy S , Clemente JC , Deckman I , Desjarlais RL , Dzordzorme KC , Flores CM , Grasberger B , Kranz JK , Lewandowski F , Liu L , Ma H , Maguire D , Macielag MJ , McDonnell ME , Mezzasalma Haarlander T , Miller R , Milligan C , Reynolds C , Kuo LC |
| Ref : Protein Science , 20 :670 , 2011 |
| Abstract : |
| PubMedSearch : Schalk-Hihi_2011_Protein.Sci_20_670 |
| PubMedID: 21308848 |
| Gene_locus related to this paper: human-MGLL |
| Title : Differential regulation of neuronal nicotinic receptor binding sites following chronic nicotine administration - Flores_1997_J.Neurochem_69_2216 |
| Author(s) : Flores CM , Davila-Garcia MI , Ulrich YM , Kellar KJ |
| Ref : Journal of Neurochemistry , 69 :2216 , 1997 |
| Abstract : |
| PubMedSearch : Flores_1997_J.Neurochem_69_2216 |
| PubMedID: 9349569 |
| Title : Neuronal nicotinic receptor expression in sensory neurons of the rat trigeminal ganglion: demonstration of alpha3beta4, a novel subtype in the mammalian nervous system - Flores_1996_J.Neurosci_16_7892 |
| Author(s) : Flores CM , DeCamp RM , Kilo S , Rogers SW , Hargreaves KM |
| Ref : Journal of Neuroscience , 16 :7892 , 1996 |
| Abstract : |
| PubMedSearch : Flores_1996_J.Neurosci_16_7892 |
| PubMedID: 8987817 |
| Title : A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment - Flores_1992_Mol.Pharmacol_41_31 |
| Author(s) : Flores CM , Rogers SW , Pabreza LA , Wolfe BB , Kellar KJ |
| Ref : Molecular Pharmacology , 41 :31 , 1992 |
| Abstract : |
| PubMedSearch : Flores_1992_Mol.Pharmacol_41_31 |
| PubMedID: 1732720 |
| Title : Naltrexone blocks nicotine-induced prolactin release - Flores_1989_Neuropharmacol_28_1287 |
| Author(s) : Flores CM , Hulihan-Giblin BA , Kellar KJ |
| Ref : Neuropharmacology , 28 :1287 , 1989 |
| Abstract : |
| PubMedSearch : Flores_1989_Neuropharmacol_28_1287 |
| PubMedID: 2594167 |