| Title : From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease - Brown_2021_Cell_184_5886 |
| Author(s) : Brown AJH , Bradley SJ , Marshall FH , Brown GA , Bennett KA , Brown J , Cansfield JE , Cross DM , de Graaf C , Hudson BD , Dwomoh L , Dias JM , Errey JC , Hurrell E , Liptrot J , Mattedi G , Molloy C , Nathan PJ , Okrasa K , Osborne G , Patel JC , Pickworth M , Robertson N , Shahabi S , Bundgaard C , Phillips K , Broad LM , Goonawardena AV , Morairty SR , Browning M , Perini F , Dawson GR , Deakin JFW , Smith RT , Sexton PM , Warneck J , Vinson M , Tasker T , Tehan BG , Teobald B , Christopoulos A , Langmead CJ , Jazayeri A , Cooke RM , Rucktooa P , Congreve MS , Weir M , Tobin AB |
| Ref : Cell , 184 :5886 , 2021 |
| Abstract : Brown_2021_Cell_184_5886 |
| ESTHER : Brown_2021_Cell_184_5886 |
| PubMedSearch : Brown_2021_Cell_184_5886 |
| PubMedID: 34822784 |
| Title : Orthosteric and allosteric modes of interaction of novel selective agonists of the M1 muscarinic acetylcholine receptor - Avlani_2010_Mol.Pharmacol_78_94 |
| Author(s) : Avlani VA , Langmead CJ , Guida E , Wood MD , Tehan BG , Herdon HJ , Watson JM , Sexton PM , Christopoulos A |
| Ref : Molecular Pharmacology , 78 :94 , 2010 |
| Abstract : Avlani_2010_Mol.Pharmacol_78_94 |
| ESTHER : Avlani_2010_Mol.Pharmacol_78_94 |
| PubMedSearch : Avlani_2010_Mol.Pharmacol_78_94 |
| PubMedID: 20413650 |
| Title : Mutagenic mapping suggests a novel binding mode for selective agonists of M1 muscarinic acetylcholine receptors - Lebon_2009_Mol.Pharmacol_75_331 |
| Author(s) : Lebon G , Langmead CJ , Tehan BG , Hulme EC |
| Ref : Molecular Pharmacology , 75 :331 , 2009 |
| Abstract : Lebon_2009_Mol.Pharmacol_75_331 |
| ESTHER : Lebon_2009_Mol.Pharmacol_75_331 |
| PubMedSearch : Lebon_2009_Mol.Pharmacol_75_331 |
| PubMedID: 19001633 |
| Title : Roof and floor of the muscarinic binding pocket: variations in the binding modes of orthosteric ligands - Goodwin_2007_Mol.Pharmacol_72_1484 |
| Author(s) : Goodwin JA , Hulme EC , Langmead CJ , Tehan BG |
| Ref : Molecular Pharmacology , 72 :1484 , 2007 |
| Abstract : Goodwin_2007_Mol.Pharmacol_72_1484 |
| ESTHER : Goodwin_2007_Mol.Pharmacol_72_1484 |
| PubMedSearch : Goodwin_2007_Mol.Pharmacol_72_1484 |
| PubMedID: 17848601 |