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| Title : Design and synthesis of systemically active metabotropic glutamate subtype-2 and -3 (mGlu2\/3) receptor positive allosteric modulators (PAMs): pharmacological characterization and assessment in a rat model of cocaine dependence - Dhanya_2014_J.Med.Chem_57_4154 |
| Author(s) : Dhanya RP , Sheffler DJ , Dahl R , Davis M , Lee PS , Yang L , Nickols HH , Cho HP , Smith LH , D'Souza MS , Conn PJ , Der-Avakian A , Markou A , Cosford ND |
| Ref : Journal of Medicinal Chemistry , 57 :4154 , 2014 |
| Abstract : Dhanya_2014_J.Med.Chem_57_4154 |
| ESTHER : Dhanya_2014_J.Med.Chem_57_4154 |
| PubMedSearch : Dhanya_2014_J.Med.Chem_57_4154 |
| PubMedID: 24735492 |
| Title : Orally active metabotropic glutamate subtype 2 receptor positive allosteric modulators: structure-activity relationships and assessment in a rat model of nicotine dependence - Sidique_2012_J.Med.Chem_55_9434 |
| Author(s) : Sidique S , Dhanya RP , Sheffler DJ , Nickols HH , Yang L , Dahl R , Mangravita-Novo A , Smith LH , D'Souza MS , Semenova S , Conn PJ , Markou A , Cosford ND |
| Ref : Journal of Medicinal Chemistry , 55 :9434 , 2012 |
| Abstract : Sidique_2012_J.Med.Chem_55_9434 |
| ESTHER : Sidique_2012_J.Med.Chem_55_9434 |
| PubMedSearch : Sidique_2012_J.Med.Chem_55_9434 |
| PubMedID: 23009245 |
| Title : Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models - Digby_2012_J.Neurosci_32_8532 |
| Author(s) : Digby GJ , Noetzel MJ , Bubser M , Utley TJ , Walker AG , Byun NE , LeBois EP , Xiang Z , Sheffler DJ , Cho HP , Davis AA , Nemirovsky NE , Mennenga SE , Camp BW , Bimonte-Nelson HA , Bode J , Italiano K , Morrison R , Daniels JS , Niswender CM , Olive MF , Lindsley CW , Jones CK , Conn PJ |
| Ref : Journal of Neuroscience , 32 :8532 , 2012 |
| Abstract : Digby_2012_J.Neurosci_32_8532 |
| ESTHER : Digby_2012_J.Neurosci_32_8532 |
| PubMedSearch : Digby_2012_J.Neurosci_32_8532 |
| PubMedID: 22723693 |
| Title : Development of a more highly selective M(1) antagonist from the continued optimization of the MLPCN Probe ML012 - Melancon_2012_Bioorg.Med.Chem.Lett_22_1044 |
| Author(s) : Melancon BJ , Lamers AP , Bridges TM , Sulikowski GA , Utley TJ , Sheffler DJ , Noetzel MJ , Morrison RD , Daniels JS , Niswender CM , Jones CK , Conn PJ , Lindsley CW , Wood MR |
| Ref : Bioorganic & Medicinal Chemistry Lett , 22 :1044 , 2012 |
| Abstract : Melancon_2012_Bioorg.Med.Chem.Lett_22_1044 |
| ESTHER : Melancon_2012_Bioorg.Med.Chem.Lett_22_1044 |
| PubMedSearch : Melancon_2012_Bioorg.Med.Chem.Lett_22_1044 |
| PubMedID: 22197142 |
| Title : Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor - Salovich_2012_Bioorg.Med.Chem.Lett_22_5084 |
| Author(s) : Salovich JM , Vinson PN , Sheffler DJ , Lamsal A , Utley TJ , Blobaum AL , Bridges TM , Le U , Jones CK , Wood MR , Daniels JS , Conn PJ , Niswender CM , Lindsley CW , Hopkins CR |
| Ref : Bioorganic & Medicinal Chemistry Lett , 22 :5084 , 2012 |
| Abstract : Salovich_2012_Bioorg.Med.Chem.Lett_22_5084 |
| ESTHER : Salovich_2012_Bioorg.Med.Chem.Lett_22_5084 |
| PubMedSearch : Salovich_2012_Bioorg.Med.Chem.Lett_22_5084 |
| PubMedID: 22738637 |
| Title : Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): the development of ML169, an MLPCN probe - Reid_2011_Bioorg.Med.Chem.Lett_21_2697 |
| Author(s) : Reid PR , Bridges TM , Sheffler DJ , Cho HP , Lewis LM , Days E , Daniels JS , Jones CK , Niswender CM , Weaver CD , Conn PJ , Lindsley CW , Wood MR |
| Ref : Bioorganic & Medicinal Chemistry Lett , 21 :2697 , 2011 |
| Abstract : Reid_2011_Bioorg.Med.Chem.Lett_21_2697 |
| ESTHER : Reid_2011_Bioorg.Med.Chem.Lett_21_2697 |
| PubMedSearch : Reid_2011_Bioorg.Med.Chem.Lett_21_2697 |
| PubMedID: 21194936 |
| Title : Discovery and development of a potent and highly selective small molecule muscarinic acetylcholine receptor subtype I (mAChR 1 or M1) antagonist in vitro and in vivo probe - Weaver_2009_Curr.Top.Med.Chem_9_1217 |
| Author(s) : Weaver CD , Sheffler DJ , Lewis LM , Bridges TM , Williams R , Nalywajko NT , Kennedy JP , Mulder MM , Jadhav S , Aldrich LA , Jones CK , Marlo JE , Niswender CM , Mock MM , Zheng F , Conn PJ , Lindsley CW |
| Ref : Curr Top Med Chem , 9 :1217 , 2009 |
| Abstract : Weaver_2009_Curr.Top.Med.Chem_9_1217 |
| ESTHER : Weaver_2009_Curr.Top.Med.Chem_9_1217 |
| PubMedSearch : Weaver_2009_Curr.Top.Med.Chem_9_1217 |
| PubMedID: 19807667 |
| Title : A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning - Sheffler_2009_Mol.Pharmacol_76_356 |
| Author(s) : Sheffler DJ , Williams R , Bridges TM , Xiang Z , Kane AS , Byun NE , Jadhav S , Mock MM , Zheng F , Lewis LM , Jones CK , Niswender CM , Weaver CD , Lindsley CW , Conn PJ |
| Ref : Molecular Pharmacology , 76 :356 , 2009 |
| Abstract : Sheffler_2009_Mol.Pharmacol_76_356 |
| ESTHER : Sheffler_2009_Mol.Pharmacol_76_356 |
| PubMedSearch : Sheffler_2009_Mol.Pharmacol_76_356 |
| PubMedID: 19407080 |