| Title : Identification of Reversible Small Molecule Inhibitors of Endothelial Lipase (EL) That Demonstrate HDL-C Increase In Vivo - Tora_2020_J.Med.Chem_63_1660 |
| Author(s) : Tora G , Kim SH , Pi Z , Johnson JA , Jiang J , Phillips M , Lloyd J , Abell LM , Lu H , Locke G , Adam LP , Taylor DS , Yin X , Behnia K , Zhao L , Yang R , Basso M , Caporuscio C , Chen AY , Liu E , Kirshgessner T , Onorato JM , Ryan C , Traeger SC , Gordon D , Wexler RR , Finlay HJ |
| Ref : Journal of Medicinal Chemistry , 63 :1660 , 2020 |
| Abstract : |
| PubMedSearch : Tora_2020_J.Med.Chem_63_1660 |
| PubMedID: 31990537 |
| Title : Benzothiazole-based compounds as potent endothelial lipase inhibitors - Meng_2019_Bioorg.Med.Chem.Lett__126673 |
| Author(s) : Meng W , Adam LP , Behnia K , Zhao L , Yang R , Kopcho LM , Locke GA , Taylor DS , Yin X , Wexler RR , Finlay H |
| Ref : Bioorganic & Medicinal Chemistry Lett , :126673 , 2019 |
| Abstract : |
| PubMedSearch : Meng_2019_Bioorg.Med.Chem.Lett__126673 |
| PubMedID: 31519373 |
| Gene_locus related to this paper: human-LIPG |
| Title : Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase - Kim_2019_Bioorg.Med.Chem.Lett_29_1918 |
| Author(s) : Kim SH , Johnson JA , Jiang J , Parkhurst B , Phillips M , Pi Z , Qiao JX , Tora G , Ye Chen A , Liu E , Yin X , Yang R , Zhao L , Taylor DS , Basso M , Behnia K , Onorato J , Chen XQ , Abell LM , Lu H , Locke G , Caporuscio C , Adam LP , Gordon D , Wexler RR , Finlay HJ |
| Ref : Bioorganic & Medicinal Chemistry Lett , 29 :1918 , 2019 |
| Abstract : |
| PubMedSearch : Kim_2019_Bioorg.Med.Chem.Lett_29_1918 |
| PubMedID: 31176700 |
| Gene_locus related to this paper: human-LIPG |
| Title : Discovery and synthesis of tetrahydropyrimidinedione-4-carboxamides as endothelial lipase inhibitors - Hu_2018_Bioorg.Med.Chem.Lett_28_3721 |
| Author(s) : Hu CH , Wang TC , Qiao JX , Haque L , Chen AYA , Taylor DS , Ying X , Onorato JM , Galella M , Shen H , Huang CS , Toussaint N , Li YX , Abell L , Adam LP , Gordon D , Wexler RR , Finlay HJ |
| Ref : Bioorganic & Medicinal Chemistry Lett , 28 :3721 , 2018 |
| Abstract : |
| PubMedSearch : Hu_2018_Bioorg.Med.Chem.Lett_28_3721 |
| PubMedID: 30348490 |
| Title : PK\/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor - Hangeland_2018_ACS.Med.Chem.Lett_9_673 |
| Author(s) : Hangeland JJ , Abell LM , Adam LP , Jiang J , Friends TJ , Haque LE , Neels J , Onorato JM , Chen AYA , Taylor DS , Yin X , Harrity TW , Basso MD , Yang R , Sleph PG , Gordon DA , Huang CS , Wexler RR , Finlay HJ , Lawrence RM |
| Ref : ACS Med Chem Lett , 9 :673 , 2018 |
| Abstract : |
| PubMedSearch : Hangeland_2018_ACS.Med.Chem.Lett_9_673 |
| PubMedID: 30034599 |
| Gene_locus related to this paper: human-LIPG |
| Title : Sulfonylated Benzothiazoles as Inhibitors of Endothelial Lipase - Johnson_2018_ACS.Med.Chem.Lett_9_1263 |
| Author(s) : Johnson JA , Tora G , Pi Z , Phillips M , Yin X , Yang R , Zhao L , Chen AY , Taylor DS , Basso M , Rose A , Behnia K , Onorato J , Chen XQ , Abell LM , Lu H , Locke G , Caporuscio C , Galella M , Adam LP , Gordon D , Wexler RR , Finlay HJ |
| Ref : ACS Med Chem Lett , 9 :1263 , 2018 |
| Abstract : |
| PubMedSearch : Johnson_2018_ACS.Med.Chem.Lett_9_1263 |
| PubMedID: 30613337 |
| Gene_locus related to this paper: human-LIPG |