Full name : Jones Carrie K
First name : Carrie K
Mail : Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232
Zip Code :
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Country : USA
Email : carrie.jones@vanderbilt.edu
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Comment
| Title : M(1)-selective muscarinic allosteric modulation enhances cognitive flexibility and effective salience in nonhuman primates - Hassani_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2216792120 |
| Author(s) : Hassani SA , Neumann A , Russell J , Jones CK , Womelsdorf T |
| Ref : Proc Natl Acad Sci U S A , 120 :e2216792120 , 2023 |
| Abstract : |
| PubMedSearch : Hassani_2023_Proc.Natl.Acad.Sci.U.S.A_120_e2216792120 |
| PubMedID: 37104474 |
| Title : M(1)\/M(4)-Preferring Muscarinic Cholinergic Receptor Agonist Xanomeline Reverses Wake and Arousal Deficits in Nonpathologically Aged Mice - Russell_2023_ACS.Chem.Neurosci__ |
| Author(s) : Russell JK , Ingram SM , Teal LB , Lindsley CW , Jones CK |
| Ref : ACS Chem Neurosci , : , 2023 |
| Abstract : |
| PubMedSearch : Russell_2023_ACS.Chem.Neurosci__ |
| PubMedID: 36655909 |
| Title : Modulation of arousal and sleep\/wake architecture by M(1) PAM VU0453595 across young and aged rodents and nonhuman primates - Gould_2020_Neuropsychopharmacology_45_2219 |
| Author(s) : Gould RW , Russell JK , Nedelcovych MT , Bubser M , Blobaum AL , Bridges TM , Newhouse PA , Lindsley CW , Conn PJ , Nader MA , Jones CK |
| Ref : Neuropsychopharmacology , 45 :2219 , 2020 |
| Abstract : |
| PubMedSearch : Gould_2020_Neuropsychopharmacology_45_2219 |
| PubMedID: 32868847 |
| Title : Roles of the M1 muscarinic acetylcholine receptor subtype in the regulation of basal ganglia function and implications for the treatment of Parkinson's disease - Xiang_2012_J.Pharmacol.Exp.Ther_340_595 |
| Author(s) : Xiang Z , Thompson AD , Jones CK , Lindsley CW , Conn PJ |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 340 :595 , 2012 |
| Abstract : |
| PubMedSearch : Xiang_2012_J.Pharmacol.Exp.Ther_340_595 |
| PubMedID: 22135383 |
| Title : Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal models - Digby_2012_J.Neurosci_32_8532 |
| Author(s) : Digby GJ , Noetzel MJ , Bubser M , Utley TJ , Walker AG , Byun NE , LeBois EP , Xiang Z , Sheffler DJ , Cho HP , Davis AA , Nemirovsky NE , Mennenga SE , Camp BW , Bimonte-Nelson HA , Bode J , Italiano K , Morrison R , Daniels JS , Niswender CM , Olive MF , Lindsley CW , Jones CK , Conn PJ |
| Ref : Journal of Neuroscience , 32 :8532 , 2012 |
| Abstract : |
| PubMedSearch : Digby_2012_J.Neurosci_32_8532 |
| PubMedID: 22723693 |
| Title : Development of a more highly selective M(1) antagonist from the continued optimization of the MLPCN Probe ML012 - Melancon_2012_Bioorg.Med.Chem.Lett_22_1044 |
| Author(s) : Melancon BJ , Lamers AP , Bridges TM , Sulikowski GA , Utley TJ , Sheffler DJ , Noetzel MJ , Morrison RD , Daniels JS , Niswender CM , Jones CK , Conn PJ , Lindsley CW , Wood MR |
| Ref : Bioorganic & Medicinal Chemistry Lett , 22 :1044 , 2012 |
| Abstract : |
| PubMedSearch : Melancon_2012_Bioorg.Med.Chem.Lett_22_1044 |
| PubMedID: 22197142 |
| Title : Emerging approaches for treatment of schizophrenia: modulation of cholinergic signaling - Foster_2012_Discov.Med_14_413 |
| Author(s) : Foster DJ , Jones CK , Conn PJ |
| Ref : Discov Med , 14 :413 , 2012 |
| Abstract : |
| PubMedSearch : Foster_2012_Discov.Med_14_413 |
| PubMedID: 23272693 |
| Title : Muscarinic receptor pharmacology and circuitry for the modulation of cognition - Bubser_2012_Handb.Exp.Pharmacol_208_121 |
| Author(s) : Bubser M , Byun N , Wood MR , Jones CK |
| Ref : Handbook of Experimental Pharmacology , :121 , 2012 |
| Abstract : |
| PubMedSearch : Bubser_2012_Handb.Exp.Pharmacol_208_121 |
| PubMedID: 22222698 |
| Title : Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor - Salovich_2012_Bioorg.Med.Chem.Lett_22_5084 |
| Author(s) : Salovich JM , Vinson PN , Sheffler DJ , Lamsal A , Utley TJ , Blobaum AL , Bridges TM , Le U , Jones CK , Wood MR , Daniels JS , Conn PJ , Niswender CM , Lindsley CW , Hopkins CR |
| Ref : Bioorganic & Medicinal Chemistry Lett , 22 :5084 , 2012 |
| Abstract : |
| PubMedSearch : Salovich_2012_Bioorg.Med.Chem.Lett_22_5084 |
| PubMedID: 22738637 |
| Title : The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease - Jones_2012_J.Pharmacol.Exp.Ther_340_404 |
| Author(s) : Jones CK , Bubser M , Thompson AD , Dickerson JW , Turle-Lorenzo N , Amalric M , Blobaum AL , Bridges TM , Morrison RD , Jadhav S , Engers DW , Italiano K , Bode J , Daniels JS , Lindsley CW , Hopkins CR , Conn PJ , Niswender CM |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 340 :404 , 2012 |
| Abstract : |
| PubMedSearch : Jones_2012_J.Pharmacol.Exp.Ther_340_404 |
| PubMedID: 22088953 |
| Title : Muscarinic and nicotinic acetylcholine receptor agonists and allosteric modulators for the treatment of schizophrenia - Jones_2012_Neuropsychopharmacology_37_16 |
| Author(s) : Jones CK , Byun N , Bubser M |
| Ref : Neuropsychopharmacology , 37 :16 , 2012 |
| Abstract : |
| PubMedSearch : Jones_2012_Neuropsychopharmacology_37_16 |
| PubMedID: 21956443 |
| Title : The evolution of histamine H(3) antagonists\/inverse agonists - Lebois_2011_Curr.Top.Med.Chem_11_648 |
| Author(s) : LeBois EP , Jones CK , Lindsley CW |
| Ref : Curr Top Med Chem , 11 :648 , 2011 |
| Abstract : |
| PubMedSearch : Lebois_2011_Curr.Top.Med.Chem_11_648 |
| PubMedID: 21261594 |
| Title : Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulator (PAM): the development of ML169, an MLPCN probe - Reid_2011_Bioorg.Med.Chem.Lett_21_2697 |
| Author(s) : Reid PR , Bridges TM , Sheffler DJ , Cho HP , Lewis LM , Days E , Daniels JS , Jones CK , Niswender CM , Weaver CD , Conn PJ , Lindsley CW , Wood MR |
| Ref : Bioorganic & Medicinal Chemistry Lett , 21 :2697 , 2011 |
| Abstract : |
| PubMedSearch : Reid_2011_Bioorg.Med.Chem.Lett_21_2697 |
| PubMedID: 21194936 |
| Title : Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system - Lebois_2010_ACS.Chem.Neurosci_1_104 |
| Author(s) : LeBois EP , Bridges TM , Lewis LM , Dawson ES , Kane AS , Xiang Z , Jadhav SB , Yin H , Kennedy JP , Meiler J , Niswender CM , Jones CK , Conn PJ , Weaver CD , Lindsley CW |
| Ref : ACS Chem Neurosci , 1 :104 , 2010 |
| Abstract : |
| PubMedSearch : Lebois_2010_ACS.Chem.Neurosci_1_104 |
| PubMedID: 21961051 |
| Title : The antipsychotic potential of muscarinic allosteric modulation - Bridges_2010_Drug.News.Perspect_23_229 |
| Author(s) : Bridges TM , LeBois EP , Hopkins CR , Wood MR , Jones CK , Conn PJ , Lindsley CW |
| Ref : Drug News Perspect , 23 :229 , 2010 |
| Abstract : |
| PubMedSearch : Bridges_2010_Drug.News.Perspect_23_229 |
| PubMedID: 20520852 |
| Title : Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins - Bridges_2009_J.Med.Chem_52_3445 |
| Author(s) : Bridges TM , Marlo JE , Niswender CM , Jones CK , Jadhav SB , Gentry PR , Plumley HC , Weaver CD , Conn PJ , Lindsley CW |
| Ref : Journal of Medicinal Chemistry , 52 :3445 , 2009 |
| Abstract : |
| PubMedSearch : Bridges_2009_J.Med.Chem_52_3445 |
| PubMedID: 19438238 |
| Title : Discovery and development of a potent and highly selective small molecule muscarinic acetylcholine receptor subtype I (mAChR 1 or M1) antagonist in vitro and in vivo probe - Weaver_2009_Curr.Top.Med.Chem_9_1217 |
| Author(s) : Weaver CD , Sheffler DJ , Lewis LM , Bridges TM , Williams R , Nalywajko NT , Kennedy JP , Mulder MM , Jadhav S , Aldrich LA , Jones CK , Marlo JE , Niswender CM , Mock MM , Zheng F , Conn PJ , Lindsley CW |
| Ref : Curr Top Med Chem , 9 :1217 , 2009 |
| Abstract : |
| PubMedSearch : Weaver_2009_Curr.Top.Med.Chem_9_1217 |
| PubMedID: 19807667 |
| Title : Subtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders - Conn_2009_Trends.Pharmacol.Sci_30_148 |
| Author(s) : Conn PJ , Jones CK , Lindsley CW |
| Ref : Trends in Pharmacological Sciences , 30 :148 , 2009 |
| Abstract : |
| PubMedSearch : Conn_2009_Trends.Pharmacol.Sci_30_148 |
| PubMedID: 19201489 |
| Title : A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning - Sheffler_2009_Mol.Pharmacol_76_356 |
| Author(s) : Sheffler DJ , Williams R , Bridges TM , Xiang Z , Kane AS , Byun NE , Jadhav S , Mock MM , Zheng F , Lewis LM , Jones CK , Niswender CM , Weaver CD , Lindsley CW , Conn PJ |
| Ref : Molecular Pharmacology , 76 :356 , 2009 |
| Abstract : |
| PubMedSearch : Sheffler_2009_Mol.Pharmacol_76_356 |
| PubMedID: 19407080 |
| Title : Synthesis and structure-activity relationships of allosteric potentiators of the m(4) muscarinic acetylcholine receptor - |
| Author(s) : Kennedy JP , Bridges TM , Gentry PR , Brogan JT , Kane AS , Jones CK , Brady AE , Shirey JK , Conn PJ , Lindsley CW |
| Ref : ChemMedChem , 4 :1600 , 2009 |
| PubMedID: 19705385 |
| Title : Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats - Brady_2008_J.Pharmacol.Exp.Ther_327_941 |
| Author(s) : Brady AE , Jones CK , Bridges TM , Kennedy JP , Thompson AD , Heiman JU , Breininger ML , Gentry PR , Yin H , Jadhav SB , Shirey JK , Conn PJ , Lindsley CW |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 327 :941 , 2008 |
| Abstract : |
| PubMedSearch : Brady_2008_J.Pharmacol.Exp.Ther_327_941 |
| PubMedID: 18772318 |
| Title : Synthesis and SAR of analogues of the M1 allosteric agonist TBPB. Part I: Exploration of alternative benzyl and privileged structure moieties - Bridges_2008_Bioorg.Med.Chem.Lett_18_5439 |
| Author(s) : Bridges TM , Brady AE , Kennedy JP , Daniels RN , Miller NR , Kim K , Breininger ML , Gentry PR , Brogan JT , Jones CK , Conn PJ , Lindsley CW |
| Ref : Bioorganic & Medicinal Chemistry Lett , 18 :5439 , 2008 |
| Abstract : |
| PubMedSearch : Bridges_2008_Bioorg.Med.Chem.Lett_18_5439 |
| PubMedID: 18805692 |
| Title : Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats - Jones_2008_J.Neurosci_28_10422 |
| Author(s) : Jones CK , Brady AE , Davis AA , Xiang Z , Bubser M , Tantawy MN , Kane AS , Bridges TM , Kennedy JP , Bradley SR , Peterson TE , Ansari MS , Baldwin RM , Kessler RM , Deutch AY , Lah JJ , Levey AI , Lindsley CW , Conn PJ |
| Ref : Journal of Neuroscience , 28 :10422 , 2008 |
| Abstract : |
| PubMedSearch : Jones_2008_J.Neurosci_28_10422 |
| PubMedID: 18842902 |
| Title : Pharmacologic interactions between the muscarinic cholinergic and dopaminergic systems in the modulation of prepulse inhibition in rats - Jones_2005_J.Pharmacol.Exp.Ther_312_1055 |
| Author(s) : Jones CK , Eberle EL , Shaw DB , McKinzie DL , Shannon HE |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 312 :1055 , 2005 |
| Abstract : |
| PubMedSearch : Jones_2005_J.Pharmacol.Exp.Ther_312_1055 |
| PubMedID: 15574685 |
| Title : Antihyperalgesic effects of the muscarinic receptor ligand vedaclidine in models involving central sensitization in rats - Shannon_2001_Pain_93_221 |
| Author(s) : Shannon HE , Jones CK , Li DL , Peters SC , Simmons RM , Iyengar S |
| Ref : Pain , 93 :221 , 2001 |
| Abstract : |
| PubMedSearch : Shannon_2001_Pain_93_221 |
| PubMedID: 11514081 |
| Title : Muscarinic cholinergic modulation of prepulse inhibition of the acoustic startle reflex - Jones_2000_J.Pharmacol.Exp.Ther_294_1017 |
| Author(s) : Jones CK , Shannon HE |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 294 :1017 , 2000 |
| Abstract : |
| PubMedSearch : Jones_2000_J.Pharmacol.Exp.Ther_294_1017 |
| PubMedID: 10945854 |
| Title : Effects of scopolamine in comparison with apomorphine and phencyclidine on prepulse inhibition in rats - Jones_2000_Eur.J.Pharmacol_391_105 |
| Author(s) : Jones CK , Shannon HE |
| Ref : European Journal of Pharmacology , 391 :105 , 2000 |
| Abstract : |
| PubMedSearch : Jones_2000_Eur.J.Pharmacol_391_105 |
| PubMedID: 10720641 |
| Title : Studies of the toxicity and of the enzyme kinelics of ethyl p-nitrophenyl thionobenzene phosphonate (EPN) - |
| Author(s) : Hodge HC , Maynard EA , Hurwitz L , Distefano V , Downs WL , Jones CK , Blanchet HJ, Jr. |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 112 :29 , 1954 |
| PubMedID: |