| Title : Structural Analysis and Development of Notum Fragment Screening Hits - Zhao_2022_ACS.Chem.Neurosci_13_2060 |
| Author(s) : Zhao Y , Mahy W , Willis NJ , Woodward HL , Steadman D , Bayle ED , Atkinson BN , Sipthorp J , Vecchia L , Ruza RR , Harlos K , Jeganathan F , Constantinou S , Costa A , Kjaer S , Bictash M , Salinas PC , Whiting P , Vincent JP , Fish PV , Jones EY |
| Ref : ACS Chem Neurosci , 13 :2060 , 2022 |
| Abstract : |
| PubMedSearch : Zhao_2022_ACS.Chem.Neurosci_13_2060 |
| PubMedID: 35731924 |
| Gene_locus related to this paper: human-NOTUM |
| Title : Design of a potent, selective and brain penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit - Willis_2022_J.Med.Chem_65_7212 |
| Author(s) : Willis NJ , Mahy W , Sipthorp J , Zhao Y , Woodward HL , Atkinson BN , Bayle ED , Svensson F , Frew S , Jeganathan F , Monaghan A , Benvegnu S , Jolly S , Vecchia L , Ruza RR , Kjaer S , Howell SA , Snidjers AP , Bictash M , Salinas PC , Vincent JP , Jones EY , Whiting P , Fish PV |
| Ref : Journal of Medicinal Chemistry , 65 :7212 , 2022 |
| Abstract : |
| PubMedSearch : Willis_2022_J.Med.Chem_65_7212 |
| PubMedID: 35536179 |
| Gene_locus related to this paper: human-NOTUM |
| Title : Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling - Bayle_2021_J.Med.Chem__ |
| Author(s) : Bayle ED , Svensson F , Atkinson BN , Steadman D , Willis NJ , Woodward HL , Whiting P , Vincent JP , Fish PV |
| Ref : Journal of Medicinal Chemistry , : , 2021 |
| Abstract : |
| PubMedSearch : Bayle_2021_J.Med.Chem__ |
| PubMedID: 33783220 |
| Gene_locus related to this paper: human-NOTUM |
| Title : 5-Phenyl-1,3,4-oxadiazol-2(3H)-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit - Mahy_2020_J.Med.Chem_63_12942 |
| Author(s) : Mahy W , Willis NJ , Zhao Y , Woodward HL , Svensson F , Sipthorp J , Vecchia L , Ruza RR , Hillier J , Kjr S , Frew S , Monaghan A , Bictash M , Salinas PC , Whiting P , Vincent JP , Jones EY , Fish PV |
| Ref : Journal of Medicinal Chemistry , 63 :12942 , 2020 |
| Abstract : |
| PubMedSearch : Mahy_2020_J.Med.Chem_63_12942 |
| PubMedID: 33124429 |
| Gene_locus related to this paper: human-NOTUM |
| Title : N-Methyl-D-aspartate (NMDA) receptor subunit NR1 forms the substrate for oligomeric assembly of the NMDA receptor - Atlason_2007_J.Biol.Chem_282_25299 |
| Author(s) : Atlason PT , Garside ML , Meddows E , Whiting P , McIlhinney RA |
| Ref : Journal of Biological Chemistry , 282 :25299 , 2007 |
| Abstract : |
| PubMedSearch : Atlason_2007_J.Biol.Chem_282_25299 |
| PubMedID: 17606616 |
| Title : Assembly of N-methyl-D-aspartate (NMDA) receptors - McIlhinney_2003_Biochem.Soc.Trans_31_865 |
| Author(s) : McIlhinney RA , Philipps E , Le Bourdelles B , Grimwood S , Wafford K , Sandhu S , Whiting P |
| Ref : Biochemical Society Transactions , 31 :865 , 2003 |
| Abstract : |
| PubMedSearch : McIlhinney_2003_Biochem.Soc.Trans_31_865 |
| PubMedID: 12887323 |
| Title : Identification of molecular determinants that are important in the assembly of N-methyl-D-aspartate receptors - Meddows_2001_J.Biol.Chem_276_18795 |
| Author(s) : Meddows E , Le Bourdelles B , Grimwood S , Wafford K , Sandhu S , Whiting P , McIlhinney RA |
| Ref : Journal of Biological Chemistry , 276 :18795 , 2001 |
| Abstract : |
| PubMedSearch : Meddows_2001_J.Biol.Chem_276_18795 |
| PubMedID: 11279200 |
| Title : Physostigmine and galanthamine: probes for a novel binding site on the alpha 4 beta 2 subtype of neuronal nicotinic acetylcholine receptors stably expressed in fibroblast cells - Pereira_1994_J.Pharmacol.Exp.Ther_270_768 |
| Author(s) : Pereira EF , Alkondon M , Reinhardt S , Maelicke A , Peng X , Lindstrom JM , Whiting P , Albuquerque EX |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 270 :768 , 1994 |
| Abstract : |
| PubMedSearch : Pereira_1994_J.Pharmacol.Exp.Ther_270_768 |
| PubMedID: 8071869 |
| Title : (+)-Anatoxin-a is a potent agonist at neuronal nicotinic acetylcholine receptors - Thomas_1993_J.Neurochem_60_2308 |
| Author(s) : Thomas P , Stephens M , Wilkie G , Amar M , Lunt GG , Whiting P , Gallagher T , Pereira E , Alkondon M , Albuquerque EX , et al. |
| Ref : Journal of Neurochemistry , 60 :2308 , 1993 |
| Abstract : |
| PubMedSearch : Thomas_1993_J.Neurochem_60_2308 |
| PubMedID: 8492133 |
| Title : Hippocampal nicotinic autoreceptors modulate acetylcholine release - |
| Author(s) : Wilkie GI , Hutson PH , Stephens MW , Whiting P , Wonnacott S |
| Ref : Biochemical Society Transactions , 21 :429 , 1993 |
| PubMedID: 8359505 |
| Title : Autoradiographic localization of nicotinic acetylcholine receptors in the brain of the zebra finch (Poephila guttata) - Watson_1988_J.Comp.Neurol_274_255 |
| Author(s) : Watson JT , Adkins-Regan E , Whiting P , Lindstrom JM , Podleski TR |
| Ref : Journal of Comparative Neurology , 274 :255 , 1988 |
| Abstract : |
| PubMedSearch : Watson_1988_J.Comp.Neurol_274_255 |
| PubMedID: 3209741 |