Full name : Thiermann Horst
First name : Horst
Mail : Bundeswehr Institute of Pharmacology and Toxicology\; Neuherbergstr. 11\; D-80937 Munich
Zip Code :
City :
Country : Germany
Email : HorstThiermann@bundeswehr.org
Phone : +498931682925
Fax :
Website :
Directory :
Comment
| Title : The phosphylated butyrylcholinesterase-derived tetrapeptide GlyGluSerAla proves exposure to organophosphorus agents with enantioselectivity - Kranawetvogl_2024_Arch.Toxicol__ |
| Author(s) : Kranawetvogl T , Siegert M , Steinritz D , Thiermann H , John H |
| Ref : Archives of Toxicology , : , 2024 |
| Abstract : |
| PubMedSearch : Kranawetvogl_2024_Arch.Toxicol__ |
| PubMedID: 38267661 |
| Title : A novel binding site in the nicotinic acetylcholine receptor for MB327 can explain its allosteric modulation relevant for organophosphorus-poisoning treatment - Kaiser_2023_Toxicol.Lett_373_160 |
| Author(s) : Kaiser J , Gertzen CGW , Bernauer T , Hofner G , Niessen KV , Seeger T , Paintner FF , Wanner KT , Worek F , Thiermann H , Gohlke H |
| Ref : Toxicol Lett , 373 :160 , 2023 |
| Abstract : |
| PubMedSearch : Kaiser_2023_Toxicol.Lett_373_160 |
| PubMedID: 36503818 |
| Title : Nontargeted High-Resolution Mass Spectrometric Workflow for the Detection of Butyrylcholinesterase-Derived Adducts with Organophosphorus Toxicants and Structural Characterization of Their Phosphyl Moiety after In-Source Fragmentation - John_2022_Anal.Chem__ |
| Author(s) : John H , Dentzel M , Siegert M , Thiermann H |
| Ref : Analytical Chemistry , : , 2022 |
| Abstract : |
| PubMedSearch : John_2022_Anal.Chem__ |
| PubMedID: 35041786 |
| Title : Oximes should be used routinely in organophosphate poisoning - Thiermann_2022_Br.J.Clin.Pharmacol__ |
| Author(s) : Thiermann H , Worek F |
| Ref : British Journal of Clinical Pharmacology , : , 2022 |
| Abstract : |
| PubMedSearch : Thiermann_2022_Br.J.Clin.Pharmacol__ |
| PubMedID: 35023196 |
| Title : Organophosphorus pesticides exhibit compound specific effects in rat precision-cut lung slices (PCLS): mechanisms involved in airway response, cytotoxicity, inflammatory activation and antioxidative defense - Tigges_2021_Arch.Toxicol__ |
| Author(s) : Tigges J , Worek F , Thiermann H , Wille T |
| Ref : Archives of Toxicology , : , 2021 |
| Abstract : |
| PubMedSearch : Tigges_2021_Arch.Toxicol__ |
| PubMedID: 34778934 |
| Title : Post-VX exposure treatment of rats with engineered phosphotriesterases - Stigler_2021_Arch.Toxicol__ |
| Author(s) : Stigler L , Kohler A , Koller M , Job L , Escher B , Potschka H , Thiermann H , Skerra A , Worek F , Wille T |
| Ref : Archives of Toxicology , : , 2021 |
| Abstract : |
| PubMedSearch : Stigler_2021_Arch.Toxicol__ |
| PubMedID: 34962578 |
| Title : Release of protein-bound nerve agents by excess fluoride from whole blood: GC-MS\/MS method development, validation, and application to a real-life denatured blood sample - Koller_2021_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_1179_122693 |
| Author(s) : Koller M , Thiermann H , Worek F , Wille T |
| Ref : Journal of Chromatography B Analyt Technol Biomed Life Sciences , 1179 :122693 , 2021 |
| Abstract : |
| PubMedSearch : Koller_2021_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_1179_122693 |
| PubMedID: 34171608 |
| Title : Evidence of exposure to organophosphorus toxicants by detection of the propionylated butyrylcholinesterase-derived nonapeptide-adduct as a novel biomarker - John_2021_Forensic.Sci.Int_323_110818 |
| Author(s) : John H , Richter A , Siegert M , Eyer F , Thiermann H |
| Ref : Forensic Science International , 323 :110818 , 2021 |
| Abstract : |
| PubMedSearch : John_2021_Forensic.Sci.Int_323_110818 |
| PubMedID: 33990018 |
| Title : Poisoning by organophosphorus nerve agents and pesticides: An overview of the principle strategies and current progress of mass spectrometry-based procedures for verification - John_2021_J.Mass.Spectrom.Adv.Clin.Lab_19_20 |
| Author(s) : John H , Thiermann H |
| Ref : J Mass Spectrom Adv Clin Lab , 19 :20 , 2021 |
| Abstract : |
| PubMedSearch : John_2021_J.Mass.Spectrom.Adv.Clin.Lab_19_20 |
| PubMedID: 34820662 |
| Title : Organophosphorus compounds and oximes: a critical review - Worek_2020_Arch.Toxicol_94_2275 |
| Author(s) : Worek F , Thiermann H , Wille T |
| Ref : Archives of Toxicology , 94 :2275 , 2020 |
| Abstract : |
| PubMedSearch : Worek_2020_Arch.Toxicol_94_2275 |
| PubMedID: 32506210 |
| Title : In Vitro Interaction of Organophosphono- and Organophosphorothioates with Human Acetylcholinesterase - Worek_2020_Molecules_25_ |
| Author(s) : Worek F , Thiermann H , Koller M , Wille T |
| Ref : Molecules , 25 : , 2020 |
| Abstract : |
| PubMedSearch : Worek_2020_Molecules_25_ |
| PubMedID: 32630769 |
| Title : A case report of cholinesterase inhibitor poisoning: cholinesterase activities and analytical methods for diagnosis and clinical decision making - Amend_2020_Arch.Toxicol__ |
| Author(s) : Amend N , Langgartner J , Siegert M , Kranawetvogl T , Koller M , John H , Pflugler C , Mogele-Schmid C , Worek F , Thiermann H , Wille T |
| Ref : Archives of Toxicology , : , 2020 |
| Abstract : |
| PubMedSearch : Amend_2020_Arch.Toxicol__ |
| PubMedID: 32303803 |
| Title : Diagnostics and treatment of nerve agent poisoning-current status and future developments - Amend_2020_Ann.N.Y.Acad.Sci__ |
| Author(s) : Amend N , Niessen KV , Seeger T , Wille T , Worek F , Thiermann H |
| Ref : Annals of the New York Academy of Sciences , : , 2020 |
| Abstract : |
| PubMedSearch : Amend_2020_Ann.N.Y.Acad.Sci__ |
| PubMedID: 32198755 |
| Title : A novel HPLC-DAD method for the simultaneous quantification of the enzyme-reactivating oximes obidoxime, pralidoxime and HI-6 in human plasma - Kranawetvogl_2020_Drug.Test.Anal__ |
| Author(s) : Kranawetvogl T , Steinritz D , Thiermann H , John H |
| Ref : Drug Test Anal , : , 2020 |
| Abstract : |
| PubMedSearch : Kranawetvogl_2020_Drug.Test.Anal__ |
| PubMedID: 32267631 |
| Title : Early diagnosis of nerve agent exposure with a mobile test kit and implications for medical countermeasures: a trigger to react - Wille_2020_BMJ.Mil.Health__ |
| Author(s) : Wille T , Djordjevic S , Worek F , Thiermann H , Vucinic S |
| Ref : BMJ Mil Health , : , 2020 |
| Abstract : |
| PubMedSearch : Wille_2020_BMJ.Mil.Health__ |
| PubMedID: 32086265 |
| Title : Efficacy of an organophosphorus hydrolase enzyme (OpdA) in human serum and minipig models of organophosphorus insecticide poisoning - Eddleston_2019_Clin.Toxicol.(Phila)__1 |
| Author(s) : Eddleston M , Clutton RE , Taylor M , Thompson A , Worek F , John H , Thiermann H , Scott C |
| Ref : Clinical Toxicology (Phila) , :1 , 2019 |
| Abstract : |
| PubMedSearch : Eddleston_2019_Clin.Toxicol.(Phila)__1 |
| PubMedID: 31452424 |
| Title : Human small bowel as model for poisoning with organophosphorus compounds - Marquart_2019_Toxicol.In.Vitro_57_76 |
| Author(s) : Marquart K , Prokopchuk O , Wilhelm D , Worek F , Thiermann H , Martignoni ME , Wille T |
| Ref : Toxicol In Vitro , 57 :76 , 2019 |
| Abstract : |
| PubMedSearch : Marquart_2019_Toxicol.In.Vitro_57_76 |
| PubMedID: 30763608 |
| Title : New Resensitizers for the Nicotinic Acetylcholine Receptor by Ligand-Based Pharmacophore Modeling - Wein_2019_Curr.Comput.Aided.Drug.Des_15_104 |
| Author(s) : Wein T , Wanner KT , Rappengluck S , Sichler S , Niessen KV , Seeger T , Worek F , Thiermann H |
| Ref : Curr Comput Aided Drug Des , 15 :104 , 2019 |
| Abstract : |
| PubMedSearch : Wein_2019_Curr.Comput.Aided.Drug.Des_15_104 |
| PubMedID: 29968541 |
| Title : Collision-induced mass spectrometric fragmentation of protonated dimethoate and omethoate generated by electrospray ionization - John_2019_Rapid.Commun.Mass.Spectrom_33_259 |
| Author(s) : John H , Siegert M , Kranawetvogl A , Thiermann H |
| Ref : Rapid Commun Mass Spectrom , 33 :259 , 2019 |
| Abstract : |
| PubMedSearch : John_2019_Rapid.Commun.Mass.Spectrom_33_259 |
| PubMedID: 30402977 |
| Title : COPD and asthma therapeutics for supportive treatment in organophosphate poisoning - Herbert_2019_Clin.Toxicol.(Phila)__1 |
| Author(s) : Herbert J , Thiermann H , Worek F , Wille T |
| Ref : Clinical Toxicology (Phila) , :1 , 2019 |
| Abstract : |
| PubMedSearch : Herbert_2019_Clin.Toxicol.(Phila)__1 |
| PubMedID: 30696282 |
| Title : The arrhythmogenic potential of nerve agents and a cardiac safety profile of antidotes - A proof-of-concept study using human induced pluripotent stem cells derived cardiomyocytes (hiPSC-CM) - Amend_2019_Toxicol.Lett_308_1 |
| Author(s) : Amend N , Thiermann H , Worek F , Wille T |
| Ref : Toxicol Lett , 308 :1 , 2019 |
| Abstract : |
| PubMedSearch : Amend_2019_Toxicol.Lett_308_1 |
| PubMedID: 30858091 |
| Title : Searching for putative binding sites of the bispyridinium compound MB327 in the nicotinic acetylcholine receptor - Wein_2018_Toxicol.Lett_293_184 |
| Author(s) : Wein T , Hofner G , Rappengluck S , Sichler S , Niessen KV , Seeger T , Worek F , Thiermann H , Wanner KT |
| Ref : Toxicol Lett , 293 :184 , 2018 |
| Abstract : |
| PubMedSearch : Wein_2018_Toxicol.Lett_293_184 |
| PubMedID: 29097222 |
| Title : Human small bowel as a useful tool to investigate smooth muscle effects of potential therapeutics in organophosphate poisoning - Marquart_2018_Toxicol.Lett_293_235 |
| Author(s) : Marquart K , Prokopchuk O , Worek F , Thiermann H , Martignoni ME , Wille T |
| Ref : Toxicol Lett , 293 :235 , 2018 |
| Abstract : |
| PubMedSearch : Marquart_2018_Toxicol.Lett_293_235 |
| PubMedID: 29154801 |
| Title : Bioanalytical verification of V-type nerve agent exposure: simultaneous detection of phosphonylated tyrosines and cysteine-containing disulfide-adducts derived from human albumin - Kranawetvogl_2018_Anal.Bioanal.Chem_410_1463 |
| Author(s) : Kranawetvogl A , Kuppers J , Siegert M , Gutschow M , Worek F , Thiermann H , Elsinghorst PW , John H |
| Ref : Anal Bioanal Chem , 410 :1463 , 2018 |
| Abstract : |
| PubMedSearch : Kranawetvogl_2018_Anal.Bioanal.Chem_410_1463 |
| PubMedID: 29322229 |
| Title : In vitro pharmacological characterization of the bispyridinium non-oxime compound MB327 and its 2- and 3-regioisomers - Niessen_2018_Toxicol.Lett_293_190 |
| Author(s) : Niessen KV , Seeger T , Rappengluck S , Wein T , Hofner G , Wanner KT , Thiermann H , Worek F |
| Ref : Toxicol Lett , 293 :190 , 2018 |
| Abstract : |
| PubMedSearch : Niessen_2018_Toxicol.Lett_293_190 |
| PubMedID: 29024789 |
| Title : Midazolam is effective to reduce cortical network activity in organotypic cultures during severe cholinergic overstimulation with soman - Drexler_2018_Toxicol.Lett_297_19 |
| Author(s) : Drexler B , Seeger T , Worek F , Thiermann H , Antkowiak B , Grasshoff C |
| Ref : Toxicol Lett , 297 :19 , 2018 |
| Abstract : |
| PubMedSearch : Drexler_2018_Toxicol.Lett_297_19 |
| PubMedID: 30165091 |
| Title : The oximes HI-6 and MMB-4 fail to reactivate soman-inhibited human and guinea pig AChE: A kinetic in vitro study - Worek_2018_Toxicol.Lett_293_216 |
| Author(s) : Worek F , Thiermann H , Wille T |
| Ref : Toxicol Lett , 293 :216 , 2018 |
| Abstract : |
| PubMedSearch : Worek_2018_Toxicol.Lett_293_216 |
| PubMedID: 28993240 |
| Title : Development of MS Binding Assays targeting the binding site of MB327 at the nicotinic acetylcholine receptor - Sichler_2018_Toxicol.Lett_293_172 |
| Author(s) : Sichler S , Hofner G , Rappengluck S , Wein T , Niessen KV , Seeger T , Worek F , Thiermann H , Paintner FF , Wanner KT |
| Ref : Toxicol Lett , 293 :172 , 2018 |
| Abstract : |
| PubMedSearch : Sichler_2018_Toxicol.Lett_293_172 |
| PubMedID: 29146291 |
| Title : Counteracting desensitization of human alpha7-nicotinic acetylcholine receptors with bispyridinium compounds as an approach against organophosphorus poisoning - Scheffel_2018_Toxicol.Lett_293_149 |
| Author(s) : Scheffel C , Niessen KV , Rappengluck S , Wanner KT , Thiermann H , Worek F , Seeger T |
| Ref : Toxicol Lett , 293 :149 , 2018 |
| Abstract : |
| PubMedSearch : Scheffel_2018_Toxicol.Lett_293_149 |
| PubMedID: 29248576 |
| Title : Interactions between acetylcholinesterase, toxic organophosphorus compounds and a short series of structurally related non-oxime reactivators: Analysis of reactivation and inhibition kinetics in vitro - Horn_2018_Toxicol.Lett_299_218 |
| Author(s) : Horn G , De Koning MC , van Grol M , Thiermann H , Worek F |
| Ref : Toxicol Lett , 299 :218 , 2018 |
| Abstract : |
| PubMedSearch : Horn_2018_Toxicol.Lett_299_218 |
| PubMedID: 30312685 |
| Title : Fatal sarin poisoning in Syria 2013: forensic verification within an international laboratory network - John_2018_Forensic.Toxicol_36_61 |
| Author(s) : John H , van der Schans MJ , Koller M , Spruit HET , Worek F , Thiermann H , Noort D |
| Ref : Forensic Toxicol , 36 :61 , 2018 |
| Abstract : |
| PubMedSearch : John_2018_Forensic.Toxicol_36_61 |
| PubMedID: 29367863 |
| Title : Synthesis of a Series of Non-Symmetric Bispyridinium and Related Compounds and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor - Rappengluck_2018_ChemMedChem_13_2653 |
| Author(s) : Rappengluck S , Sichler S , Hofner G , Wein T , Niessen KV , Seeger T , Paintner FF , Worek F , Thiermann H , Wanner KT |
| Ref : ChemMedChem , 13 :2653 , 2018 |
| Abstract : |
| PubMedSearch : Rappengluck_2018_ChemMedChem_13_2653 |
| PubMedID: 30362667 |
| Title : Synthesis of a Series of Structurally Diverse MB327 Derivatives and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor - Rappengluck_2018_ChemMedChem_13_1806 |
| Author(s) : Rappengluck S , Sichler S , Hofner G , Wein T , Niessen KV , Seeger T , Paintner FF , Worek F , Thiermann H , Wanner KT |
| Ref : ChemMedChem , 13 :1806 , 2018 |
| Abstract : |
| PubMedSearch : Rappengluck_2018_ChemMedChem_13_1806 |
| PubMedID: 29974635 |
| Title : Electrophysiological investigation of the effect of structurally different bispyridinium non-oxime compounds on human alpha7-nicotinic acetylcholine receptor activity-An in vitro structure-activity analysis - Scheffel_2018_Toxicol.Lett_293_157 |
| Author(s) : Scheffel C , Niessen KV , Rappengluck S , Wanner KT , Thiermann H , Worek F , Seeger T |
| Ref : Toxicol Lett , 293 :157 , 2018 |
| Abstract : |
| PubMedSearch : Scheffel_2018_Toxicol.Lett_293_157 |
| PubMedID: 29191791 |
| Title : Effect of cholinergic crisis on the potency of different emergency anaesthesia protocols in soman-poisoned rats - Marquart_2018_Clin.Toxicol.(Phila)__1 |
| Author(s) : Marquart K , Herbert J , Amend N , Thiermann H , Worek F , Wille T |
| Ref : Clinical Toxicology (Phila) , :1 , 2018 |
| Abstract : |
| PubMedSearch : Marquart_2018_Clin.Toxicol.(Phila)__1 |
| PubMedID: 30307341 |
| Title : Precision cut lung slices as test system for candidate therapeutics in organophosphate poisoning - Herbert_2017_Toxicology_389_94 |
| Author(s) : Herbert J , Thiermann H , Worek F , Wille T |
| Ref : Toxicology , 389 :94 , 2017 |
| Abstract : |
| PubMedSearch : Herbert_2017_Toxicology_389_94 |
| PubMedID: 28743514 |
| Title : Pseudocatalytic scavenging of the nerve agent VX with human blood components and the oximes obidoxime and HI-6 - Wille_2017_Arch.Toxicol_91_1309 |
| Author(s) : Wille T , von der Wellen J , Thiermann H , Worek F |
| Ref : Archives of Toxicology , 91 :1309 , 2017 |
| Abstract : |
| PubMedSearch : Wille_2017_Arch.Toxicol_91_1309 |
| PubMedID: 27358236 |
| Title : On-site analysis of acetylcholinesterase and butyrylcholinesterase activity with the ChE check mobile test kit-Determination of reference values and their relevance for diagnosis of exposure to organophosphorus compounds - Worek_2016_Toxicol.Lett_249_22 |
| Author(s) : Worek F , Schilha M , Neumaier K , Aurbek N , Wille T , Thiermann H , Kehe K |
| Ref : Toxicol Lett , 249 :22 , 2016 |
| Abstract : |
| PubMedSearch : Worek_2016_Toxicol.Lett_249_22 |
| PubMedID: 27033775 |
| Title : Investigation of the reactivation kinetics of a large series of bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase - Winter_2016_Toxicol.Lett_244_136 |
| Author(s) : Winter M , Wille T , Musilek K , Kuca K , Thiermann H , Worek F |
| Ref : Toxicol Lett , 244 :136 , 2016 |
| Abstract : |
| PubMedSearch : Winter_2016_Toxicol.Lett_244_136 |
| PubMedID: 26210933 |
| Title : Blaptica dubia as sentinels for exposure to chemical warfare agents - a pilot study - Worek_2016_Toxicol.Lett_262_12 |
| Author(s) : Worek F , Seeger T , Neumaier K , Wille T , Thiermann H |
| Ref : Toxicol Lett , 262 :12 , 2016 |
| Abstract : |
| PubMedSearch : Worek_2016_Toxicol.Lett_262_12 |
| PubMedID: 27639501 |
| Title : A novel fluorogenic probe for the investigation of free thiols: Application to kinetic measurements of acetylcholinesterase activity - Mertens_2016_Toxicol.Lett_244_161 |
| Author(s) : Mertens MD , Bierwisch A , Li T , Gutschow M , Thiermann H , Wille T , Elsinghorst PW |
| Ref : Toxicol Lett , 244 :161 , 2016 |
| Abstract : |
| PubMedSearch : Mertens_2016_Toxicol.Lett_244_161 |
| PubMedID: 26494253 |
| Title : Reactivation of nerve agent-inhibited human acetylcholinesterase by obidoxime, HI-6 and obidoxime+HI-6: Kinetic in vitro study with simulated nerve agent toxicokinetics and oxime pharmacokinetics - Worek_2016_Toxicology_350-352_25 |
| Author(s) : Worek F , Koller M , Thiermann H , Wille T |
| Ref : Toxicology , 350-352 :25 , 2016 |
| Abstract : |
| PubMedSearch : Worek_2016_Toxicology_350-352_25 |
| PubMedID: 27153754 |
| Title : Oximes in organophosphate poisoning: 60 years of hope and despair - Worek_2016_Chem.Biol.Interact_259_93 |
| Author(s) : Worek F , Thiermann H , Wille T |
| Ref : Chemico-Biological Interactions , 259 :93 , 2016 |
| Abstract : |
| PubMedSearch : Worek_2016_Chem.Biol.Interact_259_93 |
| PubMedID: 27125761 |
| Title : Repetitive obidoxime treatment induced increase of red blood cell acetylcholinesterase activity even in a late phase of a severe methamidophos poisoning: A case report - Steinritz_2016_Toxicol.Lett_244_121 |
| Author(s) : Steinritz D , Eyer F , Worek F , Thiermann H , John H |
| Ref : Toxicol Lett , 244 :121 , 2016 |
| Abstract : |
| PubMedSearch : Steinritz_2016_Toxicol.Lett_244_121 |
| PubMedID: 26200596 |
| Title : Functional analysis of Torpedo californica nicotinic acetylcholine receptors in multiple activation states by SSM-based electrophysiology - Niessen_2016_Toxicol.Lett_247_1 |
| Author(s) : Niessen KV , Muschik S , Langguth F , Rappengluck S , Seeger T , Thiermann H , Worek F |
| Ref : Toxicol Lett , 247 :1 , 2016 |
| Abstract : |
| PubMedSearch : Niessen_2016_Toxicol.Lett_247_1 |
| PubMedID: 26851639 |
| Title : Single treatment of VX poisoned guinea pigs with the phosphotriesterase mutant C23AL: Intraosseous versus intravenous injection - Wille_2016_Toxicol.Lett_258_198 |
| Author(s) : Wille T , Neumaier K , Koller M , Ehinger C , Aggarwal N , Ashani Y , Goldsmith M , Sussman JL , Tawfik DS , Thiermann H , Worek F |
| Ref : Toxicol Lett , 258 :198 , 2016 |
| Abstract : |
| PubMedSearch : Wille_2016_Toxicol.Lett_258_198 |
| PubMedID: 27397758 |
| Title : Catalytic efficiencies of directly evolved phosphotriesterase variants with structurally different organophosphorus compounds in vitro - Goldsmith_2016_Arch.Toxicol_90_2711 |
| Author(s) : Goldsmith M , Eckstein S , Ashani Y , Greisen P, Jr. , Leader H , Sussman JL , Aggarwal N , Ovchinnikov S , Tawfik DS , Baker D , Thiermann H , Worek F |
| Ref : Archives of Toxicology , 90 :2711 , 2016 |
| Abstract : |
| PubMedSearch : Goldsmith_2016_Arch.Toxicol_90_2711 |
| PubMedID: 26612364 |
| Title : Kinetic analysis of interactions of amodiaquine with human cholinesterases and organophosphorus compounds - Bierwisch_2016_Toxicol.Lett_246_49 |
| Author(s) : Bierwisch A , Wille T , Thiermann H , Worek F |
| Ref : Toxicol Lett , 246 :49 , 2016 |
| Abstract : |
| PubMedSearch : Bierwisch_2016_Toxicol.Lett_246_49 |
| PubMedID: 26851641 |
| Title : Catalytic bioscavengers in nerve agent poisoning: A promising approach? - Worek_2016_Toxicol.Lett_244_143 |
| Author(s) : Worek F , Thiermann H , Wille T |
| Ref : Toxicol Lett , 244 :143 , 2016 |
| Abstract : |
| PubMedSearch : Worek_2016_Toxicol.Lett_244_143 |
| PubMedID: 26200600 |
| Title : Kinetics of pesticide degradation by human fresh frozen plasma (FFP) in vitro - von der Wellen_2016_Toxicol.Lett_244_124 |
| Author(s) : von der Wellen J , Bierwisch A , Worek F , Thiermann H , Wille T |
| Ref : Toxicol Lett , 244 :124 , 2016 |
| Abstract : |
| PubMedSearch : von der Wellen_2016_Toxicol.Lett_244_124 |
| PubMedID: 26220518 |
| Title : Application of a dynamic in vitro model with real-time determination of acetylcholinesterase activity for the investigation of tabun analogues and oximes - Worek_2015_Toxicol.In.Vitro_30_514 |
| Author(s) : Worek F , Herkert NM , Koller M , Thiermann H , Wille T |
| Ref : Toxicol In Vitro , 30 :514 , 2015 |
| Abstract : |
| PubMedSearch : Worek_2015_Toxicol.In.Vitro_30_514 |
| PubMedID: 26368669 |
| Title : In vitro and in vivo toxicological studies of V nerve agents: molecular and stereoselective aspects - Reiter_2015_Toxicol.Lett_232_438 |
| Author(s) : Reiter G , Muller S , Hill I , Weatherby K , Thiermann H , Worek F , Mikler J |
| Ref : Toxicol Lett , 232 :438 , 2015 |
| Abstract : |
| PubMedSearch : Reiter_2015_Toxicol.Lett_232_438 |
| PubMedID: 25448275 |
| Title : Small-scale purification of butyrylcholinesterase from human plasma and implementation of a muLC-UV\/ESI MS\/MS method to detect its organophosphorus adducts - John_2015_Drug.Test.Anal_7_947 |
| Author(s) : John H , Breyer F , Schmidt C , Mizaikoff B , Worek F , Thiermann H |
| Ref : Drug Test Anal , 7 :947 , 2015 |
| Abstract : |
| PubMedSearch : John_2015_Drug.Test.Anal_7_947 |
| PubMedID: 25828536 |
| Title : Effect of reversible ligands on oxime-induced reactivation of sarin- and cyclosarin-inhibited human acetylcholinesterase - Scheffel_2015_Toxicol.Lett_232_557 |
| Author(s) : Scheffel C , Thiermann H , Worek F |
| Ref : Toxicol Lett , 232 :557 , 2015 |
| Abstract : |
| PubMedSearch : Scheffel_2015_Toxicol.Lett_232_557 |
| PubMedID: 25522658 |
| Title : Reactivation kinetics of 31 structurally different bispyridinium oximes with organophosphate-inhibited human butyrylcholinesterase - Horn_2015_Arch.Toxicol_89_405 |
| Author(s) : Horn G , Wille T , Musilek K , Kuca K , Thiermann H , Worek F |
| Ref : Archives of Toxicology , 89 :405 , 2015 |
| Abstract : |
| PubMedSearch : Horn_2015_Arch.Toxicol_89_405 |
| PubMedID: 24912784 |
| Title : V-type nerve agents phosphonylate ubiquitin at biologically relevant lysine residues and induce intramolecular cyclization by an isopeptide bond - Schmidt_2014_Anal.Bioanal.Chem_406_5171 |
| Author(s) : Schmidt C , Breyer F , Blum MM , Thiermann H , Worek F , John H |
| Ref : Anal Bioanal Chem , 406 :5171 , 2014 |
| Abstract : |
| PubMedSearch : Schmidt_2014_Anal.Bioanal.Chem_406_5171 |
| PubMedID: 24652148 |
| Title : Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in vivo and to detoxify structurally different nerve agents in vitro - Worek_2014_Arch.Toxicol_88_1257 |
| Author(s) : Worek F , Seeger T , Goldsmith M , Ashani Y , Leader H , Sussman JL , Tawfik DS , Thiermann H , Wille T |
| Ref : Archives of Toxicology , 88 :1257 , 2014 |
| Abstract : |
| PubMedSearch : Worek_2014_Arch.Toxicol_88_1257 |
| PubMedID: 24477626 |
| Title : Post-exposure treatment of VX poisoned guinea pigs with the engineered phosphotriesterase mutant C23: A proof-of-concept study - Worek_2014_Toxicol.Lett_231_45 |
| Author(s) : Worek F , Seeger T , Reiter G , Goldsmith M , Ashani Y , Leader H , Sussman JL , Aggarwal N , Thiermann H , Tawfik DS |
| Ref : Toxicol Lett , 231 :45 , 2014 |
| Abstract : |
| PubMedSearch : Worek_2014_Toxicol.Lett_231_45 |
| PubMedID: 25195526 |
| Title : Effectiveness of a substituted beta-cyclodextrin to prevent cyclosarin toxicity in vivo - Worek_2014_Toxicol.Lett_226_222 |
| Author(s) : Worek F , Seeger T , Zengerle M , Kubik S , Thiermann H , Wille T |
| Ref : Toxicol Lett , 226 :222 , 2014 |
| Abstract : |
| PubMedSearch : Worek_2014_Toxicol.Lett_226_222 |
| PubMedID: 24561299 |
| Title : In vitro kinetics of nerve agent degradation by fresh frozen plasma (FFP) - Wille_2014_Arch.Toxicol_88_301 |
| Author(s) : Wille T , Thiermann H , Worek F |
| Ref : Archives of Toxicology , 88 :301 , 2014 |
| Abstract : |
| PubMedSearch : Wille_2014_Arch.Toxicol_88_301 |
| PubMedID: 24057572 |
| Title : Reactions of methylphosphonic difluoride with human acetylcholinesterase and oximes - Possible therapeutic implications - Worek_2014_Toxicol.Lett_231_92 |
| Author(s) : Worek F , Elsinghorst P , Koller M , Thiermann H |
| Ref : Toxicol Lett , 231 :92 , 2014 |
| Abstract : |
| PubMedSearch : Worek_2014_Toxicol.Lett_231_92 |
| PubMedID: 25240274 |
| Title : Adaptation of a dynamic in vitro model with real-time determination of butyrylcholinesterase activity in the presence of cyclosarin and an oxime - Worek_2014_Toxicol.In.Vitro_29_162 |
| Author(s) : Worek F , Horn G , Wille T , Thiermann H |
| Ref : Toxicol In Vitro , 29 :162 , 2014 |
| Abstract : |
| PubMedSearch : Worek_2014_Toxicol.In.Vitro_29_162 |
| PubMedID: 25450746 |
| Title : New modified beta-cyclodextrin derivatives as detoxifying agents of chemical warfare agents (I). Synthesis and preliminary screening: Evaluation of the detoxification using a half-quantitative enzymatic assay - Kalakuntla_2013_Toxicol.Lett_216_200 |
| Author(s) : Kalakuntla RK , Wille T , Le Provost R , Letort S , Reiter G , Muller S , Thiermann H , Worek F , Gouhier G , Lafont O , Estour F |
| Ref : Toxicol Lett , 216 :200 , 2013 |
| Abstract : |
| PubMedSearch : Kalakuntla_2013_Toxicol.Lett_216_200 |
| PubMedID: 23201439 |
| Title : The value of novel oximes for treatment of poisoning by organophosphorus compounds - Worek_2013_Pharmacol.Ther_139_249 |
| Author(s) : Worek F , Thiermann H |
| Ref : Pharmacol Ther , 139 :249 , 2013 |
| Abstract : |
| PubMedSearch : Worek_2013_Pharmacol.Ther_139_249 |
| PubMedID: 23603539 |
| Title : Organophosphate poisoning in the developed world - A single centre experience from here to the millennium - Hrabetz_2013_Chem.Biol.Interact_206_561 |
| Author(s) : Hrabetz H , Thiermann H , Felgenhauer N , Zilker T , Haller B , Nahrig J , Saugel B , Eyer F |
| Ref : Chemico-Biological Interactions , 206 :561 , 2013 |
| Abstract : |
| PubMedSearch : Hrabetz_2013_Chem.Biol.Interact_206_561 |
| PubMedID: 23685200 |
| Title : Investigations of kinetic interactions between lipid emulsions, hydroxyethyl starch or dextran and organophosphorus compounds - Von Der Wellen_2013_Clin.Toxicol.(Phila)_51_918 |
| Author(s) : von der Wellen J , Worek F , Thiermann H , Wille T |
| Ref : Clinical Toxicology (Phila) , 51 :918 , 2013 |
| Abstract : |
| PubMedSearch : Von Der Wellen_2013_Clin.Toxicol.(Phila)_51_918 |
| PubMedID: 24199642 |
| Title : Affinities of bispyridinium non-oxime compounds to [(3)H]epibatidine binding sites of Torpedo californica nicotinic acetylcholine receptors depend on linker length - Niessen_2013_Chem.Biol.Interact_206_545 |
| Author(s) : Niessen KV , Seeger T , Tattersall JE , Timperley CM , Bird M , Green C , Thiermann H , Worek F |
| Ref : Chemico-Biological Interactions , 206 :545 , 2013 |
| Abstract : |
| PubMedSearch : Niessen_2013_Chem.Biol.Interact_206_545 |
| PubMedID: 24157926 |
| Title : Influence of organophosphate poisoning on human dendritic cells - Schafer_2013_Chem.Biol.Interact_206_472 |
| Author(s) : Schafer M , Koppe F , Stenger B , Brochhausen C , Schmidt A , Steinritz D , Thiermann H , Kirkpatrick CJ , Pohl C |
| Ref : Chemico-Biological Interactions , 206 :472 , 2013 |
| Abstract : |
| PubMedSearch : Schafer_2013_Chem.Biol.Interact_206_472 |
| PubMedID: 23994500 |
| Title : Limitations and challenges in treatment of acute chemical warfare agent poisoning - Thiermann_2013_Chem.Biol.Interact_206_435 |
| Author(s) : Thiermann H , Worek F , Kehe K |
| Ref : Chemico-Biological Interactions , 206 :435 , 2013 |
| Abstract : |
| PubMedSearch : Thiermann_2013_Chem.Biol.Interact_206_435 |
| PubMedID: 24091052 |
| Title : Investigation of kinetic interactions between approved oximes and human acetylcholinesterase inhibited by pesticide carbamates - Wille_2013_Chem.Biol.Interact_206_569 |
| Author(s) : Wille T , Kaltenbach L , Thiermann H , Worek F |
| Ref : Chemico-Biological Interactions , 206 :569 , 2013 |
| Abstract : |
| PubMedSearch : Wille_2013_Chem.Biol.Interact_206_569 |
| PubMedID: 23962483 |
| Title : Structural requirements for effective oximes - Evaluation of kinetic in vitro data with phosphylated human AChE and structurally different oximes - Worek_2013_Chem.Biol.Interact_203_125 |
| Author(s) : Worek F , Wille T , Koller M , Thiermann H |
| Ref : Chemico-Biological Interactions , 203 :125 , 2013 |
| Abstract : |
| PubMedSearch : Worek_2013_Chem.Biol.Interact_203_125 |
| PubMedID: 22827894 |
| Title : Effects of succinylcholine in an organotypic spinal cord-skeletal muscle coculture of embryonic mice - Drexler_2013_Chem.Biol.Interact_206_555 |
| Author(s) : Drexler B , Thiermann H , Antkowiak B , Grasshoff C |
| Ref : Chemico-Biological Interactions , 206 :555 , 2013 |
| Abstract : |
| PubMedSearch : Drexler_2013_Chem.Biol.Interact_206_555 |
| PubMedID: 23838346 |
| Title : Reactivation of Plasma Butyrylcholinesterase by Pralidoxime Chloride in Patients Poisoned by WHO Class II Toxicity Organophosphorus Insecticides - Konickx_2013_Toxicol.Sci_136_274 |
| Author(s) : Konickx LA , Worek F , Jayamanne S , Thiermann H , Buckley NA , Eddleston M |
| Ref : Toxicol Sci , 136 :274 , 2013 |
| Abstract : |
| PubMedSearch : Konickx_2013_Toxicol.Sci_136_274 |
| PubMedID: 24052565 |
| Title : Fourteenth International Medical Chemical Defence Conference 2013 Translation of experimental research for improved treatment of chemical warfare agents - |
| Author(s) : Wille T , Worek F , Thiermann H |
| Ref : Chemico-Biological Interactions , 206 :433 , 2013 |
| PubMedID: 23920049 |
| Title : Restoration of soman-blocked neuromuscular transmission in human and rat muscle by the bispyridinium non-oxime MB327 in vitro - Seeger_2012_Toxicology_294_80 |
| Author(s) : Seeger T , Eichhorn M , Lindner M , Niessen KV , Tattersall JE , Timperley CM , Bird M , Green AC , Thiermann H , Worek F |
| Ref : Toxicology , 294 :80 , 2012 |
| Abstract : |
| PubMedSearch : Seeger_2012_Toxicology_294_80 |
| PubMedID: 22349640 |
| Title : Reactivation kinetics of a homologous series of bispyridinium bis-oximes with nerve agent-inhibited human acetylcholinesterase - Worek_2012_Arch.Toxicol_86_1379 |
| Author(s) : Worek F , von der Wellen J , Musilek K , Kuca K , Thiermann H |
| Ref : Archives of Toxicology , 86 :1379 , 2012 |
| Abstract : |
| PubMedSearch : Worek_2012_Arch.Toxicol_86_1379 |
| PubMedID: 22437842 |
| Title : Application of an enantioselective LC-ESI MS\/MS procedure to determine R- and S-hyoscyamine following intravenous atropine administration in swine - John_2012_Drug.Test.Anal_4_194 |
| Author(s) : John H , Mikler J , Worek F , Thiermann H |
| Ref : Drug Test Anal , 4 :194 , 2012 |
| Abstract : |
| PubMedSearch : John_2012_Drug.Test.Anal_4_194 |
| PubMedID: 21964777 |
| Title : Competition radioligand binding assays for the investigation of bispyridinium compound affinities to the human muscarinic acetylcholine receptor subtype 5 (hM(5) ) - Niessen_2012_Drug.Test.Anal_4_292 |
| Author(s) : Niessen KV , Tattersall JE , Timperley CM , Bird M , Green C , Thiermann H , Worek F |
| Ref : Drug Test Anal , 4 :292 , 2012 |
| Abstract : |
| PubMedSearch : Niessen_2012_Drug.Test.Anal_4_292 |
| PubMedID: 22362630 |
| Title : Determination of acetylcholinesterase activity by the Ellman assay: a versatile tool for in vitro research on medical countermeasures against organophosphate poisoning - Worek_2012_Drug.Test.Anal_4_282 |
| Author(s) : Worek F , Eyer P , Thiermann H |
| Ref : Drug Test Anal , 4 :282 , 2012 |
| Abstract : |
| PubMedSearch : Worek_2012_Drug.Test.Anal_4_282 |
| PubMedID: 21998030 |
| Title : A role for solvents in the toxicity of agricultural organophosphorus pesticides - Eddleston_2012_Toxicology_294_94 |
| Author(s) : Eddleston M , Street JM , Self I , Thompson A , King T , Williams N , Naredo G , Dissanayake K , Yu LM , Worek F , John H , Smith S , Thiermann H , Harris JB , Eddie Clutton R |
| Ref : Toxicology , 294 :94 , 2012 |
| Abstract : |
| PubMedSearch : Eddleston_2012_Toxicology_294_94 |
| PubMedID: 22365945 |
| Title : Comparative kinetics of organophosphates and oximes with erythrocyte, muscle and brain acetylcholinesterase - Herkert_2012_Toxicol.Lett_209_173 |
| Author(s) : Herkert NM , Freude G , Kunz U , Thiermann H , Worek F |
| Ref : Toxicol Lett , 209 :173 , 2012 |
| Abstract : |
| PubMedSearch : Herkert_2012_Toxicol.Lett_209_173 |
| PubMedID: 22230262 |
| Title : Reactivation kinetics of a series of related bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase--Structure-activity relationships - Worek_2012_Biochem.Pharmacol_83_1700 |
| Author(s) : Worek F , Wille T , Koller M , Thiermann H |
| Ref : Biochemical Pharmacology , 83 :1700 , 2012 |
| Abstract : |
| PubMedSearch : Worek_2012_Biochem.Pharmacol_83_1700 |
| PubMedID: 22649796 |
| Title : Detoxification of tabun at physiological pH mediated by substituted beta-cyclodextrin and glucose derivatives containing oxime groups - Brandhuber_2012_Toxicology_302_163 |
| Author(s) : Brandhuber F , Zengerle M , Porwol L , Tenberken O , Thiermann H , Worek F , Kubik S , Reiter G |
| Ref : Toxicology , 302 :163 , 2012 |
| Abstract : |
| PubMedSearch : Brandhuber_2012_Toxicology_302_163 |
| PubMedID: 22982866 |
| Title : Quantification of pralidoxime (2-PAM) in urine by ion pair chromatography-diode array detection: application to in vivo samples from minipig - John_2012_Drug.Test.Anal_4_169 |
| Author(s) : John H , Eddleston M , Eddie Clutton R , Worek F , Thiermann H |
| Ref : Drug Test Anal , 4 :169 , 2012 |
| Abstract : |
| PubMedSearch : John_2012_Drug.Test.Anal_4_169 |
| PubMedID: 22102522 |
| Title : Interaction of bispyridinium compounds with the orthosteric binding site of human alpha7 and Torpedo californica nicotinic acetylcholine receptors (nAChRs) - Niessen_2011_Toxicol.Lett_206_100 |
| Author(s) : Niessen KV , Tattersall JE , Timperley CM , Bird M , Green C , Seeger T , Thiermann H , Worek F |
| Ref : Toxicol Lett , 206 :100 , 2011 |
| Abstract : |
| PubMedSearch : Niessen_2011_Toxicol.Lett_206_100 |
| PubMedID: 21703337 |
| Title : Evaluation of the Test-mate ChE (cholinesterase) field kit in acute organophosphorus poisoning - Rajapakse_2011_Ann.Emerg.Med_58_559 |
| Author(s) : Rajapakse BN , Thiermann H , Eyer P , Worek F , Bowe SJ , Dawson AH , Buckley NA |
| Ref : Annals of Emergency Medicine , 58 :559 , 2011 |
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| PubMedSearch : Rajapakse_2011_Ann.Emerg.Med_58_559 |
| PubMedID: 22098995 |
| Title : Immobilization of Russian VX skin depots by localized cooling: implications for decontamination and medical countermeasures - Mikler_2011_Toxicol.Lett_206_47 |
| Author(s) : Mikler J , Tenn C , Worek F , Reiter G , Thiermann H , Garrett M , Bohnert S , Sawyer TW |
| Ref : Toxicol Lett , 206 :47 , 2011 |
| Abstract : |
| PubMedSearch : Mikler_2011_Toxicol.Lett_206_47 |
| PubMedID: 21704135 |
| Title : Pre- and post-treatment effect of physostigmine on soman-inhibited human erythrocyte and muscle acetylcholinesterase in vitro - Herkert_2011_Toxicol.Appl.Pharmacol_253_7 |
| Author(s) : Herkert NM , Schulz S , Wille T , Thiermann H , Hatz RA , Worek F |
| Ref : Toxicol Appl Pharmacol , 253 :7 , 2011 |
| Abstract : |
| PubMedSearch : Herkert_2011_Toxicol.Appl.Pharmacol_253_7 |
| PubMedID: 21402092 |
| Title : Simultaneous quantification of VX and its toxic metabolite in blood and plasma samples and its application for in vivo and in vitro toxicological studies - Reiter_2011_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_879_2704 |
| Author(s) : Reiter G , Mikler J , Hill I , Weatherby K , Thiermann H , Worek F |
| Ref : Journal of Chromatography B Analyt Technol Biomed Life Sciences , 879 :2704 , 2011 |
| Abstract : |
| PubMedSearch : Reiter_2011_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_879_2704 |
| PubMedID: 21862421 |
| Title : Kinetic analysis of interactions of paraoxon and oximes with human, Rhesus monkey, swine, rabbit, rat and guinea pig acetylcholinesterase - Worek_2011_Toxicol.Lett_200_19 |
| Author(s) : Worek F , Aurbek N , Wille T , Eyer P , Thiermann H |
| Ref : Toxicol Lett , 200 :19 , 2011 |
| Abstract : |
| PubMedSearch : Worek_2011_Toxicol.Lett_200_19 |
| PubMedID: 20971170 |
| Title : Kinetic prerequisites of oximes as effective reactivators of organophosphate-inhibited acetylcholinesterase: a theoretical approach - Worek_2011_J.Enzyme.Inhib.Med.Chem_26_303 |
| Author(s) : Worek F , Aurbek N , Wille T , Eyer P , Thiermann H |
| Ref : J Enzyme Inhib Med Chem , 26 :303 , 2011 |
| Abstract : |
| PubMedSearch : Worek_2011_J.Enzyme.Inhib.Med.Chem_26_303 |
| PubMedID: 20807085 |
| Title : Evaluation of 6,6'-dithionicotinic acid as alternative chromogen in a modified Ellman method--comparison in various species - Wille_2011_Toxicol.Mech.Methods_21_533 |
| Author(s) : Wille T , Thiermann H , Worek F |
| Ref : Toxicol Mech Methods , 21 :533 , 2011 |
| Abstract : |
| PubMedSearch : Wille_2011_Toxicol.Mech.Methods_21_533 |
| PubMedID: 21470076 |
| Title : The therapeutic use of localized cooling in the treatment of VX poisoning - Sawyer_2011_Toxicol.Lett_204_52 |
| Author(s) : Sawyer TW , Mikler J , Worek F , Reiter G , Thiermann H , Tenn C , Weatherby K , Bohnert S |
| Ref : Toxicol Lett , 204 :52 , 2011 |
| Abstract : |
| PubMedSearch : Sawyer_2011_Toxicol.Lett_204_52 |
| PubMedID: 21530621 |
| Title : Reactivation of organophosphate-inhibited human acetylcholinesterase by isonitrosoacetone (MINA): a kinetic analysis - Worek_2011_Chem.Biol.Interact_194_91 |
| Author(s) : Worek F , Thiermann H |
| Ref : Chemico-Biological Interactions , 194 :91 , 2011 |
| Abstract : |
| PubMedSearch : Worek_2011_Chem.Biol.Interact_194_91 |
| PubMedID: 21930118 |
| Title : Long-term evaluation of organophosphate toxicity and antidotal therapy in co-cultures of spinal cord and muscle tissue - Drexler_2011_Toxicol.Lett_206_89 |
| Author(s) : Drexler B , Seeger T , Grasshoff C , Thiermann H , Antkowiak B |
| Ref : Toxicol Lett , 206 :89 , 2011 |
| Abstract : |
| PubMedSearch : Drexler_2011_Toxicol.Lett_206_89 |
| PubMedID: 21530620 |
| Title : Anaesthetic potency of diazepam is resistant to cholinergic overstimulation - Drexler_2011_Toxicol.Lett_206_84 |
| Author(s) : Drexler B , Zinser S , Seeger T , Thiermann H , Antkowiak B , Grasshoff C |
| Ref : Toxicol Lett , 206 :84 , 2011 |
| Abstract : |
| PubMedSearch : Drexler_2011_Toxicol.Lett_206_84 |
| PubMedID: 21699965 |
| Title : Restoration of nerve agent inhibited muscle force production in human intercostal muscle strips with HI 6 - Seeger_2011_Toxicol.Lett_206_72 |
| Author(s) : Seeger T , Niessen KV , Langer P , Gerhardus J , Worek F , Friess H , Bumm R , Mihaljevic AL , Thiermann H |
| Ref : Toxicol Lett , 206 :72 , 2011 |
| Abstract : |
| PubMedSearch : Seeger_2011_Toxicol.Lett_206_72 |
| PubMedID: 21803135 |
| Title : In vitro kinetic interactions of pyridostigmine, physostigmine and soman with erythrocyte and muscle acetylcholinesterase from different species - Herkert_2011_Toxicol.Lett_206_41 |
| Author(s) : Herkert NM , Thiermann H , Worek F |
| Ref : Toxicol Lett , 206 :41 , 2011 |
| Abstract : |
| PubMedSearch : Herkert_2011_Toxicol.Lett_206_41 |
| PubMedID: 21414391 |
| Title : In vitro kinetic interactions of DEET, pyridostigmine and organophosphorus pesticides with human cholinesterases - Wille_2011_Chem.Biol.Interact_190_79 |
| Author(s) : Wille T , Thiermann H , Worek F |
| Ref : Chemico-Biological Interactions , 190 :79 , 2011 |
| Abstract : |
| PubMedSearch : Wille_2011_Chem.Biol.Interact_190_79 |
| PubMedID: 21354413 |
| Title : In vitro kinetic interactions of DEET, pyridostigmine and organophosphorus pesticides with human cholinesterases - Response to the letter to the editor - |
| Author(s) : Wille T , Thiermann H , Worek F |
| Ref : Chemico-Biological Interactions , 193 :108 , 2011 |
| PubMedID: |
| Title : Thirteenth International Medical Chemical Defence Conference 2011 New developments in the treatment of intoxications by chemical warfare agents with focus on neurotoxic agents - |
| Author(s) : Tenberken O , Worek F , Thiermann H |
| Ref : Toxicol Lett , 206 :3 , 2011 |
| PubMedID: 21605643 |
| Title : Atropine maintenance dosage in patients with severe organophosphate pesticide poisoning - Thiermann_2011_Toxicol.Lett_206_77 |
| Author(s) : Thiermann H , Steinritz D , Worek F , Radtke M , Eyer P , Eyer F , Felgenhauer N , Zilker T |
| Ref : Toxicol Lett , 206 :77 , 2011 |
| Abstract : |
| PubMedSearch : Thiermann_2011_Toxicol.Lett_206_77 |
| PubMedID: 21771644 |
| Title : In vitro detoxification of cyclosarin (GF) by modified cyclodextrins - Muller_2011_Toxicol.Lett_200_53 |
| Author(s) : Muller S , Koller M , Le Provost R , Lafont O , Estour F , Wille T , Thiermann H , Worek F , Reiter G |
| Ref : Toxicol Lett , 200 :53 , 2011 |
| Abstract : |
| PubMedSearch : Muller_2011_Toxicol.Lett_200_53 |
| PubMedID: 21035528 |
| Title : Atropine increases sevoflurane potency in cortical but not spinal networks during cholinergic overstimulation - Drexler_2010_Toxicology_268_98 |
| Author(s) : Drexler B , Antkowiak B , Thiermann H , Grasshoff C |
| Ref : Toxicology , 268 :98 , 2010 |
| Abstract : |
| PubMedSearch : Drexler_2010_Toxicology_268_98 |
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| Title : Kinetic analysis of interactions of different sarin and tabun analogues with human acetylcholinesterase and oximes: is there a structure-activity relationship? - Aurbek_2010_Chem.Biol.Interact_187_215 |
| Author(s) : Aurbek N , Herkert NM , Koller M , Thiermann H , Worek F |
| Ref : Chemico-Biological Interactions , 187 :215 , 2010 |
| Abstract : |
| PubMedSearch : Aurbek_2010_Chem.Biol.Interact_187_215 |
| PubMedID: 20105433 |
| Title : Muscle force and acetylcholinesterase activity in mouse hemidiaphragms exposed to paraoxon and treated by oximes in vitro - Thiermann_2010_Toxicology_272_46 |
| Author(s) : Thiermann H , Eyer P , Worek F |
| Ref : Toxicology , 272 :46 , 2010 |
| Abstract : |
| PubMedSearch : Thiermann_2010_Toxicology_272_46 |
| PubMedID: 20385200 |
| Title : Pharmacokinetics of obidoxime in patients poisoned with organophosphorus compounds - Thiermann_2010_Toxicol.Lett_197_236 |
| Author(s) : Thiermann H , Eyer F , Felgenhauer N , Pfab R , Zilker T , Eyer P , Worek F |
| Ref : Toxicol Lett , 197 :236 , 2010 |
| Abstract : |
| PubMedSearch : Thiermann_2010_Toxicol.Lett_197_236 |
| PubMedID: 20542100 |
| Title : Evaluation of medical countermeasures against organophosphorus compounds: the value of experimental data and computer simulations - Worek_2010_Chem.Biol.Interact_187_259 |
| Author(s) : Worek F , Aurbek N , Herkert NM , John H , Eddleston M , Eyer P , Thiermann H |
| Ref : Chemico-Biological Interactions , 187 :259 , 2010 |
| Abstract : |
| PubMedSearch : Worek_2010_Chem.Biol.Interact_187_259 |
| PubMedID: 19917271 |
| Title : High-performance liquid-chromatographic tandem-mass spectrometric methods for atropinesterase-mediated enantioselective and chiral determination of R- and S-hyoscyamine in plasma - John_2010_Anal.Chim.Acta_680_32 |
| Author(s) : John H , Eyer F , Zilker T , Thiermann H |
| Ref : Anal Chim Acta , 680 :32 , 2010 |
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| PubMedSearch : John_2010_Anal.Chim.Acta_680_32 |
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| Title : The toxicokinetics and toxicodynamics of organophosphonates versus the pharmacokinetics and pharmacodynamics of oxime antidotes: biological consequences - Voicu_2010_Basic.Clin.Pharmacol.Toxicol_106_73 |
| Author(s) : Voicu VA , Thiermann H , Radulescu FS , Mircioiu C , Miron DS |
| Ref : Basic Clin Pharmacol Toxicol , 106 :73 , 2010 |
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| PubMedSearch : Voicu_2010_Basic.Clin.Pharmacol.Toxicol_106_73 |
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| Title : Kinetic analysis of interactions between alkylene-linked bis-pyridiniumaldoximes and human acetylcholinesterases inhibited by various organophosphorus compounds - Wille_2010_Biochem.Pharmacol_80_941 |
| Author(s) : Wille T , Ekstrom F , Lee JC , Pang YP , Thiermann H , Worek F |
| Ref : Biochemical Pharmacology , 80 :941 , 2010 |
| Abstract : |
| PubMedSearch : Wille_2010_Biochem.Pharmacol_80_941 |
| PubMedID: 20510679 |
| Title : GC-MS and LC-MS analysis of nerve agents in body fluids: intra-laboratory verification test using spiked plasma and urine samples - Koller_2010_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_878_1226 |
| Author(s) : Koller M , Becker C , Thiermann H , Worek F |
| Ref : Journal of Chromatography B Analyt Technol Biomed Life Sciences , 878 :1226 , 2010 |
| Abstract : |
| PubMedSearch : Koller_2010_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_878_1226 |
| PubMedID: 20061191 |
| Title : Reactivation of organophosphate-inhibited human, Cynomolgus monkey, swine and guinea pig acetylcholinesterase by MMB-4: a modified kinetic approach - Worek_2010_Toxicol.Appl.Pharmacol_249_231 |
| Author(s) : Worek F , Wille T , Aurbek N , Eyer P , Thiermann H |
| Ref : Toxicol Appl Pharmacol , 249 :231 , 2010 |
| Abstract : |
| PubMedSearch : Worek_2010_Toxicol.Appl.Pharmacol_249_231 |
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| Title : Matrix-assisted laser desorption\/ionization time-of-flight mass spectrometry (MALDI-TOF MS) for detection and identification of albumin phosphylation by organophosphorus pesticides and G- and V-type nerve agents - John_2010_Anal.Bioanal.Chem_398_2677 |
| Author(s) : John H , Breyer F , Thumfart JO , Hochstetter H , Thiermann H |
| Ref : Anal Bioanal Chem , 398 :2677 , 2010 |
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| PubMedSearch : John_2010_Anal.Bioanal.Chem_398_2677 |
| PubMedID: 20730528 |
| Title : Simultaneous quantification of the organophosphorus pesticides dimethoate and omethoate in porcine plasma and urine by LC-ESI-MS\/MS and flow-injection-ESI-MS\/MS - John_2010_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_878_1234 |
| Author(s) : John H , Eddleston M , Clutton RE , Worek F , Thiermann H |
| Ref : Journal of Chromatography B Analyt Technol Biomed Life Sciences , 878 :1234 , 2010 |
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| PubMedSearch : John_2010_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_878_1234 |
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| Title : Toxicokinetics of tabun enantiomers in anaesthetized swine after intravenous tabun administration - Tenberken_2010_Toxicol.Lett_198_177 |
| Author(s) : Tenberken O , Mikler J , Hill I , Weatherby K , Thiermann H , Worek F , Reiter G |
| Ref : Toxicol Lett , 198 :177 , 2010 |
| Abstract : |
| PubMedSearch : Tenberken_2010_Toxicol.Lett_198_177 |
| PubMedID: 20599598 |
| Title : Chromatographic preparation and kinetic analysis of interactions between tabun enantiomers and acetylcholinesterase - Tenberken_2010_Toxicol.Lett_195_142 |
| Author(s) : Tenberken O , Thiermann H , Worek F , Reiter G |
| Ref : Toxicol Lett , 195 :142 , 2010 |
| Abstract : |
| PubMedSearch : Tenberken_2010_Toxicol.Lett_195_142 |
| PubMedID: 20347021 |
| Title : Assessment of neuromuscular dysfunction during poisoning by organophosphorus compounds - Thiermann_2010_Chem.Biol.Interact_187_265 |
| Author(s) : Thiermann H , Seeger T , Gonder S , Herkert N , Antkowiak B , Zilker T , Eyer F , Worek F |
| Ref : Chemico-Biological Interactions , 187 :265 , 2010 |
| Abstract : |
| PubMedSearch : Thiermann_2010_Chem.Biol.Interact_187_265 |
| PubMedID: 20036651 |
| Title : Paradox findings may challenge orthodox reasoning in acute organophosphate poisoning - Eyer_2010_Chem.Biol.Interact_187_270 |
| Author(s) : Eyer P , Worek F , Thiermann H , Eddleston M |
| Ref : Chemico-Biological Interactions , 187 :270 , 2010 |
| Abstract : |
| PubMedSearch : Eyer_2010_Chem.Biol.Interact_187_270 |
| PubMedID: 19883634 |
| Title : Development and validation of a sensitive gas chromatography-ammonia chemical ionization mass spectrometry method for the determination of tabun enantiomers in hemolysed blood and plasma of different species - Tenberken_2010_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_878_1290 |
| Author(s) : Tenberken O , Worek F , Thiermann H , Reiter G |
| Ref : Journal of Chromatography B Analyt Technol Biomed Life Sciences , 878 :1290 , 2010 |
| Abstract : |
| PubMedSearch : Tenberken_2010_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_878_1290 |
| PubMedID: 19766064 |
| Title : Development of a high-throughput screening for nerve agent detoxifying materials using a fully-automated robot-assisted biological assay - Wille_2010_Toxicol.In.Vitro_24_1026 |
| Author(s) : Wille T , Thiermann H , Worek F |
| Ref : Toxicol In Vitro , 24 :1026 , 2010 |
| Abstract : |
| PubMedSearch : Wille_2010_Toxicol.In.Vitro_24_1026 |
| PubMedID: 19961920 |
| Title : Comparative study of oxime-induced reactivation of erythrocyte and muscle AChE from different animal species following inhibition by sarin or paraoxon - Herkert_2010_Toxicol.Lett_194_94 |
| Author(s) : Herkert NM , Aurbek N , Eyer P , Thiermann H , Worek F |
| Ref : Toxicol Lett , 194 :94 , 2010 |
| Abstract : |
| PubMedSearch : Herkert_2010_Toxicol.Lett_194_94 |
| PubMedID: 20156534 |
| Title : Poisoning with the S-Alkyl organophosphorus insecticides profenofos and prothiofos - Eddleston_2009_QJM_102_785 |
| Author(s) : Eddleston M , Worek F , Eyer P , Thiermann H , von Meyer L , Jeganathan K , Sheriff MH , Dawson AH , Buckley NA |
| Ref : Qjm , 102 :785 , 2009 |
| Abstract : |
| PubMedSearch : Eddleston_2009_QJM_102_785 |
| PubMedID: 19737786 |
| Title : Interaction of pentylsarin analogues with human acetylcholinesterase: a kinetic study - Worek_2009_Toxicol.Lett_187_119 |
| Author(s) : Worek F , Herkert NM , Koller M , Aurbek N , Thiermann H |
| Ref : Toxicol Lett , 187 :119 , 2009 |
| Abstract : |
| PubMedSearch : Worek_2009_Toxicol.Lett_187_119 |
| PubMedID: 19429253 |
| Title : Obidoxime in acute organophosphate poisoning: 2 - PK\/PD relationships - Thiermann_2009_Clin.Toxicol.(Phila)_47_807 |
| Author(s) : Thiermann H , Worek F , Eyer P , Eyer F , Felgenhauer N , Zilker T |
| Ref : Clinical Toxicology (Phila) , 47 :807 , 2009 |
| Abstract : |
| PubMedSearch : Thiermann_2009_Clin.Toxicol.(Phila)_47_807 |
| PubMedID: 19778190 |
| Title : Monitoring of neuromuscular transmission in organophosphate pesticide-poisoned patients - Thiermann_2009_Toxicol.Lett_191_297 |
| Author(s) : Thiermann H , Zilker T , Eyer F , Felgenhauer N , Eyer P , Worek F |
| Ref : Toxicol Lett , 191 :297 , 2009 |
| Abstract : |
| PubMedSearch : Thiermann_2009_Toxicol.Lett_191_297 |
| PubMedID: 19793545 |
| Title : Comparison of the oxime-induced reactivation of rhesus monkey, swine and guinea pig erythrocyte acetylcholinesterase following inhibition by sarin or paraoxon, using a perfusion model for the real-time determination of membrane-bound acetylcholinesterase activity - Herkert_2009_Toxicology_258_79 |
| Author(s) : Herkert NM , Lallement G , Clarencon D , Thiermann H , Worek F |
| Ref : Toxicology , 258 :79 , 2009 |
| Abstract : |
| PubMedSearch : Herkert_2009_Toxicology_258_79 |
| PubMedID: 19428926 |
| Title : Suitability of human butyrylcholinesterase as therapeutic marker and pseudo catalytic scavenger in organophosphate poisoning: a kinetic analysis - Aurbek_2009_Toxicology_259_133 |
| Author(s) : Aurbek N , Thiermann H , Eyer F , Eyer P , Worek F |
| Ref : Toxicology , 259 :133 , 2009 |
| Abstract : |
| PubMedSearch : Aurbek_2009_Toxicology_259_133 |
| PubMedID: 19428953 |
| Title : Detoxification of nerve agents by a substituted beta-cyclodextrin: application of a modified biological assay - Wille_2009_Toxicology_265_96 |
| Author(s) : Wille T , Tenberken O , Reiter G , Muller S , Le Provost R , Lafont O , Estour F , Thiermann H , Worek F |
| Ref : Toxicology , 265 :96 , 2009 |
| Abstract : |
| PubMedSearch : Wille_2009_Toxicology_265_96 |
| PubMedID: 19800384 |
| Title : Extreme variability in the formation of chlorpyrifos oxon (CPO) in patients poisoned by chlorpyrifos (CPF) - Eyer_2009_Biochem.Pharmacol_78_531 |
| Author(s) : Eyer F , Roberts DM , Buckley NA , Eddleston M , Thiermann H , Worek F , Eyer P |
| Ref : Biochemical Pharmacology , 78 :531 , 2009 |
| Abstract : |
| PubMedSearch : Eyer_2009_Biochem.Pharmacol_78_531 |
| PubMedID: 19433070 |
| Title : Obidoxime in acute organophosphate poisoning: 1 - clinical effectiveness - Eyer_2009_Clin.Toxicol.(Phila)_47_798 |
| Author(s) : Eyer F , Worek F , Eyer P , Felgenhauer N , Haberkorn M , Zilker T , Thiermann H |
| Ref : Clinical Toxicology (Phila) , 47 :798 , 2009 |
| Abstract : |
| PubMedSearch : Eyer_2009_Clin.Toxicol.(Phila)_47_798 |
| PubMedID: 19778163 |
| Title : Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun. - Carletti_2009_Biochem.J_421_97 |
| Author(s) : Carletti E , Aurbek N , Gillon E , Loiodice M , Nicolet Y , Fontecilla-Camps JC , Masson P , Thiermann H , Nachon F , Worek F |
| Ref : Biochemical Journal , 421 :97 , 2009 |
| Abstract : |
| PubMedSearch : Carletti_2009_Biochem.J_421_97 |
| PubMedID: 19368529 |
| Gene_locus related to this paper: human-BCHE |
| Title : Inhibition, reactivation and aging kinetics of highly toxic organophosphorus compounds: pig versus minipig acetylcholinesterase - Worek_2008_Toxicology_244_35 |
| Author(s) : Worek F , Aurbek N , Wetherell J , Pearce P , Mann T , Thiermann H |
| Ref : Toxicology , 244 :35 , 2008 |
| Abstract : |
| PubMedSearch : Worek_2008_Toxicology_244_35 |
| PubMedID: 18054823 |
| Title : LC-MS-based procedures for monitoring of toxic organophosphorus compounds and verification of pesticide and nerve agent poisoning - John_2008_Anal.Bioanal.Chem_391_97 |
| Author(s) : John H , Worek F , Thiermann H |
| Ref : Anal Bioanal Chem , 391 :97 , 2008 |
| Abstract : |
| PubMedSearch : John_2008_Anal.Bioanal.Chem_391_97 |
| PubMedID: 18330546 |
| Title : Inhibitory potency against human acetylcholinesterase and enzymatic hydrolysis of fluorogenic nerve agent mimics by human paraoxonase 1 and squid diisopropyl fluorophosphatase - Blum_2008_Biochemistry_47_5216 |
| Author(s) : Blum MM , Timperley CM , Williams GR , Thiermann H , Worek F |
| Ref : Biochemistry , 47 :5216 , 2008 |
| Abstract : |
| PubMedSearch : Blum_2008_Biochemistry_47_5216 |
| PubMedID: 18396898 |
| Title : Chromatographic resolution, characterisation and quantification of VX enantiomers in hemolysed swine blood samples - Reiter_2008_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_873_86 |
| Author(s) : Reiter G , Mikler J , Hill I , Weatherby K , Thiermann H , Worek F |
| Ref : Journal of Chromatography B Analyt Technol Biomed Life Sciences , 873 :86 , 2008 |
| Abstract : |
| PubMedSearch : Reiter_2008_J.Chromatogr.B.Analyt.Technol.Biomed.Life.Sci_873_86 |
| PubMedID: 18718824 |
| Title : Comparison of the oxime-induced reactivation of erythrocyte and muscle acetylcholinesterase following inhibition by sarin or paraoxon, using a perfusion model for the real-time determination of membrane-bound acetylcholinesterase activity - Eckert_2008_Biochem.Pharmacol_75_698 |
| Author(s) : Eckert S , Eyer P , Herkert N , Bumm R , Weber G , Thiermann H , Worek F |
| Ref : Biochemical Pharmacology , 75 :698 , 2008 |
| Abstract : |
| PubMedSearch : Eckert_2008_Biochem.Pharmacol_75_698 |
| PubMedID: 17977518 |
| Title : Effects of oximes on rate of decarbamylation of human red blood cell AChE measured with two different methods - Eckert_2008_Biochem.Pharmacol_75_1561 |
| Author(s) : Eckert S , Eyer P , Melzer M , Thiermann H , Worek F |
| Ref : Biochemical Pharmacology , 75 :1561 , 2008 |
| Abstract : |
| PubMedSearch : Eckert_2008_Biochem.Pharmacol_75_1561 |
| PubMedID: 18281016 |
| Title : Are we using the right dose? - a tale of mole and gram - |
| Author(s) : Eyer P , Eddleston M , Thiermann H , Worek F , Buckley NA |
| Ref : British Journal of Clinical Pharmacology , 66 :451 , 2008 |
| PubMedID: 18662291 |
| Title : Identical kinetics of human erythrocyte and muscle acetylcholinesterase with respect to carbamate pre-treatment, residual activity upon soman challenge and spontaneous reactivation after withdrawal of the inhibitors - Herkert_2008_Toxicology_246_188 |
| Author(s) : Herkert NM , Eckert S , Eyer P , Bumm R , Weber G , Thiermann H , Worek F |
| Ref : Toxicology , 246 :188 , 2008 |
| Abstract : |
| PubMedSearch : Herkert_2008_Toxicology_246_188 |
| PubMedID: 18304715 |
| Title : Development of antidotes: problems and strategies - Szinicz_2007_Toxicology_233_23 |
| Author(s) : Szinicz L , Worek F , Thiermann H , Kehe K , Eckert S , Eyer P |
| Ref : Toxicology , 233 :23 , 2007 |
| Abstract : |
| PubMedSearch : Szinicz_2007_Toxicology_233_23 |
| PubMedID: 16949190 |
| Title : Red blood cell acetylcholinesterase and plasma butyrylcholinesterase status: important indicators for the treatment of patients poisoned by organophosphorus compounds - Thiermann_2007_Arh.Hig.Rada.Toksikol_58_359 |
| Author(s) : Thiermann H , Kehe K , Steinritz D , Mikler J , Hill I , Zilker T , Eyer P , Worek F |
| Ref : Arh Hig Rada Toksikol , 58 :359 , 2007 |
| Abstract : |
| PubMedSearch : Thiermann_2007_Arh.Hig.Rada.Toksikol_58_359 |
| PubMedID: 17913691 |
| Title : Anaesthesia in patients suffering from organophosphorus intoxication--interactions between general anaesthetics and acetylcholine in cortical networks in vitro - Grasshoff_2007_Toxicology_233_214 |
| Author(s) : Grasshoff C , Thiermann H , Antkowiak B |
| Ref : Toxicology , 233 :214 , 2007 |
| Abstract : |
| PubMedSearch : Grasshoff_2007_Toxicology_233_214 |
| PubMedID: 17030394 |
| Title : Enzyme-kinetic investigation of different sarin analogues reacting with human acetylcholinesterase and butyrylcholinesterase - Bartling_2007_Toxicology_233_166 |
| Author(s) : Bartling A , Worek F , Szinicz L , Thiermann H |
| Ref : Toxicology , 233 :166 , 2007 |
| Abstract : |
| PubMedSearch : Bartling_2007_Toxicology_233_166 |
| PubMedID: 16904809 |
| Title : Lessons to be learnt from organophosphorus pesticide poisoning for the treatment of nerve agent poisoning - Thiermann_2007_Toxicology_233_145 |
| Author(s) : Thiermann H , Szinicz L , Eyer P , Felgenhauer N , Zilker T , Worek F |
| Ref : Toxicology , 233 :145 , 2007 |
| Abstract : |
| PubMedSearch : Thiermann_2007_Toxicology_233_145 |
| PubMedID: 17161895 |
| Title : Reactivation of organophosphate-inhibited human AChE by combinations of obidoxime and HI 6 in vitro - Worek_2007_J.Appl.Toxicol_27_582 |
| Author(s) : Worek F , Aurbek N , Thiermann H |
| Ref : J Appl Toxicol , 27 :582 , 2007 |
| Abstract : |
| PubMedSearch : Worek_2007_J.Appl.Toxicol_27_582 |
| PubMedID: 17370251 |
| Title : Recent advances in evaluation of oxime efficacy in nerve agent poisoning by in vitro analysis - Worek_2007_Toxicol.Appl.Pharmacol_219_226 |
| Author(s) : Worek F , Eyer P , Aurbek N , Szinicz L , Thiermann H |
| Ref : Toxicol Appl Pharmacol , 219 :226 , 2007 |
| Abstract : |
| PubMedSearch : Worek_2007_Toxicol.Appl.Pharmacol_219_226 |
| PubMedID: 17112559 |
| Title : Simulation of cholinesterase status at different scenarios of nerve agent exposure - Worek_2007_Toxicology_233_155 |
| Author(s) : Worek F , Eyer P , Szinicz L , Thiermann H |
| Ref : Toxicology , 233 :155 , 2007 |
| Abstract : |
| PubMedSearch : Worek_2007_Toxicology_233_155 |
| PubMedID: 16904807 |
| Title : Reevaluation of indirect field stimulation technique to demonstrate oxime effectiveness in OP-poisoning in muscles in vitro - Seeger_2007_Toxicology_233_209 |
| Author(s) : Seeger T , Worek F , Szinicz L , Thiermann H |
| Ref : Toxicology , 233 :209 , 2007 |
| Abstract : |
| PubMedSearch : Seeger_2007_Toxicology_233_209 |
| PubMedID: 17250944 |
| Title : Kinetic analysis of reactivation and aging of human acetylcholinesterase inhibited by different phosphoramidates - Worek_2007_Biochem.Pharmacol_73_1807 |
| Author(s) : Worek F , Aurbek N , Koller M , Becker C , Eyer P , Thiermann H |
| Ref : Biochemical Pharmacology , 73 :1807 , 2007 |
| Abstract : |
| PubMedSearch : Worek_2007_Biochem.Pharmacol_73_1807 |
| PubMedID: 17382909 |
| Title : Testing of antidotes for organophosphorus compounds: experimental procedures and clinical reality - Eyer_2007_Toxicology_233_108 |
| Author(s) : Eyer P , Szinicz L , Thiermann H , Worek F , Zilker T |
| Ref : Toxicology , 233 :108 , 2007 |
| Abstract : |
| PubMedSearch : Eyer_2007_Toxicology_233_108 |
| PubMedID: 17010492 |
| Title : Analysis of inhibition, reactivation and aging kinetics of highly toxic organophosphorus compounds with human and pig acetylcholinesterase - Aurbek_2006_Toxicology_224_91 |
| Author(s) : Aurbek N , Thiermann H , Szinicz L , Eyer P , Worek F |
| Ref : Toxicology , 224 :91 , 2006 |
| Abstract : |
| PubMedSearch : Aurbek_2006_Toxicology_224_91 |
| PubMedID: 16720069 |
| Title : Application of kinetic-based computer modelling to evaluate the efficacy of HI 6 in percutaneous VX poisoning - Aurbek_2006_Toxicology_224_74 |
| Author(s) : Aurbek N , Thiermann H , Szinicz L , Eyer P , Worek F |
| Ref : Toxicology , 224 :74 , 2006 |
| Abstract : |
| PubMedSearch : Aurbek_2006_Toxicology_224_74 |
| PubMedID: 16740352 |
| Title : Effects of oximes on muscle force and acetylcholinesterase activity in isolated mouse hemidiaphragms exposed to paraoxon - Thiermann_2005_Toxicology_214_190 |
| Author(s) : Thiermann H , Eyer P , Worek F , Szinicz L |
| Ref : Toxicology , 214 :190 , 2005 |
| Abstract : |
| PubMedSearch : Thiermann_2005_Toxicology_214_190 |
| PubMedID: 16040183 |
| Title : Correlation between red blood cell acetylcholinesterase activity and neuromuscular transmission in organophosphate poisoning - Thiermann_2005_Chem.Biol.Interact_157-158_345 |
| Author(s) : Thiermann H , Szinicz L , Eyer P , Zilker T , Worek F |
| Ref : Chemico-Biological Interactions , 157-158 :345 , 2005 |
| Abstract : |
| PubMedSearch : Thiermann_2005_Chem.Biol.Interact_157-158_345 |
| PubMedID: 16263103 |
| Title : Evaluation of oxime efficacy in nerve agent poisoning: development of a kinetic-based dynamic model - Worek_2005_Toxicol.Appl.Pharmacol_209_193 |
| Author(s) : Worek F , Szinicz L , Eyer P , Thiermann H |
| Ref : Toxicol Appl Pharmacol , 209 :193 , 2005 |
| Abstract : |
| PubMedSearch : Worek_2005_Toxicol.Appl.Pharmacol_209_193 |
| PubMedID: 15904945 |
| Title : Diagnostic aspects of organophosphate poisoning - Worek_2005_Toxicology_214_182 |
| Author(s) : Worek F , Koller M , Thiermann H , Szinicz L |
| Ref : Toxicology , 214 :182 , 2005 |
| Abstract : |
| PubMedSearch : Worek_2005_Toxicology_214_182 |
| PubMedID: 16051411 |
| Title : Effect of metoclopramide and ranitidine on the inhibition of human AChE by VX in vitro - Bartling_2005_J.Appl.Toxicol_25_568 |
| Author(s) : Bartling A , Thiermann H , Szinicz L , Worek F |
| Ref : J Appl Toxicol , 25 :568 , 2005 |
| Abstract : |
| PubMedSearch : Bartling_2005_J.Appl.Toxicol_25_568 |
| PubMedID: 16167316 |
| Title : Estimation of oxime efficacy in nerve agent poisoning: a kinetic approach - Worek_2005_Chem.Biol.Interact_157-158_349 |
| Author(s) : Worek F , Szinicz L , Thiermann H |
| Ref : Chemico-Biological Interactions , 157-158 :349 , 2005 |
| Abstract : |
| PubMedSearch : Worek_2005_Chem.Biol.Interact_157-158_349 |
| PubMedID: 16266695 |
| Title : Reactivation and aging kinetics of human acetylcholinesterase inhibited by organophosphonylcholines - Worek_2004_Arch.Toxicol_78_212 |
| Author(s) : Worek F , Thiermann H , Szinicz L |
| Ref : Archives of Toxicology , 78 :212 , 2004 |
| Abstract : |
| PubMedSearch : Worek_2004_Arch.Toxicol_78_212 |
| PubMedID: 14647978 |
| Title : Kinetic analysis of interactions between human acetylcholinesterase, structurally different organophosphorus compounds and oximes - Worek_2004_Biochem.Pharmacol_68_2237 |
| Author(s) : Worek F , Thiermann H , Szinicz L , Eyer P |
| Ref : Biochemical Pharmacology , 68 :2237 , 2004 |
| Abstract : |
| PubMedSearch : Worek_2004_Biochem.Pharmacol_68_2237 |
| PubMedID: 15498514 |
| Title : The effect of acetylcholinesterase-inhibition on depolarization-induced GABA release from rat striatal slices - Grasshoff_2003_Toxicology_184_149 |
| Author(s) : Grasshoff C , Gillessen T , Thiermann H , Wagner E , Szinicz L |
| Ref : Toxicology , 184 :149 , 2003 |
| Abstract : |
| PubMedSearch : Grasshoff_2003_Toxicology_184_149 |
| PubMedID: 12499118 |
| Title : Human parathion poisoning. A toxicokinetic analysis - Eyer_2003_Toxicol.Rev_22_143 |
| Author(s) : Eyer F , Meischner V , Kiderlen D , Thiermann H , Worek F , Haberkorn M , Felgenhauer N , Zilker T , Eyer P |
| Ref : Toxicol Rev , 22 :143 , 2003 |
| Abstract : |
| PubMedSearch : Eyer_2003_Toxicol.Rev_22_143 |
| PubMedID: 15181664 |
| Title : Equipotent cholinesterase reactivation in vitro by the nerve agent antidotes HI 6 dichloride and HI 6 dimethanesulfonate - Krummer_2002_Arch.Toxicol_76_589 |
| Author(s) : Krummer S , Thiermann H , Worek F , Eyer P |
| Ref : Archives of Toxicology , 76 :589 , 2002 |
| Abstract : |
| PubMedSearch : Krummer_2002_Arch.Toxicol_76_589 |
| PubMedID: 12373455 |
| Title : Internal standard high-performance liquid chromatography method for the determination of obidoxime in urine of organophosphate-poisoned patients - Grasshoff_2001_J.Chromatogr.B.Biomed.Sci.Appl_753_203 |
| Author(s) : Grasshoff C , Thiermann H , Gillessen T , Zilker T , Szinicz L |
| Ref : Journal of Chromatography B Biomed Sci Appl , 753 :203 , 2001 |
| Abstract : |
| PubMedSearch : Grasshoff_2001_J.Chromatogr.B.Biomed.Sci.Appl_753_203 |
| PubMedID: 11334332 |
| Title : Effect of human plasma on the reactivation of sarin-inhibited human erythrocyte acetylcholinesterase - Worek_2000_Arch.Toxicol_74_21 |
| Author(s) : Worek F , Eyer P , Kiderlen D , Thiermann H , Szinicz L |
| Ref : Archives of Toxicology , 74 :21 , 2000 |
| Abstract : |
| PubMedSearch : Worek_2000_Arch.Toxicol_74_21 |
| PubMedID: 10817663 |
| Title : Modern strategies in therapy of organophosphate poisoning - Thiermann_1999_Toxicol.Lett_107_233 |
| Author(s) : Thiermann H , Szinicz L , Eyer F , Worek F , Eyer P , Felgenhauer N , Zilker T |
| Ref : Toxicol Lett , 107 :233 , 1999 |
| Abstract : |
| PubMedSearch : Thiermann_1999_Toxicol.Lett_107_233 |
| PubMedID: 10414801 |
| Title : Acetylcholinesterase, a Versatile Protein - |
| Author(s) : Szinicz L , Thiermann H , Worek F , Eyer P |
| Ref : In: Structure and Function of Cholinesterases and Related Proteins - Proceedings of Sixth International Meeting on Cholinesterases , (Doctor, B.P., Taylor, P., Quinn, D.M., Rotundo, R.L., Gentry, M.K. Eds) Plenum Publishing Corp. :269 , 1998 |
| PubMedID: |
| Title : Cholinesterase status, pharmacokinetics and laboratory findings during obidoxime therapy in organophosphate poisoned patients - Thiermann_1997_Hum.Exp.Toxicol_16_473 |
| Author(s) : Thiermann H , Mast U , Klimmek R , Eyer P , Hibler A , Pfab R , Felgenhauer N , Zilker T |
| Ref : Hum Exp Toxicol , 16 :473 , 1997 |
| Abstract : |
| PubMedSearch : Thiermann_1997_Hum.Exp.Toxicol_16_473 |
| PubMedID: 9292288 |
| Title : Factors influencing the efficacy of obidoxime in organophosphate pesticides poisoning [editorial] - |
| Author(s) : Zilker T , Felgenhauer N , Hibler A , Pfab R , Thiermann H , Worek F , Eyer P |
| Ref : Przegl Lek , 54 :662 , 1997 |
| PubMedID: 9478082 |
| Title : Reappraisal of indications and limitations of oxime therapy in organophosphate poisoning - Worek_1997_Hum.Exp.Toxicol_16_466 |
| Author(s) : Worek F , Backer M , Thiermann H , Szinicz L , Mast U , Klimmek R , Eyer P |
| Ref : Hum Exp Toxicol , 16 :466 , 1997 |
| Abstract : |
| PubMedSearch : Worek_1997_Hum.Exp.Toxicol_16_466 |
| PubMedID: 9292287 |
| Title : Pharmacokinetics of atropine in dogs after i.m. injection with newly developed dry\/wet combination autoinjectors containing HI 6 or HLo 7 - Thiermann_1996_Arch.Toxicol_70_293 |
| Author(s) : Thiermann H , Radtke M , Spohrer U , Klimmek R , Eyer P |
| Ref : Archives of Toxicology , 70 :293 , 1996 |
| Abstract : |
| PubMedSearch : Thiermann_1996_Arch.Toxicol_70_293 |
| PubMedID: 8852700 |
| Title : HI 6 dimethanesulfonate has better dissolution properties than HI 6 dichloride for application in dry\/wet autoinjectors - Thiermann_1996_Int.J.Pharm_137_167 |
| Author(s) : Thiermann H , Seidl S , Eyer P |
| Ref : Int J Pharm , 137 :167 , 1996 |
| Abstract : |
| PubMedSearch : Thiermann_1996_Int.J.Pharm_137_167 |
| PubMedID: |
| Title : Pharmacokinetics of the oximes HI 6 and HLo 7 in dogs after i.m. injection with newly developed dry\/wet autoinjectors - Spohrer_1994_Arch.Toxicol_68_480 |
| Author(s) : Spohrer U , Thiermann H , Klimmek R , Eyer P |
| Ref : Archives of Toxicology , 68 :480 , 1994 |
| Abstract : |
| PubMedSearch : Spohrer_1994_Arch.Toxicol_68_480 |
| PubMedID: 7802588 |