Title : Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation - McAllister_2018_J.Med.Chem_61_3008 |
Author(s) : McAllister LA , Butler CR , Mente S , O'Neil SV , Fonseca KR , Piro JR , Cianfrogna JA , Foley TL , Gilbert AM , Harris AR , Helal CJ , Johnson DS , Montgomery JI , Nason DM , Noell S , Pandit J , Rogers BN , Samad TA , Shaffer CL , da Silva RG , Uccello DP , Webb D , Brodney MA |
Ref : Journal of Medicinal Chemistry , 61 :3008 , 2018 |
Abstract : |
PubMedSearch : McAllister_2018_J.Med.Chem_61_3008 |
PubMedID: 29498843 |
Gene_locus related to this paper: human-MGLL |
Title : Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury - Piro_2018_J.Neuroinflammation_15_142 |
Author(s) : Piro JR , Suidan GL , Quan J , Pi Y , O'Neill SM , Ilardi M , Pozdnyakov N , Lanz TA , Xi H , Bell RD , Samad TA |
Ref : J Neuroinflammation , 15 :142 , 2018 |
Abstract : |
PubMedSearch : Piro_2018_J.Neuroinflammation_15_142 |
PubMedID: 29759062 |
Title : Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase - Butler_2017_J.Med.Chem_60_9860 |
Author(s) : Butler CR , Beck EM , Harris A , Huang Z , McAllister LA , Am Ende CW , Fennell K , Foley TL , Fonseca K , Hawrylik SJ , Johnson DS , Knafels JD , Mente S , Noell GS , Pandit J , Phillips TB , Piro JR , Rogers BN , Samad TA , Wang J , Wan S , Brodney MA |
Ref : Journal of Medicinal Chemistry , 60 :9860 , 2017 |
Abstract : |
PubMedSearch : Butler_2017_J.Med.Chem_60_9860 |
PubMedID: 29148769 |
Gene_locus related to this paper: human-MGLL |
Title : Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice - Gao_2010_J.Neurosci_30_2017 |
Author(s) : Gao Y , Vasilyev DV , Goncalves MB , Howell FV , Hobbs C , Reisenberg M , Shen R , Zhang MY , Strassle BW , Lu P , Mark L , Piesla MJ , Deng K , Kouranova EV , Ring RH , Whiteside GT , Bates B , Walsh FS , Williams G , Pangalos MN , Samad TA , Doherty P |
Ref : Journal of Neuroscience , 30 :2017 , 2010 |
Abstract : |
PubMedSearch : Gao_2010_J.Neurosci_30_2017 |
PubMedID: 20147530 |
Title : Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system - Chanda_2010_Mol.Pharmacol_78_996 |
Author(s) : Chanda PK , Gao Y , Mark L , Btesh J , Strassle BW , Lu P , Piesla MJ , Zhang MY , Bingham B , Uveges A , Kowal D , Garbe D , Kouranova EV , Ring RH , Bates B , Pangalos MN , Kennedy JD , Whiteside GT , Samad TA |
Ref : Molecular Pharmacology , 78 :996 , 2010 |
Abstract : |
PubMedSearch : Chanda_2010_Mol.Pharmacol_78_996 |
PubMedID: 20855465 |