human-CEL
Homo sapiens (Human) bile-salt-activated lipase, BSSL BAL CEL CEH carboxyl ester lipase chr 9
Comment
The human lactating mammary gland and pancreas produce a lipolytic enzyme, carboxyl-ester lipase, earlier called bile salt-stimulated lipase. Carboxyl-ester lipase is a major component of pancreatic juice and is responsible for the hydrolysis of cholesterol esters as well as a variety of other dietary esters. The enzyme exerts its function in duodenal juice, is activated when mixed with bile salts, and plays an important role in the digestion of milk fat in newborn infants. By genomewide screen in one of their families with diabetes and exocrine pancreatic dysfunction, Raeder et al. (2006) linked diabetes to 9q34 (maximum lod score 5.07). In each of the 2 families with autosomal dominantly inherited diabetes and exocrine pancreas dysfunction described by them, Raeder et al. (2006) demonstrated a different single-base deletion causing frameshift in the variable number of tandem repeats (VNTR normal range 7-23 repeats in healthy controls) of the gene encoding carboxyl-ester lipase (CEL\; 114840).tandem repeat domain may contribute to different short and long range interactions with the globular core domain and other macromolecules, including cell membranes. CEL-MODY is a protein misfolding disease caused by a negative gain-of-function effect of the mutant proteins in pancreatic tissues. (AF081673 O75612 onco fetal isoform feto-acinar pancreatic protein.slightly different c-terminus. Human protein for lipoamidase PIR S32318 Trembl Q9UCH1) (On chromosome 9 9q34 in the NT_000529 contig, the gene is followed by a carboxyl ester lipase pseudogene which includes exons 1, 8, 9, 10, and 11 of the wildtype gene peptide ENST00000252493 gene ENSG00000130210). Numerous repeats at the c-term excluded in ESTHER (only n-term Pfam A COesterase 1 544) bile salt-dependent lipase (BSDL). The risk variant CEL-HYB1, a recombinant hybrid allele of CEL and its neighboring pseudogene (CELP), encodes a pathogenic variant of the pancreatic digestive enzyme carboxyl ester lipase (CEL). The CEL-HYB1 hybrid allele of the carboxyl ester lipase (CEL) gene and its pseudogene (CELP) has been associated with chronic pancreatitis (CP).
Relationship
Family : Cholesterol_esterase
Block : C
Position in NCBI Life Tree : Homo sapiens
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N EMolecular evidence
1F6W - Human bile-salt-activated lipase
1JMY - Human bile-salt-activated lipase
6H0T - Crystal structure of native recombinant human bile salt activated lipase
6H0V - Crystal structure of tabun surrogate NEDPA inhibited recombinant human bile salt activated lipase
6H18 - Crystal structure of sarin surrogate NIMP inhibited recombinant human bile salt activated lipase
6H19 - Crystal structure of ethyl-paraoxon inhibited recombinant human bile salt activated lipase (aged form)
6H1A - Crystal structure of VX surrogate NEMP inhibited recombinant human bile salt activated lipase
Database
Sequence
Peptide
MLTMGRLQLV VLGLTCCWAV ASAAKLGAVY TEGGFVEGVN KKLGLLGDSV DIFKGIPFAA PTKALENPQP HPGWQGTLKA KNFKKRCLQA TITQDSTYGD EDCLYLNIWV PQGRKQVSRD LPVMIWIYGG AFLMGSGHGA NFLNNYLYDG EEIATRGNVI VVTFNYRVGP LGFLSTGDAN LPGNYGLRDQ HMAIAWVKRN IAAFGGDPNN ITLFGESAGG ASVSLQTLSP YNKGLIRRAI SQSGVALSPW VIQKNPLFWA KKVAEKVGCP VGDAARMAQC LKVTDPRALT LAYKVPLAGL EYPMLHYVGF VPVIDGDFIP ADPINLYANA ADIDYIAGTN NMDGHIFASI DMPAINKGNK KVTEEDFYKL VSEFTITKGL RGAKTTFDVY TESWAQDPSQ ENKKKTVVDF ETDVLFLVPT EIALAQHRAN AKSAKTYAYL FSHPSRMPVY PKWVGADHAD DIQYVFGKPF ATPTGYRPQD RTVSKAMIAY WTNFAKTGDP NMGDSAVPTH WEPYTTENSG YLEITKKMGS SSMKRSLRTN FLRYWTLTYL ALPTVTD
References (60)
| Title : The MODY-causing mutation of the human carboxyl ester lipase gene (CEL) triggers chronic pancreatitis but not diabetes in mice - |
| Author(s) : Gravdal A , Wilhelm SJ , Lowe ME , Molven A , Xiao XK , Fjeld K |
| Ref : Gastroenterology , : , 2025 |
| PubMedID: 39956334 |
| Gene_locus related to this paper: mouse-pches , human-CEL |
| Title : Carboxyl ester lipase hybrid 1 (CEL-HYB1) haplotypes confer varying risk for chronic pancreatitis - Berke_2024_Sci.Rep_14_30965 |
| Author(s) : Berke G , Sandor M , Xiao XK , Lowe ME , Ewers M , Eross B , Masson E , Nemeth BC , Vincze A , Czako L , Rygiel AM , Rosendahl J , Chen JM , Witt H , Hegyi P , Sahin-Toth M , Hegyi E |
| Ref : Sci Rep , 14 :30965 , 2024 |
| Abstract : |
| PubMedSearch : Berke_2024_Sci.Rep_14_30965 |
| PubMedID: 39730750 |
| Gene_locus related to this paper: human-CEL |
| Title : Identification and characterization of novel carboxyl ester lipase gene variants in patients with different subtypes of diabetes - Wu_2023_BMJ.Open.Diabetes.Res.Care_11_e003127 |
| Author(s) : Wu H , Shu M , Liu C , Zhao W , Li Q , Song Y , Zhang T , Chen X , Shi Y , Shi P , Fang L , Wang R , Xu C |
| Ref : BMJ Open Diabetes Res Care , 11 : , 2023 |
| Abstract : |
| PubMedSearch : Wu_2023_BMJ.Open.Diabetes.Res.Care_11_e003127 |
| PubMedID: 36634979 |
| Gene_locus related to this paper: human-CEL |
| Title : Abnormal exocrine-endocrine cell cross-talk promotes beta-cell dysfunction and loss in MODY8 - Kahraman_2022_Nat.Metab_4_76 |
| Author(s) : Kahraman S , Dirice E , Basile G , Diegisser D , Alam J , Johansson BB , Gupta MK , Hu J , Huang L , Soh CL , Huangfu D , Muthuswamy SK , Raeder H , Molven A , Kulkarni RN |
| Ref : Nat Metab , 4 :76 , 2022 |
| Abstract : |
| PubMedSearch : Kahraman_2022_Nat.Metab_4_76 |
| PubMedID: 35058633 |
| Gene_locus related to this paper: human-CEL |
| Title : The CEL-HYB1 Hybrid Allele Promotes Digestive Enzyme Misfolding and Pancreatitis in Mice - Mao_2022_Cell.Mol.Gastroenterol.Hepatol__ |
| Author(s) : Mao XT , Zou WB , Cao Y , Wang YC , Deng SJ , Cooper DN , Ferec C , Li ZS , Chen JM , Liao Z |
| Ref : Cell Mol Gastroenterol Hepatol , : , 2022 |
| Abstract : |
| PubMedSearch : Mao_2022_Cell.Mol.Gastroenterol.Hepatol__ |
| PubMedID: 35398595 |
| Gene_locus related to this paper: human-CEL |
| Title : The genetic risk factor CEL-HYB1 causes proteotoxicity and chronic pancreatitis in mice - Fjeld_2022_Pancreatology_22_1099 |
| Author(s) : Fjeld K , Gravdal A , Brekke RS , Alam J , Wilhelm SJ , El Jellas K , Pettersen HN , Lin J , Solheim MH , Steine SJ , Johansson BB , Njlstad PR , Verbeke CS , Xiao X , Lowe ME , Molven A |
| Ref : Pancreatology , 22 :1099 , 2022 |
| Abstract : |
| PubMedSearch : Fjeld_2022_Pancreatology_22_1099 |
| PubMedID: 36379850 |
| Gene_locus related to this paper: human-CEL |
| Title : Identification of a Novel Mutation in Carboxyl Ester Lipase Gene in a Patient with MODY-like Diabetes - Kondoh_2022_Tohoku.J.Exp.Med_256_37 |
| Author(s) : Kondoh T , Nakajima Y , Yokoi K , Matsumoto Y , Inagaki H , Kato T , Ito T , Yoshikawa T , Kurahashi H |
| Ref : Tohoku J Exp Med , 256 :37 , 2022 |
| Abstract : |
| PubMedSearch : Kondoh_2022_Tohoku.J.Exp.Med_256_37 |
| PubMedID: 35082198 |
| Gene_locus related to this paper: human-CEL |
| Title : Protein misfolding in combination with other risk factors in CEL-HYB1-mediated chronic pancreatitis - Tjora_2021_Eur.J.Gastroenterol.Hepatol_33_839 |
| Author(s) : Tjora E , Gravdal A , Engjom T , Cnop M , Johansson BB , Dimcevski GG , Molven A , Fjeld K |
| Ref : European Journal of Gastroenterology & Hepatology , 33 :839 , 2021 |
| Abstract : |
| PubMedSearch : Tjora_2021_Eur.J.Gastroenterol.Hepatol_33_839 |
| PubMedID: 33079780 |
| Gene_locus related to this paper: human-CEL |
| Title : Two new mutations in the CEL gene causing diabetes and hereditary pancreatitis: How to correctly identify MODY8 cases - El Jellas_2021_J.Clin.Endocrinol.Metab__ |
| Author(s) : El Jellas K , Dusatkova P , Haldorsen IS , Molnes J , Tjora E , Johansson BB , Fjeld K , Johansson S , Pruhova S , Groop L , Lohr JM , Njolstad PR , Molven A |
| Ref : J Clinical Endocrinology Metab , : , 2021 |
| Abstract : |
| PubMedSearch : El Jellas_2021_J.Clin.Endocrinol.Metab__ |
| PubMedID: 34850019 |
| Gene_locus related to this paper: human-CEL |
| Title : Pathogenic Carboxyl Ester Lipase (CEL) Variants Interact with the Normal CEL Protein in Pancreatic Cells - Dalva_2020_Cells_9_244 |
| Author(s) : Dalva M , Lavik IK , El Jellas K , Gravdal A , Lugea A , Pandol SJ , Njolstad PR , Waldron RT , Fjeld K , Johansson BB , Molven A |
| Ref : Cells , 9 :244 , 2020 |
| Abstract : |
| PubMedSearch : Dalva_2020_Cells_9_244 |
| PubMedID: 31963687 |
| Gene_locus related to this paper: human-CEL |
| Title : Single nucleotide polymorphisms in CEL-HYB1 increase risk for chronic pancreatitis through proteotoxic misfolding - Cassidy_2020_Hum.Mutat_41_1967 |
| Author(s) : Cassidy BM , Zino S , Fjeld K , Molven A , Lowe ME , Xiao X |
| Ref : Hum Mutat , 41 :1967 , 2020 |
| Abstract : |
| PubMedSearch : Cassidy_2020_Hum.Mutat_41_1967 |
| PubMedID: 32906201 |
| Gene_locus related to this paper: human-CEL |
| Title : X-ray structures of human bile-salt activated lipase conjugated to nerve agents surrogates - Touvrey_2019_Toxicology_411_15 |
| Author(s) : Touvrey C , Courageux C , Guillon V , Terreux R , Nachon F , Brazzolotto X |
| Ref : Toxicology , 411 :15 , 2019 |
| Abstract : |
| PubMedSearch : Touvrey_2019_Toxicology_411_15 |
| PubMedID: 30359675 |
| Gene_locus related to this paper: human-CEL |
| Title : The role of the carboxyl ester lipase (CEL) gene in pancreatic disease - Johansson_2018_Pancreatology_18_12 |
| Author(s) : Johansson BB , Fjeld K , El Jellas K , Gravdal A , Dalva M , Tjora E , Raeder H , Kulkarni RN , Johansson S , Njolstad PR , Molven A |
| Ref : Pancreatology , 18 :12 , 2018 |
| Abstract : |
| PubMedSearch : Johansson_2018_Pancreatology_18_12 |
| PubMedID: 29233499 |
| Gene_locus related to this paper: human-CEL |
| Title : Copy number variants and VNTR length polymorphisms of the carboxyl-ester lipase (CEL) gene as risk factors in pancreatic cancer - Dalva_2017_Pancreatology_17_83 |
| Author(s) : Dalva M , El Jellas K , Steine SJ , Johansson BB , Ringdal M , Torsvik J , Immervoll H , Hoem D , Laemmerhirt F , Simon P , Lerch MM , Johansson S , Njolstad PR , Weiss FU , Fjeld K , Molven A |
| Ref : Pancreatology , 17 :83 , 2017 |
| Abstract : |
| PubMedSearch : Dalva_2017_Pancreatology_17_83 |
| PubMedID: 27773618 |
| Gene_locus related to this paper: human-CEL |
| Title : Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase - Kolar_2016_Biochemistry_55_4636 |
| Author(s) : Kolar MJ , Kamat SS , Parsons WH , Homan EA , Maher T , Peroni OD , Syed I , Fjeld K , Molven A , Kahn BB , Cravatt BF , Saghatelian A |
| Ref : Biochemistry , 55 :4636 , 2016 |
| Abstract : |
| PubMedSearch : Kolar_2016_Biochemistry_55_4636 |
| PubMedID: 27509211 |
| Gene_locus related to this paper: human-CEL |
| Title : A Carboxyl Ester Lipase (CEL) Mutant Causes Chronic Pancreatitis by Forming Intracellular Aggregates That Activate Apoptosis - Xiao_2016_J.Biol.Chem_291_23224 |
| Author(s) : Xiao X , Jones G , Sevilla WA , Stolz DB , Magee KE , Haughney M , Mukherjee A , Wang Y , Lowe ME |
| Ref : Journal of Biological Chemistry , 291 :23224 , 2016 |
| Abstract : |
| PubMedSearch : Xiao_2016_J.Biol.Chem_291_23224 |
| PubMedID: 27650499 |
| Gene_locus related to this paper: human-CEL |
| Title : No Association Between CEL-HYB Hybrid Allele and Chronic Pancreatitis in Asian Populations - Zou_2016_Gastroenterology_150_1558 |
| Author(s) : Zou WB , Boulling A , Masamune A , Issarapu P , Masson E , Wu H , Sun XT , Hu LH , Zhou DZ , He L , Fichou Y , Nakano E , Hamada S , Kakuta Y , Kume K , Isayama H , Paliwal S , Mani KR , Bhaskar S , Cooper DN , Ferec C , Shimosegawa T , Chandak GR , Chen JM , Li ZS , Liao Z |
| Ref : Gastroenterology , 150 :1558 , 2016 |
| Abstract : |
| PubMedSearch : Zou_2016_Gastroenterology_150_1558 |
| PubMedID: 26946345 |
| Gene_locus related to this paper: human-CEL |
| Title : A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis - Fjeld_2015_Nat.Genet_47_518 |
| Author(s) : Fjeld K , Weiss FU , Lasher D , Rosendahl J , Chen JM , Johansson BB , Kirsten H , Ruffert C , Masson E , Steine SJ , Bugert P , Cnop M , Grutzmann R , Mayerle J , Mossner J , Ringdal M , Schulz HU , Sendler M , Simon P , Sztromwasser P , Torsvik J , Scholz M , Tjora E , Ferec C , Witt H , Lerch MM , Njolstad PR , Johansson S , Molven A |
| Ref : Nat Genet , 47 :518 , 2015 |
| Abstract : |
| PubMedSearch : Fjeld_2015_Nat.Genet_47_518 |
| PubMedID: 25774637 |
| Gene_locus related to this paper: human-CEL |
| Title : The number of tandem repeats in the carboxyl-ester lipase (CEL) gene as a risk factor in alcoholic and idiopathic chronic pancreatitis - Ragvin_2013_Pancreatology_13_29 |
| Author(s) : Ragvin A , Fjeld K , Weiss FU , Torsvik J , Aghdassi A , Mayerle J , Simon P , Njolstad PR , Lerch MM , Johansson S , Molven A |
| Ref : Pancreatology , 13 :29 , 2013 |
| Abstract : |
| PubMedSearch : Ragvin_2013_Pancreatology_13_29 |
| PubMedID: 23395566 |
| Gene_locus related to this paper: human-CEL |
| Title : The galactolipase activity of some microbial lipases and pancreatic enzymes - Amara_2013_Eur.J.Lipid.Sci.Technol_115_442 |
| Author(s) : Amara S , Lafont D , Parsiegla G , Point V , Chabannes A , Rousset A , Carriere F |
| Ref : Eur J Lipid Sci Technol , 115 :442 , 2013 |
| Abstract : |
| PubMedSearch : Amara_2013_Eur.J.Lipid.Sci.Technol_115_442 |
| PubMedID: |
| Gene_locus related to this paper: bovin-balip , human-CEL |
| Title : Analysis of the discriminative inhibition of mammalian digestive lipases by 3-phenyl substituted 1,3,4-oxadiazol-2(3H)-ones. - Point_2012_Eur.J.Med.Chem_58_452 |
| Author(s) : Point V , Pavan Kumar KV , Marc S , Delorme V , Parsiegla G , Amara S , Carriere F , Buono G , Fotiadu F , Canaan S , Leclaire J , Cavalier JF |
| Ref : Eur Journal of Medicinal Chemistry , 58 :452 , 2012 |
| Abstract : |
| PubMedSearch : Point_2012_Eur.J.Med.Chem_58_452 |
| PubMedID: 23153815 |
| Gene_locus related to this paper: canfa-1lipg , cavpo-2plrp , human-CEL , human-PNLIP , human-PNLIPRP2 , pig-1plip |
| Title : Diabetes and pancreatic exocrine dysfunction due to mutations in the carboxyl ester lipase gene-maturity onset diabetes of the young (CEL-MODY): a protein misfolding disease - Johansson_2011_J.Biol.Chem_286_34593 |
| Author(s) : Johansson BB , Torsvik J , Bjorkhaug L , Vesterhus M , Ragvin A , Tjora E , Fjeld K , Hoem D , Johansson S , Raeder H , Lindquist S , Hernell O , Cnop M , Saraste J , Flatmark T , Molven A , Njolstad PR |
| Ref : Journal of Biological Chemistry , 286 :34593 , 2011 |
| Abstract : |
| PubMedSearch : Johansson_2011_J.Biol.Chem_286_34593 |
| PubMedID: 21784842 |
| Gene_locus related to this paper: human-CEL |
| Title : Mutations in the VNTR of the carboxyl-ester lipase gene (CEL) are a rare cause of monogenic diabetes - Torsvik_2010_Hum.Genet_127_55 |
| Author(s) : Torsvik J , Johansson S , Johansen A , Ek J , Minton J , Raeder H , Ellard S , Hattersley A , Pedersen O , Hansen T , Molven A , Njolstad PR |
| Ref : Hum Genet , 127 :55 , 2010 |
| Abstract : |
| PubMedSearch : Torsvik_2010_Hum.Genet_127_55 |
| PubMedID: 19760265 |
| Gene_locus related to this paper: human-CEL |
| Title : Pancreatic function in carboxyl-ester lipase knockout mice - Vesterhus_2010_Pancreatology_10_467 |
| Author(s) : Vesterhus M , Raeder H , Kurpad AJ , Kawamori D , Molven A , Kulkarni RN , Kahn CR , Njolstad PR |
| Ref : Pancreatology , 10 :467 , 2010 |
| Abstract : |
| PubMedSearch : Vesterhus_2010_Pancreatology_10_467 |
| PubMedID: 20720448 |
| Gene_locus related to this paper: human-CEL |
| Title : Pancreatic exocrine dysfunction in maturity-onset diabetes of the young type 3 - Vesterhus_2008_Diabetes.Care_31_306 |
| Author(s) : Vesterhus M , Raeder H , Johansson S , Molven A , Njolstad PR |
| Ref : Diabetes Care , 31 :306 , 2008 |
| Abstract : |
| PubMedSearch : Vesterhus_2008_Diabetes.Care_31_306 |
| PubMedID: 17989309 |
| Gene_locus related to this paper: human-CEL |
| Title : Neurological features and enzyme therapy in patients with endocrine and exocrine pancreas dysfunction due to CEL mutations - Vesterhus_2008_Diabetes.Care_31_1738 |
| Author(s) : Vesterhus M , Raeder H , Aurlien H , Gjesdal CG , Bredrup C , Holm PI , Molven A , Bindoff L , Berstad A , Njolstad PR |
| Ref : Diabetes Care , 31 :1738 , 2008 |
| Abstract : |
| PubMedSearch : Vesterhus_2008_Diabetes.Care_31_1738 |
| PubMedID: 18544793 |
| Gene_locus related to this paper: human-CEL |
| Title : Mutations in the CEL VNTR cause a syndrome of diabetes and pancreatic exocrine dysfunction. - Raeder_2006_Nat.Genet_38_54 |
| Author(s) : Raeder H , Johansson S , Holm PI , Haldorsen IS , Mas E , Sbarra V , Nermoen I , Eide SA , Grevle L , Bjorkhaug L , Sagen JV , Aksnes L , Svik O , Lombardo D , Molven A , Njolstad PR |
| Ref : Nat Genet , 38 :54 , 2006 |
| Abstract : |
| PubMedSearch : Raeder_2006_Nat.Genet_38_54 |
| PubMedID: 16369531 |
| Gene_locus related to this paper: human-CEL |
| Title : In vitro polyphenol effects on activity, expression and secretion of pancreatic bile salt-dependent lipase - Sbarra_2005_Biochim.Biophys.Acta_1736_67 |
| Author(s) : Sbarra V , Ristorcelli E , Petit-Thevenin JL , Teissedre PL , Lombardo D , Verine A |
| Ref : Biochimica & Biophysica Acta , 1736 :67 , 2005 |
| Abstract : |
| PubMedSearch : Sbarra_2005_Biochim.Biophys.Acta_1736_67 |
| PubMedID: 16099206 |
| Gene_locus related to this paper: human-CEL |
| Title : In vitro angiogenic effects of pancreatic bile salt-dependent lipase - Rebai_2005_Arterioscler.Thromb.Vasc.Biol_25_359 |
| Author(s) : Rebai O , Le Petit-Thevenin J , Bruneau N , Lombardo D , Verine A |
| Ref : Arterioscler Thromb Vasc Biol , 25 :359 , 2005 |
| Abstract : |
| PubMedSearch : Rebai_2005_Arterioscler.Thromb.Vasc.Biol_25_359 |
| PubMedID: 15569825 |
| Gene_locus related to this paper: human-CEL |
| Title : Lectin-like Ox-LDL receptor is expressed in human INT-407 intestinal cells: involvement in the transcytosis of pancreatic bile salt-dependent lipase - Bruneau_2003_Mol.Biol.Cell_14_2861 |
| Author(s) : Bruneau N , Richard S , Silvy F , Verine A , Lombardo D |
| Ref : Mol Biology of the cell , 14 :2861 , 2003 |
| Abstract : |
| PubMedSearch : Bruneau_2003_Mol.Biol.Cell_14_2861 |
| PubMedID: 12857870 |
| Gene_locus related to this paper: human-CEL |
| Title : Human bile salt-stimulated lipase has a high frequency of size variation due to a hypervariable region in exon 11 - Lindquist_2002_Eur.J.Biochem_269_759 |
| Author(s) : Lindquist S , Blackberg L , Hernell O |
| Ref : European Journal of Biochemistry , 269 :759 , 2002 |
| Abstract : |
| PubMedSearch : Lindquist_2002_Eur.J.Biochem_269_759 |
| PubMedID: 11846777 |
| Gene_locus related to this paper: human-CEL |
| Title : Transcytosis of pancreatic bile salt-dependent lipase through human Int407 intestinal cells - Bruneau_2001_Exp.Cell.Res_271_94 |
| Author(s) : Bruneau N , Nganga A , Bendayan M , Lombardo D |
| Ref : Experimental Cell Research , 271 :94 , 2001 |
| Abstract : |
| PubMedSearch : Bruneau_2001_Exp.Cell.Res_271_94 |
| PubMedID: 11697886 |
| Gene_locus related to this paper: human-CEL |
| Title : The structure of truncated recombinant human bile salt-stimulated lipase reveals bile salt-independent conformational flexibility at the active-site loop and provides insights into heparin binding - Moore_2001_J.Mol.Biol_312_511 |
| Author(s) : Moore SA , Kingston RL , Loomes KM , Hernell O , Blackberg L , Baker HM , Baker EN |
| Ref : Journal of Molecular Biology , 312 :511 , 2001 |
| Abstract : |
| PubMedSearch : Moore_2001_J.Mol.Biol_312_511 |
| PubMedID: 11563913 |
| Gene_locus related to this paper: human-CEL |
| Title : Crystal structure of the catalytic domain of human bile salt activated lipase - Terzyan_2000_Protein.Sci_9_1783 |
| Author(s) : Terzyan S , Wang CS , Downs D , Hunter B , Zhang XC |
| Ref : Protein Science , 9 :1783 , 2000 |
| Abstract : |
| PubMedSearch : Terzyan_2000_Protein.Sci_9_1783 |
| PubMedID: 11045623 |
| Gene_locus related to this paper: human-CEL |
| Title : The affinity binding sites of pancreatic bile salt-dependent lipase in pancreatic and intestinal tissues - Bruneau_2000_J.Histochem.Cytochem_48_267 |
| Author(s) : Bruneau N , Lombardo D , Bendayan M |
| Ref : Journal of Histochemistry & Cytochemistry , 48 :267 , 2000 |
| Abstract : |
| PubMedSearch : Bruneau_2000_J.Histochem.Cytochem_48_267 |
| PubMedID: 10639493 |
| Gene_locus related to this paper: human-CEL |
| Title : Structural characterization of the N-linked oligosaccharides in bile salt-stimulated lipase originated from human breast milk - Mechref_1999_Glycobiology_9_227 |
| Author(s) : Mechref Y , Chen P , Novotny MV |
| Ref : Glycobiology , 9 :227 , 1999 |
| Abstract : |
| PubMedSearch : Mechref_1999_Glycobiology_9_227 |
| PubMedID: 10024660 |
| Gene_locus related to this paper: human-CEL |
| Title : Lipid-lowering effects of WAY-121,898, an inhibitor of pancreatic cholesteryl ester hydrolase - Krause_1998_Lipids_33_489 |
| Author(s) : Krause BR , Sliskovic DR , Anderson M , Homan R |
| Ref : Lipids , 33 :489 , 1998 |
| Abstract : |
| PubMedSearch : Krause_1998_Lipids_33_489 |
| PubMedID: 9625596 |
| Gene_locus related to this paper: human-CEL , ratno-balip , mesau-a0a1u8cxs4 |
| Title : Participation of GRP94-related protein in secretion of pancreatic bile salt-dependent lipase and in its internalization by the intestinal epithelium - Bruneau_1998_J.Cell.Sci_111_2665 |
| Author(s) : Bruneau N , Lombardo D , Bendayan M |
| Ref : Journal of Cell Science , 111 :2665 , 1998 |
| Abstract : |
| PubMedSearch : Bruneau_1998_J.Cell.Sci_111_2665 |
| PubMedID: 9701565 |
| Gene_locus related to this paper: human-CEL |
| Title : An intracellular role for pancreatic bile salt-dependent lipase: evidence for modification of lipid turnover in transfected CHO cells - Le Petit-Thevenin_1998_Biochim.Biophys.Acta_1393_307 |
| Author(s) : Le Petit-Thevenin J , Bruneau N , Nobili O , Lombardo D , Verine A |
| Ref : Biochimica & Biophysica Acta , 1393 :307 , 1998 |
| Abstract : |
| PubMedSearch : Le Petit-Thevenin_1998_Biochim.Biophys.Acta_1393_307 |
| PubMedID: 9748640 |
| Gene_locus related to this paper: human-CEL |
| Title : Molecular cloning of the oncofetal isoform of the human pancreatic bile salt-dependent lipase - Pasqualini_1998_J.Biol.Chem_273_28208 |
| Author(s) : Pasqualini E , Caillol N , Panicot L , Mas E , Lloubes R , Lombardo D |
| Ref : Journal of Biological Chemistry , 273 :28208 , 1998 |
| Abstract : |
| PubMedSearch : Pasqualini_1998_J.Biol.Chem_273_28208 |
| PubMedID: 9774442 |
| Gene_locus related to this paper: human-CEL |
| Title : Purification of carboxyl ester lipase (bile salt-stimulated lipase) from human milk and pancreas - |
| Author(s) : Blackberg L , Duan RD , Sternby B |
| Ref : Methods Enzymol , 284 :185 , 1997 |
| PubMedID: 9379934 |
| Gene_locus related to this paper: human-CEL |
| Title : Established and Emerging Strategies for Inhibition of Cholesterol Absorption - Homan_1997_Curr.Pharma.Design_3_29 |
| Author(s) : Homan R , Krause BR |
| Ref : Curr.Pharma.Design , 3 :29 , 1997 |
| Abstract : |
| PubMedSearch : Homan_1997_Curr.Pharma.Design_3_29 |
| PubMedID: |
| Gene_locus related to this paper: human-CEL , ratno-balip , mesau-a0a1u8cxs4 |
| Title : O-Glycosylation of C-terminal tandem-repeated sequences regulates the secretion of rat pancreatic bile salt-dependent lipase - Bruneau_1997_J.Biol.Chem_272_27353 |
| Author(s) : Bruneau N , Nganga A , Fisher EA , Lombardo D |
| Ref : Journal of Biological Chemistry , 272 :27353 , 1997 |
| Abstract : |
| PubMedSearch : Bruneau_1997_J.Biol.Chem_272_27353 |
| PubMedID: 9341186 |
| Gene_locus related to this paper: human-CEL |
| Title : Isolation and characterization of human milk bile salt-activated lipase C-tail fragment - Wang_1995_Biochemistry_34_10639 |
| Author(s) : Wang CS , Dashti A , Jackson KW , Yeh JC , Cummings RD , Tang J |
| Ref : Biochemistry , 34 :10639 , 1995 |
| Abstract : |
| PubMedSearch : Wang_1995_Biochemistry_34_10639 |
| PubMedID: 7654718 |
| Gene_locus related to this paper: human-CEL |
| Title : Chaperone function of a Grp 94-related protein for folding and transport of the pancreatic bile salt-dependent lipase - Bruneau_1995_J.Biol.Chem_270_13524 |
| Author(s) : Bruneau N , Lombardo D |
| Ref : Journal of Biological Chemistry , 270 :13524 , 1995 |
| Abstract : |
| PubMedSearch : Bruneau_1995_J.Biol.Chem_270_13524 |
| PubMedID: 7768954 |
| Gene_locus related to this paper: human-CEL |
| Title : Expression of a 46 kDa protein in human pancreatic tumors and its possible relationship with the bile salt-dependent lipase - Roudani_1994_Eur.J.Cell.Biol_65_132 |
| Author(s) : Roudani S , Pasqualini E , Margotat A , Gastaldi M , Sbarra V , Malezet-Desmoulin C , Lombardo D |
| Ref : European Journal of Cell Biology , 65 :132 , 1994 |
| Abstract : |
| PubMedSearch : Roudani_1994_Eur.J.Cell.Biol_65_132 |
| PubMedID: 7889983 |
| Gene_locus related to this paper: human-CEL |
| Title : Bile salt-activated lipase. A multiple function lipolytic enzyme - |
| Author(s) : Wang CS , Hartsuck JA |
| Ref : Biochimica & Biophysica Acta , 1166 :1 , 1993 |
| PubMedID: 8431483 |
| Gene_locus related to this paper: human-CEL |
| Title : Bile salt-stimulated lipase in human milk. Evidence that bile salt induces lipid binding and activation via binding to different sites - Blackberg_1993_FEBS.Lett_323_207 |
| Author(s) : Blackberg L , Hernell O |
| Ref : FEBS Letters , 323 :207 , 1993 |
| Abstract : |
| PubMedSearch : Blackberg_1993_FEBS.Lett_323_207 |
| PubMedID: 8500612 |
| Gene_locus related to this paper: human-CEL |
| Title : The human carboxyl ester lipase-like (CELL) gene is ubiquitously expressed and contains a hypervariable region - Nilsson_1993_Genomics_17_416 |
| Author(s) : Nilsson J , Hellquist M , Bjursell G |
| Ref : Genomics , 17 :416 , 1993 |
| Abstract : |
| PubMedSearch : Nilsson_1993_Genomics_17_416 |
| PubMedID: 7691717 |
| Gene_locus related to this paper: human-CEL |
| Title : Human fetoacinar pancreatic protein: an oncofetal glycoform of the normally secreted pancreatic bile-salt-dependent lipase - Mas_1993_Biochem.J_289 ( Pt 2)_609 |
| Author(s) : Mas E , Abouakil N , Roudani S , Miralles F , Guy-Crotte O , Figarella C , Escribano MJ , Lombardo D |
| Ref : Biochemical Journal , 289 ( Pt 2) :609 , 1993 |
| Abstract : |
| PubMedSearch : Mas_1993_Biochem.J_289 ( Pt 2)_609 |
| PubMedID: 8424803 |
| Gene_locus related to this paper: human-CEL |
| Title : Genomic organization, sequence analysis, and chromosomal localization of the human carboxyl ester lipase (CEL) gene and a CEL-like (CELL) gene - Lidberg_1992_Genomics_13_630 |
| Author(s) : Lidberg U , Nilsson J , Stromberg K , Stenman G , Sahlin P , Enerback S , Bjursell G |
| Ref : Genomics , 13 :630 , 1992 |
| Abstract : |
| PubMedSearch : Lidberg_1992_Genomics_13_630 |
| PubMedID: 1639390 |
| Gene_locus related to this paper: human-CEL |
| Title : Structure of the human pancreatic cholesterol esterase gene - Kumar_1992_Biochemistry_31_6077 |
| Author(s) : Kumar BV , Aleman-Gomez JA , Colwell N , Lopez-Candales A , Bosner MS , Spilburg CA , Lowe M , Lange LG |
| Ref : Biochemistry , 31 :6077 , 1992 |
| Abstract : |
| PubMedSearch : Kumar_1992_Biochemistry_31_6077 |
| PubMedID: 1627550 |
| Gene_locus related to this paper: human-CEL |
| Title : cDNA cloning of carboxyl ester lipase from human pancreas reveals a unique proline-rich repeat unit - Reue_1991_J.Lipid.Res_32_267 |
| Author(s) : Reue K , Zambaux J , Wong H , Lee G , Leete TH , Ronk M , Shively JE , Sternby B , Borgstrom B , Ameis D , Schotz MC |
| Ref : J Lipid Res , 32 :267 , 1991 |
| Abstract : |
| PubMedSearch : Reue_1991_J.Lipid.Res_32_267 |
| PubMedID: 2066663 |
| Gene_locus related to this paper: human-CEL |
| Title : Structure of human milk bile salt activated lipase - Baba_1991_Biochemistry_30_500 |
| Author(s) : Baba T , Downs D , Jackson KW , Tang J , Wang CS |
| Ref : Biochemistry , 30 :500 , 1991 |
| Abstract : |
| PubMedSearch : Baba_1991_Biochemistry_30_500 |
| PubMedID: 1988041 |
| Gene_locus related to this paper: human-CEL |
| Title : Human milk bile-salt stimulated lipase. Sequence similarity with rat lysophospholipase and homology with the active site region of cholinesterases - Christie_1991_FEBS.Lett_278_190 |
| Author(s) : Christie DL , Cleverly DR , O'Connor CJ |
| Ref : FEBS Letters , 278 :190 , 1991 |
| Abstract : |
| PubMedSearch : Christie_1991_FEBS.Lett_278_190 |
| PubMedID: 1991511 |
| Gene_locus related to this paper: human-CEL |
| Title : Carboxyl ester lipase: a highly polymorphic locus on human chromosome 9qter - Taylor_1991_Genomics_10_425 |
| Author(s) : Taylor AK , Zambaux JL , Klisak I , Mohandas T , Sparkes RS , Schotz MC , Lusis AJ |
| Ref : Genomics , 10 :425 , 1991 |
| Abstract : |
| PubMedSearch : Taylor_1991_Genomics_10_425 |
| PubMedID: 1676983 |
| Gene_locus related to this paper: human-CEL |
| Title : Sequence identity between human pancreatic cholesterol esterase and bile salt-stimulated milk lipase - Hui_1990_FEBS.Lett_276_131 |
| Author(s) : Hui DY , Kissel JA |
| Ref : FEBS Letters , 276 :131 , 1990 |
| Abstract : |
| PubMedSearch : Hui_1990_FEBS.Lett_276_131 |
| PubMedID: 2265692 |
| Gene_locus related to this paper: human-CEL |
| Title : cDNA cloning of human-milk bile-salt-stimulated lipase and evidence for its identity to pancreatic carboxylic ester hydrolase - Nilsson_1990_Eur.J.Biochem_192_543 |
| Author(s) : Nilsson J , Blackberg L , Carlsson P , Enerback S , Hernell O , Bjursell G |
| Ref : European Journal of Biochemistry , 192 :543 , 1990 |
| Abstract : |
| PubMedSearch : Nilsson_1990_Eur.J.Biochem_192_543 |
| PubMedID: 1698625 |
| Gene_locus related to this paper: human-CEL |