Yoshikawa T

References (8)

Title : Improved identification of tumors in 18F-FDG-PET examination by normalizing the standard uptake in the liver based on blood test data - Alam_2024_Int.J.Comput.Assist.Radiol.Surg__
Author(s) : Alam MA , Hanaoka S , Nomura Y , Kikuchi T , Nakao T , Takenaga T , Hayashi N , Yoshikawa T , Abe O
Ref : Int J Comput Assist Radiol Surg , : , 2024
Abstract : PURPOSE: Standardized uptake values (SUVs) derived from (18)F-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography are a crucial parameter for identifying tumors or abnormalities in an organ. Moreover, exploring ways to improve the identification of tumors or abnormalities using a statistical measurement tool is important in clinical research. Therefore, we developed a fully automatic method to create a personally normalized Z-score map of the liver SUV. METHODS: The normalized Z-score map for each patient was created using the SUV mean and standard deviation estimated from blood-test-derived variables, such as alanine aminotransferase and aspartate aminotransferase, as well as other demographic information. This was performed using the least absolute shrinkage and selection operator (LASSO)-based estimation formula. We also used receiver operating characteristic (ROC) to analyze the results of people with and without hepatic tumors and compared them to the ROC curve of normal SUV. RESULTS: A total of 7757 people were selected for this study. Of these, 7744 were healthy, while 13 had abnormalities. The area under the ROC curve results indicated that the anomaly detection approach (0.91) outperformed only the maximum SUV (0.89). To build the LASSO regression, sets of covariates, including sex, weight, body mass index, blood glucose level, triglyceride, total cholesterol, gamma-glutamyl transpeptidase, total protein, creatinine, insulin, albumin, and cholinesterase, were used to determine the SUV mean, whereas weight was used to determine the SUV standard deviation. CONCLUSION: The Z-score normalizes the mean and standard deviation. It is effective in ROC curve analysis and increases the clarity of the abnormality. This normalization is a key technique for effective measurement of maximum glucose consumption by tumors in the liver.
ESTHER : Alam_2024_Int.J.Comput.Assist.Radiol.Surg__
PubMedSearch : Alam_2024_Int.J.Comput.Assist.Radiol.Surg__
PubMedID: 38180621

Title : Identification of a Novel Mutation in Carboxyl Ester Lipase Gene in a Patient with MODY-like Diabetes - Kondoh_2022_Tohoku.J.Exp.Med_256_37
Author(s) : Kondoh T , Nakajima Y , Yokoi K , Matsumoto Y , Inagaki H , Kato T , Ito T , Yoshikawa T , Kurahashi H
Ref : Tohoku J Exp Med , 256 :37 , 2022
Abstract : Maturity-onset diabetes of the young (MODY) is a form of diabetes mellitus characterized by autosomal dominant inheritance, early onset, and the absence of pancreatic autoimmune markers. MODY-causing mutations have been identified in 14 genes, and carboxyl ester lipase (CEL) has been implicated in MODY8. We report a Japanese patient with MODY who harbored a heterogeneous mutation in CEL exon 2 (NM_001807.4:c.146_147delCT; NP_001798.2:p.Ser49CysfsTer52). A 13-year-old girl experienced her first episode of diabetic ketoacidosis, during which her endogenous insulin secretion was poor. However, her insulin secretion had apparently recovered 2 months after the commencement of insulin treatment, and no further treatment was required for the following 2 years. Diabetic ketoacidosis recurred when the patient was 15 years old, when her insulin secretion was again poor. Since that time, the patient, who is now 18 years old, has been undergoing continuous insulin treatment. The large fluctuations in her insulin secretory capacity led us to suspect MODY. MODY8 patients that carry a mutation in the variable number of tandem repeats in the last exon of the CEL gene typically show pancreatic exocrine dysfunction. However, in the present case, which features premature termination, there is no involvement of exocrine dysfunction, potentially demonstrating a genotype-phenotype correlation.
ESTHER : Kondoh_2022_Tohoku.J.Exp.Med_256_37
PubMedSearch : Kondoh_2022_Tohoku.J.Exp.Med_256_37
PubMedID: 35082198
Gene_locus related to this paper: human-CEL

Title : Key role of soluble epoxide hydrolase in the neurodevelopmental disorders of offspring after maternal immune activation - Ma_2019_Proc.Natl.Acad.Sci.U.S.A_116_7083
Author(s) : Ma M , Ren Q , Yang J , Zhang K , Xiong Z , Ishima T , Pu Y , Hwang SH , Toyoshima M , Iwayama Y , Hisano Y , Yoshikawa T , Hammock BD , Hashimoto K
Ref : Proc Natl Acad Sci U S A , 116 :7083 , 2019
Abstract : Maternal infection during pregnancy increases risk of neurodevelopmental disorders such as schizophrenia and autism spectrum disorder (ASD) in offspring. In rodents, maternal immune activation (MIA) yields offspring with schizophrenia- and ASD-like behavioral abnormalities. Soluble epoxide hydrolase (sEH) plays a key role in inflammation associated with neurodevelopmental disorders. Here we found higher levels of sEH in the prefrontal cortex (PFC) of juvenile offspring after MIA. Oxylipin analysis showed decreased levels of epoxy fatty acids in the PFC of juvenile offspring after MIA, supporting increased activity of sEH in the PFC of juvenile offspring. Furthermore, expression of sEH (or EPHX2) mRNA in induced pluripotent stem cell-derived neurospheres from schizophrenia patients with the 22q11.2 deletion was higher than that of healthy controls. Moreover, the expression of EPHX2 mRNA in postmortem brain samples (Brodmann area 9 and 40) from ASD patients was higher than that of controls. Treatment with 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl)urea (TPPU), a potent sEH inhibitor, in juvenile offspring from prenatal day (P) 28 to P56 could prevent cognitive deficits and loss of parvalbumin (PV) immunoreactivity in the medial PFC of adult offspring after MIA. In addition, dosing of TPPU to pregnant mothers from E5 to P21 could prevent cognitive deficits, and social interaction deficits and PV immunoreactivity in the medial prefrontal cortex of juvenile offspring after MIA. These findings suggest that increased activity of sEH in the PFC plays a key role in the etiology of neurodevelopmental disorders in offspring after MIA. Therefore, sEH represents a promising prophylactic or therapeutic target for neurodevelopmental disorders in offspring after MIA.
ESTHER : Ma_2019_Proc.Natl.Acad.Sci.U.S.A_116_7083
PubMedSearch : Ma_2019_Proc.Natl.Acad.Sci.U.S.A_116_7083
PubMedID: 30890645

Title : Pepsinogen I\/II ratio is related to glucose, triacylglycerol, and uric acid levels - Tanaka_2012_Nutrition_28_418
Author(s) : Tanaka M , Fukui M , Kuroda M , Yamazaki M , Hasegawa G , Oda Y , Naito Y , Toda H , Yoshikawa T , Nakamura N
Ref : Nutrition , 28 :418 , 2012
Abstract : OBJECTIVE: Under- and overnutrition are associated with a worse prognosis and constitute independent risk factors for morbidity and mortality. It is increasingly important to understand the factors that affect nutritional and metabolic statuses. The purpose of this study was to assess the relation between the pepsinogen I/II ratio and several biochemical markers. METHODS: A cross-sectional study was performed in 1985 subjects who underwent a health screening test. Subjects had no medications for hyperuricemia, dyslipidemia, diabetes mellitus, or hypertension. All subjects were classified into two groups. Subjects with a pepsinogen I/II ratio below 3 were defined as having atrophic gastritis. The relations between the pepsinogen I/II ratio and several biochemical markers, including total cholesterol, triacylglycerol, uric acid, cholinesterase, and glucose levels, were evaluated. RESULTS: The presence of atrophic gastritis was significantly associated with age, smoking status, alcohol consumption, body mass index, and triacylglycerol, uric acid, cholinesterase, and hemoglobin levels. Multiple linear regression analysis demonstrated that the pepsinogen I/II ratio was an independent determinant of glucose level (beta = 0.104, P < 0.0001), triacylglycerol level (beta = 0.072, P = 0.0014), uric acid level (beta = 0.048, P = 0.0138), and hemoglobin (beta = 0.037, P = 0.0429) after adjustments for age, sex, smoking status, alcohol consumption, and body mass index. CONCLUSION: The pepsinogen I/II ratio was related to glucose, triacylglycerol, and uric acid levels. Such an association fosters the idea that a decreased pepsinogen I/II ratio seems favorable for the prevention of overnutrition.
ESTHER : Tanaka_2012_Nutrition_28_418
PubMedSearch : Tanaka_2012_Nutrition_28_418
PubMedID: 22304859

Title : Data on Wistar Hannover rats from a general toxicity study - Yamatoya_2012_Exp.Anim_61_467
Author(s) : Yamatoya H , Kawaguchi H , Yajima K , Kadokura H , Yoshikawa T , Yamashita R , Shiraishi M , Miyamoto A , Miyoshi N
Ref : Exp Anim , 61 :467 , 2012
Abstract : The aim of this study was to collect data on chronological changes in clinical laboratory tests, pathological examinations, and hepatic drug-metabolizing enzymes from Wistar Hannover rats at 8, 10, 19, and 32 weeks of age. The serum triglyceride concentration and the serum LDL cholesterol level were higher in males than in females at all ages. In contrast, serum total protein and creatinine concentrations and cholinesterase activity were lower in males than in females. In addition, sex differences were confirmed in pituitary weight and hepatic CYP3A2 and CYP2C11 activities. In conclusion, the general toxicological data noted in clinical laboratory tests, pathological examinations, and hepatic drug-metabolizing enzymes relating to chronological changes and sex differences may be useful in assessing drug-related toxicity in this strain.
ESTHER : Yamatoya_2012_Exp.Anim_61_467
PubMedSearch : Yamatoya_2012_Exp.Anim_61_467
PubMedID: 22850647

Title : Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)\/Lep(ob) mice - Yahagi_2002_J.Biol.Chem_277_19353
Author(s) : Yahagi N , Shimano H , Hasty AH , Matsuzaka T , Ide T , Yoshikawa T , Amemiya-Kudo M , Tomita S , Okazaki H , Tamura Y , Iizuka Y , Ohashi K , Osuga J , Harada K , Gotoda T , Nagai R , Ishibashi S , Yamada N
Ref : Journal of Biological Chemistry , 277 :19353 , 2002
Abstract : Obesity is a common nutritional problem often associated with diabetes, insulin resistance, and fatty liver (excess fat deposition in liver). Leptin-deficient Lep(ob)/Lep(ob) mice develop obesity and those obesity-related syndromes. Increased lipogenesis in both liver and adipose tissue of these mice has been suggested. We have previously shown that the transcription factor sterol regulatory element-binding protein-1 (SREBP-1) plays a crucial role in the regulation of lipogenesis in vivo. To explore the possible involvement of SREBP-1 in the pathogenesis of obesity and its related syndromes, we generated mice deficient in both leptin and SREBP-1. In doubly mutant Lep(ob/ob) x Srebp-1(-/-) mice, fatty livers were markedly attenuated, but obesity and insulin resistance remained persistent. The mRNA levels of lipogenic enzymes such as fatty acid synthase were proportional to triglyceride accumulation in liver. In contrast, the mRNA abundance of SREBP-1 and lipogenic enzymes in the adipose tissue of Lep(ob)/Lep(ob) mice was profoundly decreased despite sustained fat, which could explain why the SREBP-1 disruption had little effect on obesity. In conclusion, SREBP-1 regulation of lipogenesis is highly involved in the development of fatty livers but does not seem to be a determinant of obesity in Lep(ob)/Lep(ob) mice.
ESTHER : Yahagi_2002_J.Biol.Chem_277_19353
PubMedSearch : Yahagi_2002_J.Biol.Chem_277_19353
PubMedID: 11923308

Title : New acetylcholinesterase inhibitor (donepezil) treatment for Alzheimer's disease in a chronic dialysis patient - Suwata_2002_Nephron_91_330
Author(s) : Suwata J , Kamata K , Nishijima T , Yoshikawa T , Sano M
Ref : Nephron , 91 :330 , 2002
Abstract : The new-generation acetylcholinesterase inhibitor, donepezil, is useful in the treatment of mild-to-moderate Alzheimer's disease. A 72-year-old male chronic hemodialysis patient was diagnosed as having moderate Alzheimer's disease. We administered donepezil at 3 mg/day orally to the patient. After 1 month's treatment, the patient improved to a controllable psychiatric condition and was discharged from the hospital. The 24-hour plasma concentration profile of donepezil following the 3-mg once-daily dose varied from 11.1 to 18.2 ng/ml. The through level of donepezil was reduced from 12.4 to 10.9 ng/ml over a 3-month period. We did not experience any episodes of drug toxicity or adverse effects in this chronic dialysis patient. Donepezil treatment might have a beneficial impact on patients with severe renal dysfunction.
ESTHER : Suwata_2002_Nephron_91_330
PubMedSearch : Suwata_2002_Nephron_91_330
PubMedID: 12053074

Title : The effect of previous administration of nizatidine on the neuromuscular effects of vecuronium and the effect of nizatidine on gastric secretion - Wajima_2000_Anaesth.Intensive.Care_28_46
Author(s) : Wajima Z , Shitara T , Inoue T , Yoshikawa T , Ogawa R
Ref : Anaesthesia & Intensive Care , 28 :46 , 2000
Abstract : Nizatidine, a new H2-receptor antagonist, has been reported to inhibit acetylcholinesterase activity. This could lead to an interaction with neuromuscular blocking drugs. This study examined the effects of nizatidine on the actions of vecuronium. Oral nizatidine has been reported to be an effective protective agent against acid aspiration syndrome, and we reevaluated this effect. The control group (n = 10) received a placebo with water 50 ml and the nizatidine group (n = 10) received nizatidine 300 mg with water 50 ml two hours before arrival in the operating room. Gastric contents were aspirated and the volume and pH measured before induction of anaesthesia. Anaesthesia was induced in all patients with thiopentone 5 mg/kg and 1.5% isoflurane in 98.5% oxygen followed by vecuronium 0.1 mg/kg. Vecuronium onset time and duration time 25 (time from injection until recovery of 25% of vaseline twitch amplitude) were obtained using electromyography. There were no significant differences between the two groups in vecuronium onset time or duration time 25. Gastric fluid volume was greater and gastric pH was lower in the control group than in the nizatidine group. 70% of the control group and none of the nizatidine group (P < 0.005) had a gastric content pH < 2.5 or volume > 25 ml.
ESTHER : Wajima_2000_Anaesth.Intensive.Care_28_46
PubMedSearch : Wajima_2000_Anaesth.Intensive.Care_28_46
PubMedID: 10701036