Fonseca KR

Title : A novel approach for modeling in vivo enzyme turnover in the presence of a suicide inhibitor drug: A proof-of-concept brain PET study on MAG lipase - Volpi_2025_J.Cereb.Blood.Flow.Metab__271678x251329254

Author(s) : Volpi T , Holden D , Gallezot JD , Nabulsi N , Lim K , Labaree D , Gao H , Kapinos M , Keliher EJ , Fonseca KR , Trapa P , Varrone A , Halldin C , Maresca KP , Huang Y , Carson RE

Ref : Journal of Cerebral Blood Flow & Metabolism , :271678x251329254 , 2025

Abstract :

PubMedSearch : Volpi_2025_J.Cereb.Blood.Flow.Metab__271678x251329254

PubMedID: 40370302

Title : Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation - McAllister_2018_J.Med.Chem_61_3008

Author(s) : McAllister LA , Butler CR , Mente S , O'Neil SV , Fonseca KR , Piro JR , Cianfrogna JA , Foley TL , Gilbert AM , Harris AR , Helal CJ , Johnson DS , Montgomery JI , Nason DM , Noell S , Pandit J , Rogers BN , Samad TA , Shaffer CL , da Silva RG , Uccello DP , Webb D , Brodney MA

Ref : Journal of Medicinal Chemistry , 61 :3008 , 2018

Abstract :

PubMedSearch : McAllister_2018_J.Med.Chem_61_3008

PubMedID: 29498843

Gene_locus related to this paper: human-MGLL

Fonseca KR

References (2)

1. A novel approach for modeling in vivo enzyme turnover in the presence of a suicide inhibitor drug: A proof-of-concept brain PET study on MAG lipase - Volpi_2025_J.Cereb.Blood.Flow.Metab__271678x251329254

2. Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation - McAllister_2018_J.Med.Chem_61_3008